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Items: 37

1.

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO.

PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019.

2.

TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.

Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F.

PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar.

3.

EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease.

Thomas DC, Charbonnier LM, Schejtman A, Aldhekri H, Coomber EL, Dufficy ER, Beenken AE, Lee JC, Clare S, Speak AO, Thrasher AJ, Santilli G, Al-Mousa H, Alkuraya FS, Chatila TA, Smith KGC.

J Allergy Clin Immunol. 2019 Feb;143(2):782-785.e1. doi: 10.1016/j.jaci.2018.09.019. Epub 2018 Oct 9. No abstract available.

4.

Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice.

van der Weyden L, Speak AO, Swiatkowska A, Clare S, Schejtman A, Santilli G, Arends MJ, Adams DJ.

J Pathol. 2018 Nov;246(3):300-310. doi: 10.1002/path.5140. Epub 2018 Sep 19.

5.

Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.

Del Castillo Velasco-Herrera M, van der Weyden L, Nsengimana J, Speak AO, Sjöberg MK, Bishop DT, Jönsson G, Newton-Bishop J, Adams DJ.

Mol Oncol. 2018 Feb;12(2):239-255. doi: 10.1002/1878-0261.12161. Epub 2018 Jan 7.

6.

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Speak AO, Swiatkowska A, Karp NA, Arends MJ, Adams DJ, van der Weyden L.

Nat Protoc. 2017 Dec;12(12):2465-2477. doi: 10.1038/nprot.2017.118. Epub 2017 Nov 2.

PMID:
29095442
7.

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

van der Weyden L, Karp NA, Swiatkowska A, Adams DJ, Speak AO.

Sci Data. 2017 Sep 12;4:170129. doi: 10.1038/sdata.2017.129.

8.

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL; International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK.

Nat Commun. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475.

9.

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis.

Stacey MA, Clare S, Clement M, Marsden M, Abdul-Karim J, Kane L, Harcourt K, Brandt C, Fielding CA, Smith SE, Wash RS, Brias SG, Stack G, Notley G, Cambridge EL, Isherwood C, Speak AO, Johnson Z, Ferlin W, Jones SA, Kellam P, Humphreys IR.

J Clin Invest. 2017 Apr 3;127(4):1463-1474. doi: 10.1172/JCI84889. Epub 2017 Feb 27.

10.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

11.

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP.

Genes Dev. 2016 Oct 1;30(19):2152-2157.

12.

The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.

Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D, Isherwood C, Caetano SS, Reviriego CB, Swiatkowska A, Kane L, Harcourt K; Sanger Mouse Genetics Project, Adams DJ, White JK, Speak AO.

Exp Hematol. 2017 Jan;45:64-68.e5. doi: 10.1016/j.exphem.2016.09.006. Epub 2016 Sep 22.

13.

Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.

Mottram L, Speak AO, Selek RM, Cambridge EL, McIntyre Z, Kane L, Mukhopadhyay S, Grove C, Colin A, Brandt C, Duque-Correa MA, Forbester J, Nguyen TA, Hale C, Vasilliou GS, Arends MJ, Wren BW, Dougan G, Clare S.

MBio. 2016 Jun 21;7(3). pii: e00830-16. doi: 10.1128/mBio.00830-16.

14.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

15.

T cell fate and clonality inference from single-cell transcriptomes.

Stubbington MJT, Lönnberg T, Proserpio V, Clare S, Speak AO, Dougan G, Teichmann SA.

Nat Methods. 2016 Apr;13(4):329-332. doi: 10.1038/nmeth.3800. Epub 2016 Mar 7.

16.

Immune dysfunction in Niemann-Pick disease type C.

Platt N, Speak AO, Colaco A, Gray J, Smith DA, Williams IM, Wallom KL, Platt FM.

J Neurochem. 2016 Jan;136 Suppl 1:74-80. doi: 10.1111/jnc.13138. Epub 2015 Jun 4. Review.

17.

Corrigendum to "Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia" [Experimental Hematology, Vol. 42, Issue 12, p1053-1058.e1].

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2015 May;43(5):424. doi: 10.1016/j.exphem.2015.03.002. Epub 2015 Apr 1. No abstract available.

18.

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

Karp NA, Speak AO, White JK, Adams DJ, Hrabé de Angelis M, Hérault Y, Mott RF.

PLoS One. 2014 Oct 24;9(10):e111239. doi: 10.1371/journal.pone.0111239. eCollection 2014.

19.

Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice.

Guerrero JA, Bennett C, van der Weyden L, McKinney H, Chin M, Nurden P, McIntyre Z, Cambridge EL, Estabel J, Wardle-Jones H, Speak AO, Erber WN, Rendon A, Ouwehand WH, Ghevaert C.

Blood. 2014 Dec 4;124(24):3624-35. doi: 10.1182/blood-2014-04-566760. Epub 2014 Sep 25.

PMID:
25258341
20.

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2014 Dec;42(12):1053-8.e1. doi: 10.1016/j.exphem.2014.07.269. Epub 2014 Aug 12. Erratum in: Exp Hematol. 2015 May;43(5):424. Exp Hematol. 2015 May;43(5):424.

21.

Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker.

te Vruchte D, Speak AO, Wallom KL, Al Eisa N, Smith DA, Hendriksz CJ, Simmons L, Lachmann RH, Cousins A, Hartung R, Mengel E, Runz H, Beck M, Amraoui Y, Imrie J, Jacklin E, Riddick K, Yanjanin NM, Wassif CA, Rolfs A, Rimmele F, Wright N, Taylor C, Ramaswami U, Cox TM, Hastings C, Jiang X, Sidhu R, Ory DS, Arias B, Jeyakumar M, Sillence DJ, Wraith JE, Porter FD, Cortina-Borja M, Platt FM.

J Clin Invest. 2014 Mar;124(3):1320-8.

22.

Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.

Speak AO, Te Vruchte D, Davis LC, Morgan AJ, Smith DA, Yanjanin NM, Simmons L, Hartung R, Runz H, Mengel E, Beck M, Imrie J, Jacklin E, Wraith JE, Hendriksz C, Lachmann R, Cognet C, Sidhu R, Fujiwara H, Ory DS, Galione A, Porter FD, Vivier E, Platt FM.

Blood. 2014 Jan 2;123(1):51-60. doi: 10.1182/blood-2013-03-488692. Epub 2013 Nov 14.

23.

Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection.

Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O.

PLoS One. 2013;8(3):e59599. doi: 10.1371/journal.pone.0059599. Epub 2013 Mar 15.

24.

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity.

Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O.

J Allergy Clin Immunol. 2013 Apr;131(4):1048-57, 1057.e1-2. doi: 10.1016/j.jaci.2012.09.027. Epub 2012 Nov 20.

25.

Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.

Porubsky S, Speak AO, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, Singh Y, Dyson J, Luckow B, Lehuen A, Malle E, Müthing J, Platt FM, Cerundolo V, Gröne HJ.

J Immunol. 2012 Sep 15;189(6):3007-17. doi: 10.4049/jimmunol.1201483. Epub 2012 Aug 8.

26.

Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.

Speak AO, Platt N, Salio M, te Vruchte D, Smith DA, Shepherd D, Veerapen N, Besra GS, Yanjanin NM, Simmons L, Imrie J, Wraith JE, Lachmann RH, Hartung R, Runz H, Mengel E, Beck M, Hendriksz CJ, Porter FD, Cerundolo V, Platt FM.

Eur J Immunol. 2012 Jul;42(7):1886-92. doi: 10.1002/eji.201141821. Epub 2012 Jun 14.

27.

CD8α⁺β⁻ and CD8α⁺β⁺ plasmacytoid dendritic cells induce Foxp3⁺ regulatory T cells and prevent the induction of airway hyper-reactivity.

Lombardi V, Speak AO, Kerzerho J, Szely N, Akbari O.

Mucosal Immunol. 2012 Jul;5(4):432-43. doi: 10.1038/mi.2012.20. Epub 2012 Apr 4.

28.

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.

Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS.

J Lipid Res. 2011 Jul;52(7):1435-45. doi: 10.1194/jlr.D015735. Epub 2011 Apr 24.

29.

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.

Pei B, Speak AO, Shepherd D, Butters T, Cerundolo V, Platt FM, Kronenberg M.

J Immunol. 2011 Feb 1;186(3):1348-60. doi: 10.4049/jimmunol.1001008. Epub 2010 Dec 29.

30.

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V.

J Clin Invest. 2008 Dec;118(12):4036-48. doi: 10.1172/JCI36264. Epub 2008 Nov 13.

31.

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Townson KH, Speak AO, Greenshields KN, Goodyear CS, Willison HJ, Platt FM.

J Neuroimmunol. 2008 Oct 15;203(1):33-8. doi: 10.1016/j.jneuroim.2008.06.033.

PMID:
18684516
32.

CD1d presentation of glycolipids.

Speak AO, Cerundolo V, Platt FM.

Immunol Cell Biol. 2008 Oct;86(7):588-97. doi: 10.1038/icb.2008.42. Epub 2008 Jun 10. Review.

PMID:
18542099
33.

Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.

Elliot-Smith E, Speak AO, Lloyd-Evans E, Smith DA, van der Spoel AC, Jeyakumar M, Butters TD, Dwek RA, d'Azzo A, Platt FM.

Mol Genet Metab. 2008 Jun;94(2):204-11. doi: 10.1016/j.ymgme.2008.02.005. Epub 2008 Apr 1.

PMID:
18387328
34.

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.

Salio M, Speak AO, Shepherd D, Polzella P, Illarionov PA, Veerapen N, Besra GS, Platt FM, Cerundolo V.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20490-5. Epub 2007 Dec 11.

35.

Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids.

Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F.

Immunity. 2007 Oct;27(4):597-609. Epub 2007 Oct 18.

36.

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.

Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5971-6. Epub 2007 Mar 19.

37.

Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.

Porubsky S, Speak AO, Luckow B, Cerundolo V, Platt FM, Gröne HJ.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5977-82. Epub 2007 Mar 19.

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