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Items: 1 to 50 of 141

1.

MALAT1 long non-coding RNA and breast cancer.

Arun G, Spector DL.

RNA Biol. 2019 Jun;16(6):860-863. doi: 10.1080/15476286.2019.1592072. Epub 2019 Mar 22.

PMID:
30874469
2.

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.

Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR.

Genes Dev. 2018 Jul 1;32(13-14):915-928. doi: 10.1101/gad.314815.118. Epub 2018 Jun 26.

3.

Therapeutic Targeting of Long Non-Coding RNAs in Cancer.

Arun G, Diermeier SD, Spector DL.

Trends Mol Med. 2018 Mar;24(3):257-277. doi: 10.1016/j.molmed.2018.01.001. Epub 2018 Feb 12. Review.

4.

Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids.

Diermeier SD, Spector DL.

Bio Protoc. 2017 Aug 20;7(16). pii: e2511. doi: 10.21769/BioProtoc.2511.

5.

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.

Li MA, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, von Meyenn F, Paramor M, Yang F, Chen C, Nichols J, Spector DL, Kouzarides T, He L, Smith A.

Elife. 2017 Aug 18;6. pii: e23468. doi: 10.7554/eLife.23468.

6.

Identification and Characterization of a Class of MALAT1-like Genomic Loci.

Zhang B, Mao YS, Diermeier SD, Novikova IV, Nawrocki EP, Jones TA, Lazar Z, Tung CS, Luo W, Eddy SR, Sanbonmatsu KY, Spector DL.

Cell Rep. 2017 May 23;19(8):1723-1738. doi: 10.1016/j.celrep.2017.05.006.

7.

Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration.

Diermeier SD, Chang KC, Freier SM, Song J, El Demerdash O, Krasnitz A, Rigo F, Bennett CF, Spector DL.

Cell Rep. 2016 Sep 27;17(1):261-274. doi: 10.1016/j.celrep.2016.08.081.

8.

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.

Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL.

Genes Dev. 2016 Jan 1;30(1):34-51. doi: 10.1101/gad.270959.115. Epub 2015 Dec 23.

9.

Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2.

Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL.

BMC Genomics. 2015 Nov 21;16:982. doi: 10.1186/s12864-015-2137-5.

10.

Regulation of the ESC transcriptome by nuclear long noncoding RNAs.

Bergmann JH, Li J, Eckersley-Maslin MA, Rigo F, Freier SM, Spector DL.

Genome Res. 2015 Sep;25(9):1336-46. doi: 10.1101/gr.189027.114. Epub 2015 Jun 5.

11.

Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.

Hogan MS, Parfitt DE, Zepeda-Mendoza CJ, Shen MM, Spector DL.

Cell Stem Cell. 2015 Mar 5;16(3):275-88. doi: 10.1016/j.stem.2015.02.001.

12.

Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data.

Tektonidis M, Kim IH, Chen YC, Eils R, Spector DL, Rohr K.

Med Image Anal. 2015 Jan;19(1):1-14. doi: 10.1016/j.media.2014.07.006. Epub 2014 Aug 11.

PMID:
25181702
13.

Random monoallelic expression: regulating gene expression one allele at a time.

Eckersley-Maslin MA, Spector DL.

Trends Genet. 2014 Jun;30(6):237-44. doi: 10.1016/j.tig.2014.03.003. Epub 2014 Apr 26. Review.

14.

Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.

Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D, Miano JM.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1249-59. doi: 10.1161/ATVBAHA.114.303240. Epub 2014 Feb 27.

15.

Random monoallelic gene expression increases upon embryonic stem cell differentiation.

Eckersley-Maslin MA, Thybert D, Bergmann JH, Marioni JC, Flicek P, Spector DL.

Dev Cell. 2014 Feb 24;28(4):351-65. doi: 10.1016/j.devcel.2014.01.017.

16.

Long non-coding RNAs: modulators of nuclear structure and function.

Bergmann JH, Spector DL.

Curr Opin Cell Biol. 2014 Feb;26:10-8. doi: 10.1016/j.ceb.2013.08.005. Epub 2013 Sep 20. Review.

17.

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA.

Stem Cell Reports. 2013 Oct 24;1(5):371-8. doi: 10.1016/j.stemcr.2013.09.002. eCollection 2013.

18.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, Muhar M, Haslinger C, Yu M, Roeder RG, Wigler MH, Blobel GA, Zuber J, Spector DL, Young RA, Vakoc CR.

Genes Dev. 2013 Dec 15;27(24):2648-62. doi: 10.1101/gad.232710.113. Epub 2013 Nov 27.

19.

Receptor-mediated delivery of engineered nucleases for genome modification.

Chen Z, Jaafar L, Agyekum DG, Xiao H, Wade MF, Kumaran RI, Spector DL, Bao G, Porteus MH, Dynan WS, Meiler SE.

Nucleic Acids Res. 2013 Oct;41(19):e182. doi: 10.1093/nar/gkt710. Epub 2013 Aug 16.

20.

Chromatin meets its organizers.

Bodnar MS, Spector DL.

Cell. 2013 Jun 6;153(6):1187-9. doi: 10.1016/j.cell.2013.05.030.

21.

Lamin A/C is expressed in pluripotent mouse embryonic stem cells.

Eckersley-Maslin MA, Bergmann JH, Lazar Z, Spector DL.

Nucleus. 2013 Jan-Feb;4(1):53-60. doi: 10.4161/nucl.23384. Epub 2013 Jan 1.

22.

Chromatin organization and transcriptional regulation.

Hübner MR, Eckersley-Maslin MA, Spector DL.

Curr Opin Genet Dev. 2013 Apr;23(2):89-95. doi: 10.1016/j.gde.2012.11.006. Epub 2012 Dec 24. Review.

23.

The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S.

Cancer Res. 2013 Feb 1;73(3):1180-9. doi: 10.1158/0008-5472.CAN-12-2850. Epub 2012 Dec 14.

24.

The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.

Zhang B, Arun G, Mao YS, Lazar Z, Hung G, Bhattacharjee G, Xiao X, Booth CJ, Wu J, Zhang C, Spector DL.

Cell Rep. 2012 Jul 26;2(1):111-23. doi: 10.1016/j.celrep.2012.06.003. Epub 2012 Jun 28.

25.

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation.

Zhao R, Nakamura T, Fu Y, Lazar Z, Spector DL.

Nat Cell Biol. 2011 Oct 9;13(11):1295-304. doi: 10.1038/ncb2341.

26.

Immunofluorescence localization of nuclear proteins.

Spector DL.

Cold Spring Harb Protoc. 2011 Oct 1;2011(10):1276-80. doi: 10.1101/pdb.prot065755.

PMID:
21969615
27.

Biogenesis and function of nuclear bodies.

Mao YS, Zhang B, Spector DL.

Trends Genet. 2011 Aug;27(8):295-306. doi: 10.1016/j.tig.2011.05.006. Epub 2011 Jun 15. Review.

28.

Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes.

Shi L, Wang J, Hong F, Spector DL, Fang Y.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10574-8. doi: 10.1073/pnas.1017882108. Epub 2011 Jun 13.

29.

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

Hübner MR, Spector DL.

Cold Spring Harb Symp Quant Biol. 2010;75:43-9. doi: 10.1101/sqb.2010.75.020. Epub 2011 Jan 5.

PMID:
21209387
30.

Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.

Mao YS, Sunwoo H, Zhang B, Spector DL.

Nat Cell Biol. 2011 Jan;13(1):95-101. doi: 10.1038/ncb2140. Epub 2010 Dec 19.

31.

Constructing and expressing fluorescent protein fusions.

Spector DL, Goldman RD.

Cold Spring Harb Protoc. 2010 Nov 1;2010(11):pdb.top87. doi: 10.1101/pdb.top87.

PMID:
21041402
32.

Transfection of mammalian cells with fluorescent protein fusions.

Spector DL, Goldman RD.

Cold Spring Harb Protoc. 2010 Nov 1;2010(11):pdb.prot5517. doi: 10.1101/pdb.prot5517.

PMID:
21041390
33.

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.

Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.

34.

Nuclear speckles.

Spector DL, Lamond AI.

Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a000646. doi: 10.1101/cshperspect.a000646. Review.

35.

Nuclear organization and dynamics of 7SK RNA in regulating gene expression.

Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hübner MR, Spector DL.

Mol Biol Cell. 2010 Dec;21(23):4184-96. doi: 10.1091/mbc.E10-02-0105. Epub 2010 Sep 29.

36.

Nonrigid registration of 2-D and 3-D dynamic cell nuclei images for improved classification of subcellular particle motion.

Kim IH, Chen YC, Spector DL, Eils R, Rohr K.

IEEE Trans Image Process. 2011 Apr;20(4):1011-22. doi: 10.1109/TIP.2010.2076377. Epub 2010 Sep 13.

37.

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression.

Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A.

EMBO J. 2010 Sep 15;29(18):3082-93. doi: 10.1038/emboj.2010.199. Epub 2010 Aug 20.

38.

Chromatin dynamics.

Hübner MR, Spector DL.

Annu Rev Biophys. 2010;39:471-89. doi: 10.1146/annurev.biophys.093008.131348. Review.

39.

The life of an mRNA in space and time.

Ben-Ari Y, Brody Y, Kinor N, Mor A, Tsukamoto T, Spector DL, Singer RH, Shav-Tal Y.

J Cell Sci. 2010 May 15;123(Pt 10):1761-74. doi: 10.1242/jcs.062638. Epub 2010 Apr 27.

40.

Live cell imaging of plants.

Fang Y, Spector DL.

Cold Spring Harb Protoc. 2010 Feb;2010(2):pdb.top68. doi: 10.1101/pdb.top68. No abstract available.

PMID:
20150164
41.

Four-dimensional imaging of plant cells during the cell cycle.

Fang Y, Spector DL.

Cold Spring Harb Protoc. 2010 Feb;2010(2):pdb.prot5381. doi: 10.1101/pdb.prot5381. No abstract available.

PMID:
20150144
42.

BiFC imaging assay for plant protein-protein interactions.

Fang Y, Spector DL.

Cold Spring Harb Protoc. 2010 Feb;2010(2):pdb.prot5380. doi: 10.1101/pdb.prot5380. No abstract available.

PMID:
20150143
43.

An unexpected ending: noncanonical 3' end processing mechanisms.

Wilusz JE, Spector DL.

RNA. 2010 Feb;16(2):259-66. doi: 10.1261/rna.1907510. Epub 2009 Dec 9. Review.

44.

Long noncoding RNAs: functional surprises from the RNA world.

Wilusz JE, Sunwoo H, Spector DL.

Genes Dev. 2009 Jul 1;23(13):1494-504. doi: 10.1101/gad.1800909. Review.

45.

Nuclear neighborhoods and gene expression.

Zhao R, Bodnar MS, Spector DL.

Curr Opin Genet Dev. 2009 Apr;19(2):172-9. doi: 10.1016/j.gde.2009.02.007. Epub 2009 Mar 30. Review.

46.

MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.

Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL.

Genome Res. 2009 Mar;19(3):347-59. doi: 10.1101/gr.087775.108. Epub 2008 Dec 22.

47.

3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.

Wilusz JE, Freier SM, Spector DL.

Cell. 2008 Nov 28;135(5):919-32. doi: 10.1016/j.cell.2008.10.012.

48.

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

Dimitrova N, Chen YC, Spector DL, de Lange T.

Nature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008 Oct 19.

49.

Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis.

Chen YC, Kappel C, Beaudouin J, Eils R, Spector DL.

Mol Biol Cell. 2008 Jul;19(7):3147-62. doi: 10.1091/mbc.E08-01-0035. Epub 2008 May 14.

50.

Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis.

Rosin FM, Watanabe N, Cacas JL, Kato N, Arroyo JM, Fang Y, May B, Vaughn M, Simorowski J, Ramu U, McCombie RW, Spector DL, Martienssen RA, Lam E.

Plant J. 2008 Aug;55(3):514-25. doi: 10.1111/j.1365-313X.2008.03517.x. Epub 2008 Apr 12.

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