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Impact of dietary sucrose on adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid.

Togo J, Hu S, Li M, Niu C, Speakman JR.

Mol Metab. 2019 Jun 4. pii: S2212-8778(19)30294-7. doi: 10.1016/j.molmet.2019.05.010. [Epub ahead of print]


Switching off the furnace: brown adipose tissue and lactation.

Król E, Speakman JR.

Mol Aspects Med. 2019 Jul 1. pii: S0098-2997(19)30034-2. doi: 10.1016/j.mam.2019.06.003. [Epub ahead of print] Review.


The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice.

Green CL, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

J Gerontol A Biol Sci Med Sci. 2019 Apr 9. pii: glz023. doi: 10.1093/gerona/glz023. [Epub ahead of print]


No impact of hunger on male perception of female physical attractiveness in relation to adiposity: a randomized controlled trial.

Jin Z, Wang G, Hu S, Speakman JR.

Int J Obes (Lond). 2019 Jun 17. doi: 10.1038/s41366-019-0392-2. [Epub ahead of print]


Extreme events reveal an alimentary limit on sustained maximal human energy expenditure.

Thurber C, Dugas LR, Ocobock C, Carlson B, Speakman JR, Pontzer H.

Sci Adv. 2019 Jun 5;5(6):eaaw0341. doi: 10.1126/sciadv.aaw0341. eCollection 2019 Jun.


To best mimic human thermal conditions, mice should be housed slightly below thermoneutrality.

Keijer J, Li M, Speakman JR.

Mol Metab. 2019 May 28. pii: S2212-8778(19)30464-8. doi: 10.1016/j.molmet.2019.05.007. [Epub ahead of print] No abstract available.


Case Study: Muscle Atrophy, Hypertrophy, and Energy Expenditure of a Premier League Soccer Player During Rehabilitation From Anterior Cruciate Ligament Injury.

Anderson L, Close GL, Konopinski M, Rydings D, Milsom J, Hambly C, Speakman JR, Drust B, Morton JP.

Int J Sport Nutr Exerc Metab. 2019 Jun 13:1-8. doi: 10.1123/ijsnem.2018-0391. [Epub ahead of print]


What is the best housing temperature to translate mouse experiments to humans?

Keijer J, Li M, Speakman JR.

Mol Metab. 2019 Jul;25:168-176. doi: 10.1016/j.molmet.2019.04.001. Epub 2019 Apr 6.


Use of high-fat diets to study rodent obesity as a model of human obesity.

Speakman JR.

Int J Obes (Lond). 2019 Apr 9. doi: 10.1038/s41366-019-0363-7. [Epub ahead of print] No abstract available.


Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity.

Alhindi Y, Vaanholt LM, Al-Tarrah M, Gray SR, Speakman JR, Hambly C, Alanazi BS, Gabriel BM, Lionikas A, Ratkevicius A.

J Nutr Metab. 2019 Mar 3;2019:8594825. doi: 10.1155/2019/8594825. eCollection 2019.


Energy expenditure and body temperature variations in llamas living in the High Andes of Peru.

Riek A, Stölzl A, Marquina Bernedo R, Ruf T, Arnold W, Hambly C, Speakman JR, Gerken M.

Sci Rep. 2019 Mar 11;9(1):4037. doi: 10.1038/s41598-019-40576-9.


Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.

Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR.

Cell Rep. 2019 Mar 5;26(10):2720-2737.e5. doi: 10.1016/j.celrep.2019.02.015.


Dietary α-lactalbumin alters energy balance, gut microbiota composition and intestinal nutrient transporter expression in high-fat diet-fed mice.

Boscaini S, Cabrera-Rubio R, Speakman JR, Cotter PD, Cryan JF, Nilaweera KN.

Br J Nutr. 2019 May;121(10):1097-1107. doi: 10.1017/S0007114519000461. Epub 2019 Mar 5.


Nutrition and its role in human evolution.

James WPT, Johnson RJ, Speakman JR, Wallace DC, Frühbeck G, Iversen PO, Stover PJ.

J Intern Med. 2019 May;285(5):533-549. doi: 10.1111/joim.12878. Epub 2019 Feb 17. Review.


Genetic Factors Associated With Human Physical Activity: Are Your Genes Too Tight To Prevent You Exercising?

Zhang X, Speakman JR.

Endocrinology. 2019 Apr 1;160(4):840-852. doi: 10.1210/en.2018-00873.


Energetics and thermal adaptation in semifossorial pine-voles Microtus lusitanicus and Microtus duodecimcostatus.

Monarca RI, Speakman JR, Mathias MDL.

J Comp Physiol B. 2019 Apr;189(2):309-318. doi: 10.1007/s00360-019-01205-z. Epub 2019 Feb 4.


Pre- and post-diagnosis body mass index and heart failure mortality: a dose-response meta-analysis of observational studies reveals greater risk of being underweight than being overweight.

Milajerdi A, Djafarian K, Shab-Bidar S, Speakman JR.

Obes Rev. 2018 Nov 22;20(2):252-261. doi: 10.1111/obr.12777. Review.


Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study.

Roberts SB, Das SK, Suen VMM, Pihlajamäki J, Kuriyan R, Steiner-Asiedu M, Taetzsch A, Anderson AK, Silver RE, Barger K, Krauss A, Karhunen L, Zhang X, Hambly C, Schwab U, Triffoni-Melo AT, Taylor SF, Economos C, Kurpad AV, Speakman JR.

BMJ. 2018 Dec 12;363:k4864. doi: 10.1136/bmj.k4864.


Regulation of intestinal growth in response to variations in energy supply and demand.

Nilaweera KN, Speakman JR.

Obes Rev. 2018 Dec;19 Suppl 1:61-72. doi: 10.1111/obr.12780. Review.


Obesity and thermoregulation.

Speakman JR.

Handb Clin Neurol. 2018;156:431-443. doi: 10.1016/B978-0-444-63912-7.00026-6. Review.


Assessment of Energy Expenditure of a Professional Goalkeeper From the English Premier League Using the Doubly Labeled Water Method.

Anderson L, Close GL, Morgans R, Hambly C, Speakman JR, Drust B, Morton JP.

Int J Sports Physiol Perform. 2019 May 1;14(5):681-684. doi: 10.1123/ijspp.2018-0520. Epub 2019 Apr 16.


Limits to sustained energy intake. XXIX. The case of the golden hamster (Mesocricetus auratus).

Ohrnberger SA, Hambly C, Speakman JR, Valencak TG.

J Exp Biol. 2018 Oct 31;221(Pt 21). pii: jeb183749. doi: 10.1242/jeb.183749.


GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.

Lipina C, Walsh SK, Mitchell SE, Speakman JR, Wainwright CL, Hundal HS.

FASEB J. 2019 Jan;33(1):1299-1312. doi: 10.1096/fj.201800171R. Epub 2018 Aug 27.


Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice.

Hu S, Wang L, Yang D, Li L, Togo J, Wu Y, Liu Q, Li B, Li M, Wang G, Zhang X, Niu C, Li J, Xu Y, Couper E, Whittington-Davies A, Mazidi M, Luo L, Wang S, Douglas A, Speakman JR.

Cell Metab. 2018 Sep 4;28(3):415-431.e4. doi: 10.1016/j.cmet.2018.06.010. Epub 2018 Jul 12.


GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity.

Speakman JR, Loos RJF, O'Rahilly S, Hirschhorn JN, Allison DB.

Int J Obes (Lond). 2018 Aug;42(8):1524-1531. doi: 10.1038/s41366-018-0147-5. Epub 2018 Jul 6.


Limits to sustained energy intake. XXVIII. Beneficial effects of high dietary fat on lactation performance in mice.

Kagya-Agyemang JK, Vaanholt LM, Hambly C, Król E, Mitchell SE, Speakman JR.

J Exp Biol. 2018 Aug 23;221(Pt 16). pii: jeb180828. doi: 10.1242/jeb.180828.


Response to 'Fat is not just an energy store'.

Speakman JR.

J Exp Biol. 2018 Jun 22;221(Pt 12). pii: jeb184499. doi: 10.1242/jeb.184499. No abstract available.


Effects of Ramadan on food intake, glucose homeostasis, lipid profiles and body composition composition.

Nachvak SM, Pasdar Y, Pirsaheb S, Darbandi M, Niazi P, Mostafai R, Speakman JR.

Eur J Clin Nutr. 2019 Apr;73(4):594-600. doi: 10.1038/s41430-018-0189-8. Epub 2018 Jun 8.


Impact of Obesity and Ozone on the Association Between Particulate Air Pollution and Cardiovascular Disease and Stroke Mortality Among US Adults.

Mazidi M, Speakman JR.

J Am Heart Assoc. 2018 May 30;7(11). pii: e008006. doi: 10.1161/JAHA.117.008006.


The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice.

Green CL, Soltow QA, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Jones DP, Speakman JR.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):16-26. doi: 10.1093/gerona/gly058.


The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.

Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M.

Aging Cell. 2018 Jun;17(3):e12746. doi: 10.1111/acel.12746. Epub 2018 Mar 25.


Reply to VI Kraak.

Speakman JR, Mazidi M.

Am J Clin Nutr. 2018 Feb 1;107(2):290-291. doi: 10.1093/ajcn/nqx026. No abstract available.


The evolution of body fatness: trading off disease and predation risk.

Speakman JR.

J Exp Biol. 2018 Mar 7;221(Pt Suppl 1). pii: jeb167254. doi: 10.1242/jeb.167254. Review.


Beauty and the Body of the Beholder: Raters' BMI Has Only Limited Association with Ratings of Attractiveness of the Opposite Sex.

Wang G, Ekeleme-Egedigwe CA, El Hamdouchi A, Sauciuvenaite J, Bissland R, Djafarian K, Ojiambo R, Ramuth H, Holasek S, Lackner S, Diouf A, Hambly C, Vaanholt LM, Cao M, Hacker M, Kruger HS, Seru T, Faries MD, Speakman JR.

Obesity (Silver Spring). 2018 Mar;26(3):522-530. doi: 10.1002/oby.22092.


Erratum: Adiposity and Reproductive Cycling Status in Zoo African Elephants.

Chusyd DE, Brown JL, Hambly C, Johnson MS, Morfeld K, Patki A, Speakman JR, Allison DB, Nagy TR.

Obesity (Silver Spring). 2018 Mar;26(3):621. doi: 10.1002/oby.22123. Epub 2018 Jan 27. No abstract available.


The effects of Ramadan fasting on activity and energy expenditure.

Lessan N, Saadane I, Alkaf B, Hambly C, Buckley AJ, Finer N, Speakman JR, Barakat MT.

Am J Clin Nutr. 2018 Jan 1;107(1):54-61. doi: 10.1093/ajcn/nqx016.


Limits to sustained energy intake. XXVII. Trade-offs between first and second litters in lactating mice support the ecological context hypothesis.

Vaanholt LM, Duah OA, Balduci S, Mitchell SE, Hambly C, Speakman JR.

J Exp Biol. 2018 Mar 13;221(Pt 5). pii: jeb170902. doi: 10.1242/jeb.170902.


Adiposity and Reproductive Cycling Status in Zoo African Elephants.

Chusyd DE, Brown JL, Hambly C, Johnson MS, Morfeld K, Patki A, Speakman JR, Allison DB, Nagy TR.

Obesity (Silver Spring). 2018 Jan;26(1):103-110. doi: 10.1002/oby.22046. Erratum in: Obesity (Silver Spring). 2018 Mar;26(3):621.


Body macronutrient composition is predicted by lipid and not protein content of the diet.

Moatt JP, Hambly C, Heap E, Kramer A, Moon F, Speakman JR, Walling CA.

Ecol Evol. 2017 Oct 22;7(23):10056-10065. doi: 10.1002/ece3.3529. eCollection 2017 Dec.


Energy expenditure in professional flat jockeys using doubly labelled water during the racing season: Implications for body weight management.

Wilson G, Lucas D, Hambly C, Speakman JR, Morton JP, Close GL.

Eur J Sport Sci. 2018 Mar;18(2):235-242. doi: 10.1080/17461391.2017.1406996. Epub 2017 Dec 7.


The validity of a web-based FFQ assessed by doubly labelled water and multiple 24-h recalls.

Medin AC, Carlsen MH, Hambly C, Speakman JR, Strohmaier S, Andersen LF.

Br J Nutr. 2017 Dec;118(12):1106-1117. doi: 10.1017/S0007114517003178. Epub 2017 Dec 5.


Effect of Probiotic Supplementation on CD4 Cell Count in HIV-Infected Patients: A Systematic Review and Meta-analysis.

Kazemi A, Djafarian K, Speakman JR, Sabour P, Soltani S, Shab-Bidar S.

J Diet Suppl. 2018 Sep 3;15(5):776-788. doi: 10.1080/19390211.2017.1380103. Epub 2017 Nov 29. Review.


On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.

Qasim A, Turcotte M, de Souza RJ, Samaan MC, Champredon D, Dushoff J, Speakman JR, Meyre D.

Obes Rev. 2018 Feb;19(2):121-149. doi: 10.1111/obr.12625. Epub 2017 Nov 16. Review.


Why lipostatic set point systems are unlikely to evolve.

Speakman JR.

Mol Metab. 2018 Jan;7:147-154. doi: 10.1016/j.molmet.2017.10.007. Epub 2017 Oct 21.


Response to Farrokhi et al.'s statistical comments on 'no seasonal variation in physical activity of Han Chinese living in Beijing'.

Wang G, Speakman JR.

Int J Behav Nutr Phys Act. 2017 Nov 3;14(1):152. doi: 10.1186/s12966-017-0603-y. No abstract available.


Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity.

Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao J.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9474-E9482. doi: 10.1073/pnas.1707853114. Epub 2017 Oct 23.


Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo.

Li L, Li B, Li M, Niu C, Wang G, Li T, Król E, Jin W, Speakman JR.

Mol Metab. 2017 Oct;6(10):1198-1211. doi: 10.1016/j.molmet.2017.07.015. Epub 2017 Aug 5.


Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry.

Melanson EL, Swibas T, Kohrt WM, Catenacci VA, Creasy SA, Plasqui G, Wouters L, Speakman JR, Berman ESF.

Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E124-E130. doi: 10.1152/ajpendo.00241.2017. Epub 2017 Oct 3.


Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity.

Mazidi M, Speakman JR.

Sci Rep. 2017 Aug 22;7(1):9144. doi: 10.1038/s41598-017-08287-1.

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