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Items: 1 to 50 of 111

1.

Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties.

Dye BR, Youngblood RL, Oakes RS, Kasputis T, Clough DW, Spence JR, Shea LD.

Biomaterials. 2020 Mar;234:119757. doi: 10.1016/j.biomaterials.2020.119757. Epub 2020 Jan 6.

PMID:
31951973
2.

Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.

Singh AP, Hung YH, Shanahan MT, Kanke M, Bonfini A, Dame MK, Biraud M, Peck BCE, Oyesola OO, Freund JM, Cubitt RL, Curry EG, Gonzalez LM, Bewick GA, Tait-Wojno ED, Kurpios NA, Ding S, Spence JR, Dekaney CM, Buchon N, Sethupathy P.

Cell Mol Gastroenterol Hepatol. 2019 Nov 19. pii: S2352-345X(19)30156-0. doi: 10.1016/j.jcmgh.2019.11.001. [Epub ahead of print]

3.

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill DR, Ma X, Lamberg O, Schnizlein MK, Arqués JL, Spence JR, Nunez G, Patterson AD, Sun D, Young VB, Shah YM.

Cell Metab. 2020 Jan 7;31(1):115-130.e6. doi: 10.1016/j.cmet.2019.10.005. Epub 2019 Nov 7.

PMID:
31708445
4.

Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape.

Kolawole AO, Mirabelli C, Hill DR, Svoboda SA, Janowski AB, Passalacqua KD, Rodriguez BN, Dame MK, Freiden P, Berger RP, Vu DL, Hosmillo M, O'Riordan MXD, Schultz-Cherry S, Guix S, Spence JR, Wang D, Wobus CE.

PLoS Pathog. 2019 Oct 31;15(10):e1008057. doi: 10.1371/journal.ppat.1008057. eCollection 2019 Oct.

5.

Long-term flow through human intestinal organoids with the gut organoid flow chip (GOFlowChip).

Sidar B, Jenkins BR, Huang S, Spence JR, Walk ST, Wilking JN.

Lab Chip. 2019 Oct 9;19(20):3552-3562. doi: 10.1039/c9lc00653b.

PMID:
31556415
6.

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.

Chen L, Toke NH, Luo S, Vasoya RP, Aita R, Parthasarathy A, Tsai YH, Spence JR, Verzi MP.

Development. 2019 Aug 6;146(19). pii: dev179432. doi: 10.1242/dev.179432.

PMID:
31345929
7.

Epiedaphic Ground Beetle (Carabidae) Diversity in Ecosystems Transformed by Plantations of Eucalyptus pellita in the Orinoco Region of Colombia.

García-Suabita W, Pinzón J, Spence JR, Florián OPP.

Neotrop Entomol. 2019 Dec;48(6):1014-1029. doi: 10.1007/s13744-019-00700-w. Epub 2019 Jun 14.

PMID:
31201610
8.

Citrobacter rodentium Induces Tissue-Resident Memory CD4+ T Cells.

Bishu S, Hou G, El Zaatari M, Bishu SR, Popke D, Zhang M, Grasberger H, Zou W, Stidham RW, Higgins PDR, Spence JR, Kamada N, Kao JY.

Infect Immun. 2019 Jun 20;87(7). pii: e00295-19. doi: 10.1128/IAI.00295-19. Print 2019 Jul.

9.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2019 May 2;24(5):829. doi: 10.1016/j.stem.2019.04.002. No abstract available.

10.

Biologically inspired approaches to enhance human organoid complexity.

Holloway EM, Capeling MM, Spence JR.

Development. 2019 Apr 16;146(8). pii: dev166173. doi: 10.1242/dev.166173. Review.

11.

Single cell RNA sequencing identifies TGFβ as a key regenerative cue following LPS-induced lung injury.

Riemondy KA, Jansing NL, Jiang P, Redente EF, Gillen AE, Fu R, Miller AJ, Spence JR, Gerber AN, Hesselberth JR, Zemans RL.

JCI Insight. 2019 Mar 26;5. pii: 123637. doi: 10.1172/jci.insight.123637.

12.

The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development.

Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP.

Development. 2019 Mar 1;146(5). pii: dev172189. doi: 10.1242/dev.172189.

13.

CD4+ Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor α in Active Crohn's Disease.

Bishu S, El Zaatari M, Hayashi A, Hou G, Bowers N, Kinnucan J, Manoogian B, Muza-Moons M, Zhang M, Grasberger H, Bourque C, Zou W, Higgins PDR, Spence JR, Stidham RW, Kamada N, Kao JY.

J Crohns Colitis. 2019 Jul 25;13(7):905-915. doi: 10.1093/ecco-jcc/jjz010.

PMID:
30715262
14.

Generation of lung organoids from human pluripotent stem cells in vitro.

Miller AJ, Dye BR, Ferrer-Torres D, Hill DR, Overeem AW, Shea LD, Spence JR.

Nat Protoc. 2019 Feb;14(2):518-540. doi: 10.1038/s41596-018-0104-8.

15.

Organoid single cell profiling identifies a transcriptional signature of glomerular disease.

Harder JL, Menon R, Otto EA, Zhou J, Eddy S, Wys NL, O'Connor C, Luo J, Nair V, Cebrian C, Spence JR, Bitzer M, Troyanskaya OG, Hodgin JB, Wiggins RC, Freedman BS, Kretzler M; European Renal cDNA Bank (ERCB); Nephrotic Syndrome Study Network (NEPTUNE).

JCI Insight. 2019 Jan 10;4(1). pii: 122697. doi: 10.1172/jci.insight.122697. [Epub ahead of print]

16.

Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids.

Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR.

Stem Cell Reports. 2019 Feb 12;12(2):381-394. doi: 10.1016/j.stemcr.2018.12.001. Epub 2019 Jan 3.

17.

Concise, Simple, and Not Wrong: In Search of a Short-Hand Interpretation of Statistical Significance.

Spence JR, Stanley DJ.

Front Psychol. 2018 Nov 13;9:2185. doi: 10.3389/fpsyg.2018.02185. eCollection 2018.

18.

Natural succession and clearcutting as drivers of environmental heterogeneity and beta diversity in North American boreal forests.

García-Tejero S, Spence JR, O'Halloran J, Bourassa S, Oxbrough A.

PLoS One. 2018 Nov 2;13(11):e0206931. doi: 10.1371/journal.pone.0206931. eCollection 2018.

19.

Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2019 Jul;14(7):2258. doi: 10.1038/s41596-018-0079-5.

PMID:
30356140
20.

PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2018 Oct 24;:.

PMID:
30190557
21.

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.

Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C.

Development. 2018 Aug 30;145(16). pii: dev164038. doi: 10.1242/dev.164038.

22.

A Method for Cryogenic Preservation of Human Biopsy Specimens and Subsequent Organoid Culture.

Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, Spence JR.

Cell Mol Gastroenterol Hepatol. 2018 May 30;6(2):218-222.e7. doi: 10.1016/j.jcmgh.2018.04.008. eCollection 2018. No abstract available.

23.
24.

Taming the Wild West of Organoids, Enteroids, and Mini-Guts.

Spence JR.

Cell Mol Gastroenterol Hepatol. 2017 Nov 28;5(2):159-160. doi: 10.1016/j.jcmgh.2017.11.003. eCollection 2018. No abstract available.

25.

Identification, isolation and characterization of human LGR5-positive colon adenoma cells.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA.

Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049.

26.

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids.

Hill DR, Huang S, Tsai YH, Spence JR, Young VB.

J Vis Exp. 2017 Dec 18;(130). doi: 10.3791/56960.

27.

Species traits modify the species-area relationship in ground-beetle (Coleoptera: Carabidae) assemblages on islands in a boreal lake.

Bell AJ, Phillips ID, Nielsen SE, Spence JR.

PLoS One. 2017 Dec 20;12(12):e0190174. doi: 10.1371/journal.pone.0190174. eCollection 2017.

28.

In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells.

Miller AJ, Hill DR, Nagy MS, Aoki Y, Dye BR, Chin AM, Huang S, Zhu F, White ES, Lama V, Spence JR.

Stem Cell Reports. 2018 Jan 9;10(1):101-119. doi: 10.1016/j.stemcr.2017.11.012. Epub 2017 Dec 14.

29.

Clocking the Pace of Organoid Research.

Spence JR.

Cell Mol Gastroenterol Hepatol. 2017 May 13;4(1):203-204. doi: 10.1016/j.jcmgh.2017.04.006. eCollection 2017 Jul. No abstract available.

30.

Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium.

Hill DR, Huang S, Nagy MS, Yadagiri VK, Fields C, Mukherjee D, Bons B, Dedhia PH, Chin AM, Tsai YH, Thodla S, Schmidt TM, Walk S, Young VB, Spence JR.

Elife. 2017 Nov 7;6. pii: e29132. doi: 10.7554/eLife.29132.

31.

Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.

Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9608-E9617. doi: 10.1073/pnas.1712946114. Epub 2017 Oct 23.

32.

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair.

Cruz-Acuña R, Quirós M, Farkas AE, Dedhia PH, Huang S, Siuda D, García-Hernández V, Miller AJ, Spence JR, Nusrat A, García AJ.

Nat Cell Biol. 2017 Nov;19(11):1326-1335. doi: 10.1038/ncb3632. Epub 2017 Oct 23.

33.

Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine.

Schlieve CR, Fowler KL, Thornton M, Huang S, Hajjali I, Hou X, Grubbs B, Spence JR, Grikscheit TC.

Stem Cell Reports. 2017 Sep 12;9(3):883-896. doi: 10.1016/j.stemcr.2017.07.017. Epub 2017 Aug 10.

34.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2017 Jul 6;21(1):51-64.e6. doi: 10.1016/j.stem.2017.05.020. Epub 2017 Jun 22. Erratum in: Cell Stem Cell. 2019 May 2;24(5):829.

35.

Bioengineering for intestinal organoid cultures.

Kim GA, Spence JR, Takayama S.

Curr Opin Biotechnol. 2017 Oct;47:51-58. doi: 10.1016/j.copbio.2017.05.006. Epub 2017 Jun 21. Review.

36.

In Vitro Models to Study Human Lung Development, Disease and Homeostasis.

Miller AJ, Spence JR.

Physiology (Bethesda). 2017 May;32(3):246-260. doi: 10.1152/physiol.00041.2016. Review.

37.

Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface.

Hill DR, Spence JR.

Cell Mol Gastroenterol Hepatol. 2016 Dec 19;3(2):138-149. doi: 10.1016/j.jcmgh.2016.11.007. eCollection 2017 Mar. Review.

38.

Morphogenesis and maturation of the embryonic and postnatal intestine.

Chin AM, Hill DR, Aurora M, Spence JR.

Semin Cell Dev Biol. 2017 Jun;66:81-93. doi: 10.1016/j.semcdb.2017.01.011. Epub 2017 Feb 1. Review.

39.

Seed Detection and Discrimination by Ground Beetles (Coleoptera: Carabidae) Are Associated with Olfactory Cues.

Kulkarni SS, Dosdall LM, Spence JR, Willenborg CJ.

PLoS One. 2017 Jan 20;12(1):e0170593. doi: 10.1371/journal.pone.0170593. eCollection 2017.

40.

(Re)Building a Kidney.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA.

J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.

41.

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation.

Tsai YH, Hill DR, Kumar N, Huang S, Chin AM, Dye BR, Nagy MS, Verzi MP, Spence JR.

Cell Mol Gastroenterol Hepatol. 2016 Jun 23;2(5):648-662.e8. doi: 10.1016/j.jcmgh.2016.06.002. eCollection 2016 Sep.

42.

BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.

Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER.

Elife. 2017 Jan 10;6. pii: e20331. doi: 10.7554/eLife.20331.

43.

Hacking the Matrix.

Czerwinski M, Spence JR.

Cell Stem Cell. 2017 Jan 5;20(1):9-10. doi: 10.1016/j.stem.2016.12.010.

44.

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche.

Shao Y, Taniguchi K, Gurdziel K, Townshend RF, Xue X, Yong KMA, Sang J, Spence JR, Gumucio DL, Fu J.

Nat Mater. 2017 Apr;16(4):419-425. doi: 10.1038/nmat4829. Epub 2016 Dec 12.

45.

In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development.

Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence JR.

Development. 2017 Mar 15;144(6):1045-1055. doi: 10.1242/dev.138453. Epub 2016 Dec 7.

46.

Ten-year responses of ground-dwelling spiders to retention harvest in the boreal forest.

Pinzon J, Spence JR, Langor DW, Shorthouse DP.

Ecol Appl. 2016 Dec;26(8):2579-2597. doi: 10.1002/eap.1387. Epub 2016 Sep 19.

PMID:
27907260
47.

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids.

Dye BR, Dedhia PH, Miller AJ, Nagy MS, White ES, Shea LD, Spence JR.

Elife. 2016 Sep 28;5. pii: e19732. doi: 10.7554/eLife.19732.

48.

Hox6 genes modulate in vitro differentiation of mESCs to insulin-producing cells.

Larsen BM, Marty-Santos L, Newman M, Lukacs DT, Spence JR, Wellik DM.

In Vitro Cell Dev Biol Anim. 2016 Oct;52(9):974-982. Epub 2016 Jul 21.

PMID:
27444630
49.

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells.

Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR.

Stem Cell Reports. 2016 Nov 8;7(5):826-839. doi: 10.1016/j.stemcr.2016.09.004. Epub 2016 Oct 6.

50.

Prediction Interval: What to Expect When You're Expecting … A Replication.

Spence JR, Stanley DJ.

PLoS One. 2016 Sep 19;11(9):e0162874. doi: 10.1371/journal.pone.0162874. eCollection 2016.

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