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Items: 28


Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM.

Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24.


Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM.

J Pathol. 2018 Jul;245(3):337-348. doi: 10.1002/path.5086. Epub 2018 May 28.


Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.


Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH, Machesky LM.

Pigment Cell Melanoma Res. 2016 Sep;29(5):559-71. doi: 10.1111/pcmr.12506.


Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM.

Curr Biol. 2013 Jan 21;23(2):107-17. doi: 10.1016/j.cub.2012.11.059. Epub 2012 Dec 27.


Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

Spence HJ, Timpson P, Tang HR, Insall RH, Machesky LM.

Biochem J. 2012 Nov 15;448(1):35-42. doi: 10.1042/BJ20112206.


Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1.

Dawson JC, Bruche S, Spence HJ, Braga VM, Machesky LM.

PLoS One. 2012;7(3):e31141. doi: 10.1371/journal.pone.0031141. Epub 2012 Mar 27.


The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.

Zech T, Calaminus SD, Caswell P, Spence HJ, Carnell M, Insall RH, Norman J, Machesky LM.

J Cell Sci. 2011 Nov 15;124(Pt 22):3753-9. doi: 10.1242/jcs.080986. Epub 2011 Nov 23.


Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis.

Veltman DM, Auciello G, Spence HJ, Machesky LM, Rappoport JZ, Insall RH.

Biochem J. 2011 May 15;436(1):45-52. doi: 10.1042/BJ20101684.


BTB-Kelch protein Krp1 regulates proliferation and differentiation of myoblasts.

Paxton CW, Cosgrove RA, Drozd AC, Wiggins EL, Woodhouse S, Watson RA, Spence HJ, Ozanne BW, Pell JM.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1345-55. doi: 10.1152/ajpcell.00321.2010. Epub 2011 Mar 2.


The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion.

Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, König I, Anderson K, Machesky LM.

Curr Biol. 2010 Feb 23;20(4):339-45. doi: 10.1016/j.cub.2009.12.035. Epub 2010 Feb 4.


Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.

Gray CH, McGarry LC, Spence HJ, Riboldi-Tunnicliffe A, Ozanne BW.

J Biol Chem. 2009 Oct 30;284(44):30498-507. doi: 10.1074/jbc.M109.023259. Epub 2009 Sep 2.


Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC.

Dev Cell. 2007 Oct;13(4):496-510.


Transcription factors control invasion: AP-1 the first among equals.

Ozanne BW, Spence HJ, McGarry LC, Hennigan RF.

Oncogene. 2007 Jan 4;26(1):1-10. Epub 2006 Jun 26. Review.


AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.

Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW.

Mol Cell Biol. 2006 Feb;26(4):1480-95.


Invasion is a genetic program regulated by transcription factors.

Ozanne BW, Spence HJ, McGarry LC, Hennigan RF.

Curr Opin Genet Dev. 2006 Feb;16(1):65-70. Epub 2005 Dec 27. Review.


Role of Mayven, a kelch-related protein in oligodendrocyte process formation.

Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC.

J Neurosci Res. 2005 Sep 1;81(5):622-31.


Ezrin-dependent regulation of the actin cytoskeleton by beta-dystroglycan.

Spence HJ, Chen YJ, Batchelor CL, Higginson JR, Suila H, Carpen O, Winder SJ.

Hum Mol Genet. 2004 Aug 1;13(15):1657-68. Epub 2004 Jun 2.


Dystroglycan, a scaffold for the ERK-MAP kinase cascade.

Spence HJ, Dhillon AS, James M, Winder SJ.

EMBO Rep. 2004 May;5(5):484-9. Epub 2004 Apr 8.


Direct interaction of beta-dystroglycan with F-actin.

Chen YJ, Spence HJ, Cameron JM, Jess T, Ilsley JL, Winder SJ.

Biochem J. 2003 Oct 15;375(Pt 2):329-37.


Muscular dystrophies, the cytoskeleton and cell adhesion.

Spence HJ, Chen YJ, Winder SJ.

Bioessays. 2002 Jun;24(6):542-52. Review.


Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion.

Johnston IM, Spence HJ, Winnie JN, McGarry L, Vass JK, Meagher L, Stapleton G, Ozanne BW.

Oncogene. 2000 Nov 9;19(47):5348-58.


Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme.

Ozanne BW, McGarry L, Spence HJ, Johnston I, Winnie J, Meagher L, Stapleton G.

Eur J Cancer. 2000 Aug;36(13 Spec No):1640-8. Review.


Beatson International Cancer Conference: invasion and metastasis.

Stapleton G, Spence HJ.

Br J Cancer. 2000 May;82(9):1615-7. No abstract available.


The ABA-1 allergen of Ascaris lumbricoides: sequence polymorphism, stage and tissue-specific expression, lipid binding function, and protein biophysical properties.

Xia Y, Spence HJ, Moore J, Heaney N, McDermott L, Cooper A, Watson DG, Mei B, Komuniecki R, Kennedy MW.

Parasitology. 2000 Feb;120 ( Pt 2):211-24.


Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Spence HJ, Johnston I, Ewart K, Buchanan SJ, Fitzgerald U, Ozanne BW.

Oncogene. 2000 Mar 2;19(10):1266-76.


A cDNA encoding repeating units of the ABA-1 allergen of Ascaris.

Spence HJ, Moore J, Brass A, Kennedy MW.

Mol Biochem Parasitol. 1993 Feb;57(2):339-43. No abstract available.


Acromegaly in a 9 and one-half-year-old boy. Pituitary function studies before and after surgery.

Spence HJ, Trias EP, Raiti S.

Am J Dis Child. 1972 May;123(5):504-6. No abstract available.


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