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Discovery of New and Potent InhA Inhibitors as Anti-tuberculosis Agents: Structure Based Virtual Screening Validated by Biological Assays and X-ray Crystallography.

Kamsri P, Hanwarinroj C, Phusi N, Pornprom T, Chayajarus K, Punkvang A, Suttipanta N, Srimanote P, Suttisintong K, Songsiriritthigul C, Saparpakorn P, Hannongbua S, Rattanabunyong S, Seetaha S, Choowongkomon K, Sureram S, Kittakoop P, Hongmanee P, Santanirand P, Chen Z, Zhu W, Blood RA, Takebayashi Y, Hinchliffe P, Mulholland AJ, Spencer J, Pungpo P.

J Chem Inf Model. 2019 Dec 10. doi: 10.1021/acs.jcim.9b00918. [Epub ahead of print]


Testing Luminescence Dating Methods for Small Samples from Very Young Fluvial Deposits.

Spencer JQG, Huot S, Archer AW, Caldas MM.

Methods Protoc. 2019 Dec 6;2(4). pii: E90. doi: 10.3390/mps2040090.


Bile salt metabolism is not the only factor contributing to Clostridioides (Clostridium) difficile disease severity in the murine model of disease.

Jukes CA, Ijaz UZ, Buckley A, Spencer J, Irvine J, Candlish D, Li JV, Marchesi JR, Douce G.

Gut Microbes. 2019 Dec 2:1-16. doi: 10.1080/19490976.2019.1678996. [Epub ahead of print]


Who Let the Dogs Out? A Plea for Official Guidelines on Service Animals in the Teaching Laboratory.

Hammett AJM, Spencer JV.

J Microbiol Biol Educ. 2019 Oct 31;20(3). pii: 20.3.48. doi: 10.1128/jmbe.v20i3.1861. eCollection 2019.


Dietary Patterns and Risk of Obesity and Early Childhood Caries in Australian Toddlers: Findings from an Australian Cohort Study.

Bell LK, Schammer C, Devenish G, Ha D, Thomson MW, Spencer JA, Do LG, Scott JA, Golley RK.

Nutrients. 2019 Nov 19;11(11). pii: E2828. doi: 10.3390/nu11112828.


Two Loci, RiAF3 and RiAF4, Contribute to the Annual-Fruiting Trait in Rubus.

Jibran R, Spencer J, Fernandez G, Monfort A, Mnejja M, Dzierzon H, Tahir J, Davies K, Chagné D, Foster TM.

Front Plant Sci. 2019 Oct 25;10:1341. doi: 10.3389/fpls.2019.01341. eCollection 2019.


Sneddon syndrome associated with two novel ADA2 gene mutations.

Tull TJ, Martin B, Spencer J, Sangle S, Chua S, McGrath JA, D'Cruz DP, McGibbon DH.

Rheumatology (Oxford). 2019 Oct 25. pii: kez446. doi: 10.1093/rheumatology/kez446. [Epub ahead of print] No abstract available.


A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

Bauer MR, Jones RN, Tareque RK, Springett B, Dingler FA, Verduci L, Patel KJ, Fersht AR, Joerger AC, Spencer J.

Future Med Chem. 2019 Oct;11(19):2491-2504. doi: 10.4155/fmc-2019-0181.


Short communication: Reproduction outcomes in dairy heifers following a 14-d progesterone insert presynchronization protocol.

Claypool CK, Spencer JA, Zoca SM, Shafii B, Price WJ, Ahmadzadeh A, Rimbey NR, Dalton JC.

J Dairy Sci. 2019 Dec;102(12):11730-11735. doi: 10.3168/jds.2019-17000. Epub 2019 Oct 16.


In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations.

Kamsri P, Punkvang A, Hannongbua S, Suttisintong K, Kittakoop P, Spencer J, Mulholland AJ, Pungpo P.

SAR QSAR Environ Res. 2019 Nov;30(11):775-800. doi: 10.1080/1062936X.2019.1658218.


Employment changes following breast cancer diagnosis: the effects of race and place.

Spencer JC, Rotter JS, Eberth JM, Zahnd WE, Vanderpool RC, Ko LK, Davis MM, Troester MA, Olshan AF, Wheeler SB.

J Natl Cancer Inst. 2019 Oct 10. pii: djz197. doi: 10.1093/jnci/djz197. [Epub ahead of print]


Ethics of Artificial Intelligence in Radiology: Summary of the Joint European and North American Multisociety Statement.

Geis JR, Brady AP, Wu CC, Spencer J, Ranschaert E, Jaremko JL, Langer SG, Kitts AB, Birch J, Shields WF, van den Hoven van Genderen R, Kotter E, Gichoya JW, Cook TS, Morgan MB, Tang A, Safdar NM, Kohli M.

Can Assoc Radiol J. 2019 Nov;70(4):329-334. doi: 10.1016/j.carj.2019.08.010. Epub 2019 Oct 1.


Ethics of Artificial Intelligence in Radiology: Summary of the Joint European and North American Multisociety Statement.

Geis JR, Brady AP, Wu CC, Spencer J, Ranschaert E, Jaremko JL, Langer SG, Kitts AB, Birch J, Shields WF, van den Hoven van Genderen R, Kotter E, Gichoya JW, Cook TS, Morgan MB, Tang A, Safdar NM, Kohli M.

J Am Coll Radiol. 2019 Nov;16(11):1516-1521. doi: 10.1016/j.jacr.2019.07.028. Epub 2019 Oct 1.


Chan-Vese Reformulation for Selective Image Segmentation.

Roberts M, Spencer J.

J Math Imaging Vis. 2019;61(8):1173-1196. doi: 10.1007/s10851-019-00893-0. Epub 2019 Aug 5.


Ethics of Artificial Intelligence in Radiology: Summary of the Joint European and North American Multisociety Statement.

Geis JR, Brady AP, Wu CC, Spencer J, Ranschaert E, Jaremko JL, Langer SG, Borondy Kitts A, Birch J, Shields WF, van den Hoven van Genderen R, Kotter E, Wawira Gichoya J, Cook TS, Morgan MB, Tang A, Safdar NM, Kohli M.

Radiology. 2019 Nov;293(2):436-440. doi: 10.1148/radiol.2019191586. Epub 2019 Oct 1.


Ethics of artificial intelligence in radiology: summary of the joint European and North American multisociety statement.

Geis JR, Brady A, Wu CC, Spencer J, Ranschaert E, Jaremko JL, Langer SG, Kitts AB, Birch J, Shields WF, van den Hoven van Genderen R, Kotter E, Gichoya JW, Cook TS, Morgan MB, Tang A, Safdar NM, Kohli M.

Insights Imaging. 2019 Oct 1;10(1):101. doi: 10.1186/s13244-019-0785-8.


Racial differences in employment and cost-management behaviors in patients with metastatic breast cancer.

Samuel CA, Spencer JC, Rosenstein DL, Reeder-Hayes KE, Manning ML, Sellers JB, Wheeler SB.

Breast Cancer Res Treat. 2019 Sep 25. doi: 10.1007/s10549-019-05449-9. [Epub ahead of print]


Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.

Lohans CT, Freeman EI, Groesen EV, Tooke CL, Hinchliffe P, Spencer J, Brem J, Schofield CJ.

Sci Rep. 2019 Sep 20;9(1):13608. doi: 10.1038/s41598-019-49264-0.


Assessment of behaviour in groups of zebrafish (Danio rerio) using an intelligent software monitoring tool, the chromatic fish analyser.

Thomson JS, Al-Temeemy AA, Isted H, Spencer JW, Sneddon LU.

J Neurosci Methods. 2019 Dec 1;328:108433. doi: 10.1016/j.jneumeth.2019.108433. Epub 2019 Sep 11. Review.


Identification and characterization of OmpT-like proteases in uropathogenic Escherichia coli clinical isolates.

Desloges I, Taylor JA, Leclerc JM, Brannon JR, Portt A, Spencer JD, Dewar K, Marczynski GT, Manges A, Gruenheid S, Le Moual H, Thomassin JL.

Microbiologyopen. 2019 Nov;8(11):e915. doi: 10.1002/mbo3.915. Epub 2019 Sep 8.


Health Status and Access to Care for the North Carolina Medicaid Gap Population.

Spencer JC, Gertner AK, Silberman PJ.

N C Med J. 2019 Sep-Oct;80(5):269-275. doi: 10.18043/ncm.80.5.269.


A contingency management intervention to reduce cannabis use and time to relapse in early psychosis: the CIRCLE RCT.

Johnson S, Rains LS, Marwaha S, Strang J, Craig T, Weaver T, McCrone P, King M, Fowler D, Pilling S, Marston L, Omar RZ, Craig M, Spencer J, Hinton M.

Health Technol Assess. 2019 Aug;23(45):1-108. doi: 10.3310/hta23450.


Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.

Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ.

J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16.


Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children.

Curtis SW, Terrell ML, Jacobson MH, Cobb DO, Jiang VS, Neblett MF, Gerkowicz SA, Spencer JB, Marder ME, Barr DB, Conneely KN, Smith AK, Marcus M.

Environ Health. 2019 Aug 23;18(1):75. doi: 10.1186/s12940-019-0509-z.


Putting patients first: an inventive service delivering cancer treatment at home.

Yip F, Zavery B, Poulter-Clark H, Spencer J.

J Comp Eff Res. 2019 Sep;8(12):951-960. doi: 10.2217/cer-2019-0038. Epub 2019 Aug 23.


Composition and content of phenolic acids and avenanthramides in commercial oat products: Are oats an important polyphenol source for consumers?

Soycan G, Schär MY, Kristek A, Boberska J, Alsharif SNS, Corona G, Shewry PR, Spencer JPE.

Food Chem X. 2019 Jul 4;3:100047. doi: 10.1016/j.fochx.2019.100047. eCollection 2019 Sep 30.


Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial.

Sheridan Rains L, Marston L, Hinton M, Marwaha S, Craig T, Fowler D, King M, Omar RZ, McCrone P, Spencer J, Taylor J, Colman S, Harder C, Gilbert E, Randhawa A, Labuschagne K, Jones C, Stefanidou T, Christoforou M, Craig M, Strang J, Weaver T, Johnson S.

BMC Med. 2019 Aug 15;17(1):161. doi: 10.1186/s12916-019-1395-5.


Imaging rRNA Methylation in Bacteria by MR-FISH.

Ganzinger KA, Challand MR, Spencer J, Klenerman D, Ranasinghe RT.

Methods Mol Biol. 2019;2038:89-107. doi: 10.1007/978-1-4939-9674-2_7.


Emergent threats: lessons learnt from Ebola.

Piot P, Soka MJ, Spencer J.

Int Health. 2019 Sep 2;11(5):334-337. doi: 10.1093/inthealth/ihz062.


Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.

Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00564-19. doi: 10.1128/AAC.00564-19. Print 2019 Oct.


An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases.

Hirvonen VHA, Hammond K, Chudyk EI, Limb MAL, Spencer J, Mulholland AJ, van der Kamp MW.

J Chem Inf Model. 2019 Aug 26;59(8):3365-3369. doi: 10.1021/acs.jcim.9b00442. Epub 2019 Aug 7.


Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance.

Jove M, Spencer J, Clench M, Loadman PM, Twelves C.

Crit Rev Oncol Hematol. 2019 Sep;141:153-162. doi: 10.1016/j.critrevonc.2019.06.008. Epub 2019 Jul 5. Review.


Infertility among African American women with systemic lupus erythematosus compared to healthy women: A pilot study.

Angley M, Lim SS, Spencer JB, Howards PP.

Arthritis Care Res (Hoboken). 2019 Jul 8. doi: 10.1002/acr.24022. [Epub ahead of print]


The Molecular Basis of Antibiotic Action and Resistance.

Maxwell A, Dowson CG, Spencer J.

J Mol Biol. 2019 Aug 23;431(18):3367-3369. doi: 10.1016/j.jmb.2019.06.018. Epub 2019 Jun 29. No abstract available.


Cost-effectiveness of endoscopic ultrasound-directed transgastric ERCP compared with device-assisted and laparoscopic-assisted ERCP in patients with Roux-en-Y anatomy.

James HJ, James TW, Wheeler SB, Spencer JC, Baron TH.

Endoscopy. 2019 Nov;51(11):1051-1058. doi: 10.1055/a-0938-3918. Epub 2019 Jun 26.


Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.

Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD.

J Am Soc Nephrol. 2019 Aug;30(8):1385-1397. doi: 10.1681/ASN.2018090929. Epub 2019 Jun 25.


Automated monitoring of behaviour in zebrafish after invasive procedures.

Deakin AG, Buckley J, AlZu'bi HS, Cossins AR, Spencer JW, Al'Nuaimy W, Young IS, Thomson JS, Sneddon LU.

Sci Rep. 2019 Jun 21;9(1):9042. doi: 10.1038/s41598-019-45464-w.


Innate immunity and urinary tract infection.

Ching C, Schwartz L, Spencer JD, Becknell B.

Pediatr Nephrol. 2019 Jun 13. doi: 10.1007/s00467-019-04269-9. [Epub ahead of print]


Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models.

Jove M, Spencer JA, Hubbard ME, Holden EC, O'Dea RD, Brook BS, Phillips RM, Smye SW, Loadman PM, Twelves CJ.

J Pharmacol Exp Ther. 2019 Aug;370(2):242-251. doi: 10.1124/jpet.119.256693. Epub 2019 Jun 12.


Polybrominated Biphenyl Exposure and Menstrual Cycle Function.

Howards PP, Terrell ML, Jacobson MH, Taylor KC, Kesner JS, Meadows JW, Spencer JB, Manatunga AK, Marcus M.

Epidemiology. 2019 Sep;30(5):687-694. doi: 10.1097/EDE.0000000000001045.


Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.


Synthesis and Study of Multifunctional Cyclodextrin-Deferasirox Hybrids.

Gascon JM, Oliveri V, McGown A, Kaya E, Chen YL, Austin C, Walker M, Platt FM, Vecchio G, Spencer J.

ChemMedChem. 2019 Aug 20;14(16):1484-1492. doi: 10.1002/cmdc.201900334. Epub 2019 Jun 24.


Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.

Spencer J, Hunt SL, Zhang C, Walter C, Everist B.

Skeletal Radiol. 2019 Dec;48(12):1891-1898. doi: 10.1007/s00256-019-03221-0. Epub 2019 May 27.


Prefrontal cortex activation supports the emergence of early stone age toolmaking skill.

Putt SSJ, Wijeakumar S, Spencer JP.

Neuroimage. 2019 Oct 1;199:57-69. doi: 10.1016/j.neuroimage.2019.05.056. Epub 2019 May 22.


Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.

Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B.

Sci Rep. 2019 May 23;9(1):7753. doi: 10.1038/s41598-019-44219-x.


Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures.

Mascal M, Hafezi N, Wang D, Hu Y, Serra G, Dallas ML, Spencer JPE.

Sci Rep. 2019 May 23;9(1):7778. doi: 10.1038/s41598-019-44056-y.


Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt object.

Stern SA, Weaver HA, Spencer JR, Olkin CB, Gladstone GR, Grundy WM, Moore JM, Cruikshank DP, Elliott HA, McKinnon WB, Parker JW, Verbiscer AJ, Young LA, Aguilar DA, Albers JM, Andert T, Andrews JP, Bagenal F, Banks ME, Bauer BA, Bauman JA, Bechtold KE, Beddingfield CB, Behrooz N, Beisser KB, Benecchi SD, Bernardoni E, Beyer RA, Bhaskaran S, Bierson CJ, Binzel RP, Birath EM, Bird MK, Boone DR, Bowman AF, Bray VJ, Britt DT, Brown LE, Buckley MR, Buie MW, Buratti BJ, Burke LM, Bushman SS, Carcich B, Chaikin AL, Chavez CL, Cheng AF, Colwell EJ, Conard SJ, Conner MP, Conrad CA, Cook JC, Cooper SB, Custodio OS, Dalle Ore CM, Deboy CC, Dharmavaram P, Dhingra RD, Dunn GF, Earle AM, Egan AF, Eisig J, El-Maarry MR, Engelbrecht C, Enke BL, Ercol CJ, Fattig ED, Ferrell CL, Finley TJ, Firer J, Fischetti J, Folkner WM, Fosbury MN, Fountain GH, Freeze JM, Gabasova L, Glaze LS, Green JL, Griffith GA, Guo Y, Hahn M, Hals DW, Hamilton DP, Hamilton SA, Hanley JJ, Harch A, Harmon KA, Hart HM, Hayes J, Hersman CB, Hill ME, Hill TA, Hofgartner JD, Holdridge ME, Horányi M, Hosadurga A, Howard AD, Howett CJA, Jaskulek SE, Jennings DE, Jensen JR, Jones MR, Kang HK, Katz DJ, Kaufmann DE, Kavelaars JJ, Keane JT, Keleher GP, Kinczyk M, Kochte MC, Kollmann P, Krimigis SM, Kruizinga GL, Kusnierkiewicz DY, Lahr MS, Lauer TR, Lawrence GB, Lee JE, Lessac-Chenen EJ, Linscott IR, Lisse CM, Lunsford AW, Mages DM, Mallder VA, Martin NP, May BH, McComas DJ, McNutt RL Jr, Mehoke DS, Mehoke TS, Nelson DS, Nguyen HD, Núñez JI, Ocampo AC, Owen WM, Oxton GK, Parker AH, Pätzold M, Pelgrift JY, Pelletier FJ, Pineau JP, Piquette MR, Porter SB, Protopapa S, Quirico E, Redfern JA, Regiec AL, Reitsema HJ, Reuter DC, Richardson DC, Riedel JE, Ritterbush MA, Robbins SJ, Rodgers DJ, Rogers GD, Rose DM, Rosendall PE, Runyon KD, Ryschkewitsch MG, Saina MM, Salinas MJ, Schenk PM, Scherrer JR, Schlei WR, Schmitt B, Schultz DJ, Schurr DC, Scipioni F, Sepan RL, Shelton RG, Showalter MR, Simon M, Singer KN, Stahlheber EW, Stanbridge DR, Stansberry JA, Steffl AJ, Strobel DF, Stothoff MM, Stryk T, Stuart JR, Summers ME, Tapley MB, Taylor A, Taylor HW, Tedford RM, Throop HB, Turner LS, Umurhan OM, Van Eck J, Velez D, Versteeg MH, Vincent MA, Webbert RW, Weidner SE, Weigle GE 2nd, Wendel JR, White OL, Whittenburg KE, Williams BG, Williams KE, Williams SP, Winters HL, Zangari AM, Zurbuchen TH.

Science. 2019 May 17;364(6441). pii: eaaw9771. doi: 10.1126/science.aaw9771.


Solvent-Free Synthesis and Key Intermediate Isolation in Ni2Dy2 Catalyst Development in the Domino Ring-Opening Electrocyclization Reaction of Furfural and Amines.

Sampani SI, McGown A, Vargas A, Abdul-Sada A, Tizzard GJ, Coles SJ, Spencer J, Kostakis GE.

J Org Chem. 2019 Jun 7;84(11):6858-6867. doi: 10.1021/acs.joc.9b00608. Epub 2019 May 22.


Do Larger Acetabular Chondral Defects Portend Inferior Outcomes in Patients Undergoing Arthroscopic Acetabular Microfracture? A Matched-Controlled Study.

Chaharbakhshi EO, Hartigan DE, Spencer JD, Perets I, Lall AC, Domb BG.

Arthroscopy. 2019 Jul;35(7):2037-2047. doi: 10.1016/j.arthro.2019.01.047. Epub 2019 May 5.


Acute study of dose-dependent effects of (-)-epicatechin on vascular function in healthy male volunteers: A randomized controlled trial.

Alañón ME, Castle SM, Serra G, Lévèques A, Poquet L, Actis-Goretta L, Spencer JPE.

Clin Nutr. 2019 Apr 9. pii: S0261-5614(19)30156-6. doi: 10.1016/j.clnu.2019.03.041. [Epub ahead of print]


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