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Items: 1 to 50 of 129

1.

Reliable consultant level data from an Acute Medical Unit: a powerful tool for improvement.

Beckett DJ, Spears M, Thomson E.

J R Coll Physicians Edinb. 2018 Jun;48(2):108-113. doi: 10.4997/JRCPE.2018.202.

PMID:
29992198
2.

What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis.

Vale CL, Fisher DJ, White IR, Carpenter JR, Burdett S, Clarke NW, Fizazi K, Gravis G, James ND, Mason MD, Parmar MKB, Rydzewska LH, Sweeney CJ, Spears MR, Sydes MR, Tierney JF.

Ann Oncol. 2018 May 1;29(5):1249-1257. doi: 10.1093/annonc/mdy071.

3.

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer.

Chong T, Sarac A, Yao CQ, Liao L, Lyttle N, Boutros PC, Bartlett JMS, Spears M.

J Ovarian Res. 2018 Apr 4;11(1):27. doi: 10.1186/s13048-018-0399-7.

4.

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol.

Sydes MR, Spears MR, Mason MD, Clarke NW, Dearnaley DP, de Bono JS, Attard G, Chowdhury S, Cross W, Gillessen S, Malik ZI, Jones R, Parker CC, Ritchie AWS, Russell JM, Millman R, Matheson D, Amos C, Gilson C, Birtle A, Brock S, Capaldi L, Chakraborti P, Choudhury A, Evans L, Ford D, Gale J, Gibbs S, Gilbert DC, Hughes R, McLaren D, Lester JF, Nikapota A, O'Sullivan J, Parikh O, Peedell C, Protheroe A, Rudman SM, Shaffer R, Sheehan D, Simms M, Srihari N, Strebel R, Sundar S, Tolan S, Tsang D, Varughese M, Wagstaff J, Parmar MKB, James ND; STAMPEDE Investigators.

Ann Oncol. 2018 May 1;29(5):1235-1248. doi: 10.1093/annonc/mdy072.

5.

Abiraterone in Metastatic Prostate Cancer.

James ND, Spears MR, Sydes MR.

N Engl J Med. 2017 Oct 26;377(17):1696-7. doi: 10.1056/NEJMc1711029. No abstract available.

PMID:
29069563
6.

'Thursday's child has far to go'-interpreting subgroups and the STAMPEDE trial.

Spears MR, James ND, Sydes MR.

Ann Oncol. 2017 Oct 1;28(10):2327-2330. doi: 10.1093/annonc/mdx410. No abstract available.

7.

Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.

Parmar MK, Sydes MR, Cafferty FH, Choodari-Oskooei B, Langley RE, Brown L, Phillips PP, Spears MR, Rowley S, Kaplan R, James ND, Maughan T, Paton N, Royston PJ.

Clin Trials. 2017 Oct;14(5):451-461. doi: 10.1177/1740774517725697. Epub 2017 Aug 22.

8.

Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis.

Rydzewska LHM, Burdett S, Vale CL, Clarke NW, Fizazi K, Kheoh T, Mason MD, Miladinovic B, James ND, Parmar MKB, Spears MR, Sweeney CJ, Sydes MR, Tran N, Tierney JF; STOPCaP Abiraterone Collaborators.

Eur J Cancer. 2017 Oct;84:88-101. doi: 10.1016/j.ejca.2017.07.003. Epub 2017 Aug 8. Review.

9.

ISOWN: accurate somatic mutation identification in the absence of normal tissue controls.

Kalatskaya I, Trinh QM, Spears M, McPherson JD, Bartlett JMS, Stein L.

Genome Med. 2017 Jun 29;9(1):59. doi: 10.1186/s13073-017-0446-9.

10.

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.

James ND, de Bono JS, Spears MR, Clarke NW, Mason MD, Dearnaley DP, Ritchie AWS, Amos CL, Gilson C, Jones RJ, Matheson D, Millman R, Attard G, Chowdhury S, Cross WR, Gillessen S, Parker CC, Russell JM, Berthold DR, Brawley C, Adab F, Aung S, Birtle AJ, Bowen J, Brock S, Chakraborti P, Ferguson C, Gale J, Gray E, Hingorani M, Hoskin PJ, Lester JF, Malik ZI, McKinna F, McPhail N, Money-Kyrle J, O'Sullivan J, Parikh O, Protheroe A, Robinson A, Srihari NN, Thomas C, Wagstaff J, Wylie J, Zarkar A, Parmar MKB, Sydes MR; STAMPEDE Investigators.

N Engl J Med. 2017 Jul 27;377(4):338-351. doi: 10.1056/NEJMoa1702900. Epub 2017 Jun 3.

11.

Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.

Mason MD, Clarke NW, James ND, Dearnaley DP, Spears MR, Ritchie AWS, Attard G, Cross W, Jones RJ, Parker CC, Russell JM, Thalmann GN, Schiavone F, Cassoly E, Matheson D, Millman R, Rentsch CA, Barber J, Gilson C, Ibrahim A, Logue J, Lydon A, Nikapota AD, O'Sullivan JM, Porfiri E, Protheroe A, Srihari NN, Tsang D, Wagstaff J, Wallace J, Walmsley C, Parmar MKB, Sydes MR; STAMPEDE Investigators.

J Clin Oncol. 2017 May 10;35(14):1530-1541. doi: 10.1200/JCO.2016.69.0677. Epub 2017 Mar 13.

12.

Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, Bucknall C, Mansur AH, Lee W, Shepherd M, Spears M, Cowan DC, Husi H, Thomson NC; BTS Severe Asthma Network.

Respir Med. 2016 Sep;118:46-52. doi: 10.1016/j.rmed.2016.07.005. Epub 2016 Jul 9.

13.

A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial.

Spears M, Lyttle N, D'Costa A, Chen BE, Yao CQ, Boutros PC, Burnell M, Levine MN, O'Brien P, Shepherd L, Bartlett JM.

Oncotarget. 2016 Aug 2;7(31):49099-49106. doi: 10.18632/oncotarget.8542.

14.

Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.

Braunstein M, Liao L, Lyttle N, Lobo N, Taylor KJ, Krzyzanowski PM, Kalatskaya I, Yao CQ, Stein LD, Boutros PC, Twelves CJ, Marcellus R, Bartlett JM, Spears M.

Breast Cancer Res. 2016 Feb 6;18(1):16. doi: 10.1186/s13058-016-0676-6.

15.

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.

James ND, Sydes MR, Clarke NW, Mason MD, Dearnaley DP, Spears MR, Ritchie AW, Parker CC, Russell JM, Attard G, de Bono J, Cross W, Jones RJ, Thalmann G, Amos C, Matheson D, Millman R, Alzouebi M, Beesley S, Birtle AJ, Brock S, Cathomas R, Chakraborti P, Chowdhury S, Cook A, Elliott T, Gale J, Gibbs S, Graham JD, Hetherington J, Hughes R, Laing R, McKinna F, McLaren DB, O'Sullivan JM, Parikh O, Peedell C, Protheroe A, Robinson AJ, Srihari N, Srinivasan R, Staffurth J, Sundar S, Tolan S, Tsang D, Wagstaff J, Parmar MK; STAMPEDE investigators.

Lancet. 2016 Mar 19;387(10024):1163-77. doi: 10.1016/S0140-6736(15)01037-5. Epub 2015 Dec 21.

16.

Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial.

James ND, Spears MR, Clarke NW, Dearnaley DP, Mason MD, Parker CC, Ritchie AW, Russell JM, Schiavone F, Attard G, de Bono JS, Birtle A, Engeler DS, Elliott T, Matheson D, O'Sullivan J, Pudney D, Srihari N, Wallace J, Barber J, Syndikus I, Parmar MK, Sydes MR; STAMPEDE Investigators.

JAMA Oncol. 2016 Mar;2(3):348-57. doi: 10.1001/jamaoncol.2015.4350. Erratum in: JAMA Oncol. 2016 Feb;2(2):279.

17.

A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials.

Spears M, Yousif F, Lyttle N, Boutros PC, Munro AF, Twelves C, Pritchard KI, Levine MN, Shepherd L, Bartlett JM.

Oncotarget. 2015 Oct 13;6(31):31693-701. doi: 10.18632/oncotarget.5562.

18.

Effectiveness of bronchial thermoplasty in severe asthma in 'real life' patients compared with those recruited to clinical trials in the same centre.

Bicknell S, Chaudhuri R, Lee N, Shepherd M, Spears M, Pitman N, Cameron E, Cowan D, Nixon J, Thompson J, McSharry C, Thomson NC.

Ther Adv Respir Dis. 2015 Dec;9(6):267-71. doi: 10.1177/1753465815601332. Epub 2015 Aug 24.

PMID:
26307767
19.

Morphologic and cytogenetic variables affect the flow cytometric recovery of plasma cell myeloma cells in bone marrow aspirates.

Cogbill CH, Spears MD, Vantuinen P, Harrington AM, Olteanu H, Kroft SH.

Int J Lab Hematol. 2015 Dec;37(6):797-808. doi: 10.1111/ijlh.12411. Epub 2015 Jul 30.

PMID:
26224420
20.

Serum periostin in smokers and never smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Haughney J, McSharry C.

Respir Med. 2015 Jun;109(6):708-15. doi: 10.1016/j.rmed.2015.03.009. Epub 2015 Apr 3.

21.

Ultrasoft, highly deformable microgels.

Bachman H, Brown AC, Clarke KC, Dhada KS, Douglas A, Hansen CE, Herman E, Hyatt JS, Kodlekere P, Meng Z, Saxena S, Spears MW Jr, Welsch N, Lyon LA.

Soft Matter. 2015 Mar 14;11(10):2018-28. doi: 10.1039/c5sm00047e.

PMID:
25648590
22.

Results of the California Healthy Homes Indoor Air Quality Study of 2011-2013: impact of natural gas appliances on air pollutant concentrations.

Mullen NA, Li J, Russell ML, Spears M, Less BD, Singer BC.

Indoor Air. 2016 Apr;26(2):231-45. doi: 10.1111/ina.12190. Epub 2015 Mar 17.

PMID:
25647016
23.

Clinical validation of targeted next-generation sequencing for inherited disorders.

Yohe S, Hauge A, Bunjer K, Kemmer T, Bower M, Schomaker M, Onsongo G, Wilson J, Erdmann J, Zhou Y, Deshpande A, Spears MD, Beckman K, Silverstein KA, Thyagarajan B.

Arch Pathol Lab Med. 2015 Feb;139(2):204-10. doi: 10.5858/arpa.2013-0625-OA.

PMID:
25611102
24.

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

Thomson NC, Charron CE, Chaudhuri R, Spears M, Ito K, McSharry C.

Pulm Pharmacol Ther. 2015 Apr;31:1-8. doi: 10.1016/j.pupt.2015.01.001. Epub 2015 Jan 14.

PMID:
25595138
25.

Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Messow CM, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Chest. 2015 Mar;147(3):735-744. doi: 10.1378/chest.14-1119. Erratum in: Chest. 2015 Aug;148(2):572.

PMID:
25356950
26.

Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.

Kenicer J, Spears M, Lyttle N, Taylor KJ, Liao L, Cunningham CA, Lambros M, MacKay A, Yao C, Reis-Filho J, Bartlett JM.

BMC Cancer. 2014 Oct 14;14:762. doi: 10.1186/1471-2407-14-762.

27.

Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).

James ND, Spears MR, Clarke NW, Dearnaley DP, De Bono JS, Gale J, Hetherington J, Hoskin PJ, Jones RJ, Laing R, Lester JF, McLaren D, Parker CC, Parmar MKB, Ritchie AWS, Russell JM, Strebel RT, Thalmann GN, Mason MD, Sydes MR.

Eur Urol. 2015 Jun;67(6):1028-1038. doi: 10.1016/j.eururo.2014.09.032. Epub 2014 Oct 6.

28.

Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients.

McSharry C, Spears M, Chaudhuri R, Cameron EJ, Husi H, Thomson NC.

J Allergy Clin Immunol. 2014 Nov;134(5):1068-75. doi: 10.1016/j.jaci.2014.08.022. Epub 2014 Sep 26.

PMID:
25262463
29.

EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder.

Hart M, Thakral B, Yohe S, Balfour HH Jr, Singh C, Spears M, McKenna RW.

Am J Surg Pathol. 2014 Nov;38(11):1522-9. doi: 10.1097/PAS.0000000000000282.

PMID:
25007145
30.

Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma.

Chaudhuri R, McSharry C, Brady J, Grierson C, Messow CM, Spears M, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi OJ, Miller DK, Thomson NC.

Eur Respir J. 2014 Oct;44(4):895-904. doi: 10.1183/09031936.00047014. Epub 2014 Jul 3.

31.

Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial.

Attard G, Sydes MR, Mason MD, Clarke NW, Aebersold D, de Bono JS, Dearnaley DP, Parker CC, Ritchie AW, Russell JM, Thalmann G, Cassoly E, Millman R, Matheson D, Schiavone F, Spears MR, Parmar MK, James ND.

Eur Urol. 2014 Nov;66(5):799-802. doi: 10.1016/j.eururo.2014.05.038. Epub 2014 Jun 27.

32.

Tunable swelling and rolling of microgel membranes.

Zhang L, Spears MW Jr, Lyon LA.

Langmuir. 2014 Jul 8;30(26):7628-34. doi: 10.1021/la500860t. Epub 2014 Jun 26.

PMID:
24927510
33.

Implementation of Cloud based next generation sequencing data analysis in a clinical laboratory.

Onsongo G, Erdmann J, Spears MD, Chilton J, Beckman KB, Hauge A, Yohe S, Schomaker M, Bower M, Silverstein KA, Thyagarajan B.

BMC Res Notes. 2014 May 23;7:314. doi: 10.1186/1756-0500-7-314.

34.

Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis.

Anderson R, Ukoumunne OC, Sayal K, Phillips R, Taylor JA, Spears M, Araya R, Lewis G, Millings A, Montgomery AA, Stallard P.

J Child Psychol Psychiatry. 2014 Dec;55(12):1390-7. doi: 10.1111/jcpp.12248. Epub 2014 May 12.

PMID:
24813670
35.

Microgel film dynamics modulate cell adhesion behavior.

Saxena S, Spears MW Jr, Yoshida H, Gaulding JC, García AJ, Lyon LA.

Soft Matter. 2014 Mar 7;10(9):1356-64.

36.

Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

Thomson NC, Chaudhuri R, Spears M, Messow CM, Jelinsky S, Miele G, Nocka K, Takahashi E, Hilmi OJ, Shepherd MC, Miller DK, McSharry C.

Allergy. 2014 Apr;69(4):527-36. doi: 10.1111/all.12376. Epub 2014 Feb 26.

PMID:
24571371
37.

Service use in adolescents at risk of depression and self-harm: prospective longitudinal study.

Sayal K, Yates N, Spears M, Stallard P.

Soc Psychiatry Psychiatr Epidemiol. 2014 Aug;49(8):1231-40. doi: 10.1007/s00127-014-0843-y. Epub 2014 Feb 26.

PMID:
24570203
38.

Plastic deformation, wrinkling, and recovery in microgel multilayers.

Gaulding JC, Spears MW Jr, Lyon LA.

Polym Chem. 2013 Sep 21;4(18):4890-4896.

39.

Validated or not validated? That is the question.

Bartlett JM, Pritchard KI, Spears M.

J Natl Cancer Inst. 2014 Jan;106(1):djt360. doi: 10.1093/jnci/djt360. No abstract available.

PMID:
24402423
40.

Dynamic materials from microgel multilayers.

Spears MW Jr, Herman ES, Gaulding JC, Lyon LA.

Langmuir. 2014 Jun 10;30(22):6314-23. doi: 10.1021/la403058t. Epub 2013 Dec 6.

PMID:
24295444
41.

Self-harm in young adolescents (12-16 years): onset and short-term continuation in a community sample.

Stallard P, Spears M, Montgomery AA, Phillips R, Sayal K.

BMC Psychiatry. 2013 Dec 2;13:328. doi: 10.1186/1471-244X-13-328.

42.

Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD.

Chaudhuri R, McSharry C, Spears M, Brady J, Grierson C, Messow CM, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi O, Miller DK, Thomson NC.

Transl Respir Med. 2013 Dec;1(1):11. doi: 10.1186/2213-0802-1-11. Epub 2013 Jun 6.

PMID:
27234393
43.

Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.

Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB.

J Am Coll Cardiol. 2014 Feb 25;63(7):636-646. doi: 10.1016/j.jacc.2013.09.063. Epub 2013 Nov 13. Review.

44.

A cluster randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of classroom-based cognitive-behavioural therapy (CBT) in reducing symptoms of depression in high-risk adolescents.

Stallard P, Phillips R, Montgomery AA, Spears M, Anderson R, Taylor J, Araya R, Lewis G, Ukoumunne OC, Millings A, Georgiou L, Cook E, Sayal K.

Health Technol Assess. 2013 Oct;17(47):vii-xvii, 1-109. doi: 10.3310/hta17470.

45.

Inhaled corticosteroids for asthma: on-demand or continuous use.

Thomson NC, Spears M.

Expert Rev Respir Med. 2013 Dec;7(6):687-99. doi: 10.1586/17476348.2013.836062. Epub 2013 Oct 22. Review.

PMID:
24147563
46.

Factors associated with the development of self-harm amongst a socio-economically deprived cohort of adolescents in Santiago, Chile.

Spears M, Montgomery AA, Gunnell D, Araya R.

Soc Psychiatry Psychiatr Epidemiol. 2014 Apr;49(4):629-37. doi: 10.1007/s00127-013-0767-y. Epub 2013 Oct 6.

47.

Randomised controlled trial of azithromycin in smokers with asthma.

Cameron EJ, Chaudhuri R, Mair F, McSharry C, Greenlaw N, Weir CJ, Jolly L, Donnelly I, Gallacher K, Morrison D, Spears M, Evans TJ, Anderson K, Thomson NC.

Eur Respir J. 2013 Nov;42(5):1412-5. doi: 10.1183/09031936.00093913. Epub 2013 Sep 13. No abstract available.

48.

School intervention to improve mental health of students in Santiago, Chile: a randomized clinical trial.

Araya R, Fritsch R, Spears M, Rojas G, Martinez V, Barroilhet S, Vöhringer P, Gunnell D, Stallard P, Guajardo V, Gaete J, Noble S, Montgomery AA.

JAMA Pediatr. 2013 Nov;167(11):1004-10. doi: 10.1001/jamapediatrics.2013.2361.

PMID:
23999656
49.

Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study.

Spears M, McSharry C, Chaudhuri R, Weir CJ, de Wet C, Thomson NC.

PLoS One. 2013 Aug 9;8(8):e71460. doi: 10.1371/journal.pone.0071460. eCollection 2013.

50.

Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma.

Thomson NC, Chaudhuri R, Messow CM, Spears M, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Respir Med. 2013 Oct;107(10):1501-8. doi: 10.1016/j.rmed.2013.07.017. Epub 2013 Aug 6.

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