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Polymorphisms of SOCS-1 are associated with rapid HIV progression rate.

Hersberger M, Schlaepfer E, Buehler M, Bochud PY, Vernazza P, Marti-Jaun J, Nemeth J, Zwahlen M, Schmidlin K, Speck RF.

J Acquir Immune Defic Syndr. 2020 Feb 21. doi: 10.1097/QAI.0000000000002319. [Epub ahead of print]


Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.

Hernandez MM, Fahrny A, Jayaprakash A, Gers-Huber G, Dillon-White M, Audigé A, Mulder LCF, Sachidanandam R, Speck RF, Simon V.

J Virol. 2020 Feb 14;94(5). pii: e01543-19. doi: 10.1128/JVI.01543-19. Print 2020 Feb 14.


In utero Hepatitis B Immunization during Fetal Surgery for Spina Bifida.

Moehrlen U, Elrod J, Ochsenbein-Kölble N, Berger C, Speck RF, Mazzone L, Krähenmann F, Zimmermann R, Meuli M.

Fetal Diagn Ther. 2019 Nov 13:1-4. doi: 10.1159/000503447. [Epub ahead of print]


Transplantation of gene-modified haematopoietic stem cells: Application and clinical considerations.

Alessandrini M, Krause KH, Speck RF, Pepper MS.

S Afr Med J. 2019 Sep 10;109(8b):64-69. doi: 10.7196/SAMJ.2019.v109i8b.013910. Review.


Reply to Hasenkrug et al., "Different Biological Activities of Specific Interferon Alpha Subtypes".

Schlaepfer E, Fahrny A, Gruenbach M, Kuster SP, Simon V, Schreiber G, Speck RF.

mSphere. 2019 Jul 24;4(4). pii: e00275-19. doi: 10.1128/mSphere.00275-19. No abstract available.


Efficient Human Cytomegalovirus Replication in Primary Endothelial Cells Is SOCS3 Dependent.

Sonzogni O, Millard AL, Taveira A, Schneider MKJ, Duo L, Speck RF, Wulf GM, Mueller NJ.

Intervirology. 2019;62(2):80-89. doi: 10.1159/000501383. Epub 2019 Jul 17.


Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects.

Schlaepfer E, Fahrny A, Gruenbach M, Kuster SP, Simon V, Schreiber G, Speck RF.

mSphere. 2019 Feb 13;4(1). pii: e00637-18. doi: 10.1128/mSphere.00637-18.


Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown.

Rousset F, Salmon P, Bredl S, Cherpin O, Coelho M, Myburgh R, Alessandrini M, Perny M, Roccio M, Speck RF, Senn P, Krause KH.

Mol Ther Nucleic Acids. 2019 Mar 1;14:351-363. doi: 10.1016/j.omtn.2018.12.004. Epub 2018 Dec 14.


Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART.

Rochat MA, Schlaepfer E, Kuster SP, Li D, Audige A, Ivic S, Fahrny A, Speck RF.

Virol J. 2018 Dec 17;15(1):191. doi: 10.1186/s12985-018-1101-9.


Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs.

Brozy J, Schlaepfer E, Mueller CKS, Rochat MA, Rampini SK, Myburgh R, Raum T, Kufer P, Baeuerle PA, Muenz M, Speck RF.

J Virol. 2018 Jun 29;92(14). pii: e00491-18. doi: 10.1128/JVI.00491-18. Print 2018 Jul 15.


Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells.

Audigé A, Rochat MA, Li D, Ivic S, Fahrny A, Muller CKS, Gers-Huber G, Myburgh R, Bredl S, Schlaepfer E, Scherrer AU, Kuster SP, Speck RF.

BMC Immunol. 2017 May 30;18(1):28. doi: 10.1186/s12865-017-0209-9.


Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.

Rochat MA, Schlaepfer E, Speck RF.

J Virol. 2017 Jan 31;91(4). pii: e02084-16. doi: 10.1128/JVI.02084-16. Print 2017 Feb 15.


Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.

Cecchinato V, Bernasconi E, Speck RF, Proietti M, Sauermann U, D'Agostino G, Danelon G, Rezzonico Jost T, Grassi F, Raeli L, Schöni-Affolter F, Stahl-Hennig C, Uguccioni M; Swiss HIV Cohort Study.

J Immunol. 2017 Jan 1;198(1):184-195. Epub 2016 Nov 28.


Similar efficacy of broad-range ITS PCR and conventional fungal culture for diagnosing fungal infections in non-immunocompromised patients.

Rampini SK, Zbinden A, Speck RF, Bloemberg GV.

BMC Microbiol. 2016 Jun 28;16(1):132. doi: 10.1186/s12866-016-0752-1.


Interferon α-Enhanced Clearance of Group A Streptococcus Despite Neutropenia.

Uchiyama S, Keller N, Schlaepfer E, Grube C, Schuepbach RA, Speck RF, Zinkernagel AS.

J Infect Dis. 2016 Jul 15;214(2):321-8. doi: 10.1093/infdis/jiw157. Epub 2016 Apr 18.


Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies.

Thiébaut R, Jarne A, Routy JP, Sereti I, Fischl M, Ive P, Speck RF, D'Offizi G, Casari S, Commenges D, Foulkes S, Natarajan V, Croughs T, Delfraissy JF, Tambussi G, Levy Y, Lederman MM.

Clin Infect Dis. 2016 May 1;62(9):1178-1185. doi: 10.1093/cid/ciw065. Epub 2016 Feb 7.


Ribavirin Concentrations Do Not Predict Sustained Virological Response in HIV/HCV-Coinfected Patients Treated with Ribavirin and Pegylated Interferon in the Swiss HIV Cohort Study.

Kovari H, Russmann S, Ledergerber B, Müller D, Rotger M, Velli P, Cavassini M, Ambrosioni J, Bregenzer A, Stöckle M, Bernasconi E, Rauch A, Speck RF; Swiss HIV Cohort Study.

PLoS One. 2015 Jul 28;10(7):e0133879. doi: 10.1371/journal.pone.0133879. eCollection 2015.


Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.

Li D, Schlaepfer E, Audigé A, Rochat MA, Ivic S, Knowlton CN, Kim B, Keppler OT, Speck RF.

Stem Cell Res. 2015 Sep;15(2):271-80. doi: 10.1016/j.scr.2015.06.012. Epub 2015 Jul 3.


Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice.

Myburgh R, Ivic S, Pepper MS, Gers-Huber G, Li D, Audigé A, Rochat MA, Jaquet V, Regenass S, Manz MG, Salmon P, Krause KH, Speck RF.

J Virol. 2015 Jul;89(13):6761-72. doi: 10.1128/JVI.00277-15. Epub 2015 Apr 22.


Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.

Campos N, Myburgh R, Garcel A, Vautrin A, Lapasset L, Nadal ES, Mahuteau-Betzer F, Najman R, Fornarelli P, Tantale K, Basyuk E, Séveno M, Venables JP, Pau B, Bertrand E, Wainberg MA, Speck RF, Scherrer D, Tazi J.

Retrovirology. 2015 Apr 9;12:30. doi: 10.1186/s12977-015-0159-3.


Telomerase activity impacts on Epstein-Barr virus infection of AGS cells.

Rac J, Haas F, Schumacher A, Middeldorp JM, Delecluse HJ, Speck RF, Bernasconi M, Nadal D.

PLoS One. 2015 Apr 9;10(4):e0123645. doi: 10.1371/journal.pone.0123645. eCollection 2015.


Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich.

Büchler AC, Rampini SK, Stelling S, Ledergerber B, Peter S, Schweiger A, Ruef C, Zbinden R, Speck RF.

BMC Infect Dis. 2014 Nov 26;14:607. doi: 10.1186/s12879-014-0607-z.


Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction.

Myburgh R, Cherpin O, Schlaepfer E, Rehrauer H, Speck RF, Krause KH, Salmon P.

Mol Ther Nucleic Acids. 2014 Oct 28;3:e207. doi: 10.1038/mtna.2014.58.


[Prevention of HIV and other sexually transmitted infections (STI)].

Stoliaroff-Pépin A, Speck RF, Vernazza P.

Ther Umsch. 2014 Aug;71(8):515-23. doi: 10.1024/0040-5930/a000546. Review. German.


[Diagnosing HIV in Switzerland].

Schüpbach J, Berger C, Böni J, Speck RF.

Ther Umsch. 2014 Aug;71(8):451-60. doi: 10.1024/0040-5930/a000537. Review. German.


Triggering TLR2, -3, -4, -5, and -8 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV.

Schlaepfer E, Rochat MA, Duo L, Speck RF.

J Virol. 2014 Sep 1;88(17):9769-81. doi: 10.1128/JVI.01053-14. Epub 2014 Jun 18.


Activation of NF-κB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation.

Haas F, Yamauchi K, Murat M, Bernasconi M, Yamanaka N, Speck RF, Nadal D.

J Virol. 2014 Sep 1;88(17):10002-12. doi: 10.1128/JVI.01486-14. Epub 2014 Jun 18.


Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases.

Bernasconi M, Ueda S, Krukowski P, Bornhauser BC, Ladell K, Dorner M, Sigrist JA, Campidelli C, Aslandogmus R, Alessi D, Berger C, Pileri SA, Speck RF, Nadal D.

Int J Cancer. 2013 Nov 15;133(10):2341-50. doi: 10.1002/ijc.28239. Epub 2013 May 29.


Modeling HIV infection and therapies in humanized mice.

Nischang M, Gers-Huber G, Audigé A, Akkina R, Speck RF.

Swiss Med Wkly. 2012 Jul 9;142:w13618. doi: 10.4414/smw.2012.13618. eCollection 2012. Review.


Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1.

Nischang M, Sutmuller R, Gers-Huber G, Audigé A, Li D, Rochat MA, Baenziger S, Hofer U, Schlaepfer E, Regenass S, Amssoms K, Stoops B, Van Cauwenberge A, Boden D, Kraus G, Speck RF.

PLoS One. 2012;7(6):e38853. doi: 10.1371/journal.pone.0038853. Epub 2012 Jun 13.


Broad-range 16S rRNA gene polymerase chain reaction for diagnosis of culture-negative bacterial infections.

Rampini SK, Bloemberg GV, Keller PM, Büchler AC, Dollenmaier G, Speck RF, Böttger EC.

Clin Infect Dis. 2011 Dec;53(12):1245-51. doi: 10.1093/cid/cir692. Epub 2011 Oct 5.


Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-α and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models.

Audigé A, Hofer U, Dittmer U, van den Broek M, Speck RF.

Viral Immunol. 2011 Oct;24(5):375-85. doi: 10.1089/vim.2011.0006. Epub 2011 Sep 19.


HIV interferes with SOCS-1 and -3 expression levels driving immune activation.

Miller RC, Schlaepfer E, Baenziger S, Crameri R, Zeller S, Byland R, Audigé A, Nadal D, Speck RF.

Eur J Immunol. 2011 Apr;41(4):1058-69. doi: 10.1002/eji.201041198. Epub 2011 Feb 21.


Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption.

Hofmaenner D, Kovari H, Weber A, Weishaupt D, Speck RF.

BMJ Case Rep. 2011 May 3;2011. pii: bcr0320113928. doi: 10.1136/bcr.03.2011.3928.


B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted TNF-α response to TLR9 triggering.

Audigé A, Schlaepfer E, von Wyl V, Miller RC, Vernazza P, Nadal D, Speck RF; SHCS.

AIDS Res Hum Retroviruses. 2010 Oct;26(10):1063-74.


Low postseroconversion CD4 count and rapid decrease of CD4 density identify HIV+ fast progressors.

Audigé A, Taffé P, Rickenbach M, Battegay M, Vernazza P, Nadal D, Speck RF; Swiss HIV Cohort Study (SHCS).

AIDS Res Hum Retroviruses. 2010 Sep;26(9):997-1005. doi: 10.1089/aid.2009.0263.


Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.

Keller PM, Rampini SK, Büchler AC, Eich G, Wanner RM, Speck RF, Böttger EC, Bloemberg GV.

J Clin Microbiol. 2010 Sep;48(9):3397-402. doi: 10.1128/JCM.01098-10. Epub 2010 Jul 14.


TLR9 triggering in Burkitt's lymphoma cell lines suppresses the EBV BZLF1 transcription via histone modification.

Zauner L, Melroe GT, Sigrist JA, Rechsteiner MP, Dorner M, Arnold M, Berger C, Bernasconi M, Schaefer BW, Speck RF, Nadal D.

Oncogene. 2010 Aug 12;29(32):4588-98. doi: 10.1038/onc.2010.203. Epub 2010 May 31.


Inadequate clearance of translocated bacterial products in HIV-infected humanized mice.

Hofer U, Schlaepfer E, Baenziger S, Nischang M, Regenass S, Schwendener R, Kempf W, Nadal D, Speck RF.

PLoS Pathog. 2010 Apr 29;6(4):e1000867. doi: 10.1371/journal.ppat.1000867.


beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection.

Dorner M, Zucol F, Alessi D, Haerle SK, Bossart W, Weber M, Byland R, Bernasconi M, Berger C, Tugizov S, Speck RF, Nadal D.

J Virol. 2010 Jul;84(13):6667-77. doi: 10.1128/JVI.02675-09. Epub 2010 Apr 28.


Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production.

Dorner M, Brandt S, Tinguely M, Zucol F, Bourquin JP, Zauner L, Berger C, Bernasconi M, Speck RF, Nadal D.

Immunology. 2009 Dec;128(4):573-9. doi: 10.1111/j.1365-2567.2009.03143.x.


Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma.

Bihl F, Berger C, Chisholm JV 3rd, Henry LM, Bertisch B, Trojan A, Nadal D, Speck RF, Flepp M, Brander C, Mueller NJ; Swiss HIV Cohort Study.

AIDS. 2009 Sep 10;23(14):1918-22. doi: 10.1097/QAD.0b013e3283300a91.


Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection.

Hofer U, Speck RF.

Semin Immunopathol. 2009 Jul;31(2):257-66. doi: 10.1007/s00281-009-0158-3. Epub 2009 May 30.


Immuno-chemotherapy reduces recurrence of malignant pleural mesothelioma: an experimental setting.

Ampollini L, Soltermann A, Felley-Bosco E, Lardinois D, Arni S, Speck RF, Weder W, Opitz I.

Eur J Cardiothorac Surg. 2009 Mar;35(3):457-62. doi: 10.1016/j.ejcts.2008.11.030. Epub 2009 Jan 21.


RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF.

J Virol. 2008 Dec;82(24):12145-53. doi: 10.1128/JVI.01105-08. Epub 2008 Oct 8.


Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

Baenziger S, Heikenwalder M, Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.

Blood. 2009 Jan 8;113(2):377-88. doi: 10.1182/blood-2008-04-151712. Epub 2008 Sep 29.


Human T cell development and HIV infection in human hemato-lymphoid system mice.

Baenziger S, Ziegler P, Mazzucchelli L, Bronz L, Speck RF, Manz MG.

Curr Top Microbiol Immunol. 2008;324:125-31. Review.


Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering.

Schlaepfer E, Speck RF.

PLoS One. 2008 Apr 23;3(4):e1999. doi: 10.1371/journal.pone.0001999.


Antigen kinetics determines immune reactivity.

Johansen P, Storni T, Rettig L, Qiu Z, Der-Sarkissian A, Smith KA, Manolova V, Lang KS, Senti G, Müllhaupt B, Gerlach T, Speck RF, Bot A, Kündig TM.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5189-94. doi: 10.1073/pnas.0706296105. Epub 2008 Mar 24.

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