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Items: 23


Inference of complex population histories using whole-genome sequences from multiple populations.

Steinrücken M, Kamm J, Spence JP, Song YS.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17115-17120. doi: 10.1073/pnas.1905060116. Epub 2019 Aug 6.


Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4.

Spence JP, Reiter JL, Qiu B, Gu H, Garcia DK, Zhang L, Graves T, Williams KE, Bice PJ, Zou Y, Lai Z, Yong W, Liang T.

Front Genet. 2018 Dec 4;9:513. doi: 10.3389/fgene.2018.00513. eCollection 2018.


Early human dispersals within the Americas.

Moreno-Mayar JV, Vinner L, de Barros Damgaard P, de la Fuente C, Chan J, Spence JP, Allentoft ME, Vimala T, Racimo F, Pinotti T, Rasmussen S, Margaryan A, Iraeta Orbegozo M, Mylopotamitaki D, Wooller M, Bataille C, Becerra-Valdivia L, Chivall D, Comeskey D, Devièse T, Grayson DK, George L, Harry H, Alexandersen V, Primeau C, Erlandson J, Rodrigues-Carvalho C, Reis S, Bastos MQR, Cybulski J, Vullo C, Morello F, Vilar M, Wells S, Gregersen K, Hansen KL, Lynnerup N, Mirazón Lahr M, Kjær K, Strauss A, Alfonso-Durruty M, Salas A, Schroeder H, Higham T, Malhi RS, Rasic JT, Souza L, Santos FR, Malaspinas AS, Sikora M, Nielsen R, Song YS, Meltzer DJ, Willerslev E.

Science. 2018 Dec 7;362(6419). pii: eaav2621. doi: 10.1126/science.aav2621. Epub 2018 Nov 8.


Independent investigator incubator (I3): a comprehensive mentorship program to jumpstart productive research careers for junior faculty.

Spence JP, Buddenbaum JL, Bice PJ, Welch JL, Carroll AE.

BMC Med Educ. 2018 Aug 6;18(1):186. doi: 10.1186/s12909-018-1290-3.


Inference of population history using coalescent HMMs: review and outlook.

Spence JP, Steinrücken M, Terhorst J, Song YS.

Curr Opin Genet Dev. 2018 Dec;53:70-76. doi: 10.1016/j.gde.2018.07.002. Epub 2018 Jul 26. Review.


Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans.

Steinrücken M, Spence JP, Kamm JA, Wieczorek E, Song YS.

Mol Ecol. 2018 Oct;27(19):3873-3888. doi: 10.1111/mec.14565. Epub 2018 Apr 17.


Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.

Burack WR, Spence JM, Spence JP, Spence SA, Rock PJ, Shenoy GN, Shultz LD, Bankert RB, Bernstein SH.

Blood Adv. 2017 Jul 7;1(16):1263-1273. doi: 10.1182/bloodadvances.2017005892. eCollection 2017 Jul 11.


The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D.

Nature. 2016 Oct 13;538(7624):201-206. doi: 10.1038/nature18964. Epub 2016 Sep 21.


Two-Locus Likelihoods Under Variable Population Size and Fine-Scale Recombination Rate Estimation.

Kamm JA, Spence JP, Chan J, Song YS.

Genetics. 2016 Jul;203(3):1381-99. doi: 10.1534/genetics.115.184820. Epub 2016 May 10.


The Site Frequency Spectrum for General Coalescents.

Spence JP, Kamm JA, Song YS.

Genetics. 2016 Apr;202(4):1549-61. doi: 10.1534/genetics.115.184101. Epub 2016 Feb 16.


Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation.

Spence JM, Spence JP, Abumoussa A, Burack WR.

Genome Med. 2015 Mar 12;7(1):24. doi: 10.1186/s13073-015-0147-1. eCollection 2015.


Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.

Spence JM, Abumoussa A, Spence JP, Burack WR.

J Immunol. 2014 Nov 15;193(10):4888-94. doi: 10.4049/jimmunol.1401699. Epub 2014 Oct 13.


Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.

Molosh AI, Johnson PL, Spence JP, Arendt D, Federici LM, Bernabe C, Janasik SP, Segu ZM, Khanna R, Goswami C, Zhu W, Park SJ, Li L, Mechref YS, Clapp DW, Shekhar A.

Nat Neurosci. 2014 Nov;17(11):1583-90. doi: 10.1038/nn.3822. Epub 2014 Sep 21.


Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.

Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T.

Alcohol Clin Exp Res. 2014 May;38(5):1275-83. doi: 10.1111/acer.12379. Epub 2014 Mar 10.


From QTL to candidate gene: a genetic approach to alcoholism research.

Spence JP, Liang T, Liu L, Johnson PL, Foroud T, Carr LG, Shekhar A.

Curr Drug Abuse Rev. 2009 May;2(2):127-34. Review.


Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats.

Carr LG, Habegger K, Spence JP, Liu L, Lumeng L, Foroud T.

Behav Genet. 2006 Mar;36(2):285-90. Epub 2006 Feb 10.


Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians.

Ehlers CL, Spence JP, Wall TL, Gilder DA, Carr LG.

Alcohol Clin Exp Res. 2004 Oct;28(10):1481-6.


Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring rats.

Liang T, Habegger K, Spence JP, Foroud T, Ellison JA, Lumeng L, Li TK, Carr LG.

Alcohol Clin Exp Res. 2004 Nov;28(11):1622-8.


AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit.

Carr LG, Spence JP, Peter Eriksson CJ, Lumeng L, Li TK.

Alcohol. 2003 Aug-Oct;31(1-2):93-7.


Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations.

Spence JP, Liang T, Eriksson CJ, Taylor RE, Wall TL, Ehlers CL, Carr LG.

Alcohol Clin Exp Res. 2003 Sep;27(9):1389-94.

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