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Items: 1 to 50 of 54

1.

A composite immune signature parallels disease progression across T1D subjects.

Speake C, Skinner SO, Berel D, Whalen E, Dufort MJ, Young WC, Odegard JM, Pesenacker AM, Gorus FK, James EA, Levings MK, Linsley PS, Akirav EM, Pugliese A, Hessner MJ, Nepom GT, Gottardo R, Long SA.

JCI Insight. 2019 Oct 31. pii: 126917. doi: 10.1172/jci.insight.126917. [Epub ahead of print]

2.

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.

Speake C, Bahnson HT, Wesley JD, Perdue N, Friedrich D, Pham MN, Lanxon-Cookson E, Kwok WW, Sehested Hansen B, von Herrath M, Greenbaum CJ.

Front Immunol. 2019 Sep 13;10:2023. doi: 10.3389/fimmu.2019.02023. eCollection 2019.

3.

In-vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes.

Hao W, Bahnson HT, Speake C, Cerosaletti K, Greenbaum CJ.

Clin Exp Immunol. 2019 Sep 26. doi: 10.1111/cei.13375. [Epub ahead of print]

PMID:
31557315
4.

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.

Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C.

Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9.

PMID:
31442418
5.

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.

Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM.

Diabetes. 2019 Jul;68(7):1366-1379. doi: 10.2337/db19-0119.

PMID:
31221801
6.

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.

Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. No abstract available.

PMID:
31010952
7.

A method for reducing the adverse effects of stray-capacitance on capacitive sensor circuits.

Gettings C, Speake CC.

Rev Sci Instrum. 2019 Feb;90(2):025004. doi: 10.1063/1.5080016.

PMID:
30831753
8.

B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.

Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ.

JCI Insight. 2019 Feb 21;4(4). pii: 126136. doi: 10.1172/jci.insight.126136. eCollection 2019 Feb 21.

9.

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes.

Dufort MJ, Greenbaum CJ, Speake C, Linsley PS.

JCI Insight. 2019 Feb 21;4(4). pii: 125556. doi: 10.1172/jci.insight.125556. eCollection 2019 Feb 21.

10.

Treg gene signatures predict and measure type 1 diabetes trajectory.

Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK.

JCI Insight. 2019 Mar 21;4(6). pii: 123879. doi: 10.1172/jci.insight.123879. eCollection 2019 Mar 21.

11.

Characterization of regulatory T cells in obese omental adipose tissue in humans.

Wu D, Han JM, Yu X, Lam AJ, Hoeppli RE, Pesenacker AM, Huang Q, Chen V, Speake C, Yorke E, Nguyen N, Sampath S, Harris D, Levings MK.

Eur J Immunol. 2019 Feb;49(2):336-347. doi: 10.1002/eji.201847570. Epub 2019 Jan 8.

PMID:
30566246
12.

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group.

Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10.

PMID:
30530850
13.

DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes.

James EA, Gillette L, Durinovic-Bello I, Speake C, Bondinas GP, Moustakas AK, Greenbaum CJ, Papadopoulos GK, Kwok WW.

J Immunol. 2018 Dec 15;201(12):3524-3533. doi: 10.4049/jimmunol.1800723. Epub 2018 Nov 19.

PMID:
30455401
14.

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells.

Blahnik G, Uchtenhagen H, Chow IT, Speake C, Greenbaum C, Kwok WW, James EA.

Cell Immunol. 2019 Jan;335:68-75. doi: 10.1016/j.cellimm.2018.11.004. Epub 2018 Nov 7.

PMID:
30428974
15.

Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control.

Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL.

Matrix Biol. 2019 Jul;80:46-58. doi: 10.1016/j.matbio.2018.09.003. Epub 2018 Sep 6.

PMID:
30196101
16.

Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes.

Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ; Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group, Chen YG, Hessner MJ.

Diabetologia. 2018 Nov;61(11):2356-2370. doi: 10.1007/s00125-018-4708-x. Epub 2018 Aug 30.

17.

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.

Greenbaum CJ, Speake C, Krischer J, Buckner J, Gottlieb PA, Schatz DA, Herold KC, Atkinson MA.

Diabetes. 2018 Jul;67(7):1216-1225. doi: 10.2337/db18-0065. Epub 2018 May 16.

18.

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee.

Diabetologia. 2018 Mar;61(3):658-670. doi: 10.1007/s00125-017-4508-8. Epub 2017 Dec 1.

PMID:
29196783
19.

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9171. doi: 10.1126/scitranslmed.aam9171.

20.

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

Schwedhelm K, Thorpe J, Murray SA, Gavin M, Speake C, Greenbaum C, Cerosaletti K, Buckner J, Long SA.

Clin Immunol. 2017 Aug;181:67-74. doi: 10.1016/j.clim.2017.06.004. Epub 2017 Jun 20.

21.

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS.

J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31.

22.

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

Yang J, Wen X, Xu H, Torres-Chinn N, Speake C, Greenbaum CJ, Nepom GT, Kwok WW.

J Immunol. 2017 Jul 1;199(1):91-96. doi: 10.4049/jimmunol.1601570. Epub 2017 May 26.

23.

Measurement of Pro-Islet Amyloid Polypeptide (1-48) in Diabetes and Islet Transplants.

Courtade JA, Klimek-Abercrombie AM, Chen YC, Patel N, Lu PYT, Speake C, Orban PC, Najafian B, Meneilly G, Greenbaum CJ, Warnock GL, Panagiotopoulos C, Verchere CB.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2595-2603. doi: 10.1210/jc.2016-2773.

PMID:
28368485
24.

Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis.

Jourde-Chiche N, Whalen E, Gondouin B, Speake C, Gersuk V, Dussol B, Burtey S, Pascual V, Chaussabel D, Chiche L.

Rheumatology (Oxford). 2017 Mar 1;56(3):477-487. doi: 10.1093/rheumatology/kew439.

25.

Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home.

Speake C, Whalen E, Gersuk VH, Chaussabel D, Odegard JM, Greenbaum CJ.

Clin Exp Immunol. 2017 May;188(2):226-233. doi: 10.1111/cei.12916. Epub 2017 Mar 2.

26.

Correction: Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.

Speake C, Pichugin A, Sahu T, Malkov V, Morrison R, Pei Y, Juompan L, Milman N, Zarling S, Anderson C, MacDonald NJ, Wong-Madden S, Wendler J, Ishizuka A, MacMillen ZW, Garcia V, Kappe SH, Krzych U, Duffy PE.

PLoS One. 2016 Oct 20;11(10):e0165489. doi: 10.1371/journal.pone.0165489. eCollection 2016.

27.

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.

Speake C, Pichugin A, Sahu T, Malkov V, Morrison R, Pei Y, Juompan L, Milman N, Zarling S, Anderson C, Wong-Madden S, Wendler J, Ishizuka A, MacMillen ZW, Garcia V, Kappe SH, Krzych U, Duffy PE.

PLoS One. 2016 Jul 19;11(7):e0159449. doi: 10.1371/journal.pone.0159449. eCollection 2016. Erratum in: PLoS One. 2016 Oct 20;11(10 ):e0165489.

28.

A cryogenic optical feedthrough using polarization maintaining fibers.

Nelson MJ, Collins CJ, Speake CC.

Rev Sci Instrum. 2016 Mar;87(3):033111. doi: 10.1063/1.4943678.

PMID:
27036762
29.

NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count.

Qin J, Fu S, Speake C, Greenbaum CJ, Odegard JM.

Clin Exp Immunol. 2016 Jun;184(3):318-22. doi: 10.1111/cei.12783. Epub 2016 Apr 13.

30.

Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation.

Speake C, Odegard JM.

Biomark Insights. 2015 Sep 29;10(Suppl 4):19-24. doi: 10.4137/BMI.S29697. eCollection 2015. Review.

31.

The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types.

Linsley PS, Chaussabel D, Speake C.

PLoS One. 2015 Sep 23;10(9):e0138726. doi: 10.1371/journal.pone.0138726. eCollection 2015.

32.

Pseudo-cat's eye for improved tilt-immune interferometry.

Speake CC, Bradshaw MJ.

Appl Opt. 2015 Aug 20;54(24):7387-95. doi: 10.1364/AO.54.007387.

PMID:
26368776
33.

An interactive web application for the dissemination of human systems immunology data.

Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D.

J Transl Med. 2015 Jun 19;13:196. doi: 10.1186/s12967-015-0541-x.

34.

Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis.

Linsley PS, Speake C, Whalen E, Chaussabel D.

PLoS One. 2014 Oct 14;9(10):e109760. doi: 10.1371/journal.pone.0109760. eCollection 2014.

35.

The Newtonian constant of gravitation-a constant too difficult to measure? An introduction.

Quinn T, Speake C.

Philos Trans A Math Phys Eng Sci. 2014 Oct 13;372(2026). pii: 20140253. doi: 10.1098/rsta.2014.0253. Epub 2014 Sep 8. No abstract available.

36.

The BIPM measurements of the Newtonian constant of gravitation, G.

Quinn T, Speake C, Parks H, Davis R.

Philos Trans A Math Phys Eng Sci. 2014 Oct 13;372(2026). pii: 20140032. Epub 2014 Sep 8. Review.

PMID:
25201995
37.

Improved determination of G using two methods.

Quinn T, Parks H, Speake C, Davis R.

Phys Rev Lett. 2013 Sep 6;111(10):101102. Epub 2013 Sep 5. Erratum in: Phys Rev Lett. 2014 Jul 18;13(3):039901.

PMID:
25166649
38.

Low HERV-K(C4) copy number is associated with type 1 diabetes.

Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT.

Diabetes. 2014 May;63(5):1789-95. doi: 10.2337/db13-1382. Epub 2014 Jan 15.

39.

Shared Mycobacterium avium genotypes observed among unlinked clinical and environmental isolates.

Dirac MA, Weigel KM, Yakrus MA, Becker AL, Chen HL, Fridley G, Sikora A, Speake C, Hilborn ED, Pfaller S, Cangelosi GA.

Appl Environ Microbiol. 2013 Sep;79(18):5601-7. doi: 10.1128/AEM.01443-13. Epub 2013 Jul 12.

40.

Interferometric measurement of angular motion.

Peña Arellano FE, Panjwani H, Carbone L, Speake CC.

Rev Sci Instrum. 2013 Apr;84(4):043101. doi: 10.1063/1.4795549.

PMID:
23635175
41.

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D.

Immunity. 2013 Apr 18;38(4):831-44. doi: 10.1016/j.immuni.2012.12.008.

42.

Mirror tilt immunity interferometry with a cat's eye retroreflector.

Peña-Arellano FE, Speake CC.

Appl Opt. 2011 Mar 1;50(7):981-91. doi: 10.1364/AO.50.000981.

PMID:
21364721
43.

Antigens for pre-erythrocytic malaria vaccines: building on success.

Speake C, Duffy PE.

Parasite Immunol. 2009 Sep;31(9):539-46. doi: 10.1111/j.1365-3024.2009.01139.x. Review.

44.

Malaria sporozoite proteome leaves a trail.

Vignali M, Speake C, Duffy PE.

Genome Biol. 2009;10(4):216. doi: 10.1186/gb-2009-10-4-216. Epub 2009 Apr 21. Review.

45.

Development of a second generation torsion balance based on a spherical superconducting suspension.

Hammond GD, Speake CC, Matthews AJ, Rocco E, Peña-Arellano F.

Rev Sci Instrum. 2008 Feb;79(2 Pt 1):025103. doi: 10.1063/1.2835714.

PMID:
18315325
46.

New constraints on short-range forces coupling mass to intrinsic spin.

Hammond GD, Speake CC, Trenkel C, Patón AP.

Phys Rev Lett. 2007 Feb 23;98(8):081101. Epub 2007 Feb 23.

PMID:
17359083
47.

Physics: gravity passes a little test.

Speake C.

Nature. 2007 Mar 1;446(7131):31-2. No abstract available.

PMID:
17330029
48.

Newton's constant and the twenty-first century laboratory.

Speake CC.

Philos Trans A Math Phys Eng Sci. 2005 Sep 15;363(1834):2265-87. Review.

PMID:
16147509
49.

Forces between conducting surfaces due to spatial variations of surface potential.

Speake CC, Trenkel C.

Phys Rev Lett. 2003 Apr 25;90(16):160403. Epub 2003 Apr 23.

PMID:
12731962
50.

A new determination of G using two methods.

Quinn TJ, Speake CC, Richman SJ, Davis RS, Picard A.

Phys Rev Lett. 2001 Sep 10;87(11):111101. Epub 2001 Aug 27.

PMID:
11531510

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