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Items: 1 to 50 of 210

1.

S100a14 is Increased in Activated Nk Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte-Nk crosstalk.

Colón K, Speicher DW, Smith P, Taylor M, Metzger DS, Montaner LJ, Tomescu C.

J Acquir Immune Defic Syndr. 2018 Nov 5. doi: 10.1097/QAI.0000000000001911. [Epub ahead of print]

PMID:
30422902
2.

SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells.

Wu S, Fatkhutdinov N, Fukumoto T, Bitler BG, Park PH, Kossenkov AV, Trizzino M, Tang HY, Zhang L, Gardini A, Speicher DW, Zhang R.

Nat Commun. 2018 Oct 8;9(1):4116. doi: 10.1038/s41467-018-06656-6.

3.

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.

Singha B, Harper SL, Goldman AR, Bitler BG, Aird KM, Borowsky ME, Cadungog MG, Liu Q, Zhang R, Jean S, Drapkin R, Speicher DW.

Sci Rep. 2018 Oct 3;8(1):14725. doi: 10.1038/s41598-018-32885-2.

4.

Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility.

Kaur A, Ecker BL, Douglass SM, Kugel CH, Webster MR, Almeida FV, Somasundaram R, Hayden J, Ban E, Ahmadzadeh H, Franco-Barraza J, Shah N, Mellis IA, Keeney F, Kossenkov A, Tang HY, Yin X, Liu Q, Xu X, Fane M, Brafford P, Herlyn M, Speicher DW, Wargo JA, Tetzlaff MT, Haydu LE, Raj A, Shenoy V, Cukierman E, Weeraratna AT.

Cancer Discov. 2018 Oct 2. pii: CD-18-0193. doi: 10.1158/2159-8290.CD-18-0193. [Epub ahead of print]

PMID:
30279173
5.

Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements.

Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC.

Cancer Res. 2018 Aug 1;78(15):4215-4228. doi: 10.1158/0008-5472.CAN-18-0595. Epub 2018 Jun 13.

PMID:
29898993
6.

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.

Fukumoto T, Park PH, Wu S, Fatkhutdinov N, Karakashev S, Nacarelli T, Kossenkov AV, Speicher DW, Jean S, Zhang L, Wang TL, Shih IM, Conejo-Garcia JR, Bitler BG, Zhang R.

Cell Rep. 2018 Mar 27;22(13):3393-3400. doi: 10.1016/j.celrep.2018.03.019.

7.

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR.

Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9.

PMID:
29530483
8.

Protein Detection in Gels Using Fixation.

Beer LA, Speicher DW.

Curr Protoc Protein Sci. 2018 Feb 21;91:10.5.1-10.5.20. doi: 10.1002/cpps.48.

PMID:
29516479
9.

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.

Karakashev S, Zhu H, Wu S, Yokoyama Y, Bitler BG, Park PH, Lee JH, Kossenkov AV, Gaonkar KS, Yan H, Drapkin R, Conejo-Garcia JR, Speicher DW, Ordog T, Zhang R.

Nat Commun. 2018 Feb 12;9(1):631. doi: 10.1038/s41467-018-03031-3.

10.

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.

Bhattacharjee S, Coppens I, Mbengue A, Suresh N, Ghorbal M, Slouka Z, Safeukui I, Tang HY, Speicher DW, Stahelin RV, Mohandas N, Haldar K.

Blood. 2018 Mar 15;131(11):1234-1247. doi: 10.1182/blood-2017-11-814665. Epub 2018 Jan 23.

11.

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth.

Pestell TG, Jiao X, Kumar M, Peck AR, Prisco M, Deng S, Li Z, Ertel A, Casimiro MC, Ju X, Di Rocco A, Di Sante G, Katiyar S, Shupp A, Lisanti MP, Jain P, Wu K, Rui H, Hooper DC, Yu Z, Goldman AR, Speicher DW, Laury-Kleintop L, Pestell RG.

Oncotarget. 2017 Aug 4;8(47):81754-81775. doi: 10.18632/oncotarget.19953. eCollection 2017 Oct 10.

12.

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.

Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Puré E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI.

Cancer Cell. 2017 Nov 13;32(5):654-668.e5. doi: 10.1016/j.ccell.2017.10.005.

13.

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.

14.

ARID1A-mutated ovarian cancers depend on HDAC6 activity.

Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ III, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R.

Nat Cell Biol. 2017 Aug;19(8):962-973. doi: 10.1038/ncb3582. Epub 2017 Jul 24.

15.

Efficient Quantitative Comparisons of Plasma Proteomes Using Label-Free Analysis with MaxQuant.

Beer LA, Liu P, Ky B, Barnhart KT, Speicher DW.

Methods Mol Biol. 2017;1619:339-352. doi: 10.1007/978-1-4939-7057-5_23.

16.

Quantitative Comparisons of Large Numbers of Human Plasma Samples Using TMT10plex Labeling.

Liu P, Beer LA, Ky B, Barnhart KT, Speicher DW.

Methods Mol Biol. 2017;1619:319-337. doi: 10.1007/978-1-4939-7057-5_22.

17.

In-Depth, Reproducible Analysis of Human Plasma Using IgY 14 and SuperMix Immunodepletion.

Beer LA, Ky B, Barnhart KT, Speicher DW.

Methods Mol Biol. 2017;1619:81-101. doi: 10.1007/978-1-4939-7057-5_7.

18.

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay.

Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov AV, Wickramasinghe J, Showe LC, Skordalakes E, Tang HY, Speicher DW, Nishikura K.

Nat Struct Mol Biol. 2017 Jun;24(6):534-543. doi: 10.1038/nsmb.3403. Epub 2017 Apr 24.

19.

Full-Length Anion Exchanger 1 Structure and Interactions with Ankyrin-1 Determined by Zero Length Crosslinking of Erythrocyte Membranes.

Rivera-Santiago R, Harper SL, Sriswasdi S, Hembach P, Speicher DW.

Structure. 2017 Jan 3;25(1):132-145. doi: 10.1016/j.str.2016.11.017. Epub 2016 Dec 15.

20.

Detection of the Ubiquitinome in Cells Undergoing Oncogene-Induced Senescence.

Zhu H, Le L, Tang HY, Speicher DW, Zhang R.

Methods Mol Biol. 2017;1534:127-137.

21.

The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level.

Goldman AR, Bitler BG, Schug Z, Conejo-Garcia JR, Zhang R, Speicher DW.

Mol Cell Proteomics. 2016 Nov;15(11):3348-3360. Epub 2016 Sep 21.

22.

Detection of Proteins on Blot Membranes.

Goldman A, Harper S, Speicher DW.

Curr Protoc Protein Sci. 2016 Nov 1;86:10.8.1-10.8.11. doi: 10.1002/cpps.15.

23.

Baseline Immunoglobulin E Levels as a Marker of Doxorubicin- and Trastuzumab-Associated Cardiac Dysfunction.

Beer LA, Kossenkov AV, Liu Q, Luning Prak E, Domchek S, Speicher DW, Ky B.

Circ Res. 2016 Oct 28;119(10):1135-1144. Epub 2016 Aug 31.

24.

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC.

Cancer Cell. 2016 Aug 8;30(2):257-272. doi: 10.1016/j.ccell.2016.07.004.

25.

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC.

PLoS Biol. 2016 Jul 7;14(7):e1002507. doi: 10.1371/journal.pbio.1002507. eCollection 2016 Jul.

26.

Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Sep 8;537(7619):254. doi: 10.1038/nature18939. Epub 2016 Jul 6. No abstract available.

PMID:
27383789
27.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Apr 14;532(7598):250-4. doi: 10.1038/nature17392. Epub 2016 Apr 4.

28.

Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity.

Zhou S, Sorokina EM, Harper S, Li H, Ralat L, Dodia C, Speicher DW, Feinstein SI, Fisher AB.

Free Radic Biol Med. 2016 May;94:145-56. doi: 10.1016/j.freeradbiomed.2016.02.012. Epub 2016 Feb 16.

29.

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

Fan MH, Zhu Q, Li HH, Ra HJ, Majumdar S, Gulick DL, Jerome JA, Madsen DH, Christofidou-Solomidou M, Speicher DW, Bachovchin WW, Feghali-Bostwick C, Puré E.

J Biol Chem. 2016 Apr 8;291(15):8070-89. doi: 10.1074/jbc.M115.701433. Epub 2015 Dec 9.

30.

Electroblotting from Polyacrylamide Gels.

Goldman A, Ursitti JA, Mozdzanowski J, Speicher DW.

Curr Protoc Protein Sci. 2015 Nov 2;82:10.7.1-16. doi: 10.1002/0471140864.ps1007s82.

31.

In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature.

Pesciotta EN, Lam HS, Kossenkov A, Ge J, Showe LC, Mason PJ, Bessler M, Speicher DW.

PLoS One. 2015 Oct 16;10(10):e0140036. doi: 10.1371/journal.pone.0140036. eCollection 2015.

32.

Proteome analysis of the triton-insoluble erythrocyte membrane skeleton.

Basu A, Harper S, Pesciotta EN, Speicher KD, Chakrabarti A, Speicher DW.

J Proteomics. 2015 Oct 14;128:298-305. doi: 10.1016/j.jprot.2015.08.004. Epub 2015 Aug 10.

33.

Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2015 Jun 18;6:7605. doi: 10.1038/ncomms8605. No abstract available.

34.

Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays.

Olia AS, Barker K, McCullough CE, Tang HY, Speicher DW, Qiu J, LaBaer J, Marmorstein R.

ACS Chem Biol. 2015 Sep 18;10(9):2034-47. doi: 10.1021/acschembio.5b00342. Epub 2015 Jun 23.

35.

The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap.

Brown JW, Bullitt E, Sriswasdi S, Harper S, Speicher DW, McKnight CJ.

PLoS Comput Biol. 2015 Jun 11;11(6):e1004302. doi: 10.1371/journal.pcbi.1004302. eCollection 2015 Jun.

36.

Probing structures of large protein complexes using zero-length cross-linking.

Rivera-Santiago RF, Sriswasdi S, Harper SL, Speicher DW.

Methods. 2015 Nov 1;89:99-111. doi: 10.1016/j.ymeth.2015.04.031. Epub 2015 May 1. Review.

37.

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts.

Bengsch F, Tu Z, Tang HY, Zhu H, Speicher DW, Zhang R.

Cell Cycle. 2015;14(10):1540-7. doi: 10.1080/15384101.2015.1026492.

38.

Solution structure of the reduced form of human peroxiredoxin-6 elucidated using zero-length chemical cross-linking and homology modelling.

Rivera-Santiago RF, Harper SL, Zhou S, Sriswasdi S, Feinstein SI, Fisher AB, Speicher DW.

Biochem J. 2015 May 15;468(1):87-98. doi: 10.1042/BJ20141463.

39.

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.

Bitler BG, Aird KM, Garipov A, Li H, Amatangelo M, Kossenkov AV, Schultz DC, Liu Q, Shih IeM, Conejo-Garcia JR, Speicher DW, Zhang R.

Nat Med. 2015 Mar;21(3):231-8. doi: 10.1038/nm.3799. Epub 2015 Feb 16.

40.

Identification of secreted proteins that reflect autophagy dynamics within tumor cells.

Kraya AA, Piao S, Xu X, Zhang G, Herlyn M, Gimotty P, Levine B, Amaravadi RK, Speicher DW.

Autophagy. 2015;11(1):60-74. doi: 10.4161/15548627.2014.984273.

41.

Spectrin tetramer formation is not required for viable development in Drosophila.

Khanna MR, Mattie FJ, Browder KC, Radyk MD, Crilly SE, Bakerink KJ, Harper SL, Speicher DW, Thomas GH.

J Biol Chem. 2015 Jan 9;290(2):706-15. doi: 10.1074/jbc.M114.615427. Epub 2014 Nov 7.

42.

LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.

43.

Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients.

Pesciotta EN, Sriswasdi S, Tang HY, Speicher DW, Mason PJ, Bessler M.

PLoS One. 2014 Jan 14;9(1):e85504. doi: 10.1371/journal.pone.0085504. eCollection 2014.

44.

Probing large conformational rearrangements in wild-type and mutant spectrin using structural mass spectrometry.

Sriswasdi S, Harper SL, Tang HY, Gallagher PG, Speicher DW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1801-6. doi: 10.1073/pnas.1317620111. Epub 2014 Jan 22.

45.

Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells.

Swift J, Harada T, Buxboim A, Shin JW, Tang HY, Speicher DW, Discher DE.

Nucleus. 2013 Nov-Dec;4(6):450-9. doi: 10.4161/nucl.27413. Epub 2013 Dec 6.

46.

Enhanced identification of zero-length chemical cross-links using label-free quantitation and high-resolution fragment ion spectra.

Sriswasdi S, Harper SL, Tang HY, Speicher DW.

J Proteome Res. 2014 Feb 7;13(2):898-914. doi: 10.1021/pr400953w. Epub 2014 Jan 7.

47.

Serial cervicovaginal exposures with replication-deficient SIVsm induce higher dendritic cell (pDC) and CD4+ T-cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques.

Abdulhaqq SA, Martinez MI, Kang G, Foulkes AS, Rodriguez IV, Nichols SM, Hunter M, Sariol CA, Ruiz LA, Ross BN, Yin X, Speicher DW, Haase AT, Marx PA, Li Q, Kraiselburd EN, Montaner LJ.

J Acquir Immune Defic Syndr. 2014 Apr 1;65(4):405-13. doi: 10.1097/QAI.0000000000000047.

48.

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma.

Villanueva J, Infante JR, Krepler C, Reyes-Uribe P, Samanta M, Chen HY, Li B, Swoboda RK, Wilson M, Vultur A, Fukunaba-Kalabis M, Wubbenhorst B, Chen TY, Liu Q, Sproesser K, DeMarini DJ, Gilmer TM, Martin AM, Marmorstein R, Schultz DC, Speicher DW, Karakousis GC, Xu W, Amaravadi RK, Xu X, Schuchter LM, Herlyn M, Nathanson KL.

Cell Rep. 2013 Sep 26;4(6):1090-9. doi: 10.1016/j.celrep.2013.08.023. Epub 2013 Sep 19.

49.

Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target.

Rasanen K, Sriswasdi S, Valiga A, Tang HY, Zhang G, Perego M, Somasundaram R, Li L, Speicher K, Klein-Szanto AJ, Basu D, Rustgi AK, Speicher DW, Herlyn M.

Mol Cell Proteomics. 2013 Dec;12(12):3778-92. doi: 10.1074/mcp.M113.029587. Epub 2013 Sep 13.

50.

Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE.

Science. 2013 Aug 30;341(6149):1240104. doi: 10.1126/science.1240104.

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