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Items: 1 to 50 of 131

1.

ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.

Luo X, Feurstein S, Mohan S, Porter CC, Jackson SA, Keel S, Chicka M, Brown AL, Kesserwan C, Agarwal A, Luo M, Li Z, Ross JE, Baliakas P, Pineda-Alvarez D, DiNardo CD, Bertuch AA, Mehta N, Vulliamy T, Wang Y, Nichols KE, Malcovati L, Walsh MF, Rawlings LH, McWeeney SK, Soulier J, Raimbault A, Routbort MJ, Zhang L, Ryan G, Speck NA, Plon SE, Wu D, Godley LA.

Blood Adv. 2019 Oct 22;3(20):2962-2979. doi: 10.1182/bloodadvances.2019000644.

2.

Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth.

Bennett L, Mumau M, Speck NA.

Immunity. 2019 Jun 18;50(6):1342-1344. doi: 10.1016/j.immuni.2019.05.017.

PMID:
31216456
3.

RUNX1 and the endothelial origin of blood.

Gao L, Tober J, Gao P, Chen C, Tan K, Speck NA.

Exp Hematol. 2018 Dec;68:2-9. doi: 10.1016/j.exphem.2018.10.009. Epub 2018 Oct 31. Review.

4.

A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells.

Cai X, Zheng Y, Speck NA.

J Vis Exp. 2018 Aug 22;(138). doi: 10.3791/56855.

5.

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis.

Yzaguirre AD, Howell ED, Li Y, Liu Z, Speck NA.

Development. 2018 Jan 29;145(2). pii: dev158162. doi: 10.1242/dev.158162.

6.

RUNX1 Mutations in Inherited and Sporadic Leukemia.

Bellissimo DC, Speck NA.

Front Cell Dev Biol. 2017 Dec 20;5:111. doi: 10.3389/fcell.2017.00111. eCollection 2017. Review.

7.

Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions.

Kulkeaw K, Inoue T, Iino T, Tani K, Akashi K, Speck NA, Nakanishi Y, Sugiyama D.

Blood Adv. 2017 Aug 31;1(20):1672-1681. doi: 10.1182/bloodadvances.2017006056. eCollection 2017 Sep 12.

8.

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.

Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA.

J Exp Med. 2018 Feb 5;215(2):645-659. doi: 10.1084/jem.20161594. Epub 2017 Dec 27.

9.

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.

Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH.

Leuk Lymphoma. 2018 Sep;59(9):2188-2200. doi: 10.1080/10428194.2017.1410882. Epub 2017 Dec 18.

10.

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.

Zhen T, Kwon EM, Zhao L, Hsu J, Hyde RK, Lu Y, Alemu L, Speck NA, Liu PP.

Blood. 2017 Nov 30;130(22):2431-2442. doi: 10.1182/blood-2017-04-780106. Epub 2017 Oct 10.

11.

CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.

Li Y, Gao L, Hadland B, Tan K, Speck NA.

Blood. 2017 Jul 20;130(3):372-376. doi: 10.1182/blood-2017-03-776849. Epub 2017 Jun 6. No abstract available.

12.

Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.

Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, Le L, Jambhekar M, Raman P, Hayer KE, Wertheim G, Speck NA, Tong W, Viatour P.

J Exp Med. 2017 Jul 3;214(7):1901-1912. doi: 10.1084/jem.20160719. Epub 2017 May 26.

13.

Conversion of adult endothelium to immunocompetent haematopoietic stem cells.

Lis R, Karrasch CC, Poulos MG, Kunar B, Redmond D, Duran JGB, Badwe CR, Schachterle W, Ginsberg M, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck NA, Butler JM, Scandura JM, Rafii S.

Nature. 2017 May 25;545(7655):439-445. doi: 10.1038/nature22326. Epub 2017 May 17.

14.

The Role of Runx1 in Embryonic Blood Cell Formation.

Yzaguirre AD, de Bruijn MF, Speck NA.

Adv Exp Med Biol. 2017;962:47-64. doi: 10.1007/978-981-10-3233-2_4. Review.

15.

Stress Can Be a Good Thing for Blood Formation.

Speck NA.

Cell Stem Cell. 2016 Sep 1;19(3):279-80. doi: 10.1016/j.stem.2016.08.011.

16.

Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites.

Yzaguirre AD, Speck NA.

Dev Dyn. 2016 Oct;245(10):1011-28. doi: 10.1002/dvdy.24430. Epub 2016 Aug 17.

17.

Taking the Leap: Runx1 in the Formation of Blood from Endothelium.

Tober J, Maijenburg MW, Speck NA.

Curr Top Dev Biol. 2016;118:113-62. doi: 10.1016/bs.ctdb.2016.01.008. Epub 2016 Feb 18. Review.

PMID:
27137656
18.

Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos.

Yzaguirre AD, Speck NA.

Dev Biol. 2016 Jul 1;415(1):111-121. doi: 10.1016/j.ydbio.2016.04.004. Epub 2016 Apr 20.

19.

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.

Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA.

Elife. 2015 Oct 13;4:e07780. doi: 10.7554/eLife.07780.

20.

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.

Cai X, Gao L, Teng L, Ge J, Oo ZM, Kumar AR, Gilliland DG, Mason PJ, Tan K, Speck NA.

Cell Stem Cell. 2015 Aug 6;17(2):165-77. doi: 10.1016/j.stem.2015.06.002. Epub 2015 Jul 9.

21.

Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.

Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg MW, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M.

Arthritis Rheumatol. 2015 Oct;67(10):2679-90. doi: 10.1002/art.39243.

22.

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.

Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G.

Nat Cell Biol. 2015 May;17(5):580-91. doi: 10.1038/ncb3161. Epub 2015 Apr 27.

23.

Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.

Tamplin OJ, Durand EM, Carr LA, Childs SJ, Hagedorn EJ, Li P, Yzaguirre AD, Speck NA, Zon LI.

Cell. 2015 Jan 15;160(1-2):241-52. doi: 10.1016/j.cell.2014.12.032.

24.

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, Speck NA.

Genes Dev. 2014 Dec 1;28(23):2597-612. doi: 10.1101/gad.253302.114. Epub 2014 Nov 13.

25.

Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.

Satpathy AT, Briseño CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T.

Blood. 2014 May 8;123(19):2968-77. doi: 10.1182/blood-2013-11-539643. Epub 2014 Mar 27.

26.

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.

Tober J, Yzaguirre AD, Piwarzyk E, Speck NA.

Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7.

27.

The expression of Sox17 identifies and regulates haemogenic endothelium.

Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G.

Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724. Epub 2013 Apr 21.

28.

Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis.

Richard C, Drevon C, Canto PY, Villain G, Bollérot K, Lempereur A, Teillet MA, Vincent C, Rosselló Castillo C, Torres M, Piwarzyk E, Speck NA, Souyri M, Jaffredo T.

Dev Cell. 2013 Mar 25;24(6):600-11. doi: 10.1016/j.devcel.2013.02.011.

29.

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.

DeKelver RC, Yan M, Ahn EY, Shia WJ, Speck NA, Zhang DE.

Blood. 2013 May 2;121(18):3714-7. doi: 10.1182/blood-2012-11-465641. Epub 2013 Feb 20.

30.

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, Mills JA, Choi JK, Speck NA, Gadue P, Hardison RC, Nemiroff RL, French DL, Weiss MJ.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573-8. doi: 10.1073/pnas.1211175109. Epub 2012 Oct 8.

31.

Tyrosyl phosphorylation toggles a Runx1 switch.

Neel BG, Speck NA.

Genes Dev. 2012 Jul 15;26(14):1520-6. doi: 10.1101/gad.198051.112.

32.

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.

Guo H, Ma O, Speck NA, Friedman AD.

Blood. 2012 May 10;119(19):4408-18. doi: 10.1182/blood-2011-12-397091. Epub 2012 Mar 26.

33.

Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.

Soung do Y, Talebian L, Matheny CJ, Guzzo R, Speck ME, Lieberman JR, Speck NA, Drissi H.

J Bone Miner Res. 2012 Jul;27(7):1585-97. doi: 10.1002/jbmr.1601.

34.

Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos.

Yokomizo T, Yamada-Inagawa T, Yzaguirre AD, Chen MJ, Speck NA, Dzierzak E.

Nat Protoc. 2012 Feb 9;7(3):421-31. doi: 10.1038/nprot.2011.441.

36.

Runx1 loss minimally impacts long-term hematopoietic stem cells.

Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA.

PLoS One. 2011;6(12):e28430. doi: 10.1371/journal.pone.0028430. Epub 2011 Dec 1.

37.

Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.

Chen MJ, Li Y, De Obaldia ME, Yang Q, Yzaguirre AD, Yamada-Inagawa T, Vink CS, Bhandoola A, Dzierzak E, Speck NA.

Cell Stem Cell. 2011 Dec 2;9(6):541-52. doi: 10.1016/j.stem.2011.10.003. Erratum in: Cell Stem Cell. 2012 Mar 2;10(3):345-6.

38.

Notch signaling in mammalian hematopoietic stem cells.

Pajcini KV, Speck NA, Pear WS.

Leukemia. 2011 Oct;25(10):1525-32. doi: 10.1038/leu.2011.127. Epub 2011 Jun 7. Review.

39.

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.

Swiers G, de Bruijn M, Speck NA.

Int J Dev Biol. 2010;54(6-7):1151-63. doi: 10.1387/ijdb.103106gs. Review.

40.

Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.

Corpora T, Roudaia L, Oo ZM, Chen W, Manuylova E, Cai X, Chen MJ, Cierpicki T, Speck NA, Bushweller JH.

J Mol Biol. 2010 Sep 24;402(3):560-77. doi: 10.1016/j.jmb.2010.08.007. Epub 2010 Aug 11.

41.

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model.

Sinenko SA, Hung T, Moroz T, Tran QM, Sidhu S, Cheney MD, Speck NA, Banerjee U.

Blood. 2010 Nov 25;116(22):4612-20. doi: 10.1182/blood-2010-03-276998. Epub 2010 Aug 5.

42.

PAF is in the cabal of MLL1-interacting proteins that promote leukemia.

Speck NA, Vakoc CR.

Cancer Cell. 2010 Jun 15;17(6):531-2. doi: 10.1016/j.ccr.2010.05.019.

43.

Visualizing blood cell emergence from aortic endothelium.

Swiers G, Speck NA, de Bruijn MF.

Cell Stem Cell. 2010 Apr 2;6(4):289-90. doi: 10.1016/j.stem.2010.03.007.

44.

DNA specificity determinants associate with distinct transcription factor functions.

Hollenhorst PC, Chandler KJ, Poulsen RL, Johnson WE, Speck NA, Graves BJ.

PLoS Genet. 2009 Dec;5(12):e1000778. doi: 10.1371/journal.pgen.1000778. Epub 2009 Dec 18.

45.

The role of CBFbeta in AML1-ETO's activity.

Park S, Speck NA, Bushweller JH.

Blood. 2009 Sep 24;114(13):2849-50. doi: 10.1182/blood-2009-07-231233. No abstract available.

PMID:
19779050
46.

Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation.

Speck NA, Iruela-Arispe ML.

Blood Cells Mol Dis. 2009 Jul-Aug;43(1):6-11. doi: 10.1016/j.bcmd.2009.01.010. Epub 2009 Feb 28. Review.

47.

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck NA, Bushweller JH.

Blood. 2009 Apr 9;113(15):3558-67. doi: 10.1182/blood-2008-06-161307. Epub 2009 Feb 9.

48.

CBFbeta is critical for AML1-ETO and TEL-AML1 activity.

Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA.

Blood. 2009 Mar 26;113(13):3070-9. doi: 10.1182/blood-2008-03-147207. Epub 2009 Jan 29.

49.

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.

Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA.

Nature. 2009 Feb 12;457(7231):887-91. doi: 10.1038/nature07619. Epub 2009 Jan 7.

50.

A MENage à Trois in leukemia.

Roudaia L, Speck NA.

Cancer Cell. 2008 Jul 8;14(1):3-5. doi: 10.1016/j.ccr.2008.06.009.

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