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Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

Moore MD, Bunka DH, Forzan M, Spear PG, Stockley PG, McGowan I, James W.

J Gen Virol. 2011 Jul;92(Pt 7):1493-9. doi: 10.1099/vir.0.030601-0. Epub 2011 Apr 6.


Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection.

Yoon M, Kopp SJ, Taylor JM, Storti CS, Spear PG, Muller WJ.

PLoS One. 2011 Jan 24;6(1):e16122. doi: 10.1371/journal.pone.0016122.


T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.

Cheung TC, Oborne LM, Steinberg MW, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.

J Immunol. 2009 Dec 1;183(11):7286-96. doi: 10.4049/jimmunol.0902490. Epub 2009 Nov 13.


Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB.

Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H.

J Virol. 2009 Dec;83(24):13042-5. doi: 10.1128/JVI.00792-09. Epub 2009 Oct 7.


Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1.

Kopp SJ, Banisadr G, Glajch K, Maurer UE, Grünewald K, Miller RJ, Osten P, Spear PG.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17916-20. doi: 10.1073/pnas.0908892106. Epub 2009 Oct 5.


Insertional mutations in herpes simplex virus type 1 gL identify functional domains for association with gH and for membrane fusion.

Fan Q, Lin E, Spear PG.

J Virol. 2009 Nov;83(22):11607-15. doi: 10.1128/JVI.01369-09. Epub 2009 Sep 2.


The virological synapse facilitates herpes simplex virus entry into T cells.

Aubert M, Yoon M, Sloan DD, Spear PG, Jerome KR.

J Virol. 2009 Jun;83(12):6171-83. doi: 10.1128/JVI.02163-08. Epub 2009 Apr 1.


Unconventional ligand activation of herpesvirus entry mediator signals cell survival.

Cheung TC, Steinberg MW, Oborne LM, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6244-9. doi: 10.1073/pnas.0902115106. Epub 2009 Mar 30. Erratum in: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16535-6.


Cross-regulation between herpesviruses and the TNF superfamily members.

Sedý JR, Spear PG, Ware CF.

Nat Rev Immunol. 2008 Nov;8(11):861-73. doi: 10.1038/nri2434. Review.


PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.

Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H.

Cell. 2008 Mar 21;132(6):935-44. doi: 10.1016/j.cell.2008.01.043.


Alternative entry receptors for herpes simplex virus and their roles in disease.

Taylor JM, Lin E, Susmarski N, Yoon M, Zago A, Ware CF, Pfeffer K, Miyoshi J, Takai Y, Spear PG.

Cell Host Microbe. 2007 Jul 12;2(1):19-28.


Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B.

Lin E, Spear PG.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13140-5. Epub 2007 Jul 31.


The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.

Lawrence R, Yabe T, Hajmohammadi S, Rhodes J, McNeely M, Liu J, Lamperti ED, Toselli PA, Lech M, Spear PG, Rosenberg RD, Shworak NW.

Matrix Biol. 2007 Jul;26(6):442-55. Epub 2007 Mar 30.


Biochemistry. Viral glycoproteins and an evolutionary conundrum.

Steven AC, Spear PG.

Science. 2006 Jul 14;313(5784):177-8. No abstract available.


Inhibition of TCR signaling by herpes simplex virus.

Sloan DD, Han JY, Sandifer TK, Stewart M, Hinz AJ, Yoon M, Johnson DC, Spear PG, Jerome KR.

J Immunol. 2006 Feb 1;176(3):1825-33.


Different receptors binding to distinct interfaces on herpes simplex virus gD can trigger events leading to cell fusion and viral entry.

Spear PG, Manoj S, Yoon M, Jogger CR, Zago A, Myscofski D.

Virology. 2006 Jan 5;344(1):17-24. Review.


Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.

Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13218-23. Epub 2005 Aug 30.


Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion.

Zago A, Jogger CR, Spear PG.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17498-503. Epub 2004 Dec 6.


Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase.

Kamimura K, Rhodes JM, Ueda R, McNeely M, Shukla D, Kimata K, Spear PG, Shworak NW, Nakato H.

J Cell Biol. 2004 Sep 27;166(7):1069-79.


Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism.

Manoj S, Jogger CR, Myscofski D, Yoon M, Spear PG.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12414-21. Epub 2004 Jul 23.


Herpes simplex virus: receptors and ligands for cell entry.

Spear PG.

Cell Microbiol. 2004 May;6(5):401-10. Review.


Herpesvirus entry: an update.

Spear PG, Longnecker R.

J Virol. 2003 Oct;77(19):10179-85. Review. No abstract available.


Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals.

Struyf F, Posavad CM, Keyaerts E, Van Ranst M, Corey L, Spear PG.

J Infect Dis. 2002 Jan 1;185(1):36-44. Epub 2001 Dec 14.


Portable sulphotransferase domain determines sequence specificity of heparan sulphate 3-O-sulphotransferases.

Yabe T, Shukla D, Spear PG, Rosenberg RD, Seeberger PH, Shworak NW.

Biochem J. 2001 Oct 1;359(Pt 1):235-41.


Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse.

Haarr L, Shukla D, Rødahl E, Dal Canto MC, Spear PG.

Virology. 2001 Sep 1;287(2):301-9.


Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry.

Shukla D, Spear PG.

J Clin Invest. 2001 Aug;108(4):503-10. Review. No abstract available.


Use of chimeric nectin-1(HveC)-related receptors to demonstrate that ability to bind alphaherpesvirus gD is not necessarily sufficient for viral entry.

Geraghty RJ, Fridberg A, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG.

Virology. 2001 Jul 5;285(2):366-75.


Organization of the rat Tage4 gene and herpesvirus entry activity of the encoded protein.

Baury B, Geraghty RJ, Masson D, Lustenberger P, Spear PG, Denis MG.

Gene. 2001 Mar 7;265(1-2):185-94.


Contributions of gD receptors and glycosaminoglycan sulfation to cell fusion mediated by herpes simplex virus 1.

Terry-Allison T, Montgomery RI, Warner MS, Geraghty RJ, Spear PG.

Virus Res. 2001 Apr;74(1-2):39-45.


Three classes of cell surface receptors for alphaherpesvirus entry.

Spear PG, Eisenberg RJ, Cohen GH.

Virology. 2000 Sep 15;275(1):1-8. Review. No abstract available.


Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.

Wei G, Bai X, Gabb MM, Bame KJ, Koshy TI, Spear PG, Esko JD.

J Biol Chem. 2000 Sep 8;275(36):27733-40.

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