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Items: 1 to 50 of 137

1.

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation.

Gauthier JM, Lin A, Nic Dhonnchadha BÁ, Spealman RD, Man HY, Kantak KM.

Addict Biol. 2017 Jan;22(1):152-162. doi: 10.1111/adb.12313. Epub 2015 Sep 18.

2.

Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.

Rüedi-Bettschen D, Spealman RD, Platt DM.

Psychopharmacology (Berl). 2015 Aug;232(16):2959-68. doi: 10.1007/s00213-015-3932-z. Epub 2015 Apr 17.

3.

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O.

Cell Stem Cell. 2015 Mar 5;16(3):269-74. doi: 10.1016/j.stem.2015.01.018. Epub 2015 Feb 26.

4.

Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking.

Achat-Mendes C, Nic Dhonnchadha BÁ, Platt DM, Kantak KM, Spealman RD.

Neuropsychopharmacology. 2012 Dec;37(13):2837-45. doi: 10.1038/npp.2012.155. Epub 2012 Sep 5.

5.

Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys.

Achat-Mendes C, Platt DM, Spealman RD.

J Pharmacol Exp Ther. 2012 Oct;343(1):214-24. doi: 10.1124/jpet.112.196295. Epub 2012 Jul 18.

6.

Models of neurological disease (substance abuse): self-administration in monkeys.

Platt DM, Carey G, Spealman RD.

Curr Protoc Pharmacol. 2011 Dec;Chapter 10:Unit10.5. doi: 10.1002/0471141755.ph1005s56.

7.

Inhibiting glycine transporter-1 facilitates cocaine-cue extinction and attenuates reacquisition of cocaine-seeking behavior.

Nic Dhonnchadha BÁ, Pinard E, Alberati D, Wettstein JG, Spealman RD, Kantak KM.

Drug Alcohol Depend. 2012 Apr 1;122(1-2):119-26. doi: 10.1016/j.drugalcdep.2011.09.017. Epub 2011 Oct 10.

8.

Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.

Xu TX, Ma Q, Spealman RD, Yao WD.

J Neurochem. 2010 Dec;115(6):1643-54. doi: 10.1111/j.1471-4159.2010.07073.x. Epub 2010 Nov 19.

9.

Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.

Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD.

J Pharmacol Exp Ther. 2010 Aug;334(2):556-65. doi: 10.1124/jpet.110.167619. Epub 2010 May 21.

10.

Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle.

Platt DM, Rowlett JK, Spealman RD.

J Pharmacol Exp Ther. 2010 Mar;332(3):985-95. doi: 10.1124/jpet.109.162941. Epub 2009 Dec 4.

11.

Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.

Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, Yao WD.

J Neurosci. 2009 Nov 11;29(45):14086-99. doi: 10.1523/JNEUROSCI.0974-09.2009.

12.

Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.

Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM.

Psychopharmacology (Berl). 2010 Jun;210(2):169-77. doi: 10.1007/s00213-009-1705-2. Epub 2009 Oct 27.

13.

D-cycloserine deters reacquisition of cocaine self-administration by augmenting extinction learning.

Nic Dhonnchadha BA, Szalay JJ, Achat-Mendes C, Platt DM, Otto MW, Spealman RD, Kantak KM.

Neuropsychopharmacology. 2010 Jan;35(2):357-67. doi: 10.1038/npp.2009.139.

14.

The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys.

Achat-Mendes C, Platt DM, Newman AH, Spealman RD.

Psychopharmacology (Berl). 2009 Sep;206(1):73-84. doi: 10.1007/s00213-009-1581-9. Epub 2009 Jun 10.

15.

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.

Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O.

Neurobiol Dis. 2009 Sep;35(3):348-51. doi: 10.1016/j.nbd.2009.05.018. Epub 2009 Jun 6.

16.

Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine.

Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2009 Jun;204(3):489-98. doi: 10.1007/s00213-009-1480-0. Epub 2009 Feb 19.

17.

Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine.

Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2008 Oct;200(2):167-76. doi: 10.1007/s00213-008-1191-y. Epub 2008 May 29.

18.

Intravenous self-administration techniques in monkeys.

Platt DM, Carey G, Spealman RD.

Curr Protoc Neurosci. 2005 Aug;Chapter 9:Unit 9.21. doi: 10.1002/0471142301.ns0921s32.

PMID:
18428630
19.

Dopaminergic signaling in dendritic spines.

Yao WD, Spealman RD, Zhang J.

Biochem Pharmacol. 2008 Jun 1;75(11):2055-69. doi: 10.1016/j.bcp.2008.01.018. Epub 2008 Feb 12. Review.

20.

Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms.

Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD.

J Pharmacol Exp Ther. 2007 Nov;323(2):525-33. Epub 2007 Aug 16.

PMID:
17702903
21.

Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Platt DM, Rowlett JK, Spealman RD.

J Pharmacol Exp Ther. 2007 Aug;322(2):894-902. Epub 2007 May 15.

PMID:
17505018
22.

Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys.

Rowlett JK, Platt DM, Yao WD, Spealman RD.

J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43. Epub 2007 Mar 9.

PMID:
17351103
23.
24.

Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys.

Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK.

J Pharmacol Exp Ther. 2005 May;313(2):658-67. Epub 2005 Jan 13.

PMID:
15650112
25.

Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis.

Rowlett JK, Rodefer JS, Spealman RD.

J Pharmacol Exp Ther. 2005 Mar;312(3):1289-97. Epub 2004 Nov 18.

PMID:
15550572
26.

Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine.

Lee B, Platt DM, Rowlett JK, Adewale AS, Spealman RD.

J Pharmacol Exp Ther. 2005 Mar;312(3):1232-40. Epub 2004 Nov 18.

PMID:
15550570
27.

Triggers of relapse: nonhuman primate models of reinstated cocaine seeking.

Spealman RD, Lee B, Tiefenbacher S, Platt DM, Rowlett JK, Khroyan TV.

Nebr Symp Motiv. 2004;50:57-84. Review. No abstract available.

PMID:
15160638
28.

Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors.

Rowlett JK, Platt DM, Spealman RD.

J Pharmacol Exp Ther. 2004 Jul;310(1):342-8. Epub 2004 Feb 25.

PMID:
14985417
29.

Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys.

Lee B, Tiefenbacher S, Platt DM, Spealman RD.

Neuropsychopharmacology. 2004 Apr;29(4):686-93.

30.

Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.

Platt DM, Rowlett JK, Izenwasser S, Spealman RD.

J Pharmacol Exp Ther. 2004 Mar;308(3):1030-9. Epub 2003 Nov 21.

PMID:
14634035
31.

Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.

Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ.

Eur J Pharmacol. 2003 Oct 31;479(1-3):41-51.

PMID:
14612136
32.

Noninvasive technique for the repeated sampling of salivary free cortisol in awake, unrestrained squirrel monkeys.

Tiefenbacher S, Lee B, Meyer JS, Spealman RD.

Am J Primatol. 2003 Jun;60(2):69-75.

PMID:
12784287
33.

Role of the hypothalamic-pituitary-adrenal axis in reinstatement of cocaine-seeking behavior in squirrel monkeys.

Lee B, Tiefenbacher S, Platt DM, Spealman RD.

Psychopharmacology (Berl). 2003 Jul;168(1-2):177-183. doi: 10.1007/s00213-003-1391-4. Epub 2003 Mar 22.

PMID:
12652344
34.

Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates.

Khroyan TV, Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2003 Jul;168(1-2):124-131. doi: 10.1007/s00213-002-1365-y. Epub 2003 Feb 27.

PMID:
12607074
35.

Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys.

Platt DM, Rodefer JS, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2003 Mar;166(3):298-305. Epub 2003 Feb 13.

PMID:
12589523
37.

Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors.

Rowlett JK, Spealman RD, Lelas S, Cook JM, Yin W.

Psychopharmacology (Berl). 2003 Jan;165(3):209-15. Epub 2002 Nov 6.

PMID:
12420154
38.

Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys.

Platt DM, Rowlett JK, Spealman RD, Cook J, Ma C.

Psychopharmacology (Berl). 2002 Nov;164(2):151-9. Epub 2002 Sep 4.

PMID:
12404077
39.

Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development.

Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82. Epub 2002 Jul 17. Review.

PMID:
12373428
40.

Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys.

Lelas S, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W.

Psychopharmacology (Berl). 2002 May;161(2):180-8. Epub 2002 Mar 13.

PMID:
11981598
41.
42.

Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam.

Lelas S, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2001 Nov;158(2):181-9.

PMID:
11702092
43.

Similar enhancement of the discriminative stimulus effects of cocaine and GBR 12909 by heroin in squirrel monkeys.

Rowlett JK, Spealman RD, Platt DM.

Psychopharmacology (Berl). 2001 Sep;157(3):313-9.

PMID:
11605088
44.
45.

Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys.

Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2001 Sep;157(2):208-16.

PMID:
11594448
46.
47.

Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors.

Rowlett JK, Lelas S, Spealman RD.

Eur J Pharmacol. 2000 Oct 6;406(1):R9-R10.

PMID:
11011051
48.

Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines.

Lelas S, Spealman RD, Rowlett JK.

Exp Clin Psychopharmacol. 2000 Aug;8(3):294-311. Review.

PMID:
10975618
49.

Dopaminergic mechanisms in relapse to cocaine-seeking behavior. Implications for medications development.

Spealman RD, Khroyan TV, Barrett-Larimore RL, Rowlett JK, Platt DM.

Ann N Y Acad Sci. 2000;909:273-4. No abstract available.

PMID:
10911940
50.

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