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Items: 1 to 50 of 196

1.

The C7orf43/TRAPPC14 component links the TRAPPII complex to RABIN8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.

Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ.

J Biol Chem. 2019 Aug 29. pii: jbc.RA119.008615. doi: 10.1074/jbc.RA119.008615. [Epub ahead of print]

2.

MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement.

Donkervoort S, Sabouny R, Yun P, Gauquelin L, Chao KR, Hu Y, Al Khatib I, Töpf A, Mohassel P, Cummings BB, Kaur R, Saade D, Moore SA, Waddell LB, Farrar MA, Goodrich JK, Uapinyoying P, Chan SHS, Javed A, Leach ME, Karachunski P, Dalton J, Medne L, Harper A, Thompson C, Thiffault I, Specht S, Lamont RE, Saunders C, Racher H, Bernier FP, Mowat D, Witting N, Vissing J, Hanson R, Coffman KA, Hainlen M, Parboosingh JS, Carnevale A, Yoon G, Schnur RE; Care4Rare Canada Consortium, Boycott KM, Mah JK, Straub V, Foley AR, Innes AM, Bönnemann CG, Shutt TE.

Acta Neuropathol. 2019 Aug 29. doi: 10.1007/s00401-019-02059-z. [Epub ahead of print]

PMID:
31463572
3.

Amputation Versus Staged Reconstruction for Severe Fibular Hemimelia: Assessment of Psychosocial and Quality-of-Life Status and Physical Functioning in Childhood.

Birch JG, Paley D, Herzenberg JE, Morton A, Ward S, Riddle R, Specht S, Cummings D, Tulchin-Francis K.

JB JS Open Access. 2019 Apr 5;4(2):e0053. doi: 10.2106/JBJS.OA.18.00053. eCollection 2019 Apr-Jun.

4.

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, Ritt DA, Semler E, Specht S, Stauffer J, Morrison DK, Lorentzen E, Westlake CJ.

Dev Cell. 2019 Jul 22;50(2):229-246.e7. doi: 10.1016/j.devcel.2019.05.022. Epub 2019 Jun 13.

PMID:
31204173
5.

Basophils Are Dispensable for the Control of a Filarial Infection.

Hartmann W, Linnemann LC, Reitz M, Specht S, Voehringer D, Breloer M.

Immunohorizons. 2018 Sep 26;2(8):296-304. doi: 10.4049/immunohorizons.1800018.

PMID:
31022700
6.

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells.

Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G.

Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019.

7.

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.

Taylor MJ, von Geldern TW, Ford L, Hübner MP, Marsh K, Johnston KL, Sjoberg HT, Specht S, Pionnier N, Tyrer HE, Clare RH, Cook DAN, Murphy E, Steven A, Archer J, Bloemker D, Lenz F, Koschel M, Ehrens A, Metuge HM, Chunda VC, Ndongmo Chounna PW, Njouendou AJ, Fombad FF, Carr R, Morton HE, Aljayyoussi G, Hoerauf A, Wanji S, Kempf DJ, Turner JD, Ward SA.

Sci Transl Med. 2019 Mar 13;11(483). pii: eaau2086. doi: 10.1126/scitranslmed.aau2086.

PMID:
30867321
8.

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ.

PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb.

9.

Elimination of lymphatic filariasis in South East Asia.

Specht S, Suma TK, Pedrique B, Hoerauf A.

BMJ. 2019 Jan 22;364:k5198. doi: 10.1136/bmj.k5198. No abstract available.

10.

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

Hübner MP, Ehrens A, Koschel M, Dubben B, Lenz F, Frohberger SJ, Specht S, Quirynen L, Lachau-Durand S, Tekle F, Baeten B, Engelen M, Mackenzie CD, Hoerauf A.

PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006320. doi: 10.1371/journal.pntd.0006320. eCollection 2019 Jan.

11.

Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus.

Stein K, Lysson M, Schumak B, Vilz T, Specht S, Heesemann J, Roers A, Kalff JC, Wehner S.

Front Immunol. 2018 Nov 13;9:2599. doi: 10.3389/fimmu.2018.02599. eCollection 2018.

12.

Probing the Transformation of Boron Nitride Catalysts under Oxidative Dehydrogenation Conditions.

Love AM, Thomas B, Specht SE, Hanrahan MP, Venegas JM, Burt SP, Grant JT, Cendejas MC, McDermott WP, Rossini AJ, Hermans I.

J Am Chem Soc. 2019 Jan 9;141(1):182-190. doi: 10.1021/jacs.8b08165. Epub 2018 Dec 20.

PMID:
30525543
13.

Tyrosine substitution of a conserved active-site histidine residue activates Plasmodium falciparum peroxiredoxin 6.

Feld K, Geissel F, Liedgens L, Schumann R, Specht S, Deponte M.

Protein Sci. 2019 Jan;28(1):100-110. doi: 10.1002/pro.3490. Epub 2018 Oct 31.

PMID:
30056630
14.

River blindness: reducing the prevalence of clinical disease.

Mackenzie C, Kollmann M, Specht S, Sodhalon Y.

Community Eye Health. 2018;31(101):25. No abstract available.

15.

Deep brain stimulation of the pedunculopontine nucleus for treatment of gait and balance disorder in progressive supranuclear palsy: Effects of frequency modulations and clinical outcome.

Galazky I, Kaufmann J, Lorenzl S, Ebersbach G, Gandor F, Zaehle T, Specht S, Stallforth S, Sobieray U, Wirkus E, Casjens F, Heinze HJ, Kupsch A, Voges J.

Parkinsonism Relat Disord. 2018 May;50:81-86. doi: 10.1016/j.parkreldis.2018.02.027. Epub 2018 Feb 19.

PMID:
29503154
16.

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.

Schmidt KE, Kuepper JM, Schumak B, Alferink J, Hofmann A, Howland SW, Rénia L, Limmer A, Specht S, Hoerauf A.

PLoS One. 2018 Feb 13;13(2):e0192717. doi: 10.1371/journal.pone.0192717. eCollection 2018.

17.

A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast.

Specht S, Liedgens L, Duarte M, Stiegler A, Wirth U, Eberhardt M, Tomás A, Hell K, Deponte M.

Redox Biol. 2018 May;15:363-374. doi: 10.1016/j.redox.2017.12.010. Epub 2017 Dec 23.

18.

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A.

PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan.

19.

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

Karadjian G, Fercoq F, Pionnier N, Vallarino-Lhermitte N, Lefoulon E, Nieguitsila A, Specht S, Carlin LM, Martin C.

PLoS Negl Trop Dis. 2017 May 9;11(5):e0005596. doi: 10.1371/journal.pntd.0005596. eCollection 2017 May.

20.

Upper Extremity Nerve Function and Pain in Human Volunteers with Narrow versus Wide Tourniquets.

Kovar F, Jauregui JJ, Specht SC, Baker E, Bhave A, Herzenberg JE.

J Long Term Eff Med Implants. 2016;26(2):173-181. doi: 10.1615/JLongTermEffMedImplants.2016015914.

PMID:
28094742
21.

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial.

Klarmann-Schulz U, Specht S, Debrah AY, Batsa L, Ayisi-Boateng NK, Osei-Mensah J, Mubarik Y, Konadu P, Ricchiuto A, Fimmers R, Arriens S, Dubben B, Ford L, Taylor M, Hoerauf A.

PLoS Negl Trop Dis. 2017 Jan 5;11(1):e0005156. doi: 10.1371/journal.pntd.0005156. eCollection 2017 Jan.

22.

PRECICE® magnetically-driven, telescopic, intramedullary lengthening nail: pre-clinical testing and first 30 patients.

Wagner P, Burghardt RD, Green SA, Specht SC, Standard SC, Herzenberg JE.

SICOT J. 2017;3:19. doi: 10.1051/sicotj/2016048. Epub 2017 Mar 6.

23.

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae.

Ajendra J, Specht S, Ziewer S, Schiefer A, Pfarr K, Parčina M, Kufer TA, Hoerauf A, Hübner MP.

Sci Rep. 2016 Dec 22;6:39648. doi: 10.1038/srep39648.

24.

Selective oxidative dehydrogenation of propane to propene using boron nitride catalysts.

Grant JT, Carrero CA, Goeltl F, Venegas J, Mueller P, Burt SP, Specht SE, McDermott WP, Chieregato A, Hermans I.

Science. 2016 Dec 23;354(6319):1570-1573. doi: 10.1126/science.aaf7885. Epub 2016 Dec 1.

PMID:
27934702
25.

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.

Ritt DA, Abreu-Blanco MT, Bindu L, Durrant DE, Zhou M, Specht SI, Stephen AG, Holderfield M, Morrison DK.

Mol Cell. 2016 Dec 1;64(5):875-887. doi: 10.1016/j.molcel.2016.10.029. Epub 2016 Nov 23.

26.

Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism.

Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiss M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A.

J Biol Chem. 2016 Sep 9;291(37):19517-31. doi: 10.1074/jbc.M116.746594. Epub 2016 Jul 29.

27.

Abciximab as a bridging strategy to overcome morphine-prasugrel interaction in STEMI patients.

Siller-Matula JM, Specht S, Kubica J, Alexopoulos D, De Caterina R, Hobl EL, Jilma B, Christ G, Lang IM.

Br J Clin Pharmacol. 2016 Nov;82(5):1343-1350. doi: 10.1111/bcp.13053. Epub 2016 Jul 24.

28.

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses.

Ehlen L, Tödtmann J, Specht S, Kallies R, Papies J, Müller MA, Junglen S, Drosten C, Eckerle I.

Virol J. 2016 May 4;13:74. doi: 10.1186/s12985-016-0531-5.

29.

Nostalgia and Perceptions of Artwork.

Specht SM, Kreiger TC.

Psychol Rep. 2016 Feb;118(1):57-69. doi: 10.1177/0033294115626818.

PMID:
29693530
30.

Patient Satisfaction After Limb Lengthening With Internal and External Devices.

Landge V, Shabtai L, Gesheff M, Specht SC, Herzenberg JE.

J Surg Orthop Adv. 2015 Fall;24(3):174-9.

PMID:
26688988
31.

Litomosoides sigmodontis: a jird urine metabolome study.

Globisch D, Specht S, Pfarr KM, Eubanks LM, Hoerauf A, Janda KD.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5804-7. doi: 10.1016/j.bmcl.2015.10.037. Epub 2015 Oct 23.

PMID:
26573416
32.

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis.

McNulty SN, Rosa BA, Fischer PU, Rumsey JM, Erdmann-Gilmore P, Curtis KC, Specht S, Townsend RR, Weil GJ, Mitreva M.

Mol Cell Proteomics. 2015 Dec;14(12):3224-33. doi: 10.1074/mcp.M115.051953. Epub 2015 Oct 15.

33.

A histochemical study of the Nras/let-60 activity in filarial nematodes.

Geary JF, Lovato R, Wanji S, Guderian R, O'Neill M, Specht S, Madrill N, Geary TG, Mackenzie CD.

Parasit Vectors. 2015 Jul 1;8:353. doi: 10.1186/s13071-015-0947-6.

34.

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial.

Debrah AY, Specht S, Klarmann-Schulz U, Batsa L, Mand S, Marfo-Debrekyei Y, Fimmers R, Dubben B, Kwarteng A, Osei-Atweneboana M, Boakye D, Ricchiuto A, Büttner M, Adjei O, Mackenzie CD, Hoerauf A.

Clin Infect Dis. 2015 Aug 15;61(4):517-26. doi: 10.1093/cid/civ363. Epub 2015 May 6.

35.

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals.

Arndts K, Klarmann-Schulz U, Batsa L, Debrah AY, Epp C, Fimmers R, Specht S, Layland LE, Hoerauf A.

Parasit Vectors. 2015 Mar 28;8:184. doi: 10.1186/s13071-015-0786-5.

36.

Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia.

Mizuguchi Y, Specht S, Isse K, Sasatomi E, Lunz JG 3rd, Takizawa T, Demetris AJ.

J Hepatol. 2015 Aug;63(2):399-407. doi: 10.1016/j.jhep.2015.02.047. Epub 2015 Mar 12.

PMID:
25770659
37.

Analysis of nematode motion using an improved light-scatter based system.

Nutting CS, Eversole RR, Blair K, Specht S, Nutman TB, Klion AD, Wanji S, Boussinesq M, Mackenzie CD.

PLoS Negl Trop Dis. 2015 Feb 19;9(2):e0003523. doi: 10.1371/journal.pntd.0003523. eCollection 2015 Feb.

38.

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.

Gondorf F, Berbudi A, Buerfent BC, Ajendra J, Bloemker D, Specht S, Schmidt D, Neumann AL, Layland LE, Hoerauf A, Hübner MP.

PLoS Pathog. 2015 Jan 22;11(1):e1004616. doi: 10.1371/journal.ppat.1004616. eCollection 2015 Jan.

39.

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

Katawa G, Layland LE, Debrah AY, von Horn C, Batsa L, Kwarteng A, Arriens S, W Taylor D, Specht S, Hoerauf A, Adjobimey T.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3414. doi: 10.1371/journal.pntd.0003414. eCollection 2015 Jan.

40.

Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.

Majerciak V, Pripuzova N, Chan C, Temkin N, Specht SI, Zheng ZM.

J Virol. 2015 Mar;89(6):3256-74. doi: 10.1128/JVI.03721-14. Epub 2015 Jan 7.

41.

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.

Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basáñez MG.

Clin Infect Dis. 2015 Apr 15;60(8):1199-207. doi: 10.1093/cid/ciu1152. Epub 2014 Dec 23.

42.

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.

Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A, Altmeyer R, Taylor MJ.

Int J Parasitol Drugs Drug Resist. 2014 Sep 16;4(3):278-86. doi: 10.1016/j.ijpddr.2014.09.001. eCollection 2014 Dec.

43.

BMP-7 versus BMP-2 for the treatment of long bone nonunion.

Conway JD, Shabtai L, Bauernschub A, Specht SC.

Orthopedics. 2014 Dec;37(12):e1049-57. doi: 10.3928/01477447-20141124-50.

PMID:
25437077
44.

Worldwide spread of the Ponseti method for clubfoot.

Shabtai L, Specht SC, Herzenberg JE.

World J Orthop. 2014 Nov 18;5(5):585-90. doi: 10.5312/wjo.v5.i5.585. eCollection 2014 Nov 18. Review.

45.

Sequential harvesting of bone graft from the intramedullary canal of the femur.

Conway JD, Shabtai L, Specht SC, Herzenberg JE.

Orthopedics. 2014 Sep;37(9):e796-803. doi: 10.3928/01477447-20140825-56.

PMID:
25350622
46.

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites.

Lentz CS, Sattler JM, Fendler M, Gottwalt S, Halls VS, Strassel S, Arriens S, Hannam JS, Specht S, Famulok M, Mueller AK, Hoerauf A, Pfarr KM.

Antimicrob Agents Chemother. 2015 Jan;59(1):654-8. doi: 10.1128/AAC.02383-14. Epub 2014 Oct 13.

47.

Antibiotic cement-coated rods: an effective treatment for infected long bones and prosthetic joint nonunions.

Conway J, Mansour J, Kotze K, Specht S, Shabtai L.

Bone Joint J. 2014 Oct;96-B(10):1349-54. doi: 10.1302/0301-620X.96B10.33799.

PMID:
25274920
48.

Helpful or a hindrance: co-infections with helminths during malaria.

Layland LE, Specht S.

Adv Exp Med Biol. 2014;828:99-129. doi: 10.1007/978-1-4939-1489-0_5. Review. No abstract available.

PMID:
25253029
49.

ICH: Strengths, Weaknesses, and Future Tasks.

Specht S, Klingmann I.

Ther Innov Regul Sci. 2014 May;48(3):357-361. doi: 10.1177/2168479013520161.

PMID:
30235539
50.

Limb-length discrepancy after total hip arthroplasty: novel treatment and proposed algorithm for care.

Thakral R, Johnson AJ, Specht SC, Conway JD, Issa K, Mont MA, Herzenberg JE.

Orthopedics. 2014 Feb;37(2):101-6. doi: 10.3928/01477447-20140124-06.

PMID:
24679191

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