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Items: 1 to 50 of 186

1.

Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes.

Sundqvist M, Christenson K, Björnsdottir H, Osla V, Karlsson A, Dahlgren C, Speert DP, Fasth A, Brown KL, Bylund J.

Front Immunol. 2017 Dec 21;8:1828. doi: 10.3389/fimmu.2017.01828. eCollection 2017.

2.

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants.

Slogrove AL, Esser MM, Cotton MF, Speert DP, Kollmann TR, Singer J, Bettinger JA.

Pediatr Infect Dis J. 2017 Feb;36(2):e38-e44. doi: 10.1097/INF.0000000000001391.

3.

Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection.

Silva IN, Santos PM, Santos MR, Zlosnik JE, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, Moreira LM.

mSystems. 2016 May 24;1(3). pii: e00029-16. eCollection 2016 May-Jun.

4.

Activity of Tobramycin against Cystic Fibrosis Isolates of Burkholderia cepacia Complex Grown as Biofilms.

Kennedy S, Beaudoin T, Yau YC, Caraher E, Zlosnik JE, Speert DP, LiPuma JJ, Tullis E, Waters V.

Antimicrob Agents Chemother. 2015 Oct 26;60(1):348-55. doi: 10.1128/AAC.02068-15. Print 2016 Jan.

5.

Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses.

LaFayette SL, Houle D, Beaudoin T, Wojewodka G, Radzioch D, Hoffman LR, Burns JL, Dandekar AA, Smalley NE, Chandler JR, Zlosnik JE, Speert DP, Bernier J, Matouk E, Brochiero E, Rousseau S, Nguyen D.

Sci Adv. 2015 Jul;1(6). pii: e1500199. Epub 2015 Jul 31.

6.

Surgical masks reduce airborne spread of Pseudomonas aeruginosa in colonized patients with cystic fibrosis.

Vanden Driessche K, Hens N, Tilley P, Quon BS, Chilvers MA, de Groot R, Cotton MF, Marais BJ, Speert DP, Zlosnik JE.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):897-9. doi: 10.1164/rccm.201503-0481LE. No abstract available.

PMID:
26426786
7.

Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia.

Loutet SA, El-Halfawy OM, Jassem AN, López JM, Medarde AF, Speert DP, Davies JE, Valvano MA.

Int J Antimicrob Agents. 2015 Oct;46(4):376-80. doi: 10.1016/j.ijantimicag.2015.05.010. Epub 2015 Jun 22.

PMID:
26187366
8.

Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia.

Sadarangani M, Harvey M, McDonald A, Speert DP, Dix D.

J Pediatr Hematol Oncol. 2015 Aug;37(6):e384-6. doi: 10.1097/MPH.0000000000000351.

PMID:
25985238
9.

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada. 30 years' experience.

Zlosnik JE, Zhou G, Brant R, Henry DA, Hird TJ, Mahenthiralingam E, Chilvers MA, Wilcox P, Speert DP.

Ann Am Thorac Soc. 2015 Jan;12(1):70-8. doi: 10.1513/AnnalsATS.201408-395OC.

PMID:
25474359
10.

In vitro efficacy of high-dose tobramycin against Burkholderia cepacia complex and Stenotrophomonas maltophilia isolates from cystic fibrosis patients.

Ratjen A, Yau Y, Wettlaufer J, Matukas L, Zlosnik JE, Speert DP, LiPuma JJ, Tullis E, Waters V.

Antimicrob Agents Chemother. 2015 Jan;59(1):711-3. doi: 10.1128/AAC.04123-14. Epub 2014 Oct 27.

11.

Swimming motility in a longitudinal collection of clinical isolates of Burkholderia cepacia complex bacteria from people with cystic fibrosis.

Zlosnik JE, Mori PY, To D, Leung J, Hird TJ, Speert DP.

PLoS One. 2014 Sep 9;9(9):e106428. doi: 10.1371/journal.pone.0106428. eCollection 2014.

12.

Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.

Smolen KK, Cai B, Fortuno ES Rd, Gelinas L, Larsen M, Speert DP, Chamekh M, Cooper PJ, Esser M, Marchant A, Kollmann TR.

J Immunol. 2014 Sep 15;193(6):3003-3012. doi: 10.4049/jimmunol.1400895. Epub 2014 Aug 18.

13.

Fosmidomycin decreases membrane hopanoids and potentiates the effects of colistin on Burkholderia multivorans clinical isolates.

Malott RJ, Wu CH, Lee TD, Hird TJ, Dalleska NF, Zlosnik JE, Newman DK, Speert DP.

Antimicrob Agents Chemother. 2014 Sep;58(9):5211-9. doi: 10.1128/AAC.02705-14. Epub 2014 Jun 23.

14.

Altered innate immune development in HIV-exposed uninfected infants.

Reikie BA, Adams RCM, Leligdowicz A, Ho K, Naidoo S, Rusk CE, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR.

J Acquir Immune Defic Syndr. 2014 Jul 1;66(3):245-255. doi: 10.1097/QAI.0000000000000161.

15.

Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis.

Jassem AN, Forbes CM, Speert DP.

Ann Clin Microbiol Antimicrob. 2014 Jan 6;13:2. doi: 10.1186/1476-0711-13-2.

16.

Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients.

de la Fuente-Núñez C, Mansour SC, Wang Z, Jiang L, Breidenstein EB, Elliott M, Reffuveille F, Speert DP, Reckseidler-Zenteno SL, Shen Y, Haapasalo M, Hancock RE.

Antibiotics (Basel). 2014;3(4):509-26. doi: 10.3390/antibiotics3040509.

17.

Pseudomonas aeruginosa enhances production of a non-alginate exopolysaccharide during long-term colonization of the cystic fibrosis lung.

Huse HK, Kwon T, Zlosnik JE, Speert DP, Marcotte EM, Whiteley M.

PLoS One. 2013 Dec 6;8(12):e82621. doi: 10.1371/journal.pone.0082621. eCollection 2013.

18.

Pattern recognition receptor-mediated cytokine response in infants across 4 continents.

Smolen KK, Ruck CE, Fortuno ES 3rd, Ho K, Dimitriu P, Mohn WW, Speert DP, Cooper PJ, Esser M, Goetghebuer T, Marchant A, Kollmann TR.

J Allergy Clin Immunol. 2014 Mar;133(3):818-26.e4. doi: 10.1016/j.jaci.2013.09.038. Epub 2013 Nov 28.

19.

Total protein extraction and 2-D gel electrophoresis methods for Burkholderia species.

Velapatiño B, Zlosnik JE, Hird TJ, Speert DP.

J Vis Exp. 2013 Oct 15;(80):e50730. doi: 10.3791/50730.

20.

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation.

Dias C, McDonald A, Sincan M, Rupps R, Markello T, Salvarinova R, Santos RF, Menghrajani K, Ahaghotu C, Sutherland DP, Fortuno ES 3rd, Kollmann TR, Demos M, Friedman JM, Speert DP, Gahl WA, Boerkoel CF.

Eur J Hum Genet. 2013 Nov;21(11):1232-9. doi: 10.1038/ejhg.2013.20. Epub 2013 Feb 27.

21.

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.

Reikie BA, Naidoo S, Ruck CE, Slogrove AL, de Beer C, la Grange H, Adams RC, Ho K, Smolen K, Speert DP, Cotton MF, Preiser W, Esser M, Kollmann TR.

Clin Vaccine Immunol. 2013 Jan;20(1):33-8. doi: 10.1128/CVI.00557-12. Epub 2012 Oct 31.

22.

Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.

Reikie BA, Adams RC, Ruck CE, Ho K, Leligdowicz A, Pillay S, Naidoo S, Fortuno ES 3rd, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR.

PLoS One. 2012;7(9):e44763. doi: 10.1371/journal.pone.0044763. Epub 2012 Sep 13.

23.

Serum susceptibility in clinical isolates of Burkholderia cepacia complex bacteria: development of a growth-based assay for high throughput determination.

Zlosnik JE, Gunaratnam LC, Speert DP.

Front Cell Infect Microbiol. 2012 May 28;2:67. doi: 10.3389/fcimb.2012.00067. eCollection 2012.

24.

Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections.

Behrends V, Ryall B, Zlosnik JE, Speert DP, Bundy JG, Williams HD.

Environ Microbiol. 2013 Feb;15(2):398-408. doi: 10.1111/j.1462-2920.2012.02840.x. Epub 2012 Aug 8.

PMID:
22882524
25.

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

Waters V, Zlosnik JE, Yau YC, Speert DP, Aaron SD, Guttman DS.

Eur J Clin Microbiol Infect Dis. 2012 Dec;31(12):3341-50. doi: 10.1007/s10096-012-1701-z. Epub 2012 Jul 29.

PMID:
22843295
26.

Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.

Lavoie PM, Ladd M, Hirschfeld AF, Huusko J, Mahlman M, Speert DP, Hallman M, Lacaze-Masmonteil T, Turvey SE.

PLoS One. 2012;7(2):e31351. doi: 10.1371/journal.pone.0031351. Epub 2012 Feb 14.

27.

Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis.

Velapatiño B, Limmathurotsakul D, Peacock SJ, Speert DP.

Microbes Infect. 2012 Apr;14(4):335-40. doi: 10.1016/j.micinf.2011.11.011. Epub 2011 Nov 30.

PMID:
22172334
28.

Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.

Malott RJ, Steen-Kinnaird BR, Lee TD, Speert DP.

Antimicrob Agents Chemother. 2012 Jan;56(1):464-71. doi: 10.1128/AAC.00602-11. Epub 2011 Oct 17.

29.

Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

Silva IN, Ferreira AS, Becker JD, Zlosnik JE, Speert DP, He J, Mil-Homens D, Moreira LM.

Microbiology. 2011 Nov;157(Pt 11):3124-37. doi: 10.1099/mic.0.050989-0. Epub 2011 Aug 11.

PMID:
21835880
30.

In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation.

Christenson K, Björkman L, Karlsson J, Sundqvist M, Movitz C, Speert DP, Dahlgren C, Bylund J.

J Leukoc Biol. 2011 Dec;90(6):1055-63. doi: 10.1189/jlb.0111051. Epub 2011 Jun 22.

PMID:
21697259
31.

In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides.

Jassem AN, Zlosnik JE, Henry DA, Hancock RE, Ernst RK, Speert DP.

Antimicrob Agents Chemother. 2011 May;55(5):2256-64. doi: 10.1128/AAC.01434-10. Epub 2011 Feb 14.

32.

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, Arkwright PD, McDonald D, Geha RS, Takada H, Krause JC, Creech CB, Ku CL, Ehl S, Maródi L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H, Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, Hoarau C, Kumararatne DS, Thrasher AJ, Davies EG, Bethune C, Sirvent N, de Ricaud D, Camcioglu Y, Vasconcelos J, Guedes M, Vitor AB, Rodrigo C, Almazán F, Méndez M, Aróstegui JI, Alsina L, Fortuny C, Reichenbach J, Verbsky JW, Bossuyt X, Doffinger R, Abel L, Puel A, Casanova JL.

Medicine (Baltimore). 2010 Nov;89(6):403-25. doi: 10.1097/MD.0b013e3181fd8ec3.

33.

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.

Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt AM, Audibert F, Speert DP, Lacaze-Masmonteil T, Soudeyns H, Kollmann TR.

J Infect Dis. 2010 Dec 1;202(11):1754-63. doi: 10.1086/657143. Epub 2010 Oct 26.

34.

Parallel evolution in Pseudomonas aeruginosa over 39,000 generations in vivo.

Huse HK, Kwon T, Zlosnik JE, Speert DP, Marcotte EM, Whiteley M.

MBio. 2010 Sep 21;1(4). pii: e00199-10. doi: 10.1128/mBio.00199-10.

35.

Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis.

Xie F, Hu Y, Speert DP, Turvey SE, Peng G, Money DM, Magee LA, von Dadelszen P; Toxaemia Study Group.

Hypertens Pregnancy. 2010;29(4):390-8. doi: 10.3109/10641950903242659.

PMID:
20818954
36.

Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections.

Zlosnik JE, Costa PS, Brant R, Mori PY, Hird TJ, Fraenkel MC, Wilcox PG, Davidson AG, Speert DP.

Am J Respir Crit Care Med. 2011 Jan 1;183(1):67-72. doi: 10.1164/rccm.201002-0203OC. Epub 2010 Aug 13.

PMID:
20709823
37.
38.

Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.

Hickey TB, Ziltener HJ, Speert DP, Stokes RW.

Cell Microbiol. 2010 Nov;12(11):1634-47. doi: 10.1111/j.1462-5822.2010.01496.x.

PMID:
20633027
39.

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Turvey S, Finlay BB, Speert DP, Hancock RE.

J Transl Med. 2010 Jan 27;8:6. doi: 10.1186/1479-5876-8-6.

40.

Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.

Hickey TB, Thorson LM, Speert DP, Daffé M, Stokes RW.

Infect Immun. 2009 Aug;77(8):3389-401. doi: 10.1128/IAI.00143-09. Epub 2009 May 26.

41.

Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov.

Vanlaere E, Baldwin A, Gevers D, Henry D, De Brandt E, LiPuma JJ, Mahenthiralingam E, Speert DP, Dowson C, Vandamme P.

Int J Syst Evol Microbiol. 2009 Jan;59(Pt 1):102-11. doi: 10.1099/ijs.0.001123-0.

PMID:
19126732
42.

Biofilm formation by persistent and non-persistent isolates of Staphylococcus epidermidis from a neonatal intensive care unit.

Eftekhar F, Speert DP.

J Hosp Infect. 2009 Feb;71(2):112-6. doi: 10.1016/j.jhin.2008.09.008. Epub 2008 Nov 14.

PMID:
19013672
43.

Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation.

Mena A, Smith EE, Burns JL, Speert DP, Moskowitz SM, Perez JL, Oliver A.

J Bacteriol. 2008 Dec;190(24):7910-7. doi: 10.1128/JB.01147-08. Epub 2008 Oct 10.

44.

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease.

Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott MR, Falsafi R, Hancock RE, Speert DP.

Clin Immunol. 2008 Oct;129(1):90-102. doi: 10.1016/j.clim.2008.06.005. Epub 2008 Jul 26.

PMID:
18676204
45.
46.

Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex.

Zlosnik JE, Hird TJ, Fraenkel MC, Moreira LM, Henry DA, Speert DP.

J Clin Microbiol. 2008 Apr;46(4):1470-3. doi: 10.1128/JCM.02273-07. Epub 2008 Feb 6.

47.

Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.

Baldwin A, Mahenthiralingam E, Drevinek P, Pope C, Waine DJ, Henry DA, Speert DP, Carter P, Vandamme P, LiPuma JJ, Dowson CG.

J Clin Microbiol. 2008 Jan;46(1):290-5. Epub 2007 Nov 21.

48.

Recurrent systemic pneumococcal disease and IRAK4 deficiency.

Turvey SE, Speert DP.

Pediatr Infect Dis J. 2007 Nov;26(11):1074; author reply 1074. No abstract available.

PMID:
17984826
49.

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

Ernst RK, Moskowitz SM, Emerson JC, Kraig GM, Adams KN, Harvey MD, Ramsey B, Speert DP, Burns JL, Miller SI.

J Infect Dis. 2007 Oct 1;196(7):1088-92. Epub 2007 Aug 22.

50.

Environmental Burkholderia cepacia complex isolates in human infections.

Baldwin A, Mahenthiralingam E, Drevinek P, Vandamme P, Govan JR, Waine DJ, LiPuma JJ, Chiarini L, Dalmastri C, Henry DA, Speert DP, Honeybourne D, Maiden MC, Dowson CG.

Emerg Infect Dis. 2007 Mar;13(3):458-61.

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