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Lipophilic antioxidants and lipid peroxidation in yellow perch subjected to various anthropogenic influences along the St. Lawrence River (QC, Canada).

Landry C, Houde M, Brodeur P, Spear P, Boily M.

Ecotoxicol Environ Saf. 2017 May;139:316-325. doi: 10.1016/j.ecoenv.2017.01.051. Epub 2017 Feb 7.


Relationships between polybrominated diphenyl ethers and transcription and activity of type 1 deiodinase in a gull highly exposed to flame retardants.

François A, Técher R, Houde M, Spear P, Verreault J.

Environ Toxicol Chem. 2016 Sep;35(9):2215-22. doi: 10.1002/etc.3372. Epub 2016 Jun 23.


Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry.

Silva E, Betleja E, John E, Spear P, Moresco JJ, Zhang S, Yates JR 3rd, Mitchell BJ, Mahjoub MR.

Mol Biol Cell. 2016 Jan 1;27(1):48-63. doi: 10.1091/mbc.E15-07-0474. Epub 2015 Nov 4.


A double-hotdog with a new trick: structure and mechanism of the trans-acyltransferase polyketide synthase enoyl-isomerase.

Gay DC, Spear PJ, Keatinge-Clay AT.

ACS Chem Biol. 2014 Oct 17;9(10):2374-81. doi: 10.1021/cb500459b. Epub 2014 Aug 14.


Consequences of metal exposure on retinoid metabolism in vertebrates: a review.

Defo MA, Spear PA, Couture P.

Toxicol Lett. 2014 Feb 10;225(1):1-11. doi: 10.1016/j.toxlet.2013.11.024. Epub 2013 Nov 27. Review.


ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.

Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R, Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT, Rosenfeld M, Diaz KA, Olbrich H, Wolf WE, Sheridan E, Batten TF, Halbritter J, Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns KA, Ferkol TW, Sagel SD, Olivier KN, Morgan LC, Werner C, Raidt J, Pennekamp P, Sun Z, Zhou W, Airik R, Natarajan S, Allen SJ, Amirav I, Wieczorek D, Landwehr K, Nielsen K, Schwerk N, Sertic J, Köhler G, Washburn J, Levy S, Fan S, Koerner-Rettberg C, Amselem S, Williams DS, Mitchell BJ, Drummond IA, Otto EA, Omran H, Knowles MR, Hildebrandt F.

Am J Hum Genet. 2013 Aug 8;93(2):336-45. doi: 10.1016/j.ajhg.2013.06.007. Epub 2013 Jul 25.


NKG2D ligands as therapeutic targets.

Spear P, Wu MR, Sentman ML, Sentman CL.

Cancer Immun. 2013 May 1;13:8. Print 2013. Review.


Thermally assisted quantum annealing of a 16-qubit problem.

Dickson NG, Johnson MW, Amin MH, Harris R, Altomare F, Berkley AJ, Bunyk P, Cai J, Chapple EM, Chavez P, Cioata F, Cirip T, Debuen P, Drew-Brook M, Enderud C, Gildert S, Hamze F, Hilton JP, Hoskinson E, Karimi K, Ladizinsky E, Ladizinsky N, Lanting T, Mahon T, Neufeld R, Oh T, Perminov I, Petroff C, Przybysz A, Rich C, Spear P, Tcaciuc A, Thom MC, Tolkacheva E, Uchaikin S, Wang J, Wilson AB, Merali Z, Rose G.

Nat Commun. 2013;4:1903. doi: 10.1038/ncomms2920.


NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors.

Spear P, Barber A, Rynda-Apple A, Sentman CL.

Immunol Cell Biol. 2013 Jul;91(6):435-40. doi: 10.1038/icb.2013.17. Epub 2013 Apr 30.


Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals.

Defo MA, Pierron F, Spear PA, Bernatchez L, Campbell PG, Couture P.

Ecotoxicol Environ Saf. 2012 Nov;85:88-95. doi: 10.1016/j.ecoenv.2012.08.017. Epub 2012 Sep 7.


Apical movement during interkinetic nuclear migration is a two-step process.

Spear PC, Erickson CA.

Dev Biol. 2012 Oct 1;370(1):33-41. doi: 10.1016/j.ydbio.2012.06.031. Epub 2012 Aug 4.


Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF.

Spear P, Barber A, Rynda-Apple A, Sentman CL.

J Immunol. 2012 Jun 15;188(12):6389-98. doi: 10.4049/jimmunol.1103019. Epub 2012 May 14. Erratum in: J Immunol. 2014 Aug 1;193(3):1513.


Interkinetic nuclear migration: a mysterious process in search of a function.

Spear PC, Erickson CA.

Dev Growth Differ. 2012 Apr;54(3):306-16. doi: 10.1111/j.1440-169X.2012.01342.x. Review.


Oxidation of retinoic acids in hepatic microsomes of wild bullfrogs Lithobates catesbeianus environmentally-exposed to a gradient of agricultural contamination.

Thibodeau J, Filion S, Spear P, Paquin J, Boily M.

Ecotoxicology. 2012 Jul;21(5):1358-70. doi: 10.1007/s10646-012-0889-0. Epub 2012 Apr 1.


Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

Moore MD, Bunka DH, Forzan M, Spear PG, Stockley PG, McGowan I, James W.

J Gen Virol. 2011 Jul;92(Pt 7):1493-9. doi: 10.1099/vir.0.030601-0. Epub 2011 Apr 6.


Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection.

Yoon M, Kopp SJ, Taylor JM, Storti CS, Spear PG, Muller WJ.

PLoS One. 2011 Jan 24;6(1):e16122. doi: 10.1371/journal.pone.0016122.


T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.

Cheung TC, Oborne LM, Steinberg MW, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.

J Immunol. 2009 Dec 1;183(11):7286-96. doi: 10.4049/jimmunol.0902490. Epub 2009 Nov 13.


Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB.

Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H.

J Virol. 2009 Dec;83(24):13042-5. doi: 10.1128/JVI.00792-09. Epub 2009 Oct 7.


Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1.

Kopp SJ, Banisadr G, Glajch K, Maurer UE, Grünewald K, Miller RJ, Osten P, Spear PG.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17916-20. doi: 10.1073/pnas.0908892106. Epub 2009 Oct 5.


Insertional mutations in herpes simplex virus type 1 gL identify functional domains for association with gH and for membrane fusion.

Fan Q, Lin E, Spear PG.

J Virol. 2009 Nov;83(22):11607-15. doi: 10.1128/JVI.01369-09. Epub 2009 Sep 2.


The virological synapse facilitates herpes simplex virus entry into T cells.

Aubert M, Yoon M, Sloan DD, Spear PG, Jerome KR.

J Virol. 2009 Jun;83(12):6171-83. doi: 10.1128/JVI.02163-08. Epub 2009 Apr 1.


Unconventional ligand activation of herpesvirus entry mediator signals cell survival.

Cheung TC, Steinberg MW, Oborne LM, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6244-9. doi: 10.1073/pnas.0902115106. Epub 2009 Mar 30. Erratum in: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16535-6.


Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery.

Li W, Zha J, Spear PA, Li Z, Yang L, Wang Z.

Aquat Toxicol. 2009 Apr 2;92(1):50-7. doi: 10.1016/j.aquatox.2009.01.006. Epub 2009 Feb 15.


Study design, water quality, morphometrics and age of the bullfrog, Rana catesbeiana, in sub-watersheds of the Yamaska River drainage basin, Québec, Canada.

Spear PA, Boily M, Giroux I, Deblois C, Leclair MH, Levasseur M, Leclair R.

Aquat Toxicol. 2009 Jan 31;91(2):110-7. doi: 10.1016/j.aquatox.2008.09.011. Epub 2008 Oct 1.


Combined effects of agricultural activity and parasites on biomarkers in the bullfrog, Rana catasbeiana.

Marcogliese DJ, King KC, Salo HM, Fournier M, Brousseau P, Spear P, Champoux L, McLaughlin JD, Boily M.

Aquat Toxicol. 2009 Jan 31;91(2):126-34. doi: 10.1016/j.aquatox.2008.10.001. Epub 2008 Oct 14.


Cross-regulation between herpesviruses and the TNF superfamily members.

Sedý JR, Spear PG, Ware CF.

Nat Rev Immunol. 2008 Nov;8(11):861-73. doi: 10.1038/nri2434. Review.


Occurrence and distribution of organochlorine pesticides - lindane, p,p'-DDT, and heptachlor epoxide - in surface water of China.

Gao J, Liu L, Liu X, Lu J, Zhou H, Huang S, Wang Z, Spear PA.

Environ Int. 2008 Nov;34(8):1097-103. doi: 10.1016/j.envint.2008.03.011. Epub 2008 May 27.


PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.

Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H.

Cell. 2008 Mar 21;132(6):935-44. doi: 10.1016/j.cell.2008.01.043.


Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada).

Abdelouahab N, Mergler D, Takser L, Vanier C, St-Jean M, Baldwin M, Spear PA, Chan HM.

Environ Res. 2008 Jul;107(3):380-92. doi: 10.1016/j.envres.2008.01.006. Epub 2008 Mar 4.


Comparison of ethinylestradiol and nonylphenol effects on reproduction of Chinese rare minnows (Gobiocypris rarus).

Zha J, Sun L, Spear PA, Wang Z.

Ecotoxicol Environ Saf. 2008 Oct;71(2):390-9. doi: 10.1016/j.ecoenv.2007.11.017. Epub 2008 Feb 21.


Assessment of 17alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus).

Zha J, Sun L, Zhou Y, Spear PA, Ma M, Wang Z.

Toxicol Appl Pharmacol. 2008 Feb 1;226(3):298-308. Epub 2007 Oct 12.


Alternative entry receptors for herpes simplex virus and their roles in disease.

Taylor JM, Lin E, Susmarski N, Yoon M, Zago A, Ware CF, Pfeffer K, Miyoshi J, Takai Y, Spear PG.

Cell Host Microbe. 2007 Jul 12;2(1):19-28.


Effects of HMX-lead mixtures on reproduction of the earthworm Eisenia andrei.

Savard K, Berthelot Y, Auroy A, Spear PA, Trottier B, Robidoux PY.

Arch Environ Contam Toxicol. 2007 Oct;53(3):351-8. Epub 2007 Aug 9.


Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B.

Lin E, Spear PG.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13140-5. Epub 2007 Jul 31.


Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes).

Sun L, Zha J, Spear PA, Wang Z.

Environ Toxicol Pharmacol. 2007 Jul;24(1):23-9. doi: 10.1016/j.etap.2007.01.003. Epub 2007 Jan 20.


The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.

Lawrence R, Yabe T, Hajmohammadi S, Rhodes J, McNeely M, Liu J, Lamperti ED, Toselli PA, Lech M, Spear PG, Rosenberg RD, Shworak NW.

Matrix Biol. 2007 Jul;26(6):442-55. Epub 2007 Mar 30.


Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults.

Sun L, Zha J, Spear PA, Wang Z.

Comp Biochem Physiol C Toxicol Pharmacol. 2007 May;145(4):533-41. Epub 2007 Feb 22.


In vitro degradation of hexanitrohexaazaisowurtzitane (CL-20) by cytosolic enzymes of Japanese quail and the rabbit.

Bardai GK, Halasz A, Sunahara GI, Dodard S, Spear PA, Grosse S, Hoang J, Hawari J.

Environ Toxicol Chem. 2006 Dec;25(12):3221-9.


Biochemistry. Viral glycoproteins and an evolutionary conundrum.

Steven AC, Spear PG.

Science. 2006 Jul 14;313(5784):177-8. No abstract available.


Inhibition of TCR signaling by herpes simplex virus.

Sloan DD, Han JY, Sandifer TK, Stewart M, Hinz AJ, Yoon M, Johnson DC, Spear PG, Jerome KR.

J Immunol. 2006 Feb 1;176(3):1825-33.


Contamination and biomarkers in the great blue heron, an indicator of the state of the st. Lawrence river.

Champoux L, Rodrigue J, Trudeau S, Boily MH, Spear PA, Hontela A.

Ecotoxicology. 2006 Feb;15(1):83-96. Epub 2006 Jan 7.


Different receptors binding to distinct interfaces on herpes simplex virus gD can trigger events leading to cell fusion and viral entry.

Spear PG, Manoj S, Yoon M, Jogger CR, Zago A, Myscofski D.

Virology. 2006 Jan 5;344(1):17-24. Review.


Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.

Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13218-23. Epub 2005 Aug 30.

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