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Items: 1 to 50 of 89

1.

Predicting Failure After Primary Arthroscopic Bankart Repair: Analysis of a Statistical Model Using Anatomic Risk Factors.

Yian EH, Weathers M, Knott JR, Sodl JF, Spencer HT.

Arthroscopy. 2020 Jan 8. pii: S0749-8063(19)31099-0. doi: 10.1016/j.arthro.2019.11.109. [Epub ahead of print]

PMID:
31926270
2.

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions.

Fleischer LC, Spencer HT, Raikar SS.

J Hematol Oncol. 2019 Dec 29;12(1):141. doi: 10.1186/s13045-019-0801-y. Review.

3.

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr.

J Thromb Haemost. 2020 Jan;18(1):57-69. doi: 10.1111/jth.14621. Epub 2019 Sep 8.

PMID:
31454152
4.

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model.

Zoine JT, Knight KA, Fleischer LC, Sutton KS, Goldsmith KC, Doering CB, Spencer HT.

Oncoimmunology. 2019 May 27;8(8):1593804. doi: 10.1080/2162402X.2019.1593804. eCollection 2019.

5.

Maximal Force Generated by Magnetically Controlled Growing Rods Decreases With Rod Lengthening.

Poon S, Spencer HT, Fayssoux RS, Sever R, Cho RH.

Spine Deform. 2018 Nov - Dec;6(6):787-790. doi: 10.1016/j.jspd.2018.03.009.

PMID:
30348359
6.

Beta-blocker subtypes and risk of low birth weight in newborns.

Duan L, Ng A, Chen W, Spencer HT, Lee MS.

J Clin Hypertens (Greenwich). 2018 Nov;20(11):1603-1609. doi: 10.1111/jch.13397. Epub 2018 Sep 28.

7.

Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A.

Doering CB, Denning G, Shields JE, Fine EJ, Parker ET, Srivastava A, Lollar P, Spencer HT.

Hum Gene Ther. 2018 Oct;29(10):1183-1201. doi: 10.1089/hum.2018.137.

8.

Maternal and fetal outcomes in pregnant women with heart failure.

Ng AT, Duan L, Win T, Spencer HT, Lee MS.

Heart. 2018 Dec;104(23):1949-1954. doi: 10.1136/heartjnl-2018-313156. Epub 2018 May 25.

PMID:
29802180
9.

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A.

Brown HC, Zakas PM, George SN, Parker ET, Spencer HT, Doering CB.

Mol Ther Methods Clin Dev. 2018 Jan 31;9:57-69. doi: 10.1016/j.omtm.2018.01.004. eCollection 2018 Jun 15.

10.

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines.

Raikar SS, Fleischer LC, Moot R, Fedanov A, Paik NY, Knight KA, Doering CB, Spencer HT.

Oncoimmunology. 2017 Dec 26;7(3):e1407898. doi: 10.1080/2162402X.2017.1407898. eCollection 2018.

11.

Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists.

Petersen CT, Hassan M, Morris AB, Jeffery J, Lee K, Jagirdar N, Staton AD, Raikar SS, Spencer HT, Sulchek T, Flowers CR, Waller EK.

Blood Adv. 2018 Feb 13;2(3):210-223. doi: 10.1182/bloodadvances.2017011254.

12.

Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.

Tran R, Myers DR, Denning G, Shields JE, Lytle AM, Alrowais H, Qiu Y, Sakurai Y, Li WC, Brand O, Le Doux JM, Spencer HT, Doering CB, Lam WA.

Mol Ther. 2017 Oct 4;25(10):2372-2382. doi: 10.1016/j.ymthe.2017.07.002. Epub 2017 Jul 8.

13.

β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies.

Duan L, Ng A, Chen W, Spencer HT, Nguyen J, Shen AY, Lee MS.

JAMA Intern Med. 2017 Jun 1;177(6):885-887. doi: 10.1001/jamainternmed.2017.0608. No abstract available.

14.

Comparison of Intraoperative Fluoroscopic Dunn View With Magnetic Resonance Imaging to Determine Femoral Version.

Lee CB, Spencer HT.

Arthroscopy. 2017 Jun;33(6):1186-1193. doi: 10.1016/j.arthro.2017.01.022. Epub 2017 Mar 13.

PMID:
28302428
15.

Warfarin use and the risk of mortality, stroke, and bleeding in hemodialysis patients with atrial fibrillation.

Kai B, Bogorad Y, Nguyen LN, Yang SJ, Chen W, Spencer HT, Shen AY, Lee MS.

Heart Rhythm. 2017 May;14(5):645-651. doi: 10.1016/j.hrthm.2017.01.047. Epub 2017 Feb 6.

PMID:
28185918
16.

Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors.

Moot R, Raikar SS, Fleischer L, Querrey M, Tylawsky DE, Nakahara H, Doering CB, Spencer HT.

Mol Ther Oncolytics. 2016 Dec 7;3:16026. eCollection 2016.

17.

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction.

Zakas PM, Brown HC, Knight K, Meeks SL, Spencer HT, Gaucher EA, Doering CB.

Nat Biotechnol. 2017 Jan;35(1):35-37. doi: 10.1038/nbt.3677. Epub 2016 Sep 26.

18.

Femoral cam deformity due to anterior capsular force: A theoretical model with MRI and cadaveric correlation.

Lee CB, Spencer HT, Nygaard KF.

J Orthop. 2016 Jul 5;13(4):331-6. doi: 10.1016/j.jor.2016.06.012. eCollection 2016 Dec.

19.

State of the art: gene therapy of haemophilia.

Spencer HT, Riley BE, Doering CB.

Haemophilia. 2016 Jul;22 Suppl 5:66-71. doi: 10.1111/hae.13011. Review.

PMID:
27405679
20.

Bioengineering and serum free expansion of blood-derived γδ T cells.

Sutton KS, Dasgupta A, McCarty D, Doering CB, Spencer HT.

Cytotherapy. 2016 Jul;18(7):881-92. doi: 10.1016/j.jcyt.2016.04.001.

PMID:
27260209
21.

Atrial Fibrillation and Atrial Flutter in Pregnant Women-A Population-Based Study.

Lee MS, Chen W, Zhang Z, Duan L, Ng A, Spencer HT, Kwan DM, Shen AY.

J Am Heart Assoc. 2016 Apr 13;5(4):e003182. doi: 10.1161/JAHA.115.003182.

22.

Radiographic failure and rates of re-operation after acromioclavicular joint reconstruction: a comparison of surgical techniques.

Spencer HT, Hsu L, Sodl J, Arianjam A, Yian EH.

Bone Joint J. 2016 Apr;98-B(4):512-8. doi: 10.1302/0301-620X.98B4.35935.

PMID:
27037434
23.

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell-directed gene therapy of murine hemophilia A.

Lytle AM, Brown HC, Paik NY, Knight KA, Wright JF, Spencer HT, Doering CB.

Mol Ther Methods Clin Dev. 2016 Feb 10;3:15056. doi: 10.1038/mtm.2015.56. eCollection 2016.

24.

Replacing bad (F)actors: hemophilia.

Doering CB, Spencer HT.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):461-7. doi: 10.1182/asheducation-2014.1.461. Epub 2014 Nov 18. Review.

PMID:
25696895
25.

Abnormal rib count in scoliosis surgery: impact on the reporting of spinal fusion levels.

Spencer HT, Gold ME, Hresko MT.

J Child Orthop. 2014 Dec;8(6):497-503. doi: 10.1007/s11832-014-0623-y. Epub 2014 Nov 5.

26.

High-throughput screening identifies compounds that enhance lentiviral transduction.

Johnston JM, Denning G, Moot R, Whitehead D, Shields J, Le Doux JM, Doering CB, Spencer HT.

Gene Ther. 2014 Dec;21(12):1008-20. doi: 10.1038/gt.2014.80. Epub 2014 Sep 18.

PMID:
25231175
27.

Volar plate fixation failure for volar shearing distal radius fractures with small lunate facet fragments.

Beck JD, Harness NG, Spencer HT.

J Hand Surg Am. 2014 Apr;39(4):670-8. doi: 10.1016/j.jhsa.2014.01.006. Epub 2014 Mar 6.

PMID:
24613588
28.

Gain in spinal height from surgical correction of idiopathic scoliosis.

Spencer HT, Gold ME, Karlin LI, Hedequist DJ, Hresko MT.

J Bone Joint Surg Am. 2014 Jan 1;96(1):59-65. doi: 10.2106/JBJS.L.01333.

PMID:
24382726
29.

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery.

Brown HC, Wright JF, Zhou S, Lytle AM, Shields JE, Spencer HT, Doering CB.

Mol Ther Methods Clin Dev. 2014 Aug 6;1:14036. doi: 10.1038/mtm.2014.36. eCollection 2014.

30.

The effect of mydriatic solutions on cognitive function.

Dersu II, Spencer HT, Grigorian PA, Evans M, Harper R.

Semin Ophthalmol. 2015 Jan;30(1):36-9. doi: 10.3109/08820538.2013.810289. Epub 2013 Aug 16.

PMID:
23952181
31.

Rapid generation of stable cell lines expressing high levels of erythropoietin, factor VIII, and an antihuman CD20 antibody using lentiviral vectors.

Baranyi L, Doering CB, Denning G, Gautney RE, Harris KT, Spencer HT, Roy A, Zayed H, Dropulic B.

Hum Gene Ther Methods. 2013 Aug;24(4):214-27. doi: 10.1089/hgtb.2013.002.

PMID:
23879627
32.

Detection of pars injury by SPECT in patients younger than age 10 with low back pain.

Spencer HT, Sokol LO, Glotzbecker MP, Grant FD, d'Hemecourt PA, Micheli LJ, Treves ST.

J Pediatr Orthop. 2013 Jun;33(4):383-8. doi: 10.1097/BPO.0b013e318285c3be.

PMID:
23653026
33.

Engineered drug resistant γδ T cells kill glioblastoma cell lines during a chemotherapy challenge: a strategy for combining chemo- and immunotherapy.

Lamb LS Jr, Bowersock J, Dasgupta A, Gillespie GY, Su Y, Johnson A, Spencer HT.

PLoS One. 2013;8(1):e51805. doi: 10.1371/journal.pone.0051805. Epub 2013 Jan 11.

34.

Development and characterization of recombinant ovine coagulation factor VIII.

Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB.

PLoS One. 2012;7(11):e49481. doi: 10.1371/journal.pone.0049481. Epub 2012 Nov 9.

35.

Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report.

Spencer HT, Hsu JT, McDonald DR, Karlin LI.

Spine J. 2012 Aug;12(8):e1-6. doi: 10.1016/j.spinee.2012.08.425.

PMID:
23021035
36.

Generation of an optimized lentiviral vector encoding a high-expression factor VIII transgene for gene therapy of hemophilia A.

Johnston JM, Denning G, Doering CB, Spencer HT.

Gene Ther. 2013 Jun;20(6):607-15. doi: 10.1038/gt.2012.76. Epub 2012 Sep 20.

37.

Type II supracondylar humerus fractures: can some be treated nonoperatively?

Spencer HT, Dorey FJ, Zionts LE, Dichter DH, Wong MA, Moazzaz P, Silva M.

J Pediatr Orthop. 2012 Oct-Nov;32(7):675-81. doi: 10.1097/BPO.0b013e318269c459.

PMID:
22955530
38.

Biomechanical testing of pin configurations in supracondylar humeral fractures: the effect of medial column comminution.

Silva M, Knutsen AR, Kalma JJ, Borkowski SL, Bernthal NM, Spencer HT, Sangiorgio SN, Ebramzadeh E.

J Orthop Trauma. 2013 May;27(5):275-80. doi: 10.1097/BOT.0b013e31826fc05e.

PMID:
22932754
39.

Treatment of a solid tumor using engineered drug-resistant immunocompetent cells and cytotoxic chemotherapy.

Dasgupta A, Shields JE, Spencer HT.

Hum Gene Ther. 2012 Jul;23(7):711-21. doi: 10.1089/hum.2011.172. Epub 2012 Apr 18.

40.

Communication for all your patients.

Lewis VO, McLaurin T, Spencer HT, Otsuka NY, Jimenez RL.

Instr Course Lect. 2012;61:569-80.

PMID:
22301262
41.

Engineered Hematopoietic Stem Cells as Therapeutics for Hemophilia A.

Zakas PM, Spencer HT, Doering CB.

J Genet Syndr Gene Ther. 2011 Nov 16;1(3). pii: 2410. No abstract available.

42.

Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC.

Porada CD, Sanada C, Kuo CJ, Colletti E, Mandeville W, Hasenau J, Zanjani ED, Moot R, Doering C, Spencer HT, Almeida-Porada G.

Exp Hematol. 2011 Dec;39(12):1124-1135.e4. doi: 10.1016/j.exphem.2011.09.001. Epub 2011 Sep 8.

43.

The effects of surgical delay on the outcome of pediatric supracondylar humeral fractures.

Bales JG, Spencer HT, Wong MA, Fong YJ, Zionts LE, Silva M.

J Pediatr Orthop. 2010 Dec;30(8):785-91. doi: 10.1097/BPO.0b013e3181f9fc03.

PMID:
21102202
44.

Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.

Spencer HT, Denning G, Gautney RE, Dropulic B, Roy AJ, Baranyi L, Gangadharan B, Parker ET, Lollar P, Doering CB.

Mol Ther. 2011 Feb;19(2):302-9. doi: 10.1038/mt.2010.239. Epub 2010 Nov 16.

45.

Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells.

Doering CB, Archer D, Spencer HT.

Adv Drug Deliv Rev. 2010 Sep 30;62(12):1204-12. doi: 10.1016/j.addr.2010.09.005. Epub 2010 Sep 30. Review.

46.

Advancements in gene transfer-based therapy for hemophilia A.

Doering CB, Spencer HT.

Expert Rev Hematol. 2009 Dec;2(6):673-683.

47.

Bone mineral density and functional measures in patients with arthrogryposis.

Spencer HT, Bowen RE, Caputo K, Green TA, Lawrence JF.

J Pediatr Orthop. 2010 Jul-Aug;30(5):514-8. doi: 10.1097/BPO.0b013e3181df6185.

PMID:
20574273
48.

Prospective longitudinal evaluation of elbow motion following pediatric supracondylar humeral fractures.

Spencer HT, Wong M, Fong YJ, Penman A, Silva M.

J Bone Joint Surg Am. 2010 Apr;92(4):904-10. doi: 10.2106/JBJS.I.00736.

PMID:
20360514
49.

Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A.

Ide LM, Iwakoshi NN, Gangadharan B, Jobe S, Moot R, McCarty D, Doering CB, Spencer HT.

J Gene Med. 2010 Apr;12(4):333-44. doi: 10.1002/jgm.1442.

PMID:
20209485
50.

Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule.

Taylor JL, Rohatgi P, Spencer HT, Doyle DF, Azizi B.

BMC Biotechnol. 2010 Feb 18;10:15. doi: 10.1186/1472-6750-10-15.

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