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Items: 1 to 50 of 138

1.

The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.

Buffone C, Kutzner J, Opp S, Martinez-Lopez A, Selyutina A, Coggings SA, Studdard LR, Ding L, Kim B, Spearman P, Schaller T, Diaz-Griffero F.

Virology. 2019 May;531:260-268. doi: 10.1016/j.virol.2019.03.018. Epub 2019 Mar 30.

2.

Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period.

Spearman P, Tomaras GD, Montefiori DC, Huang Y, Elizaga ML, Ferrari G, Alam SM, Isaacs A, Ahmed H, Hural J, McElrath MJ, Ouedraogo L, Pensiero M, Butler C, Kalams SA, Overton ET, Barnett SW; HVTN 088 Protocol Team and the NIH/NIAID HIV Vaccine Trials Network.

J Infect Dis. 2019 May 5;219(11):1755-1765. doi: 10.1093/infdis/jiz008.

PMID:
30615119
3.

The future of careers in pediatric infectious diseases: a call to action.

Spearman P, Bryson YJ.

Curr Opin Pediatr. 2019 Feb;31(1):144-147. doi: 10.1097/MOP.0000000000000723.

PMID:
30531403
4.

DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial.

Houser KV, Yamshchikov GV, Bellamy AR, May J, Enama ME, Sarwar U, Larkin B, Bailer RT, Koup R, Paskel M, Subbarao K, Anderson E, Bernstein DI, Creech B, Keyserling H, Spearman P, Wright PF, Graham BS, Ledgerwood JE; VRC 702 study team.

PLoS One. 2018 Nov 2;13(11):e0206837. doi: 10.1371/journal.pone.0206837. eCollection 2018.

5.

Targeted Elimination of Tumorigenic Human Pluripotent Stem Cells Using Suicide-Inducing Virus-like Particles.

Rampoldi A, Crooke SN, Preininger MK, Jha R, Maxwell J, Ding L, Spearman P, Finn MG, Xu C.

ACS Chem Biol. 2018 Aug 17;13(8):2329-2338. doi: 10.1021/acschembio.8b00490. Epub 2018 Jul 19.

6.

A novel Ebola virus antibody-dependent cell-mediated cytotoxicity (Ebola ADCC) assay.

Singh K, Marasini B, Chen X, Spearman P.

J Immunol Methods. 2018 Sep;460:10-16. doi: 10.1016/j.jim.2018.06.002. Epub 2018 Jun 15.

PMID:
29894746
7.

Pediatric Infectious Diseases Meets the Future.

Gilsdorf JR, Spearman P, Englund JA, Tan TQ, Bryant KA.

J Pediatric Infect Dis Soc. 2019 Mar 28;8(1):9-12. doi: 10.1093/jpids/piy042.

PMID:
29788443
8.

HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment Is Required for Particle Incorporation.

Kirschman J, Qi M, Ding L, Hammonds J, Dienger-Stambaugh K, Wang JJ, Lapierre LA, Goldenring JR, Spearman P.

J Virol. 2018 Feb 12;92(5). pii: e01893-17. doi: 10.1128/JVI.01893-17. Print 2018 Mar 1.

9.

Viral interactions with host cell Rab GTPases.

Spearman P.

Small GTPases. 2018 Mar 4;9(1-2):192-201. doi: 10.1080/21541248.2017.1346552. Epub 2017 Sep 18. Review.

10.

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.

Heit A, Schmitz F, Gerdts S, Flach B, Moore MS, Perkins JA, Robins HS, Aderem A, Spearman P, Tomaras GD, De Rosa SC, McElrath MJ.

J Exp Med. 2017 Jul 3;214(7):2139-2152. doi: 10.1084/jem.20161794. Epub 2017 Jun 21.

11.

HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages.

Staitieh BS, Ding L, Neveu WA, Spearman P, Guidot DM, Fan X.

J Leukoc Biol. 2017 Aug;102(2):517-525. doi: 10.1189/jlb.4A0616-282RR. Epub 2017 May 26.

12.

A Urea Potentiometric Biosensor Based on a Thiophene Copolymer.

Lai CK, Foot PJ, Brown JW, Spearman P.

Biosensors (Basel). 2017 Mar 3;7(1). pii: E13. doi: 10.3390/bios7010013.

13.

HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1.

Yuan Z, Fan X, Staitieh B, Bedi C, Spearman P, Guidot DM, Sadikot RT.

Sci Rep. 2017 Feb 9;7:42028. doi: 10.1038/srep42028.

14.

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Hammonds JE, Beeman N, Ding L, Takushi S, Francis AC, Wang JJ, Melikyan GB, Spearman P.

PLoS Pathog. 2017 Jan 27;13(1):e1006181. doi: 10.1371/journal.ppat.1006181. eCollection 2017 Jan.

15.

Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells.

Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER.

Nat Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168. Epub 2016 Dec 15.

16.

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B.

J Virol. 2017 Jan 31;91(4). pii: e01844-16. doi: 10.1128/JVI.01844-16. Print 2017 Feb 15.

17.

A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.

St Gelais C, Kim SH, Ding L, Yount JS, Ivanov D, Spearman P, Wu L.

J Biol Chem. 2016 Dec 16;291(51):26332-26342. Epub 2016 Nov 4.

18.

A phase 1, randomized, controlled dose-escalation study of EP-1300 polyepitope DNA vaccine against Plasmodium falciparum malaria administered via electroporation.

Spearman P, Mulligan M, Anderson EJ, Shane AL, Stephens K, Gibson T, Hartwell B, Hannaman D, Watson NL, Singh K.

Vaccine. 2016 Nov 4;34(46):5571-5578. doi: 10.1016/j.vaccine.2016.09.041. Epub 2016 Sep 30.

19.

A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques.

Lee S, Nguyen MT, Currier MG, Jenkins JB, Strobert EA, Kajon AE, Madan-Lala R, Bochkov YA, Gern JE, Roy K, Lu X, Erdman DD, Spearman P, Moore ML.

Nat Commun. 2016 Sep 22;7:12838. doi: 10.1038/ncomms12838.

20.

Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.

Iyer SS, Gangadhara S, Victor B, Shen X, Chen X, Nabi R, Kasturi SP, Sabula MJ, Labranche CC, Reddy PB, Tomaras GD, Montefiori DC, Moss B, Spearman P, Pulendran B, Kozlowski PA, Amara RR.

J Virol. 2016 Sep 12;90(19):8842-54. doi: 10.1128/JVI.01163-16. Print 2016 Oct 1.

21.

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.

Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE Jr.

PLoS One. 2016 Jul 13;11(7):e0158861. doi: 10.1371/journal.pone.0158861. eCollection 2016.

22.

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS Jr, Power UF, Moore ML.

PLoS Pathog. 2016 May 6;12(5):e1005622. doi: 10.1371/journal.ppat.1005622. eCollection 2016 May.

23.

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.

Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE Jr.

Mol Immunol. 2016 Feb;70:94-103. doi: 10.1016/j.molimm.2015.12.002. Epub 2015 Dec 31.

24.

HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and Are Commonly Detected in Plasma From HIV-infected humans.

Williams KL, Cortez V, Dingens AS, Gach JS, Rainwater S, Weis JF, Chen X, Spearman P, Forthal DN, Overbaugh J.

EBioMedicine. 2015 Oct;2(10):1464-77.

25.

Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells.

Strauss JD, Hammonds JE, Yi H, Ding L, Spearman P, Wright ER.

J Virol. 2015 Nov 18;90(3):1507-21. doi: 10.1128/JVI.01880-15. Print 2016 Feb 1.

26.
27.

Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.

Chukwuma VU, Hicar MD, Chen X, Nicholas KJ, Joyner A, Kalams SA, Landucci G, Forthal DN, Spearman PW, Crowe JE Jr.

PLoS One. 2015 Jul 30;10(7):e0133509. doi: 10.1371/journal.pone.0133509. eCollection 2015.

28.

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions.

Giroud C, Marin M, Hammonds J, Spearman P, Melikyan GB.

J Virol. 2015 Sep;89(18):9368-82. doi: 10.1128/JVI.01178-15. Epub 2015 Jul 1.

29.

Native immunogold labeling of cell surface proteins and viral glycoproteins for cryo-electron microscopy and cryo-electron tomography applications.

Yi H, Strauss JD, Ke Z, Alonas E, Dillard RS, Hampton CM, Lamb KM, Hammonds JE, Santangelo PJ, Spearman PW, Wright ER.

J Histochem Cytochem. 2015 Oct;63(10):780-92. doi: 10.1369/0022155415593323. Epub 2015 Jun 11.

30.

A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions.

Qi M, Chu H, Chen X, Choi J, Wen X, Hammonds J, Ding L, Hunter E, Spearman P.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7575-80. doi: 10.1073/pnas.1504174112. Epub 2015 Jun 1.

31.

Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition.

Sakurai Y, Fitch-Tewfik JL, Qiu Y, Ahn B, Myers DR, Tran R, Fay ME, Ding L, Spearman PW, Michelson AD, Flaumenhaft R, Lam WA.

Blood. 2015 Jul 23;126(4):531-8. doi: 10.1182/blood-2014-11-607614. Epub 2015 May 11.

32.

Development of Gd(III) porphyrin-conjugated chitosan nanoparticles as contrast agents for magnetic resonance imaging.

Jahanbin T, Sauriat-Dorizon H, Spearman P, Benderbous S, Korri-Youssoufi H.

Mater Sci Eng C Mater Biol Appl. 2015;52:325-32. doi: 10.1016/j.msec.2015.03.007. Epub 2015 Apr 10.

PMID:
25953574
33.

Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial.

Mulligan MJ, Bernstein DI, Frey S, Winokur P, Rouphael N, Dickey M, Edupuganti S, Spearman P, Anderson E, Graham I, Noah DL, Mangal B, Kim S, Hill H, Whitaker J, Emery W, Beck A, Stephens K, Hartwell B, Ogilvie M, Rimann N, Osinski E, Destefano E, Gajadhar T, Strudwick A, Pierce K, Lai L, Yue L, Wang D, Ying C, Cline A, Foltz T, Wagner N, Dull G, Pacatte T, Taggart B, Johnson V, Haller L, Looney C, Li S, May M, Myers B, May R, Parker L, Cochran N, Bowen D, Bell M, Scoggins J, Burns A, Stablein C, Wolff M, Jolles B, Leung B, Lambert L, Shorer S, Buchanan W, Murray S, Chang S, Gorman R.

Open Forum Infect Dis. 2014 Nov 18;1(3):ofu102. doi: 10.1093/ofid/ofu102. eCollection 2014 Dec.

34.

Acute pancreatitis associated with dolutegravir and lamivudine/abacavir administration.

Thompson AB, Wynn BA, O Akerele D, A Rostad C, Anderson EJ, Camacho-Gonzalez AF, Spearman P, Chakraborty R.

AIDS. 2015 Jan 28;29(3):390-2. doi: 10.1097/QAD.0000000000000542. No abstract available.

PMID:
25686687
35.

Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies.

Johnson EL, Chu H, Byrareddy SN, Spearman P, Chakraborty R.

J Int AIDS Soc. 2015 Jan 22;18:19385. doi: 10.7448/IAS.18.1.19385. eCollection 2015.

36.

Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial.

Belshe RB, Frey SE, Graham IL, Anderson EL, Jackson LA, Spearman P, Edupuganti S, Mulligan MJ, Rouphael N, Winokur P, Dolor RJ, Woods CW, Walter EB, Chen WH, Turley C, Edwards KM, Creech CB, Hill H, Bellamy AR; National Institute of Allergy and Infectious Diseases–Funded Vaccine and Treatment Evaluation Units.

JAMA. 2014 Oct 8;312(14):1420-8. doi: 10.1001/jama.2014.12609.

PMID:
25291578
37.

Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial.

Mulligan MJ, Bernstein DI, Winokur P, Rupp R, Anderson E, Rouphael N, Dickey M, Stapleton JT, Edupuganti S, Spearman P, Ince D, Noah DL, Hill H, Bellamy AR; DMID 13-0032 H7N9 Vaccine Study Group.

JAMA. 2014 Oct 8;312(14):1409-19. doi: 10.1001/jama.2014.12854.

PMID:
25291577
38.

Microscale generation of cardiospheres promotes robust enrichment of cardiomyocytes derived from human pluripotent stem cells.

Nguyen DC, Hookway TA, Wu Q, Jha R, Preininger MK, Chen X, Easley CA, Spearman P, Deshpande SR, Maher K, Wagner MB, McDevitt TC, Xu C.

Stem Cell Reports. 2014 Aug 12;3(2):260-8. doi: 10.1016/j.stemcr.2014.06.002. Epub 2014 Jul 4.

39.

Immunogenicity and safety of four different dosing regimens of anthrax vaccine adsorbed for post-exposure prophylaxis for anthrax in adults.

Bernstein DI, Jackson L, Patel SM, El Sahly HM, Spearman P, Rouphael N, Rudge TL Jr, Hill H, Goll JB.

Vaccine. 2014 Oct 29;32(47):6284-93. doi: 10.1016/j.vaccine.2014.08.076. Epub 2014 Sep 17.

40.

An siRNA screen of membrane trafficking genes highlights pathways common to HIV-1 and M-PMV virus assembly and release.

Wen X, Ding L, Hunter E, Spearman P.

PLoS One. 2014 Sep 4;9(9):e106151. doi: 10.1371/journal.pone.0106151. eCollection 2014.

41.

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.

Ellebedy AH, Krammer F, Li GM, Miller MS, Chiu C, Wrammert J, Chang CY, Davis CW, McCausland M, Elbein R, Edupuganti S, Spearman P, Andrews SF, Wilson PC, García-Sastre A, Mulligan MJ, Mehta AK, Palese P, Ahmed R.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13133-8. doi: 10.1073/pnas.1414070111. Epub 2014 Aug 25.

42.

Methicillin-resistant Staphylococcus aureus empyema Necessitatis in a breast-fed neonate.

Rosebush J, Summers R, Snitzer J, Jerris R, Satola S, Spearman P.

Pediatr Infect Dis J. 2014 Jun;33(6):668-9. doi: 10.1097/INF.0000000000000275. No abstract available. Erratum in: Pediatr Infect Dis J. 2014 Sep;33:(9):978.

PMID:
24830520
43.

ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events.

Wen X, Ding L, Wang JJ, Qi M, Hammonds J, Chu H, Chen X, Hunter E, Spearman P.

J Virol. 2014 Jun;88(12):6906-21. doi: 10.1128/JVI.00023-14. Epub 2014 Apr 2.

44.

Electron-beam nanopatterning and spectral modulation of organic molecular light-emitting single crystals.

Persano L, Camposeo A, Pisignano D, Burini A, Spearman P, Tavazzi S.

Langmuir. 2014 Feb 18;30(6):1643-9. doi: 10.1021/la4033833. Epub 2014 Feb 3.

PMID:
24490972
45.

Direct evidence for intracellular anterograde co-transport of M-PMV Gag and Env on microtubules.

Pereira LE, Clark J, Grznarova P, Wen X, LaCasse R, Ruml T, Spearman P, Hunter E.

Virology. 2014 Jan 20;449:109-19. doi: 10.1016/j.virol.2013.11.006. Epub 2013 Nov 28.

46.

A Mason-Pfizer Monkey virus Gag-GFP fusion vector allows visualization of capsid transport in live cells and demonstrates a role for microtubules.

Clark J, Grznarova P, Stansell E, Diehl W, Lipov J, Spearman P, Ruml T, Hunter E.

PLoS One. 2013 Dec 26;8(12):e83863. doi: 10.1371/journal.pone.0083863. eCollection 2013.

47.

Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.

Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, Wright ER.

Microsc Microanal. 2014 Feb;20(1):164-74. doi: 10.1017/S1431927613013937. Epub 2013 Nov 26.

48.

Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex.

Qi M, Williams JA, Chu H, Chen X, Wang JJ, Ding L, Akhirome E, Wen X, Lapierre LA, Goldenring JR, Spearman P.

PLoS Pathog. 2013;9(4):e1003278. doi: 10.1371/journal.ppat.1003278. Epub 2013 Apr 4.

49.

Neonatal infectious diseases: evaluation of neonatal sepsis.

Camacho-Gonzalez A, Spearman PW, Stoll BJ.

Pediatr Clin North Am. 2013 Apr;60(2):367-89. doi: 10.1016/j.pcl.2012.12.003. Epub 2013 Jan 17. Review.

50.

Unraveling the structural basis of HIV-1 neutralization.

Wright ER, Spearman PW.

Future Microbiol. 2012 Nov;7(11):1251-4. doi: 10.2217/fmb.12.104.

PMID:
23075444

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