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Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.

Feng Y, Livingston-Rosanoff D, Roback L, Sundararajan A, Speck SH, Mocarski ES, Daley-Bauer LP.

J Immunol. 2018 Oct 15;201(8):2244-2255. doi: 10.4049/jimmunol.1800110. Epub 2018 Sep 7.


Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo.

Terrell S, Speck SH.

PLoS Pathog. 2017 Aug 2;13(8):e1006543. doi: 10.1371/journal.ppat.1006543. eCollection 2017 Aug.


Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta.

Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X.

Nucleic Acids Res. 2017 Mar 17;45(5):2503-2515. doi: 10.1093/nar/gkx057.


Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential.

Wakeman BS, Izumiya Y, Speck SH.

J Virol. 2016 Dec 16;91(1). pii: e01434-16. doi: 10.1128/JVI.01434-16. Print 2017 Jan 1.


CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.

O'Flaherty BM, Matar CG, Wakeman BS, Garcia A, Wilke CA, Courtney CL, Moore BB, Speck SH.

PLoS One. 2015 Aug 28;10(8):e0135719. doi: 10.1371/journal.pone.0135719. eCollection 2015.


Does EBV alter the pathogenesis of malaria?

Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM.

Parasite Immunol. 2015 Sep;37(9):433-45. doi: 10.1111/pim.12212. Review.


Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity.

Matar CG, Anthony NR, O'Flaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ.

PLoS Pathog. 2015 May 21;11(5):e1004858. doi: 10.1371/journal.ppat.1004858. eCollection 2015 May.


Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection.

Pinelli DF, Wakeman BS, Wagener ME, Speck SH, Ford ML.

Am J Transplant. 2015 Oct;15(10):2576-87. doi: 10.1111/ajt.13326. Epub 2015 May 19.


Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency.

Collins CM, Speck SH.

PLoS Pathog. 2015 Apr 13;11(4):e1004831. doi: 10.1371/journal.ppat.1004831. eCollection 2015 Apr. Erratum in: PLoS Pathog. 2015 May;11(5):e1004922.


Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo.

Rangaswamy US, O'Flaherty BM, Speck SH.

PLoS One. 2014 Aug 14;9(8):e105197. doi: 10.1371/journal.pone.0105197. eCollection 2014.


The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells.

O'Flaherty BM, Soni T, Wakeman BS, Speck SH.

PLoS Pathog. 2014 Aug 7;10(8):e1004302. doi: 10.1371/journal.ppat.1004302. eCollection 2014 Aug.


Murine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP-1.

Matar CG, Rangaswamy US, Wakeman BS, Iwakoshi N, Speck SH.

J Virol. 2014 Oct;88(19):11600-10. doi: 10.1128/JVI.01876-14. Epub 2014 Jul 30.


Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW.

Science. 2014 Aug 1;345(6196):573-7. doi: 10.1126/science.1254517. Epub 2014 Jun 26.


RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7753-8. doi: 10.1073/pnas.1401857111. Epub 2014 May 12.


Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.

Collins CM, Speck SH.

PLoS Pathog. 2014 May 1;10(5):e1004106. doi: 10.1371/journal.ppat.1004106. eCollection 2014 May.


Identification of alternative transcripts encoding the essential murine gammaherpesvirus lytic transactivator RTA.

Wakeman BS, Johnson LS, Paden CR, Gray KS, Virgin HW, Speck SH.

J Virol. 2014 May;88(10):5474-90. doi: 10.1128/JVI.03110-13. Epub 2014 Feb 26.


Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells.

Rangaswamy US, Speck SH.

PLoS Pathog. 2014 Jan;10(1):e1003858. doi: 10.1371/journal.ppat.1003858. Epub 2014 Jan 2.


Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.

Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS.

PLoS One. 2013 Aug 5;8(8):e71221. doi: 10.1371/journal.pone.0071221. Print 2013.


Insights into chronic gamma-herpesvirus infections.

Jung JU, Speck SH.

Curr Opin Virol. 2013 Jun;3(3):225-6. doi: 10.1016/j.coviro.2013.05.018. Epub 2013 Jun 3. No abstract available.


CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth.

Liang X, Crepeau RL, Zhang W, Speck SH, Usherwood EJ.

J Virol. 2013 May;87(10):6051-4. doi: 10.1128/JVI.00375-13. Epub 2013 Mar 20.


The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells.

Krug LT, Evans AG, Gargano LM, Paden CR, Speck SH.

J Virol. 2013 Mar;87(6):3597-604. doi: 10.1128/JVI.01953-12. Epub 2013 Jan 9.


Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle.

Stahl JA, Paden CR, Chavan SS, MacLeod V, Edmondson RD, Speck SH, Forrest JC.

J Virol. 2012 Dec;86(24):13253-62. doi: 10.1128/JVI.01432-12. Epub 2012 Sep 26.


Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.

Paden CR, Forrest JC, Tibbetts SA, Speck SH.

PLoS Pathog. 2012 Sep;8(9):e1002906. doi: 10.1371/journal.ppat.1002906. Epub 2012 Sep 6.


Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.

Gray KS, Collins CM, Speck SH.

PLoS One. 2012;7(8):e43196. doi: 10.1371/journal.pone.0043196. Epub 2012 Aug 29.


Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo.

Collins CM, Speck SH.

PLoS One. 2012;7(3):e33230. doi: 10.1371/journal.pone.0033230. Epub 2012 Mar 13.


Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen.

Liang X, Paden CR, Morales FM, Powers RP, Jacob J, Speck SH.

PLoS Pathog. 2011 Sep;7(9):e1002220. doi: 10.1371/journal.ppat.1002220. Epub 2011 Sep 8.


Pathogenesis and host control of gammaherpesviruses: lessons from the mouse.

Barton E, Mandal P, Speck SH.

Annu Rev Immunol. 2011;29:351-97. doi: 10.1146/annurev-immunol-072710-081639. Review.


Viral latency and its regulation: lessons from the gamma-herpesviruses.

Speck SH, Ganem D.

Cell Host Microbe. 2010 Jul 22;8(1):100-15. doi: 10.1016/j.chom.2010.06.014. Review.


Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis.

Krug LT, Torres-González E, Qin Q, Sorescu D, Rojas M, Stecenko A, Speck SH, Mora AL.

Am J Pathol. 2010 Aug;177(2):608-21. doi: 10.2353/ajpath.2010.091122. Epub 2010 Jun 21.


Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.

Paden CR, Forrest JC, Moorman NJ, Speck SH.

J Virol. 2010 Jul;84(14):7214-24. doi: 10.1128/JVI.00133-10. Epub 2010 May 5.


The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency.

Gray KS, Forrest JC, Speck SH.

J Virol. 2010 May;84(10):4946-59. doi: 10.1128/JVI.00060-10. Epub 2010 Mar 3.


Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes.

Liang X, Collins CM, Mendel JB, Iwakoshi NN, Speck SH.

PLoS Pathog. 2009 Nov;5(11):e1000677. doi: 10.1371/journal.ppat.1000677. Epub 2009 Nov 26.


Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses.

Siegel AM, Rangaswamy US, Napier RJ, Speck SH.

J Virol. 2010 Jan;84(2):674-85. doi: 10.1128/JVI.01306-09. Epub 2009 Nov 4.


Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein.

Collins CM, Boss JM, Speck SH.

J Virol. 2009 Jul;83(13):6484-93. doi: 10.1128/JVI.00297-09. Epub 2009 Apr 22.


NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.

Krug LT, Collins CM, Gargano LM, Speck SH.

J Virol. 2009 May;83(10):4732-48. doi: 10.1128/JVI.00111-09. Epub 2009 Mar 4.


Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo.

Gargano LM, Forrest JC, Speck SH.

J Virol. 2009 Feb;83(3):1474-82. doi: 10.1128/JVI.01717-08. Epub 2008 Nov 19.


Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency.

Gray KS, Allen RD 3rd, Farrell ML, Forrest JC, Speck SH.

J Virol. 2009 Jan;83(1):314-28. doi: 10.1128/JVI.01444-08. Epub 2008 Oct 29.


Identification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene.

DeZalia M, Speck SH.

J Virol. 2008 Aug;82(15):7411-21. doi: 10.1128/JVI.00651-08. Epub 2008 May 14.


The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation.

Siegel AM, Herskowitz JH, Speck SH.

PLoS Pathog. 2008 Apr 4;4(4):e1000039. doi: 10.1371/journal.ppat.1000039.


A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.

Evans AG, Moser JM, Krug LT, Pozharskaya V, Mora AL, Speck SH.

J Exp Med. 2008 Mar 17;205(3):669-84. doi: 10.1084/jem.20071135. Epub 2008 Mar 10.


Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.

Stapler D, Lee ED, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S.

J Immunol. 2008 Mar 1;180(5):3190-200.


Role for MyD88 signaling in murine gammaherpesvirus 68 latency.

Gargano LM, Moser JM, Speck SH.

J Virol. 2008 Apr;82(8):3853-63. doi: 10.1128/JVI.02577-07. Epub 2008 Feb 6.


Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.

Herskowitz JH, Siegel AM, Jacoby MA, Speck SH.

J Virol. 2008 Apr;82(7):3295-310. doi: 10.1128/JVI.02234-07. Epub 2008 Jan 30.


ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication.

Forrest JC, Paden CR, Allen RD 3rd, Collins J, Speck SH.

J Virol. 2007 Nov;81(21):11957-71. Epub 2007 Aug 15.


Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication.

Allen RD 3rd, DeZalia MN, Speck SH.

Virology. 2007 Sep 1;365(2):250-9. Epub 2007 May 2.


Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.

Mora AL, Torres-González E, Rojas M, Xu J, Ritzenthaler J, Speck SH, Roman J, Brigham K, Stecenko A.

Am J Respir Crit Care Med. 2007 Jun 1;175(11):1139-50. Epub 2007 Mar 15.


Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.

Krug LT, Moser JM, Dickerson SM, Speck SH.

PLoS Pathog. 2007 Jan;3(1):e11.


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