Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 123


In vitro release testing methods for drug-releasing vaginal rings.

Boyd P, Variano B, Spence P, McCoy CF, Murphy DJ, Dallal Bashi YH, Malcolm RK.

J Control Release. 2019 Nov 10;313:54-69. doi: 10.1016/j.jconrel.2019.10.015. Epub 2019 Oct 15. Review.


Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma.

Smalley I, Kim E, Li J, Spence P, Wyatt CJ, Eroglu Z, Sondak VK, Messina JL, Babacan NA, Maria-Engler SS, De Armas L, Williams SL, Gatenby RA, Chen YA, Anderson ARA, Smalley KSM.

EBioMedicine. 2019 Oct;48:178-190. doi: 10.1016/j.ebiom.2019.09.023. Epub 2019 Oct 5.


Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers.

Dallal Bashi YH, McCoy CF, Murphy DJ, Boyd P, Spence P, Kleinbeck K, Devlin B, Malcolm RK.

Int J Pharm. 2019 Oct 5;569:118574. doi: 10.1016/j.ijpharm.2019.118574. Epub 2019 Jul 26.


Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions.

Murphy DJ, McCoy CF, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK.

Int J Pharm. 2019 Jun 30;565:351-357. doi: 10.1016/j.ijpharm.2019.05.027. Epub 2019 May 11.


Southern Hemisphere westerlies as a driver of the early deglacial atmospheric CO2 rise.

Menviel L, Spence P, Yu J, Chamberlain MA, Matear RJ, Meissner KJ, England MH.

Nat Commun. 2018 Jun 27;9(1):2503. doi: 10.1038/s41467-018-04876-4.


Fine-tuning polyoxometalate non-linear optical chromophores: a molecular electronic "Goldilocks" effect.

Al-Yasari A, Spence P, El Moll H, Van Steerteghem N, Horton PN, Brunschwig BS, Clays K, Fielden J.

Dalton Trans. 2018 Aug 21;47(31):10415-10419. doi: 10.1039/c8dt01491d. Epub 2018 Jun 27.


The Effects Combining Cryocompression Therapy following an Acute Bout of Resistance Exercise on Performance and Recovery.

DuPont WH, Meuris BJ, Hardesty VH, Barnhart EC, Tompkins LH, Golden MJP, Usher CJ, Spence PA, Caldwell LK, Post EM, Beeler MK, Kraemer WJ.

J Sports Sci Med. 2017 Aug 8;16(3):333-342. eCollection 2017 Sep.


Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring.

McCoy CF, Murphy DJ, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK.

J Pharm Sci. 2017 Aug;106(8):2015-2025. doi: 10.1016/j.xphs.2017.04.026. Epub 2017 Apr 26.


Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection.

Brugat T, Reid AJ, Lin J, Cunningham D, Tumwine I, Kushinga G, McLaughlin S, Spence P, Böhme U, Sanders M, Conteh S, Bushell E, Metcalf T, Billker O, Duffy PE, Newbold C, Berriman M, Langhorne J.

Nat Microbiol. 2017 Feb 6;2:16276. doi: 10.1038/nmicrobiol.2016.276.


Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women.

Nel A, van Niekerk N, Kapiga S, Bekker LG, Gama C, Gill K, Kamali A, Kotze P, Louw C, Mabude Z, Miti N, Kusemererwa S, Tempelman H, Carstens H, Devlin B, Isaacs M, Malherbe M, Mans W, Nuttall J, Russell M, Ntshele S, Smit M, Solai L, Spence P, Steytler J, Windle K, Borremans M, Resseler S, Van Roey J, Parys W, Vangeneugden T, Van Baelen B, Rosenberg Z; Ring Study Team.

N Engl J Med. 2016 Dec 1;375(22):2133-2143.


Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition.

Sharma R, Fedorenko I, Spence PT, Sondak VK, Smalley KS, Koomen JM.

J Proteome Res. 2016 Dec 2;15(12):4476-4489. Epub 2016 Nov 17.


Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma.

Tran TA, Leong HS, Pavia-Jimenez A, Fedyshyn S, Yang J, Kucejova B, Sivanand S, Spence P, Xie XJ, Peña-Llopis S, Power N, Brugarolas J.

Mol Cell Biol. 2016 Jun 15;36(13):1836-55. doi: 10.1128/MCB.00189-16. Print 2016 Jul 1.


Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence.

Spence P, Nel A, van Niekerk N, Derrick T, Wilder S, Devlin B.

J Pharm Biomed Anal. 2016 Jun 5;125:94-100. doi: 10.1016/j.jpba.2016.03.023. Epub 2016 Mar 14.


Using Caffeine as a Water Quality Indicator in the Ambient Monitoring Program for Third Fork Creek Watershed, Durham, North Carolina.

Spence PL.

Environ Health Insights. 2015 Jun 25;9(Suppl 2):29-34. doi: 10.4137/EHI.S19588. eCollection 2015.


Mosquitoes Reset Malaria Parasites.

Spence PJ, Brugat T, Langhorne J.

PLoS Pathog. 2015 Jul 2;11(7):e1004987. doi: 10.1371/journal.ppat.1004987. eCollection 2015 Jul. No abstract available.


Recent work on vaginal rings containing antiviral agents for HIV prevention.

Spence P, Bhatia Garg A, Woodsong C, Devin B, Rosenberg Z.

Curr Opin HIV AIDS. 2015 Jul;10(4):264-70. doi: 10.1097/COH.0000000000000157. Review.


Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.

Nahrendorf W, Spence PJ, Tumwine I, Lévy P, Jarra W, Sauerwein RW, Langhorne J.

Elife. 2015 Feb 25;4. doi: 10.7554/eLife.05165.


Ecosystem Service and Environmental Health.

Spence PL, Floyd MF, Howard J, Simmons C.

Environ Health Insights. 2016 Apr 25;9(Suppl 2):35-8. doi: 10.4137/EHi.s38845. eCollection 2015. No abstract available.


The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

Polito D, Cukras S, Wang X, Spence P, Moreau L, D'Andrea AD, Kee Y.

J Biol Chem. 2014 Mar 7;289(10):7003-10. doi: 10.1074/jbc.M113.533976. Epub 2014 Jan 22.


Microfluidic device for trapping and monitoring three dimensional multicell spheroids using electrical impedance spectroscopy.

Luongo K, Holton A, Kaushik A, Spence P, Ng B, Deschenes R, Sundaram S, Bhansali S.

Biomicrofluidics. 2013 Jun 5;7(3):34108. doi: 10.1063/1.4809590. eCollection 2013.


Nonphysiologic blood flow triggers endothelial and arterial remodeling in vivo: implications for novel left ventricular assist devices with a peripheral anastomosis.

Bartoli CR, Spence PA, Siess T, Raess DH, Koenig SC, Dowling RD.

J Thorac Cardiovasc Surg. 2014 Jul;148(1):311-21. doi: 10.1016/j.jtcvs.2013.10.027. Epub 2013 Dec 9.


Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support.

Bartoli CR, Dassanayaka S, Brittian KR, Luckett A, Sithu S, Siess T, Raess DH, Spence PA, Koenig SC, Dowling RD, D'Souza SE.

J Thorac Cardiovasc Surg. 2014 May;147(5):1634-43. doi: 10.1016/j.jtcvs.2013.08.043. Epub 2013 Oct 15.


Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner.

Brugat T, Cunningham D, Sodenkamp J, Coomes S, Wilson M, Spence PJ, Jarra W, Thompson J, Scudamore C, Langhorne J.

Cell Microbiol. 2014 May;16(5):687-700. doi: 10.1111/cmi.12212. Epub 2013 Sep 30.


Vector transmission regulates immune control of Plasmodium virulence.

Spence PJ, Jarra W, Lévy P, Reid AJ, Chappell L, Brugat T, Sanders M, Berriman M, Langhorne J.

Nature. 2013 Jun 13;498(7453):228-31. doi: 10.1038/nature12231. Epub 2013 May 29.


Effects of nitrogen inputs on freshwater wetland ecosystem services - a Bayesian network analysis.

Spence PL, Jordan SJ.

J Environ Manage. 2013 Jul 30;124:91-9. doi: 10.1016/j.jenvman.2013.03.029. Epub 2013 May 1.


Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi.

Spence PJ, Jarra W, Lévy P, Nahrendorf W, Langhorne J.

Malar J. 2012 Dec 6;11:407. doi: 10.1186/1475-2875-11-407.


BAP1 loss defines a new class of renal cell carcinoma.

Peña-Llopis S, Vega-Rubín-de-Celis S, Liao A, Leng N, Pavía-Jiménez A, Wang S, Yamasaki T, Zhrebker L, Sivanand S, Spence P, Kinch L, Hambuch T, Jain S, Lotan Y, Margulis V, Sagalowsky AI, Summerour PB, Kabbani W, Wong SW, Grishin N, Laurent M, Xie XJ, Haudenschild CD, Ross MT, Bentley DR, Kapur P, Brugarolas J.

Nat Genet. 2012 Jun 10;44(7):751-9. doi: 10.1038/ng.2323. Erratum in: Nat Genet. 2012 Sep;44(9):1072.


A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.

Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J.

Sci Transl Med. 2012 Jun 6;4(137):137ra75. doi: 10.1126/scitranslmed.3003643.


T cell control of malaria pathogenesis.

Spence PJ, Langhorne J.

Curr Opin Immunol. 2012 Aug;24(4):444-8. doi: 10.1016/j.coi.2012.05.003. Epub 2012 May 30. Review.


Counterpulsation with symphony prevents retrograde carotid, aortic, and coronary flows observed with intra-aortic balloon pump support.

Giridharan GA, Bartoli CR, Spence PA, Dowling RD, Koenig SC.

Artif Organs. 2012 Jul;36(7):600-6. doi: 10.1111/j.1525-1594.2012.01456.x. Epub 2012 May 16.


IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.

Freitas do Rosário AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, O'Garra A, Langhorne J.

J Immunol. 2012 Feb 1;188(3):1178-90. doi: 10.4049/jimmunol.1102755. Epub 2011 Dec 28.


Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling.

Giridharan GA, Lederer C, Berthe A, Goubergrits L, Hutzenlaub J, Slaughter MS, Dowling RD, Spence PA, Koenig SC.

Med Eng Phys. 2011 Dec;33(10):1193-202. doi: 10.1016/j.medengphy.2011.05.008. Epub 2011 Jun 15.


Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance.

Breslow JM, Meissler JJ Jr, Hartzell RR, Spence PB, Truant A, Gaughan J, Eisenstein TK.

Infect Immun. 2011 Aug;79(8):3317-27. doi: 10.1128/IAI.00069-11. Epub 2011 May 16.


Transformation of the rodent malaria parasite Plasmodium chabaudi.

Spence PJ, Cunningham D, Jarra W, Lawton J, Langhorne J, Thompson J.

Nat Protoc. 2011 Apr;6(4):553-561. doi: 10.1038/nprot.2011.313. Epub 2011 Mar 31.


Communicating risks: examining hazard and outrage in multiple contexts.

Lachlan K, Spence PR.

Risk Anal. 2010 Dec;30(12):1872-86. doi: 10.1111/j.1539-6924.2010.01511.x. Epub 2010 Oct 12.


A novel subcutaneous counterpulsation device: acute hemodynamic efficacy during pharmacologically induced hypertension, hypotension, and heart failure.

Bartoli CR, Wilson GC, Giridharan GA, Slaughter MS, Sherwood LC, Spence PA, Prabhu SD, Koenig SC.

Artif Organs. 2010 Jul;34(7):537-45. doi: 10.1111/j.1525-1594.2010.01009.x. Epub 2010 May 31.


Novel J stents reduce the risk of embolic stroke in vitro.

Bartoli CR, Spence PA, Giridharan GA.

Neuroradiology. 2010 May;52(5):345-7. doi: 10.1007/s00234-009-0545-4. Epub 2009 Jun 20.


Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function.

Koenig SC, Litwak KN, Giridharan GA, Pantalos GM, Dowling RD, Prabhu SD, Slaughter MS, Sobieski MA, Spence PA.

ASAIO J. 2008 Nov-Dec;54(6):578-84. doi: 10.1097/MAT.0b013e318186891f.


Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.

Gupta V, Palmer KJ, Spence P, Hudson A, Stephens DJ.

Traffic. 2008 Nov;9(11):1850-66. doi: 10.1111/j.1600-0854.2008.00811.x. Epub 2008 Aug 9.


Optimising the precision for localising fluorescent proteins in living cells by 2D Gaussian fitting of digital images: application to COPII-coated endoplasmic reticulum exit sites.

Spence P, Gupta V, Stephens DJ, Hudson AJ.

Eur Biophys J. 2008 Oct;37(8):1335-49. doi: 10.1007/s00249-008-0343-7. Epub 2008 May 27.


Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development.

Spence PJ, Green EA.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):973-8. doi: 10.1073/pnas.0709071105. Epub 2008 Jan 15.


Media use and information needs of the disabled during a natural disaster.

Spence PR, Lachlan K, Burke JM, Seeger MW.

J Health Care Poor Underserved. 2007 May;18(2):394-404.


Hemodynamic and left ventricular pressure-volume responses to counterpulsation in mock circulation and acute large animal models.

Koenig SC, Pantalos GM, Litwak KN, Gillars KJ, Giridharan GA, Maguire M, Spence PA.

Conf Proc IEEE Eng Med Biol Soc. 2004;2004:3761-4.


Hemodynamic effects of partial ventricular support in chronic heart failure: results of simulation validated with in vivo data.

Morley D, Litwak K, Ferber P, Spence P, Dowling R, Meyns B, Griffith B, Burkhoff D.

J Thorac Cardiovasc Surg. 2007 Jan;133(1):21-8.


Development and early testing of a simple subcutaneous counterpulsation device.

Koenig SC, Spence PA, Pantalos GM, Dowling RD, Litwak KN.

ASAIO J. 2006 Jul-Aug;52(4):362-7.


Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical approach.

Giridharan GA, Pantalos GM, Litwak KN, Spence PA, Koenig SC.

ASAIO J. 2006 Jan-Feb;52(1):39-46.


N2O emissions from streams in the Neuse river watershed, North Carolina.

Stow CA, Walker JT, Cardoch L, Spence P, Geron C.

Environ Sci Technol. 2005 Sep 15;39(18):6999-7004.


Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection.

Lin Y, Roberts TJ, Spence PM, Brutkiewicz RR.

J Leukoc Biol. 2005 Feb;77(2):151-8. Epub 2004 Nov 17.


Supplemental Content

Loading ...
Support Center