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BOLD hemodynamic response function changes significantly with healthy aging.

West KL, Zuppichini MD, Turner MP, Sivakolundu DK, Zhao Y, Abdelkarim D, Spence JS, Rypma B.

Neuroimage. 2018 Dec 6;188:198-207. doi: 10.1016/j.neuroimage.2018.12.012. [Epub ahead of print]


Concise, Simple, and Not Wrong: In Search of a Short-Hand Interpretation of Statistical Significance.

Spence JR, Stanley DJ.

Front Psychol. 2018 Nov 13;9:2185. doi: 10.3389/fpsyg.2018.02185. eCollection 2018.


Assessing the social climate of physical (in)activity in Canada.

Yun L, Vanderloo L, Berry TR, Latimer-Cheung AE, O'Reilly N, Rhodes RE, Spence JC, Tremblay MS, Faulkner G.

BMC Public Health. 2018 Nov 27;18(1):1301. doi: 10.1186/s12889-018-6166-2.


The short-term effects of a mass reach physical activity campaign: an evaluation using hierarchy of effects model and intention profiles.

Berry TR, Rhodes RE, Ori EM, McFadden K, Faulkner G, Latimer-Cheung AE, O'Reilly N, Spence JC, Tremblay MS, Vanderloo LM.

BMC Public Health. 2018 Nov 27;18(1):1300. doi: 10.1186/s12889-018-6218-7.


Impact of deprescribing rounds on discharge prescriptions: an interventional trial.

Edey R, Edwards N, Von Sychowski J, Bains A, Spence J, Martinusen D.

Int J Clin Pharm. 2018 Nov 27. doi: 10.1007/s11096-018-0753-2. [Epub ahead of print]


Results from Canada's 2018 Report Card on Physical Activity for Children and Youth.

Barnes JD, Cameron C, Carson V, Chaput JP, Colley RC, Faulkner GEJ, Janssen I, Kramers R, Saunders TJ, Spence JC, Tucker P, Vanderloo LM, Tremblay MS.

J Phys Act Health. 2018 Nov 1;15(S2):S328-S330. doi: 10.1123/jpah.2018-0454. No abstract available.


Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample.

Tillman GD, Spence JS, Briggs RW, Haley RW, Hart J Jr, Kraut MA.

Psychiatry Res Neuroimaging. 2018 Nov 10;283:7-15. doi: 10.1016/j.pscychresns.2018.11.006. [Epub ahead of print]


Early human dispersals within the Americas.

Moreno-Mayar JV, Vinner L, de Barros Damgaard P, de la Fuente C, Chan J, Spence JP, Allentoft ME, Vimala T, Racimo F, Pinotti T, Rasmussen S, Margaryan A, Iraeta Orbegozo M, Mylopotamitaki D, Wooller M, Bataille C, Becerra-Valdivia L, Chivall D, Comeskey D, Devièse T, Grayson DK, George L, Harry H, Alexandersen V, Primeau C, Erlandson J, Rodrigues-Carvalho C, Reis S, Bastos MQR, Cybulski J, Vullo C, Morello F, Vilar M, Wells S, Gregersen K, Hansen KL, Lynnerup N, Mirazón Lahr M, Kjær K, Strauss A, Alfonso-Durruty M, Salas A, Schroeder H, Higham T, Malhi RS, Rasic JT, Souza L, Santos FR, Malaspinas AS, Sikora M, Nielsen R, Song YS, Meltzer DJ, Willerslev E.

Science. 2018 Dec 7;362(6419). pii: eaav2621. doi: 10.1126/science.aav2621. Epub 2018 Nov 8.


Natural succession and clearcutting as drivers of environmental heterogeneity and beta diversity in North American boreal forests.

García-Tejero S, Spence JR, O'Halloran J, Bourassa S, Oxbrough A.

PLoS One. 2018 Nov 2;13(11):e0206931. doi: 10.1371/journal.pone.0206931. eCollection 2018.


Harm With High Levels of Serum B12 in Elderly Persons.

Spence JD.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):137. doi: 10.1093/gerona/gly185. No abstract available.


Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Oct 24. doi: 10.1038/s41596-018-0079-5. [Epub ahead of print]


Decline in the Severity of Carotid Atherosclerosis and Associated Risk Factors From 2002 to 2014.

Hackam DG, Spence JD.

Stroke. 2018 Nov;49(11):2786-2788. doi: 10.1161/STROKEAHA.118.021445.


When and how should we cluster and cross over: methodological and ethical issues (letter 2).

Lee SF, Bangdiwala SI, Spence J, Connolly S.

Can J Anaesth. 2018 Oct 19. doi: 10.1007/s12630-018-1238-4. [Epub ahead of print] No abstract available.


When and how should we cluster and cross over: methodological and ethical issues (letter 1).

Spence J, Belley-Côté E, Oczkowski S, Jacobsohn E, Whitlock R, Devereaux PJ, Connolly S.

Can J Anaesth. 2018 Oct 17. doi: 10.1007/s12630-018-1237-5. [Epub ahead of print] No abstract available.


Cardiovascular benefit of egg consumption is most unlikely.

Spence JD, Jenkins D.

Heart. 2018 Nov;104(21):1805-1806. doi: 10.1136/heartjnl-2018-313687. No abstract available.


Conjoint differences in inhibitory control and processing speed in childhood to older adult cohorts: Discriminant functions from a Go/No-Go task.

Motes MA, Spence JS, Brier MR, Chiang HS, DeLaRosa BL, Eroh J, Maguire MJ, Mudar RA, Tillman GD, Kraut MA, Hart J.

Psychol Aging. 2018 Nov;33(7):1070-1078. doi: 10.1037/pag0000299. Epub 2018 Oct 4.


Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.

Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarria V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG; NAVIGATE ESUS Investigators.

Lancet Neurol. 2018 Dec;17(12):1053-1060. doi: 10.1016/S1474-4422(18)30319-3. Epub 2018 Sep 28. Erratum in: Lancet Neurol. 2018 Oct 23;:.


Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome.

Woitowich NC, Halavaty AS, Waltz P, Kupitz C, Valera J, Tracy G, Gallagher KD, Claesson E, Nakane T, Pandey S, Nelson G, Tanaka R, Nango E, Mizohata E, Owada S, Tono K, Joti Y, Nugent AC, Patel H, Mapara A, Hopkins J, Duong P, Bizhga D, Kovaleva SE, St Peter R, Hernandez CN, Ozarowski WB, Roy-Chowdhuri S, Yang JH, Edlund P, Takala H, Ihalainen J, Brayshaw J, Norwood T, Poudyal I, Fromme P, Spence JCH, Moffat K, Westenhoff S, Schmidt M, Stojković EA.

IUCrJ. 2018 Aug 29;5(Pt 5):619-634. doi: 10.1107/S2052252518010631. eCollection 2018 Sep 1.


PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2018 Oct 24;:.


The phase problem for two-dimensional crystals. II. Simulations.

Arnal RD, Zhao Y, Mitra AK, Spence JCH, Millane RP.

Acta Crystallogr A Found Adv. 2018 Sep 1;74(Pt 5):537-544. doi: 10.1107/S2053273318008707. Epub 2018 Sep 1.


Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.

Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C.

Development. 2018 Aug 30;145(16). pii: dev164038. doi: 10.1242/dev.164038.


Assessing the quality of evidence supporting patent foramen ovale closure over medical therapy after cryptogenic stroke.

McIntyre WF, Spence J, Belley-Cote EP.

Eur Heart J. 2018 Oct 14;39(39):3618-3619. doi: 10.1093/eurheartj/ehy496. No abstract available.


Context Matters: Examining Perceived Health and Fitness Outcomes of Physical Activity Participation Among South Korean Adults and Youth.

Curtin KD, Lee EY, Yun L, Spence JC.

Int J Behav Med. 2018 Oct;25(5):548-557. doi: 10.1007/s12529-018-9743-y.


A Method for Cryogenic Preservation of Human Biopsy Specimens and Subsequent Organoid Culture.

Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, Spence JR.

Cell Mol Gastroenterol Hepatol. 2018 May 30;6(2):218-222.e7. doi: 10.1016/j.jcmgh.2018.04.008. eCollection 2018. No abstract available.


Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications.

Pignanelli M, Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Urquhart BL, Ruetz KN, Velenosi TJ, Spence JD.

J Ren Nutr. 2018 Aug 9. pii: S1051-2276(18)30128-6. doi: 10.1053/j.jrn.2018.05.007. [Epub ahead of print]


Independent investigator incubator (I3): a comprehensive mentorship program to jumpstart productive research careers for junior faculty.

Spence JP, Buddenbaum JL, Bice PJ, Welch JL, Carroll AE.

BMC Med Educ. 2018 Aug 6;18(1):186. doi: 10.1186/s12909-018-1290-3.


Elevated level of lecithin:cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden.

Gebhard C, Rhainds D, He G, Rodés-Cabau J, Lavi S, Spence JD, Title L, Kouz S, L'Allier PL, Grégoire J, Ibrahim R, Cossette M, Guertin MC, Beanlands R, Rhéaume E, Tardif JC.

Atherosclerosis. 2018 Sep;276:131-139. doi: 10.1016/j.atherosclerosis.2018.07.025. Epub 2018 Jul 19.


Inference of population history using coalescent HMMs: review and outlook.

Spence JP, Steinrücken M, Terhorst J, Song YS.

Curr Opin Genet Dev. 2018 Dec;53:70-76. doi: 10.1016/j.gde.2018.07.002. Epub 2018 Jul 26. Review.


Fractal dimension based carotid plaque characterization from three-dimensional ultrasound images.

Zhou R, Luo Y, Fenster A, Spence JD, Ding M.

Med Biol Eng Comput. 2018 Jul 26. doi: 10.1007/s11517-018-1865-5. [Epub ahead of print]


Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids.

Han X, Lee A, Huang S, Gao J, Spence JR, Owyang C.

Gut Microbes. 2018 Jul 24:1-18. doi: 10.1080/19490976.2018.1479625. [Epub ahead of print]


Cardioembolic stroke: everything has changed.

Spence JD.

Stroke Vasc Neurol. 2018 Mar 9;3(2):76-83. doi: 10.1136/svn-2018-000143. eCollection 2018 Jun. Review.


Diet for stroke prevention.

Spence JD.

Stroke Vasc Neurol. 2018 Jan 13;3(2):44-50. doi: 10.1136/svn-2017-000130. eCollection 2018 Jun. Review.


Controlling resistant hypertension.

Spence JD.

Stroke Vasc Neurol. 2018 Feb 24;3(2):69-75. doi: 10.1136/svn-2017-000138. eCollection 2018 Jun. Review.


Stroke Prevention: Editorial to accompany June issue of SVN.

Spence JD.

Stroke Vasc Neurol. 2018 Jun 26;3(2):43. doi: 10.1136/svn-2018-000171. eCollection 2018 Jun. Review. No abstract available.


How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting.

Paraskevas KI, Veith FJ, Spence JD.

Stroke Vasc Neurol. 2018 Feb 24;3(2):92-100. doi: 10.1136/svn-2017-000129. eCollection 2018 Jun. Review.


[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events.

Cocker MS, Spence JD, Hammond R, deKemp RA, Lum C, Wells G, Bernick J, Hill A, Nagpal S, Stotts G, Alturkustani M, Adeeko A, Yerofeyeva Y, Rayner K, Peterson J, Khan AR, Naidas AC, Garrard L, Yaffe MJ, Leung E, Prato FS, Tardif JC, Beanlands RSB; Canadian Atherosclerosis Imaging Network (CAIN) - Project II.

Int J Cardiol. 2018 Nov 15;271:378-386. doi: 10.1016/j.ijcard.2018.05.057. Epub 2018 Jun 2.


Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study.

Mrkobrada M, Chan MTV, Cowan D, Spence J, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Brown C, Sigamani A, Szczeklik W, Dmytriw AA, Agid R, Smith EE, Hill MD, Sharma M, Sharma M, Tsai S, Mensinkai A, Sahlas DJ, Guyatt G, Pettit S, Copland I, Wu WKK, Yu SCH, Gin T, Loh PS, Ramli N, Siow YL, Short TG, Waymouth E, Kumar J, Dasgupta M, Murkin JM, Fuentes M, Ortiz-Soriano V, Lindroth H, Simpson S, Sessler D, Devereaux PJ.

BMJ Open. 2018 Jul 6;8(7):e021521. doi: 10.1136/bmjopen-2018-021521.


Mediating Mechanisms in a Physical Activity Intervention: A Test of Habit Formation.

Kaushal N, Rhodes RE, Meldrum JT, Spence JC.

J Sport Exerc Psychol. 2018 Apr 1;40(2):101-110. doi: 10.1123/jsep.2017-0307. Epub 2018 Jun 26.


Hypertension in Blacks: Individualized Therapy Based on Renin/Aldosterone Phenotyping.

Spence JD, Rayner BL.

Hypertension. 2018 Aug;72(2):263-269. doi: 10.1161/HYPERTENSIONAHA.118.11064. Epub 2018 Jun 25. Review. No abstract available.


Mediterranean Diet Score: Associations with Metabolic Products of the Intestinal Microbiome, Carotid Plaque Burden, and Renal Function.

Pignanelli M, Just C, Bogiatzi C, Dinculescu V, Gloor GB, Allen-Vercoe E, Reid G, Urquhart BL, Ruetz KN, Velenosi TJ, Spence JD.

Nutrients. 2018 Jun 16;10(6). pii: E779. doi: 10.3390/nu10060779.


Data on the gut and saliva microbiota from a cohort of atherosclerosis patients determined by 16S rRNA gene sequencing.

Gloor GB, Wong RG, Allen-Vercoe E, Dinculescu V, Pignanelli M, Bogiatzi C, Reid G, Spence JD.

Data Brief. 2018 May 11;19:481-485. doi: 10.1016/j.dib.2018.05.032. eCollection 2018 Aug.


Influential Cognitive Processes on Framing Biases in Aging.

Perez AM, Spence JS, Kiel LD, Venza EE, Chapman SB.

Front Psychol. 2018 May 11;9:661. doi: 10.3389/fpsyg.2018.00661. eCollection 2018.


Supplemental Vitamins and Minerals for CVD Prevention and Treatment.

Jenkins DJA, Spence JD, Giovannucci EL, Kim YI, Josse R, Vieth R, Blanco Mejia S, Viguiliouk E, Nishi S, Sahye-Pudaruth S, Paquette M, Patel D, Mitchell S, Kavanagh M, Tsirakis T, Bachiri L, Maran A, Umatheva N, McKay T, Trinidad G, Bernstein D, Chowdhury A, Correa-Betanzo J, Del Principe G, Hajizadeh A, Jayaraman R, Jenkins A, Jenkins W, Kalaichandran R, Kirupaharan G, Manisekaran P, Qutta T, Shahid R, Silver A, Villegas C, White J, Kendall CWC, Pichika SC, Sievenpiper JL.

J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020. Review.


Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.

Olmos JL Jr, Pandey S, Martin-Garcia JM, Calvey G, Katz A, Knoska J, Kupitz C, Hunter MS, Liang M, Oberthuer D, Yefanov O, Wiedorn M, Heyman M, Holl M, Pande K, Barty A, Miller MD, Stern S, Roy-Chowdhury S, Coe J, Nagaratnam N, Zook J, Verburgt J, Norwood T, Poudyal I, Xu D, Koglin J, Seaberg MH, Zhao Y, Bajt S, Grant T, Mariani V, Nelson G, Subramanian G, Bae E, Fromme R, Fung R, Schwander P, Frank M, White TA, Weierstall U, Zatsepin N, Spence J, Fromme P, Chapman HN, Pollack L, Tremblay L, Ourmazd A, Phillips GN Jr, Schmidt M.

BMC Biol. 2018 May 31;16(1):59. doi: 10.1186/s12915-018-0524-5.


The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension.

Spence JD.

Ann Intern Med. 2018 May 15;168(10):753-754. doi: 10.7326/L18-0025. No abstract available.


Problems with polypills.

Spence JD.

Int J Stroke. 2018 Aug;13(6):NP16-NP17. doi: 10.1177/1747493018778118. Epub 2018 May 15. No abstract available.


X-ray lasers for structure and dynamics in biology.

Spence JCH.

IUCrJ. 2018 Apr 12;5(Pt 3):236-237. doi: 10.1107/S2052252518005365. eCollection 2018 May 1.


B Vitamins for Stroke Prevention: Interaction of Low Platelet Count and High Plasma Total Homocysteine.

Spence JD, Hachinski V.

J Am Coll Cardiol. 2018 May 15;71(19):2147-2148. doi: 10.1016/j.jacc.2018.03.024. No abstract available.


Postoperative Rehabilitation May Reduce the Risk of Readmission After Groin Hernia Repair.

Mercier G, Spence J, Ferreira C, Delay JM, Meunier C, Millat B, Nguyen TL, Seguret F.

Sci Rep. 2018 Apr 30;8(1):6759. doi: 10.1038/s41598-018-25276-0.


Accuracy of Cardiovascular Risk Prediction Varies by Neighborhood Socioeconomic Position.

Spence JD.

Ann Intern Med. 2018 May 1;168(9):680-681. doi: 10.7326/L18-0007. No abstract available.


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