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Items: 14


Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.

Muzzarelli KM, Kuiper B, Spellmon N, Brunzelle J, Hackett J, Amblard F, Zhou S, Liu P, Kovari IA, Yang Z, Schinazi RF, Kovari LC.

Biochemistry. 2019 Feb 19;58(7):900-907. doi: 10.1021/acs.biochem.8b01063. Epub 2019 Jan 16.


A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.

Cornett EM, Dickson BM, Krajewski K, Spellmon N, Umstead A, Vaughan RM, Shaw KM, Versluis PP, Cowles MW, Brunzelle J, Yang Z, Vega IE, Sun ZW, Rothbart SB.

Sci Adv. 2018 Nov 28;4(11):eaav2623. doi: 10.1126/sciadv.aav2623. eCollection 2018 Nov.


SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains.

Holcomb J, Doughan M, Spellmon N, Lewis B, Perry E, Zhang Y, Nico L, Wan J, Chakravarthy S, Shang W, Miao Q, Stemmler T, Yang Z.

PLoS One. 2018 Jan 18;13(1):e0191371. doi: 10.1371/journal.pone.0191371. eCollection 2018.


Protein crystallization: Eluding the bottleneck of X-ray crystallography.

Holcomb J, Spellmon N, Zhang Y, Doughan M, Li C, Yang Z.

AIMS Biophys. 2017;4(4):557-575. doi: 10.3934/biophy.2017.4.557. Epub 2017 Sep 26.


Allosterically targeting EGFR drug-resistance gatekeeper mutations.

Spellmon N, Li C, Yang Z.

J Thorac Dis. 2017 Jul;9(7):1756-1758. doi: 10.21037/jtd.2017.06.43. No abstract available.


Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.

Kuiper BD, Slater K, Spellmon N, Holcomb J, Medapureddy P, Muzzarelli KM, Yang Z, Ovadia R, Amblard F, Kovari IA, Schinazi RF, Kovari LC.

Biochem Biophys Res Commun. 2017 Oct 28;492(4):668-673. doi: 10.1016/j.bbrc.2017.03.108. Epub 2017 Mar 22.


Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.

Spellmon N, Holcomb J, Niu A, Choudhary V, Sun X, Zhang Y, Wan J, Doughan M, Hayden S, Hachem F, Brunzelle J, Li C, Yang Z.

Biochem Biophys Res Commun. 2017 Apr 1;485(2):529-534. doi: 10.1016/j.bbrc.2017.02.010. Epub 2017 Feb 6.


New open conformation of SMYD3 implicates conformational selection and allostery.

Spellmon N, Sun X, Xue W, Holcomb J, Chakravarthy S, Shang W, Edwards B, Sirinupong N, Li C, Yang Z.

AIMS Biophys. 2017;4(1):1-18. doi: 10.3934/biophy.2017.1.1. Epub 2016 Dec 20.


SMYD proteins in immunity: dawning of a new era.

Doughan M, Spellmon N, Li C, Yang Z.

AIMS Biophys. 2016;3(4):450-455. Epub 2016 Oct 17. No abstract available.


Molecular Dynamics Simulation Reveals Correlated Inter-Lobe Motion in Protein Lysine Methyltransferase SMYD2.

Spellmon N, Sun X, Sirinupong N, Edwards B, Li C, Yang Z.

PLoS One. 2015 Dec 30;10(12):e0145758. doi: 10.1371/journal.pone.0145758. eCollection 2015.


Purification of Histone Lysine Methyltransferase SMYD2 and Co-Crystallization with a Target Peptide from Estrogen Receptor α.

Jiang Y, Holcomb J, Spellmon N, Yang Z.

Methods Mol Biol. 2016;1366:207-217. doi: 10.1007/978-1-4939-3127-9_16.


Structure and function of SET and MYND domain-containing proteins.

Spellmon N, Holcomb J, Trescott L, Sirinupong N, Yang Z.

Int J Mol Sci. 2015 Jan 8;16(1):1406-28. doi: 10.3390/ijms16011406. Review.


PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis.

Holcomb J, Spellmon N, Trescott L, Sun F, Li C, Yang Z.

Curr Drug Targets. 2015;16(9):945-50. Review.


Targeting the Root Cause of Cystic Fibrosis.

Trescott L, Holcomb J, Spellmon N, Mcleod C, Aljehane L, Sun F, Li C, Yang Z.

Curr Drug Targets. 2015;16(9):933-44. Review.


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