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Limits to sustained energy intake XXIX: the case of the golden hamster (Mesocricetus auratus).

Ohrnberger SA, Hambly C, Speakman JR, Valencak TG.

J Exp Biol. 2018 Sep 18. pii: jeb.183749. doi: 10.1242/jeb.183749. [Epub ahead of print]


GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.

Lipina C, Walsh SK, Mitchell SE, Speakman JR, Wainwright CL, Hundal HS.

FASEB J. 2018 Aug 27:fj201800171R. doi: 10.1096/fj.201800171R. [Epub ahead of print]


Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice.

Hu S, Wang L, Yang D, Li L, Togo J, Wu Y, Liu Q, Li B, Li M, Wang G, Zhang X, Niu C, Li J, Xu Y, Couper E, Whittington-Davies A, Mazidi M, Luo L, Wang S, Douglas A, Speakman JR.

Cell Metab. 2018 Sep 4;28(3):415-431.e4. doi: 10.1016/j.cmet.2018.06.010. Epub 2018 Jul 12.


GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity.

Speakman JR, Loos RJF, O'Rahilly S, Hirschhorn JN, Allison DB.

Int J Obes (Lond). 2018 Aug;42(8):1524-1531. doi: 10.1038/s41366-018-0147-5. Epub 2018 Jul 6.


Limits to sustained energy intake. XXVIII. Beneficial effects of high dietary fat on lactation performance in mice.

Kagya-Agyemang JK, Vaanholt LM, Hambly C, Król E, Mitchell SE, Speakman JR.

J Exp Biol. 2018 Aug 23;221(Pt 16). pii: jeb180828. doi: 10.1242/jeb.180828.


Response to 'Fat is not just an energy store'.

Speakman JR.

J Exp Biol. 2018 Jun 22;221(Pt 12). pii: jeb184499. doi: 10.1242/jeb.184499. No abstract available.


Effects of Ramadan on food intake, glucose homeostasis, lipid profiles and body composition composition.

Nachvak SM, Pasdar Y, Pirsaheb S, Darbandi M, Niazi P, Mostafai R, Speakman JR.

Eur J Clin Nutr. 2018 Jun 8. doi: 10.1038/s41430-018-0189-8. [Epub ahead of print]


Impact of Obesity and Ozone on the Association Between Particulate Air Pollution and Cardiovascular Disease and Stroke Mortality Among US Adults.

Mazidi M, Speakman JR.

J Am Heart Assoc. 2018 May 30;7(11). pii: e008006. doi: 10.1161/JAHA.117.008006.


The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice.

Green CL, Soltow QA, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Jones DP, Speakman JR.

J Gerontol A Biol Sci Med Sci. 2018 Apr 30. doi: 10.1093/gerona/gly058. [Epub ahead of print]


The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.

Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M.

Aging Cell. 2018 Jun;17(3):e12746. doi: 10.1111/acel.12746. Epub 2018 Mar 25.


Reply to VI Kraak.

Speakman JR, Mazidi M.

Am J Clin Nutr. 2018 Feb 1;107(2):290-291. doi: 10.1093/ajcn/nqx026. No abstract available.


The evolution of body fatness: trading off disease and predation risk.

Speakman JR.

J Exp Biol. 2018 Mar 7;221(Pt Suppl 1). pii: jeb167254. doi: 10.1242/jeb.167254. Review.


Beauty and the Body of the Beholder: Raters' BMI Has Only Limited Association with Ratings of Attractiveness of the Opposite Sex.

Wang G, Ekeleme-Egedigwe CA, El Hamdouchi A, Sauciuvenaite J, Bissland R, Djafarian K, Ojiambo R, Ramuth H, Holasek S, Lackner S, Diouf A, Hambly C, Vaanholt LM, Cao M, Hacker M, Kruger HS, Seru T, Faries MD, Speakman JR.

Obesity (Silver Spring). 2018 Mar;26(3):522-530. doi: 10.1002/oby.22092.


Erratum: Adiposity and Reproductive Cycling Status in Zoo African Elephants.

Chusyd DE, Brown JL, Hambly C, Johnson MS, Morfeld K, Patki A, Speakman JR, Allison DB, Nagy TR.

Obesity (Silver Spring). 2018 Mar;26(3):621. doi: 10.1002/oby.22123. Epub 2018 Jan 27. No abstract available.


The effects of Ramadan fasting on activity and energy expenditure.

Lessan N, Saadane I, Alkaf B, Hambly C, Buckley AJ, Finer N, Speakman JR, Barakat MT.

Am J Clin Nutr. 2018 Jan 1;107(1):54-61. doi: 10.1093/ajcn/nqx016.


Limits to sustained energy intake. XXVII. Trade-offs between first and second litters in lactating mice support the ecological context hypothesis.

Vaanholt LM, Duah OA, Balduci S, Mitchell SE, Hambly C, Speakman JR.

J Exp Biol. 2018 Mar 13;221(Pt 5). pii: jeb170902. doi: 10.1242/jeb.170902.


Adiposity and Reproductive Cycling Status in Zoo African Elephants.

Chusyd DE, Brown JL, Hambly C, Johnson MS, Morfeld K, Patki A, Speakman JR, Allison DB, Nagy TR.

Obesity (Silver Spring). 2018 Jan;26(1):103-110. doi: 10.1002/oby.22046. Erratum in: Obesity (Silver Spring). 2018 Mar;26(3):621.


Body macronutrient composition is predicted by lipid and not protein content of the diet.

Moatt JP, Hambly C, Heap E, Kramer A, Moon F, Speakman JR, Walling CA.

Ecol Evol. 2017 Oct 22;7(23):10056-10065. doi: 10.1002/ece3.3529. eCollection 2017 Dec.


Energy expenditure in professional flat jockeys using doubly labelled water during the racing season: Implications for body weight management.

Wilson G, Lucas D, Hambly C, Speakman JR, Morton JP, Close GL.

Eur J Sport Sci. 2018 Mar;18(2):235-242. doi: 10.1080/17461391.2017.1406996. Epub 2017 Dec 7.


The validity of a web-based FFQ assessed by doubly labelled water and multiple 24-h recalls.

Medin AC, Carlsen MH, Hambly C, Speakman JR, Strohmaier S, Andersen LF.

Br J Nutr. 2017 Dec;118(12):1106-1117. doi: 10.1017/S0007114517003178. Epub 2017 Dec 5.


Effect of Probiotic Supplementation on CD4 Cell Count in HIV-Infected Patients: A Systematic Review and Meta-analysis.

Kazemi A, Djafarian K, Speakman JR, Sabour P, Soltani S, Shab-Bidar S.

J Diet Suppl. 2018 Sep 3;15(5):776-788. doi: 10.1080/19390211.2017.1380103. Epub 2017 Nov 29.


On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.

Qasim A, Turcotte M, de Souza RJ, Samaan MC, Champredon D, Dushoff J, Speakman JR, Meyre D.

Obes Rev. 2018 Feb;19(2):121-149. doi: 10.1111/obr.12625. Epub 2017 Nov 16. Review.


Why lipostatic set point systems are unlikely to evolve.

Speakman JR.

Mol Metab. 2018 Jan;7:147-154. doi: 10.1016/j.molmet.2017.10.007. Epub 2017 Oct 21.


Response to Farrokhi et al.'s statistical comments on 'no seasonal variation in physical activity of Han Chinese living in Beijing'.

Wang G, Speakman JR.

Int J Behav Nutr Phys Act. 2017 Nov 3;14(1):152. doi: 10.1186/s12966-017-0603-y. No abstract available.


Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity.

Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao J.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9474-E9482. doi: 10.1073/pnas.1707853114. Epub 2017 Oct 23.


Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo.

Li L, Li B, Li M, Niu C, Wang G, Li T, Król E, Jin W, Speakman JR.

Mol Metab. 2017 Oct;6(10):1198-1211. doi: 10.1016/j.molmet.2017.07.015. Epub 2017 Aug 5.


Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry.

Melanson EL, Swibas T, Kohrt WM, Catenacci VA, Creasy SA, Plasqui G, Wouters L, Speakman JR, Berman ESF.

Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E124-E130. doi: 10.1152/ajpendo.00241.2017. Epub 2017 Oct 3.


Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity.

Mazidi M, Speakman JR.

Sci Rep. 2017 Aug 22;7(1):9144. doi: 10.1038/s41598-017-08287-1.


Seasonal changes in energy expenditure, body temperature and activity patterns in llamas (Lama glama).

Riek A, Brinkmann L, Gauly M, Perica J, Ruf T, Arnold W, Hambly C, Speakman JR, Gerken M.

Sci Rep. 2017 Aug 8;7(1):7600. doi: 10.1038/s41598-017-07946-7.


The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.

Derous D, Mitchell SE, Wang L, Green CL, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

Aging (Albany NY). 2017 Jul 31;9(7):1770-1824. doi: 10.18632/aging.101269.


The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue.

Derous D, Mitchell SE, Green CL, Wang Y, Han JDJ, Chen L, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):279-288. doi: 10.1093/gerona/glx101.


Higher densities of fast-food and full-service restaurants are not associated with obesity prevalence.

Mazidi M, Speakman JR.

Am J Clin Nutr. 2017 Aug;106(2):603-613. doi: 10.3945/ajcn.116.151407. Epub 2017 May 31.


Cold adaptation in pigs depends on UCP3 in beige adipocytes.

Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman JR, Wang Y, Jin W, Zhao J.

J Mol Cell Biol. 2017 Oct 1;9(5):364-375. doi: 10.1093/jmcb/mjx018.


Activity-specific metabolic rates for diving, transiting, and resting at sea can be estimated from time-activity budgets in free-ranging marine mammals.

Jeanniard-du-Dot T, Trites AW, Arnould JPY, Speakman JR, Guinet C.

Ecol Evol. 2017 Mar 23;7(9):2969-2976. doi: 10.1002/ece3.2546. eCollection 2017 May.


No seasonal variation in physical activity of Han Chinese living in Beijing.

Wang G, Li B, Zhang X, Niu C, Li J, Li L, Speakman JR.

Int J Behav Nutr Phys Act. 2017 Apr 17;14(1):48. doi: 10.1186/s12966-017-0503-1.


Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.

Nilaweera KN, Cabrera-Rubio R, Speakman JR, O'Connor PM, McAuliffe A, Guinane CM, Lawton EM, Crispie F, Aguilera M, Stanley M, Boscaini S, Joyce S, Melgar S, Cryan JF, Cotter PD.

Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E1-E11. doi: 10.1152/ajpendo.00356.2016. Epub 2017 Mar 21.


DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.

Wu R, Liu XM, Sun JG, Chen H, Ma J, Dong M, Peng S, Wang JQ, Ding JQ, Li DH, Speakman JR, Ning G, Jin W, Yuan Z.

Cell Discov. 2017 Feb 14;3:16054. doi: 10.1038/celldisc.2016.54. eCollection 2017.


The effects of graded levels of calorie restriction: VIII. Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse.

Mitchell SE, Tang Z, Kerbois C, Delville C, Derous D, Green CL, Wang Y, Han JJ, Chen L, Douglas A, Lusseau D, Promislow DE, Speakman JR.

Oncotarget. 2017 Mar 14;8(11):17453-17474. doi: 10.18632/oncotarget.15294.


Daily energy expenditure in the face of predation: hedgehog energetics in rural landscapes.

Pettett CE, Johnson PJ, Moorhouse TP, Hambly C, Speakman JR, Macdonald DW.

J Exp Biol. 2017 Feb 1;220(Pt 3):460-468. doi: 10.1242/jeb.150359.


The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice.

Green CL, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

Aging Cell. 2017 Jun;16(3):529-540. doi: 10.1111/acel.12570. Epub 2017 Jan 31.


Mechanisms of Action of Surgical Interventions on Weight-Related Diseases: the Potential Role of Bile Acids.

Mazidi M, de Caravatto PP, Speakman JR, Cohen RV.

Obes Surg. 2017 Mar;27(3):826-836. doi: 10.1007/s11695-017-2549-1. Review.


Energy Intake and Expenditure of Professional Soccer Players of the English Premier League: Evidence of Carbohydrate Periodization.

Anderson L, Orme P, Naughton RJ, Close GL, Milsom J, Rydings D, O'Boyle A, Di Michele R, Louis J, Hambly C, Speakman JR, Morgans R, Drust B, Morton JP.

Int J Sport Nutr Exerc Metab. 2017 Jun;27(3):228-238. doi: 10.1123/ijsnem.2016-0259. Epub 2017 Jan 4.


Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized controlled trial.

Da Boit M, Sibson R, Sivasubramaniam S, Meakin JR, Greig CA, Aspden RM, Thies F, Jeromson S, Hamilton DL, Speakman JR, Hambly C, Mangoni AA, Preston T, Gray SR.

Am J Clin Nutr. 2017 Jan;105(1):151-158. doi: 10.3945/ajcn.116.140780. Epub 2016 Nov 16.


Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance.

Jothery AH, Vaanholt LM, Mody N, Arnous A, Lykkesfeldt J, Bünger L, Hill WG, Mitchell SE, Allison DB, Speakman JR.

Sci Rep. 2016 Nov 14;6:36353. doi: 10.1038/srep36353.


The Assessment of Total Energy Expenditure During a 14-Day In-Season Period of Professional Rugby League Players Using the Doubly Labelled Water Method.

Morehen JC, Bradley WJ, Clarke J, Twist C, Hambly C, Speakman JR, Morton JP, Close GL.

Int J Sport Nutr Exerc Metab. 2016 Oct;26(5):464-472. Epub 2016 Aug 24.


Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of 'healthy obesity'?

Liu XY, Yang DB, Xu YC, Gronning MO, Zhang F, Wang DH, Speakman JR.

Dis Model Mech. 2016 Nov 1;9(11):1357-1366. Epub 2016 Sep 30.


Renal cell carcinoma survival and body mass index: a dose-response meta-analysis reveals another potential paradox within a paradox.

Bagheri M, Speakman JR, Shemirani F, Djafarian K.

Int J Obes (Lond). 2016 Dec;40(12):1817-1822. doi: 10.1038/ijo.2016.171. Epub 2016 Sep 30. Review.


Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the "Thrifty Gene" Hypothesis.

Wang G, Speakman JR.

Cell Metab. 2016 Oct 11;24(4):531-541. doi: 10.1016/j.cmet.2016.08.014. Epub 2016 Sep 22.


Flipper strokes can predict energy expenditure and locomotion costs in free-ranging northern and Antarctic fur seals.

Jeanniard-du-Dot T, Trites AW, Arnould JP, Speakman JR, Guinet C.

Sci Rep. 2016 Sep 23;6:33912. doi: 10.1038/srep33912.

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