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Does Palliative Care Utilization Facilitate Conversion to Hospice Care? A Qualitative Study of the "Soft No".

Spencer KL, Mrig EH, Talaie AK.

Am J Hosp Palliat Care. 2020 Jan 23:1049909119900640. doi: 10.1177/1049909119900640. [Epub ahead of print]


Time to Surgery Following Short-Course Radiotherapy in Rectal Cancer and its Impact on Postoperative Outcomes. A Population-Based Study Across the English National Health Service, 2009-2014.

Levick BA, Gilbert AJ, Spencer KL, Downing A, Taylor JC, Finan PJ, Sebag-Montefiore DJ, Morris EJA.

Clin Oncol (R Coll Radiol). 2020 Feb;32(2):e46-e52. doi: 10.1016/j.clon.2019.08.008. Epub 2019 Aug 30.


Potential contamination of the coastal zone by eroding historic landfills.

Brand JH, Spencer KL.

Mar Pollut Bull. 2019 Sep;146:282-291. doi: 10.1016/j.marpolbul.2019.06.017. Epub 2019 Jun 20.


Systematic Review of the Role of Stereotactic Radiotherapy for Bone Metastases.

Spencer KL, van der Velden JM, Wong E, Seravalli E, Sahgal A, Chow E, Verlaan JJ, Verkooijen HM, van der Linden YM.

J Natl Cancer Inst. 2019 Oct 1;111(10):1023-1032. doi: 10.1093/jnci/djz101.


Sediment structure and physicochemical changes following tidal inundation at a large open coast managed realignment site.

Dale J, Cundy AB, Spencer KL, Carr SJ, Croudace IW, Burgess HM, Nash DJ.

Sci Total Environ. 2019 Apr 10;660:1419-1432. doi: 10.1016/j.scitotenv.2018.12.323. Epub 2018 Dec 28.


The Impact of Metal-Rich Sediments Derived from Mining on Freshwater Stream Life.

Jones JI, Murphy JF, Collins AL, Spencer KL, Rainbow PS, Arnold A, Pretty JL, Moorhouse AML, Aguilera V, Edwards P, Parsonage F, Potter H, Whitehouse P.

Rev Environ Contam Toxicol. 2020;248:111-189. doi: 10.1007/398_2018_21.


Surgery or radiotherapy for stage I lung cancer? An intention-to-treat analysis.

Spencer KL, Kennedy MPT, Lummis KL, Ellames DAB, Snee M, Brunelli A, Franks K, Callister MEJ.

Eur Respir J. 2019 Jun 20;53(6). pii: 1801568. doi: 10.1183/13993003.01568-2018. Print 2019 Jun.


The contaminant legacy from historic coastal landfills and their potential as sources of diffuse pollution.

O'Shea FT, Cundy AB, Spencer KL.

Mar Pollut Bull. 2018 Mar;128:446-455. doi: 10.1016/j.marpolbul.2017.12.047. Epub 2018 Feb 6.


Transforming Patient Compliance Research in an Era of Biomedicalization.

Spencer KL.

J Health Soc Behav. 2018 Jun;59(2):170-184. doi: 10.1177/0022146518756860. Epub 2018 Feb 14.


Political economy of hope as a cultural facet of biomedicalization: A qualitative examination of constraints to hospice utilization among U.S. end-stage cancer patients.

Mrig EH, Spencer KL.

Soc Sci Med. 2018 Mar;200:107-113. doi: 10.1016/j.socscimed.2018.01.033. Epub 2018 Jan 28.


Unravelling metal mobility under complex contaminant signatures.

de Souza Machado AA, Spencer KL, Zarfl C, O'Shea FT.

Sci Total Environ. 2018 May 1;622-623:373-384. doi: 10.1016/j.scitotenv.2017.11.239. Epub 2017 Dec 13.


Quantifying the Structure and Composition of Flocculated Suspended Particulate Matter Using Focused Ion Beam Nanotomography.

Wheatland JAT, Bushby AJ, Spencer KL.

Environ Sci Technol. 2017 Aug 15;51(16):8917-8925. doi: 10.1021/acs.est.7b00770. Epub 2017 Jul 24.


The impact of pre-restoration land-use and disturbance on sediment structure, hydrology and the sediment geochemical environment in restored saltmarshes.

Spencer KL, Carr SJ, Diggens LM, Tempest JA, Morris MA, Harvey GL.

Sci Total Environ. 2017 Jun 1;587-588:47-58. doi: 10.1016/j.scitotenv.2016.11.032. Epub 2017 Feb 16.


Fluoride in the diet of 2-years-old children.

Martinez-Mier EA, Spencer KL, Sanders BJ, Jones JE, Soto-Rojas AE, Tomlin AM, Vinson LA, Weddell JA, Eckert GJ.

Community Dent Oral Epidemiol. 2017 Jun;45(3):251-257. doi: 10.1111/cdoe.12283. Epub 2017 Feb 1.


The effects of sulfur amendments on the geochemistry of sulfur, phosphorus and iron in the mangrove plant (Kandelia obovata (S. L.)) rhizosphere.

Jian L, Junyi Y, Jingchun L, Chongling Y, Haoliang L, Spencer KL.

Mar Pollut Bull. 2017 Jan 30;114(2):733-741. doi: 10.1016/j.marpolbul.2016.10.070. Epub 2016 Nov 3.


What is the future of research on medical decision making? (And is it bright?): A response to Drewniak and colleagues.

Spencer KL.

Soc Sci Med. 2016 Nov;168:175-177. doi: 10.1016/j.socscimed.2016.09.017. Epub 2016 Sep 10. No abstract available.


Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study.

Restrepo NA, Spencer KL, Goodloe R, Garrett TA, Heiss G, Bůžková P, Jorgensen N, Jensen RA, Matise TC, Hindorff LA, Klein BE, Klein R, Wong TY, Cheng CY, Cornes BK, Tai ES, Ritchie MD, Haines JL, Crawford DC.

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6839-50. doi: 10.1167/iovs.14-14246.


Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.

Carlson CS, Matise TC, North KE, Haiman CA, Fesinmeyer MD, Buyske S, Schumacher FR, Peters U, Franceschini N, Ritchie MD, Duggan DJ, Spencer KL, Dumitrescu L, Eaton CB, Thomas F, Young A, Carty C, Heiss G, Le Marchand L, Crawford DC, Hindorff LA, Kooperberg CL; PAGE Consortium.

PLoS Biol. 2013 Sep;11(9):e1001661. doi: 10.1371/journal.pbio.1001661. Epub 2013 Sep 17.


Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.

Fesinmeyer MD, Meigs JB, North KE, Schumacher FR, Bůžková P, Franceschini N, Haessler J, Goodloe R, Spencer KL, Voruganti VS, Howard BV, Jackson R, Kolonel LN, Liu S, Manson JE, Monroe KR, Mukamal K, Dilks HH, Pendergrass SA, Nato A, Wan P, Wilkens LR, Le Marchand L, Ambite JL, Buyske S, Florez JC, Crawford DC, Hindorff LA, Haiman CA, Peters U, Pankow JS.

BMC Med Genet. 2013 Sep 25;14:98. doi: 10.1186/1471-2350-14-98.


Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study.

Zhang L, Spencer KL, Voruganti VS, Jorgensen NW, Fornage M, Best LG, Brown-Gentry KD, Cole SA, Crawford DC, Deelman E, Franceschini N, Gaffo AL, Glenn KR, Heiss G, Jenny NS, Kottgen A, Li Q, Liu K, Matise TC, North KE, Umans JG, Kao WH.

Am J Epidemiol. 2013 May 1;177(9):923-32. doi: 10.1093/aje/kws330. Epub 2013 Apr 3.


Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study.

Carty CL, Spencer KL, Setiawan VW, Fernandez-Rhodes L, Malinowski J, Buyske S, Young A, Jorgensen NW, Cheng I, Carlson CS, Brown-Gentry K, Goodloe R, Park A, Parikh NI, Henderson B, Le Marchand L, Wactawski-Wende J, Fornage M, Matise TC, Hindorff LA, Arnold AM, Haiman CA, Franceschini N, Peters U, Crawford DC.

Hum Reprod. 2013 Jun;28(6):1695-706. doi: 10.1093/humrep/det071. Epub 2013 Mar 18.


Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.

Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L, Chunyuanwu, Matise TC, Carlson CS, Brennan K, Park A, Rajkovic A, Hindorff LA, Buyske S, Crawford DC.

PLoS One. 2013;8(2):e55258. doi: 10.1371/journal.pone.0055258. Epub 2013 Feb 12.


Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study.

Bush WS, Boston J, Pendergrass SA, Dumitrescu L, Goodloe R, Brown-Gentry K, Wilson S, McClellan B, Torstenson E, Basford MA, Spencer KL, Ritchie MD, Crawford DC.

Pac Symp Biocomput. 2013:373-84.


Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Blake JF, Xu R, Bencsik JR, Xiao D, Kallan NC, Schlachter S, Mitchell IS, Spencer KL, Banka AL, Wallace EM, Gloor SL, Martinson M, Woessner RD, Vigers GP, Brandhuber BJ, Liang J, Safina BS, Li J, Zhang B, Chabot C, Do S, Lee L, Oeh J, Sampath D, Lee BB, Lin K, Liederer BM, Skelton NJ.

J Med Chem. 2012 Sep 27;55(18):8110-27. Epub 2012 Sep 18.


Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium.

Haiman CA, Fesinmeyer MD, Spencer KL, Buzková P, Voruganti VS, Wan P, Haessler J, Franceschini N, Monroe KR, Howard BV, Jackson RD, Florez JC, Kolonel LN, Buyske S, Goodloe RJ, Liu S, Manson JE, Meigs JB, Waters K, Mukamal KJ, Pendergrass SA, Shrader P, Wilkens LR, Hindorff LA, Ambite JL, North KE, Peters U, Crawford DC, Le Marchand L, Pankow JS.

Diabetes. 2012 Jun;61(6):1642-7. doi: 10.2337/db11-1296. Epub 2012 Apr 3.


Population differences in genetic risk for age-related macular degeneration and implications for genetic testing.

Spencer KL, Glenn K, Brown-Gentry K, Haines JL, Crawford DC.

Arch Ophthalmol. 2012 Jan;130(1):116-7. doi: 10.1001/archopthalmol.2011.1370. No abstract available.


Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration.

Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Agarwal A, Iannaccone A, Kritchevsky SB, Garcia M, Nalls MA, Newman AB, Scott WK, Pericak-Vance MA, Haines JL.

PLoS One. 2011 Mar 24;6(3):e17784. doi: 10.1371/journal.pone.0017784.


Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Xu R, Banka A, Blake JF, Mitchell IS, Wallace EM, Bencsik JR, Kallan NC, Spencer KL, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2335-40. doi: 10.1016/j.bmcl.2011.02.098. Epub 2011 Feb 26.


A novel tracer technique for the assessment of fine sediment dynamics in urban water management systems.

Spencer KL, Droppo IG, He C, Grapentine L, Exall K.

Water Res. 2011 Apr;45(8):2595-606. doi: 10.1016/j.watres.2011.02.012. Epub 2011 Feb 18.


Discovery and SAR of spirochromane Akt inhibitors.

Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2410-4. doi: 10.1016/j.bmcl.2011.02.073. Epub 2011 Feb 18.


Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.

Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Wang G, Scott WK, Agarwal A, Jakobsdottir J, Conley Y, Weeks DE, Gorin MB, Pericak-Vance MA, Haines JL.

Invest Ophthalmol Vis Sci. 2011 Mar 28;52(3):1748-54. doi: 10.1167/iovs.09-5112. Print 2011 Mar.


Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.

Bencsik JR, Xiao D, Blake JF, Kallan NC, Mitchell IS, Spencer KL, Xu R, Gloor SL, Martinson M, Risom T, Woessner RD, Dizon F, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ, Prior WW, Murray LJ.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):7037-41. doi: 10.1016/j.bmcl.2010.09.112. Epub 2010 Sep 29.


Discovery of pyrrolopyrimidine inhibitors of Akt.

Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5607-12. doi: 10.1016/j.bmcl.2010.08.053. Epub 2010 Aug 13.


The distribution of acid-volatile sulfide and simultaneously extracted metals in sediments from a mangrove forest and adjacent mudflat in Zhangjiang Estuary, China.

Jingchun L, Chongling Y, Spencer KL, Ruifeng Z, Haoliang L.

Mar Pollut Bull. 2010 Aug;60(8):1209-16. doi: 10.1016/j.marpolbul.2010.03.029.


Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.

Wang G, Spencer KL, Scott WK, Whitehead P, Court BL, Ayala-Haedo J, Mayo P, Schwartz SG, Kovach JL, Gallins P, Polk M, Agarwal A, Postel EA, Haines JL, Pericak-Vance MA.

Hum Genet. 2010 Mar;127(5):595-602. doi: 10.1007/s00439-010-0805-8. Epub 2010 Feb 25.


Use of principal components analysis (PCA) on estuarine sediment datasets: the effect of data pre-treatment.

Reid MK, Spencer KL.

Environ Pollut. 2009 Aug-Sep;157(8-9):2275-81. doi: 10.1016/j.envpol.2009.03.033. Epub 2009 May 1.


Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria.

Wang G, Spencer KL, Court BL, Olson LM, Scott WK, Haines JL, Pericak-Vance MA.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3084-90. doi: 10.1167/iovs.08-3240. Epub 2009 Feb 28.


C3 R102G polymorphism increases risk of age-related macular degeneration.

Spencer KL, Olson LM, Anderson BM, Schnetz-Boutaud N, Scott WK, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Hum Mol Genet. 2008 Jun 15;17(12):1821-4. doi: 10.1093/hmg/ddn075. Epub 2008 Mar 6.


Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration.

Spencer KL, Hauser MA, Olson LM, Schmidt S, Scott WK, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Hum Mol Genet. 2008 Apr 1;17(7):971-7. Epub 2007 Dec 15.


Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration.

Spencer KL, Hauser MA, Olson LM, Schnetz-Boutaud N, Scott WK, Schmidt S, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4277-83.


Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.

Spencer KL, Hauser MA, Olson LM, Schmidt S, Scott WK, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Hum Mol Genet. 2007 Aug 15;16(16):1986-92. Epub 2007 Jun 18.


Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration.

Scott WK, Schmidt S, Hauser MA, Gallins P, Schnetz-Boutaud N, Spencer KL, Gilbert JR, Agarwal A, Postel EA, Haines JL, Pericak-Vance MA.

Ophthalmology. 2007 Jun;114(6):1151-6. Epub 2007 Jan 22.


3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.

Fraley ME, Steen JT, Brnardic EJ, Arrington KL, Spencer KL, Hanney BA, Kim Y, Hartman GD, Stirdivant SM, Drakas BA, Rickert K, Walsh ES, Hamilton K, Buser CA, Hardwick J, Tao W, Beck SC, Mao X, Lobell RB, Sepp-Lorenzino L, Yan Y, Ikuta M, Munshi SK, Kuo LC, Kreatsoulas C.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6049-53. Epub 2006 Sep 15.


Source and distribution of trace metals in the Medway and Swale estuaries, Kent, UK.

Spencer KL, MacLeod CL, Tuckett A, Johnson SM.

Mar Pollut Bull. 2006 Feb;52(2):226-31. Epub 2005 Dec 6. No abstract available.


Potential impacts of water injection dredging on water quality and ecotoxicity in Limehouse Basin, River Thames, SE England, UK.

Spencer KL, Dewhurst RE, Penna P.

Chemosphere. 2006 Apr;63(3):509-21. Epub 2005 Nov 3.


Will loss of snow cover during climatic warming expose New Zealand alpine plants to increased frost damage?

Bannister P, Maegli T, Dickinson KJ, Halloy SR, Knight A, Lord JM, Mark AF, Spencer KL.

Oecologia. 2005 Jun;144(2):245-56. Epub 2005 May 11.


Complement factor H variant increases the risk of age-related macular degeneration.

Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Pericak-Vance MA.

Science. 2005 Apr 15;308(5720):419-21. Epub 2005 Mar 10.


Bringing end-of-life care out of the shadows.

Rushton CH, Spencer KL, Johanson W.

Holist Nurs Pract. 2004 Nov-Dec;18(6):313-7. Review.


The Nurse Manager Academy: an innovative approach to managerial competency development.

Maguire MP, Spencer KL, Sabatier KH.

Nurs Leadersh Forum. 2004 Summer;8(4):133-7. Review.


Bringing end-of-life care out of the shadows.

Rushton CH, Spencer KL, Johanson W.

Nurs Manage. 2004 Mar;35(3):34, 36-40. Review.


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