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Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.

Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD.

N Engl J Med. 2019 Oct 17;381(16):1513-1523. doi: 10.1056/NEJMoa1811424.


Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.

Spechler SJ.

J Gastroenterol. 2019 Oct;54(10):837-844. doi: 10.1007/s00535-019-01604-7. Epub 2019 Jul 24. Review.


Efficacy of Prophylactic Hemoclips in Prevention of Delayed Post-Polypectomy Bleeding in Patients With Large Colonic Polyps.

Feagins LA, Smith AD, Kim D, Halai A, Duttala S, Chebaa B, Lunsford T, Vizuete J, Mara M, Mascarenhas R, Meghani R, Kundrotas L, Dunbar KB, Cipher DJ, Harford WV, Spechler SJ.

Gastroenterology. 2019 Oct;157(4):967-976.e1. doi: 10.1053/j.gastro.2019.05.003. Epub 2019 May 31.


Pathogenesis and Cells of Origin of Barrett's Esophagus.

Que J, Garman KS, Souza RF, Spechler SJ.

Gastroenterology. 2019 Aug;157(2):349-364.e1. doi: 10.1053/j.gastro.2019.03.072. Epub 2019 May 10. Review.


Gastroesophageal Reflux Disease and Eosinophilic Esophagitis.

Spechler SJ.

Gastroenterol Hepatol (N Y). 2019 Feb;15(2):111-113. No abstract available.


Aberrant p53 Immunostaining in Barrett's Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses.

Snyder P, Dunbar K, Cipher DJ, Souza RF, Spechler SJ, Konda VJA.

Dig Dis Sci. 2019 May;64(5):1089-1097. doi: 10.1007/s10620-019-05586-7. Epub 2019 Mar 26.


Proton Pump Inhibitors: What the Internist Needs to Know.

Spechler SJ.

Med Clin North Am. 2019 Jan;103(1):1-14. doi: 10.1016/j.mcna.2018.08.001. Epub 2018 Oct 23. Review.


Can Eosinophilic Esophagitis Cause Achalasia and Other Esophageal Motility Disorders?

Spechler SJ, Konda V, Souza R.

Am J Gastroenterol. 2018 Nov;113(11):1594-1599. doi: 10.1038/s41395-018-0240-3. Epub 2018 Oct 12. Review.


Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett's Cells.

Zhang Q, Agoston AT, Pham TH, Zhang W, Zhang X, Huo X, Peng S, Bajpai M, Das K, Odze RD, Spechler SJ, Souza RF.

Gastroenterology. 2019 Jan;156(1):130-144.e10. doi: 10.1053/j.gastro.2018.09.046. Epub 2018 Sep 27.


Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of Reflux Esophagitis.

Agoston AT, Pham TH, Odze RD, Wang DH, Das KM, Spechler SJ, Souza RF.

Cell Mol Gastroenterol Hepatol. 2018 Jun 27;6(4):389-404. doi: 10.1016/j.jcmgh.2018.06.007. eCollection 2018.


Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.

Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ.

Gastroenterology. 2018 Oct;155(4):1022-1033.e10. doi: 10.1053/j.gastro.2018.07.009. Epub 2018 Sep 6. Review.


Speculation as to why the Frequency of Eosinophilic Esophagitis Is Increasing.

Spechler SJ.

Curr Gastroenterol Rep. 2018 May 16;20(6):26. doi: 10.1007/s11894-018-0633-x. Review.


Management options for patients with GERD and persistent symptoms on proton pump inhibitors: recommendations from an expert panel.

Yadlapati R, Vaezi MF, Vela MF, Spechler SJ, Shaheen NJ, Richter J, Lacy BE, Katzka D, Katz PO, Kahrilas PJ, Gyawali PC, Gerson L, Fass R, Castell DO, Craft J, Hillman L, Pandolfino JE.

Am J Gastroenterol. 2018 Jul;113(7):980-986. doi: 10.1038/s41395-018-0045-4. Epub 2018 Apr 24.


Cardiac Metaplasia: Follow, Treat, or Ignore?

Spechler SJ.

Dig Dis Sci. 2018 Aug;63(8):2052-2058. doi: 10.1007/s10620-018-5063-y. Review.


New Screening Techniques in Barrett's Esophagus: Great Ideas or Great Practice?

Spechler SJ, Katzka DA, Fitzgerald RC.

Gastroenterology. 2018 May;154(6):1594-1601. doi: 10.1053/j.gastro.2018.03.031. Epub 2018 Mar 23. Review. No abstract available.


New Eosinophilic Esophagitis Concepts Call for Change in Proton Pump Inhibitor Management Before Diagnostic Endoscopy.

Odiase E, Schwartz A, Souza RF, Martin J, Konda V, Spechler SJ.

Gastroenterology. 2018 Apr;154(5):1217-1221.e3. doi: 10.1053/j.gastro.2018.03.003. Epub 2018 Mar 3. No abstract available.


Incidence of Colorectal Cancer and Extracolonic Cancers in Veteran Patients With Inflammatory Bowel Disease.

Mosher CA, Brown GR, Weideman RA, Crook TW, Cipher DJ, Spechler SJ, Feagins LA.

Inflamm Bowel Dis. 2018 Feb 15;24(3):617-623. doi: 10.1093/ibd/izx046.


Obtaining adequate lamina propria for subepithelial fibrosis evaluation in pediatric eosinophilic esophagitis.

Wang J, Park JY, Huang R, Souza RF, Spechler SJ, Cheng E.

Gastrointest Endosc. 2018 May;87(5):1207-1214.e3. doi: 10.1016/j.gie.2017.12.020. Epub 2018 Jan 5.


Endoscopic eradication therapy and the test of time.

Konda VJA, Spechler SJ.

Gastrointest Endosc. 2018 Jan;87(1):85-87. doi: 10.1016/j.gie.2017.07.033. No abstract available.


Of Mice and Men and Metaplasia.

Spechler SJ.

Cell Mol Gastroenterol Hepatol. 2017 May 10;4(1):183-184. doi: 10.1016/j.jcmgh.2017.04.002. eCollection 2017 Jul. No abstract available.


Oesophagus: A new candidate for the progenitor cell of Barrett metaplasia.

Souza RF, Spechler SJ.

Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):7-8. doi: 10.1038/nrgastro.2017.167. Epub 2017 Nov 29. No abstract available.


A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.

Souza RF, Bayeh L, Spechler SJ, Tambar UK, Bruick RK.

Curr Opin Pharmacol. 2017 Dec;37:93-99. doi: 10.1016/j.coph.2017.10.004. Epub 2017 Nov 5. Review.


The Durability of Antireflux Surgery.

Spechler SJ.

JAMA. 2017 Sep 12;318(10):913-915. doi: 10.1001/jama.2017.11461. No abstract available.


Unique Clinical Features of Los Angeles Grade D Esophagitis Suggest That Factors Other Than Gastroesophageal Reflux Contribute to its Pathogenesis.

Nguyen AD, Spechler SJ, Shuler MN, Souza RF, Dunbar KB.

J Clin Gastroenterol. 2019 Jan;53(1):9-14. doi: 10.1097/MCG.0000000000000870.


A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.

Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3. No abstract available.


Patients with cirrhosis who have coronary artery disease treated with cardiac stents have high rates of gastrointestinal bleeding, but no increased mortality.

Krill T, Brown G, Weideman RA, Cipher DJ, Spechler SJ, Brilakis E, Feagins LA.

Aliment Pharmacol Ther. 2017 Jul;46(2):183-192. doi: 10.1111/apt.14121. Epub 2017 May 9.


Aspirin prevents NF-κB activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus.

Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Lynch JP, Wang DH, Bresalier RS, Spechler SJ, Souza RF.

Gut. 2018 Apr;67(4):606-615. doi: 10.1136/gutjnl-2016-313584. Epub 2017 Apr 25.


Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux.

Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R, Spechler SJ, Das KM.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G615-G622. doi: 10.1152/ajpgi.00268.2016. Epub 2017 Mar 23.


A Comparison of the Rate of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants or Warfarin.

Cangemi DJ, Krill T, Weideman R, Cipher DJ, Spechler SJ, Feagins LA.

Am J Gastroenterol. 2017 May;112(5):734-739. doi: 10.1038/ajg.2017.39. Epub 2017 Feb 28.


Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis.

Kroep S, Heberle CR, Curtius K, Kong CY, Lansdorp-Vogelaar I, Ali A, Wolf WA, Shaheen NJ, Spechler SJ, Rubenstein JH, Nishioka NS, Meltzer SJ, Hazelton WD, van Ballegooijen M, Tramontano AC, Gazelle GS, Luebeck EG, Inadomi JM, Hur C.

Clin Gastroenterol Hepatol. 2017 Sep;15(9):1471-1474. doi: 10.1016/j.cgh.2016.12.034. Epub 2017 Jan 12. No abstract available.


The influence of Helicobacter pylori on the ethnic distribution of Barrett's metaplasia.

Sonnenberg A, Turner KO, Spechler SJ, Genta RM.

Aliment Pharmacol Ther. 2017 Jan;45(2):283-290. doi: 10.1111/apt.13854. Epub 2016 Nov 9.


NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells.

Nadatani Y, Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Theiss A, Pham TH, Wang DH, Watanabe T, Fujiwara Y, Arakawa T, Spechler SJ, Souza RF.

Cell Mol Gastroenterol Hepatol. 2016 Mar 19;2(4):439-453. eCollection 2016 Jul.


Benchmarks for the interpretation of esophageal high-resolution manometry.

Yadlapati R, Keswani RN, Dunbar KB, Gawron AJ, Gyawali CP, Kahrilas PJ, Katz PO, Katzka D, Spechler SJ, Tatum R, Pandolfino JE.

Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12971. Epub 2016 Oct 13.


Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.

Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF.

Gut. 2017 Sep;66(9):1542-1554. doi: 10.1136/gutjnl-2016-312595. Epub 2016 Sep 30.


Letter: proton pump inhibitor-responsive oesophageal eosinophilia - more than just gastro-oesophageal reflux disease.

Molina-Infante J, Katzka DA, Spechler SJ.

Aliment Pharmacol Ther. 2016 Oct;44(8):911-2. doi: 10.1111/apt.13781. No abstract available.


Clarifying misunderstandings and misinterpretations about proton pump inhibitor-responsive oesophageal eosinophilia.

Molina-Infante J, Hirano I, Spechler SJ; PPI-REE Task Force of the European Society of Eosinophilic Oesophagitis (EUREOS).

Gut. 2017 Jun;66(6):1173-1174. doi: 10.1136/gutjnl-2016-312851. Epub 2016 Sep 13. No abstract available.


A System to Assess the Competency for Interpretation of Esophageal Manometry Identifies Variation in Learning Curves.

Yadlapati R, Keswani RN, Ciolino JD, Grande DP, Listernick ZI, Carlson DA, Castell DO, Dunbar KB, Gawron AJ, Gyawali CP, Katz PO, Katzka D, Lacy BE, Spechler SJ, Tatum R, Vela MF, Pandolfino JE.

Clin Gastroenterol Hepatol. 2017 Nov;15(11):1708-1714.e3. doi: 10.1016/j.cgh.2016.07.024. Epub 2016 Jul 27.


JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE.

Cheng E, Zhang X, Wilson KS, Wang DH, Park JY, Huo X, Yu C, Zhang Q, Spechler SJ, Souza RF.

PLoS One. 2016 Jun 16;11(6):e0157376. doi: 10.1371/journal.pone.0157376. eCollection 2016.


Cardiac mucosa, Barrett's oesophagus and cancer of the gastro-oesophageal junction: what's in a name?

Spechler SJ.

Gut. 2017 Aug;66(8):1355-1357. doi: 10.1136/gutjnl-2016-311948. Epub 2016 May 6. No abstract available.


Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes.

Dunbar KB, Agoston AT, Odze RD, Huo X, Pham TH, Cipher DJ, Castell DO, Genta RM, Souza RF, Spechler SJ.

JAMA. 2016 May 17;315(19):2104-12. doi: 10.1001/jama.2016.5657.


Clinical Implications of Histologic Abnormalities in Ileocolonic Biopsies of Patients With Crohn's Disease in Remission.

Brennan GT, Melton SD, Spechler SJ, Feagins LA.

J Clin Gastroenterol. 2017 Jan;51(1):43-48.


Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.

Molina-Infante J, Bredenoord AJ, Cheng E, Dellon ES, Furuta GT, Gupta SK, Hirano I, Katzka DA, Moawad FJ, Rothenberg ME, Schoepfer A, Spechler SJ, Wen T, Straumann A, Lucendo AJ; PPI-REE Task Force of the European Society of Eosinophilic Oesophagitis (EUREOS).

Gut. 2016 Mar;65(3):524-31. doi: 10.1136/gutjnl-2015-310991. Epub 2015 Dec 18.


Identification of Quality Measures for Performance of and Interpretation of Data From Esophageal Manometry.

Yadlapati R, Gawron AJ, Keswani RN, Bilimoria K, Castell DO, Dunbar KB, Gyawali CP, Jobe BA, Katz PO, Katzka DA, Lacy BE, Massey BT, Richter JE, Schnoll-Sussman F, Spechler SJ, Tatum R, Vela MF, Pandolfino JE.

Clin Gastroenterol Hepatol. 2016 Apr;14(4):526-534.e1. doi: 10.1016/j.cgh.2015.10.006. Epub 2015 Oct 20.


Quality indicators for the management of Barrett's esophagus, dysplasia, and esophageal adenocarcinoma: international consensus recommendations from the American Gastroenterological Association Symposium.

Sharma P, Katzka DA, Gupta N, Ajani J, Buttar N, Chak A, Corley D, El-Serag H, Falk GW, Fitzgerald R, Goldblum J, Gress F, Ilson DH, Inadomi JM, Kuipers EJ, Lynch JP, McKeon F, Metz D, Pasricha PJ, Pech O, Peek R, Peters JH, Repici A, Seewald S, Shaheen NJ, Souza RF, Spechler SJ, Vennalaganti P, Wang K.

Gastroenterology. 2015 Nov;149(6):1599-606. doi: 10.1053/j.gastro.2015.08.007. Epub 2015 Aug 19.


Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.

Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G146-61. doi: 10.1152/ajpgi.00462.2014. Epub 2015 Jun 4.


Diagnosis of Esophageal Motility Disorders: Esophageal Pressure Topography vs. Conventional Line Tracing.

Carlson DA, Ravi K, Kahrilas PJ, Gyawali CP, Bredenoord AJ, Castell DO, Spechler SJ, Halland M, Kanuri N, Katzka DA, Leggett CL, Roman S, Saenz JB, Sayuk GS, Wong AC, Yadlapati R, Ciolino JD, Fox MR, Pandolfino JE.

Am J Gastroenterol. 2015 Jul;110(7):967-77; quiz 978. doi: 10.1038/ajg.2015.159. Epub 2015 Jun 2.


The Effect of Proton Pump Inhibitors on Barrett's Esophagus.

Dunbar KB, Souza RF, Spechler SJ.

Gastroenterol Clin North Am. 2015 Jun;44(2):415-24. doi: 10.1016/j.gtc.2015.02.010. Epub 2015 Mar 18. Review.


In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.

Asanuma K, Huo X, Agoston A, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, Souza RF.

Gut. 2016 Sep;65(9):1416-26. doi: 10.1136/gutjnl-2015-309272. Epub 2015 May 18.


Cardiac mucosa: the heart of the problem.

Spechler SJ.

Gut. 2015 Nov;64(11):1673-4. doi: 10.1136/gutjnl-2015-309407. Epub 2015 Mar 25. No abstract available.


2014 SSAT State-of-the-Art Conference: advances in diagnosis and management of gastroesophageal reflux disease.

Perry KA, Pham TH, Spechler SJ, Hunter JG, Melvin WS, Velanovich V.

J Gastrointest Surg. 2015 Mar;19(3):458-66. doi: 10.1007/s11605-014-2724-9. Epub 2014 Dec 18.


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