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Items: 12

1.

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.

Spear ED, Hsu ET, Nie L, Carpenter EP, Hrycyna CA, Michaelis S.

Dis Model Mech. 2018 Jul 13;11(7). pii: dmm033670. doi: 10.1242/dmm.033670.

2.

Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast.

Maurer MJ, Spear ED, Yu AT, Lee EJ, Shahzad S, Michaelis S.

G3 (Bethesda). 2016 Jul 7;6(7):1853-66. doi: 10.1534/g3.116.027953.

3.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.

4.

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM.

Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.

5.

Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals.

Kogan K, Spear ED, Kaiser CA, Fass D.

J Mol Biol. 2010 Sep 17;402(2):388-98. doi: 10.1016/j.jmb.2010.07.034. Epub 2010 Jul 23.

PMID:
20655927
6.

The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.

7.

Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.

Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU.

Science. 2008 Nov 28;322(5906):1369-73. doi: 10.1126/science.1165886. Epub 2008 Oct 30.

8.

Yos9p detects and targets misfolded glycoproteins for ER-associated degradation.

Kim W, Spear ED, Ng DT.

Mol Cell. 2005 Sep 16;19(6):753-64.

9.

Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation.

Spear ED, Ng DT.

J Cell Biol. 2005 Apr 11;169(1):73-82. Epub 2005 Apr 4.

10.
11.

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding.

Vashist S, Kim W, Belden WJ, Spear ED, Barlowe C, Ng DT.

J Cell Biol. 2001 Oct 29;155(3):355-68. Epub 2001 Oct 22.

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