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Current and future perspectives of liquid biopsies in genomics-driven oncology.

Heitzer E, Haque IS, Roberts CES, Speicher MR.

Nat Rev Genet. 2018 Nov 8. doi: 10.1038/s41576-018-0071-5. [Epub ahead of print] Review.


One size does not fit all: Size-based plasma DNA diagnostics.

Heitzer E, Speicher MR.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaav3873. doi: 10.1126/scitranslmed.aav3873. Review.


The Jefferson Scale of Empathy: a nationwide study of measurement properties, underlying components, latent variable structure, and national norms in medical students.

Hojat M, DeSantis J, Shannon SC, Mortensen LH, Speicher MR, Bragan L, LaNoue M, Calabrese LH.

Adv Health Sci Educ Theory Pract. 2018 Jul 2. doi: 10.1007/s10459-018-9839-9. [Epub ahead of print]


The potential of liquid biopsies for the early detection of cancer.

Heitzer E, Perakis S, Geigl JB, Speicher MR.

NPJ Precis Oncol. 2017 Oct 17;1(1):36. doi: 10.1038/s41698-017-0039-5. eCollection 2017. Review.


Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide.

Belic J, Graf R, Bauernhofer T, Cherkas Y, Ulz P, Waldispuehl-Geigl J, Perakis S, Gormley M, Patel J, Li W, Geigl JB, Smirnov D, Heitzer E, Gross M, Speicher MR.

Int J Cancer. 2018 Sep 1;143(5):1236-1248. doi: 10.1002/ijc.31397. Epub 2018 Apr 10.


Digital Circulating Tumor Cell Analyses for Prostate Cancer Precision Oncology.

Heitzer E, Speicher MR.

Cancer Discov. 2018 Mar;8(3):269-271. doi: 10.1158/2159-8290.CD-18-0075.


Association Between Undergraduate Performance Predictors and Academic and Clinical Performance of Osteopathic Medical Students.

Agahi F, Speicher MR, Cisek G.

J Am Osteopath Assoc. 2018 Feb 1;118(2):106-114. doi: 10.7556/jaoa.2018.025.


Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, Fagagna FDD, Günes C, Rudolph KL.

EMBO J. 2017 Oct 2;36(19):2922-2924. doi: 10.15252/embj.201797470. No abstract available.


Single-Stranded DNA Library Preparation Does Not Preferentially Enrich Circulating Tumor DNA.

Moser T, Ulz P, Zhou Q, Perakis S, Geigl JB, Speicher MR, Heitzer E.

Clin Chem. 2017 Oct;63(10):1656-1659. doi: 10.1373/clinchem.2017.277988. Epub 2017 Aug 14. No abstract available.


Searching for cancer vulnerabilities amid genetic chaos.

Speicher MR.

Genome Biol. 2017 Aug 3;18(1):147. doi: 10.1186/s13059-017-1283-2.


Patient monitoring through liquid biopsies using circulating tumor DNA.

Ulz P, Heitzer E, Geigl JB, Speicher MR.

Int J Cancer. 2017 Sep 1;141(5):887-896. doi: 10.1002/ijc.30759. Epub 2017 May 25. Review.


Emerging concepts in liquid biopsies.

Perakis S, Speicher MR.

BMC Med. 2017 Apr 6;15(1):75. doi: 10.1186/s12916-017-0840-6. Review.


mFast-SeqS as a Monitoring and Pre-screening Tool for Tumor-Specific Aneuploidy in Plasma DNA.

Belic J, Koch M, Ulz P, Auer M, Gerhalter T, Mohan S, Fischereder K, Petru E, Bauernhofer T, Geigl JB, Speicher MR, Heitzer E.

Adv Exp Med Biol. 2016;924:147-155.


Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.

Bettermann K, Mehta AK, Hofer EM, Wohlrab C, Golob-Schwarzl N, Svendova V, Schimek MG, Stumptner C, Thüringer A, Speicher MR, Lackner C, Zatloukal K, Denk H, Haybaeck J.

Oncotarget. 2016 Nov 8;7(45):73309-73322. doi: 10.18632/oncotarget.12325.


Inferring expressed genes by whole-genome sequencing of plasma DNA.

Ulz P, Thallinger GG, Auer M, Graf R, Kashofer K, Jahn SW, Abete L, Pristauz G, Petru E, Geigl JB, Heitzer E, Speicher MR.

Nat Genet. 2016 Oct;48(10):1273-8. doi: 10.1038/ng.3648. Epub 2016 Aug 29.


Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

Ulz P, Belic J, Graf R, Auer M, Lafer I, Fischereder K, Webersinke G, Pummer K, Augustin H, Pichler M, Hoefler G, Bauernhofer T, Geigl JB, Heitzer E, Speicher MR.

Nat Commun. 2016 Jun 22;7:12008. doi: 10.1038/ncomms12008.


Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.

Al-Zoughbi W, Pichler M, Gorkiewicz G, Guertl-Lackner B, Haybaeck J, Jahn SW, Lackner C, Liegl-Atzwanger B, Popper H, Schauer S, Nusshold E, Kindt AS, Trajanoski Z, Speicher MR, Haemmerle G, Zimmermann R, Zechner R, Vesely PW, Hoefler G.

Oncotarget. 2016 Jun 7;7(23):33832-40. doi: 10.18632/oncotarget.9418.


Advising Needs of Osteopathic Medical Students Preparing for the Match.

Speicher MR, Pradhan SR.

J Am Osteopath Assoc. 2016 Apr;116(4):228-33. doi: 10.7556/jaoa.2016.047.


Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Mlecnik B, Bindea G, Angell HK, Maby P, Angelova M, Tougeron D, Church SE, Lafontaine L, Fischer M, Fredriksen T, Sasso M, Bilocq AM, Kirilovsky A, Obenauf AC, Hamieh M, Berger A, Bruneval P, Tuech JJ, Sabourin JC, Le Pessot F, Mauillon J, Rafii A, Laurent-Puig P, Speicher MR, Trajanoski Z, Michel P, Sesboüe R, Frebourg T, Pagès F, Valge-Archer V, Latouche JB, Galon J.

Immunity. 2016 Mar 15;44(3):698-711. doi: 10.1016/j.immuni.2016.02.025.


The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Mlecnik B, Bindea G, Kirilovsky A, Angell HK, Obenauf AC, Tosolini M, Church SE, Maby P, Vasaturo A, Angelova M, Fredriksen T, Mauger S, Waldner M, Berger A, Speicher MR, Pagès F, Valge-Archer V, Galon J.

Sci Transl Med. 2016 Feb 24;8(327):327ra26. doi: 10.1126/scitranslmed.aad6352.


Co-occurrence of MYC amplification and TP53 mutations in human cancer.

Ulz P, Heitzer E, Speicher MR.

Nat Genet. 2016 Feb;48(2):104-6. doi: 10.1038/ng.3468. No abstract available.


Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.

Heitzer E, Ulz P, Geigl JB, Speicher MR.

Mol Oncol. 2016 Mar;10(3):494-502. doi: 10.1016/j.molonc.2015.12.004. Epub 2015 Dec 17. Review.


Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.

Murali R, Chandramohan R, Möller I, Scholz SL, Berger M, Huberman K, Viale A, Pirun M, Socci ND, Bouvier N, Bauer S, Artl M, Schilling B, Schimming T, Sucker A, Schwindenhammer B, Grabellus F, Speicher MR, Schaller J, Hillen U, Schadendorf D, Mentzel T, Cheng DT, Wiesner T, Griewank KG.

Oncotarget. 2015 Nov 3;6(34):36041-52. doi: 10.18632/oncotarget.5936.


The biology of circulating tumor cells.

Pantel K, Speicher MR.

Oncogene. 2016 Mar 10;35(10):1216-24. doi: 10.1038/onc.2015.192. Epub 2015 Jun 8. Review.


Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach.

Belic J, Koch M, Ulz P, Auer M, Gerhalter T, Mohan S, Fischereder K, Petru E, Bauernhofer T, Geigl JB, Speicher MR, Heitzer E.

Clin Chem. 2015 Jun;61(6):838-49. doi: 10.1373/clinchem.2014.234286. Epub 2015 Apr 20.


Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, d'Adda di Fagagna F, Günes C, Rudolph KL.

EMBO J. 2015 May 12;34(10):1371-84. doi: 10.15252/embj.201490070. Epub 2015 Mar 27. Erratum in: EMBO J. 2017 Oct 2;36(19):2922-2924.


Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Boland CR, Kumanogoh A, Sill H.

Nat Commun. 2014 Oct 13;5:5191. doi: 10.1038/ncomms6191.


Preexisting TP53 mutation in therapy-related acute myeloid leukemia.

Schulz E, Kashofer K, Heitzer E, Mhatre KN, Speicher MR, Hoefler G, Sill H.

Ann Hematol. 2015 Mar;94(3):527-9. doi: 10.1007/s00277-014-2191-0. Epub 2014 Aug 20. No abstract available.


The dynamic range of circulating tumor DNA in metastatic breast cancer.

Heidary M, Auer M, Ulz P, Heitzer E, Petru E, Gasch C, Riethdorf S, Mauermann O, Lafer I, Pristauz G, Lax S, Pantel K, Geigl JB, Speicher MR.

Breast Cancer Res. 2014 Aug 9;16(4):421. doi: 10.1186/s13058-014-0421-y.


Hematogenous dissemination of glioblastoma multiforme.

Müller C, Holtschmidt J, Auer M, Heitzer E, Lamszus K, Schulte A, Matschke J, Langer-Freitag S, Gasch C, Stoupiec M, Mauermann O, Peine S, Glatzel M, Speicher MR, Geigl JB, Westphal M, Pantel K, Riethdorf S.

Sci Transl Med. 2014 Jul 30;6(247):247ra101. doi: 10.1126/scitranslmed.3009095.


A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmüller J, Steinmetz MO, Enzinger C, Thiele H, Höhne W, Nürnberg G, Baig SM, Ansar M, Nürnberg P, Vincent JB, Speicher MR, Gönczy P, Windpassinger C.

Hum Mol Genet. 2014 Nov 15;23(22):5940-9. doi: 10.1093/hmg/ddu318. Epub 2014 Jun 20.


The Picmonic(®) Learning System: enhancing memory retention of medical sciences, using an audiovisual mnemonic Web-based learning platform.

Yang A, Goel H, Bryan M, Robertson R, Lim J, Islam S, Speicher MR.

Adv Med Educ Pract. 2014 May 8;5:125-32. doi: 10.2147/AMEP.S61875. eCollection 2014.


Tumor signatures in the blood.

Speicher MR, Pantel K.

Nat Biotechnol. 2014 May;32(5):441-3. doi: 10.1038/nbt.2897. No abstract available.


PTEN action in leukaemia dictated by the tissue microenvironment.

Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, Wu G, Lintault L, Auer M, Premsrirut PK, Teruya-Feldstein J, Hicks J, Benveniste H, Speicher MR, Downing JR, Lowe SW.

Nature. 2014 Jun 19;510(7505):402-6. doi: 10.1038/nature13239. Epub 2014 May 4.


Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

Mohan S, Heitzer E, Ulz P, Lafer I, Lax S, Auer M, Pichler M, Gerger A, Eisner F, Hoefler G, Bauernhofer T, Geigl JB, Speicher MR.

PLoS Genet. 2014 Mar 27;10(3):e1004271. doi: 10.1371/journal.pgen.1004271. eCollection 2014 Mar.


Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.

Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, Lafontaine L, Bilocq AM, Kirilovsky A, Tosolini M, Waldner M, Berger A, Fridman WH, Rafii A, Valge-Archer V, Pagès F, Speicher MR, Galon J.

Sci Transl Med. 2014 Mar 19;6(228):228ra37. doi: 10.1126/scitranslmed.3007240.


Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.

Bernkopf M, Webersinke G, Tongsook C, Koyani CN, Rafiq MA, Ayaz M, Müller D, Enzinger C, Aslam M, Naeem F, Schmidt K, Gruber K, Speicher MR, Malle E, Macheroux P, Ayub M, Vincent JB, Windpassinger C, Duba HC.

Hum Mol Genet. 2014 Aug 1;23(15):4015-23. doi: 10.1093/hmg/ddu115. Epub 2014 Mar 13.


Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course.

Fried I, Artl M, Cota C, Müller H, Bartolo E, Boi S, Chiarelli C, Vale E, Schmuth M, Wiesner T, Speicher MR, Cerroni L.

J Am Acad Dermatol. 2014 Apr;70(4):716-723. doi: 10.1016/j.jaad.2013.11.028. Epub 2014 Jan 14.


Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma.

Heitzer E, Lax S, Lafer I, Müller SM, Pristauz G, Ulz P, Jahn S, Högenauer C, Petru E, Speicher MR, Geigl JB.

BMC Med Genet. 2013 Dec 29;14:129. doi: 10.1186/1471-2350-14-129.


Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pagès F, Speicher MR, Trajanoski Z, Galon J.

Immunity. 2013 Oct 17;39(4):782-95. doi: 10.1016/j.immuni.2013.10.003.


Circulating tumor cells and DNA as liquid biopsies.

Heitzer E, Auer M, Ulz P, Geigl JB, Speicher MR.

Genome Med. 2013 Aug 23;5(8):73. doi: 10.1186/gm477. eCollection 2013. Review.


Single-cell analysis: toward the clinic.

Speicher MR.

Genome Med. 2013 Aug 27;5(8):74. doi: 10.1186/gm478. eCollection 2013. No abstract available.


Single circulating tumor cell sequencing for monitoring.

Auer M, Heitzer E, Ulz P, Geigl JB, Speicher MR.

Oncotarget. 2013 Jun;4(6):812-3. No abstract available.


Complete and pure trisomy 18p due to a complex chromosomal rearrangement in a male adult with mild intellectual disability.

Orendi K, Uhrig S, Mach M, Tschepper P, Speicher MR.

Am J Med Genet A. 2013 Jul;161A(7):1806-12. doi: 10.1002/ajmg.a.35986. Epub 2013 May 21. Review. No abstract available.


Molecular cytogenetics and multiplex reverse-transcriptase polymerase chain reaction for risk stratification in acute myeloid leukemia.

Orendi K, Emberger W, Speicher MR, Hoefler G, Sill H.

J Clin Oncol. 2013 Jun 20;31(18):2360-1. doi: 10.1200/JCO.2013.48.8189. Epub 2013 May 6. No abstract available.


Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG, Westekemper H, Murali R, Mach M, Schilling B, Wiesner T, Schimming T, Livingstone E, Sucker A, Grabellus F, Metz C, Süsskind D, Hillen U, Speicher MR, Woodman SE, Steuhl KP, Schadendorf D.

Clin Cancer Res. 2013 Jun 15;19(12):3143-52. doi: 10.1158/1078-0432.CCR-13-0163. Epub 2013 Apr 30.


Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

Heitzer E, Ulz P, Belic J, Gutschi S, Quehenberger F, Fischereder K, Benezeder T, Auer M, Pischler C, Mannweiler S, Pichler M, Eisner F, Haeusler M, Riethdorf S, Pantel K, Samonigg H, Hoefler G, Augustin H, Geigl JB, Speicher MR.

Genome Med. 2013 Apr 5;5(4):30. doi: 10.1186/gm434. eCollection 2013.


Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.

Heitzer E, Auer M, Gasch C, Pichler M, Ulz P, Hoffmann EM, Lax S, Waldispuehl-Geigl J, Mauermann O, Lackner C, Höfler G, Eisner F, Sill H, Samonigg H, Pantel K, Riethdorf S, Bauernhofer T, Geigl JB, Speicher MR.

Cancer Res. 2013 May 15;73(10):2965-75. doi: 10.1158/0008-5472.CAN-12-4140. Epub 2013 Mar 7.


A survey of tools for variant analysis of next-generation genome sequencing data.

Pabinger S, Dander A, Fischer M, Snajder R, Sperk M, Efremova M, Krabichler B, Speicher MR, Zschocke J, Trajanoski Z.

Brief Bioinform. 2014 Mar;15(2):256-78. doi: 10.1093/bib/bbs086. Epub 2013 Jan 21.

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