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CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.

Moure CJ, Diplas BH, Chen LH, Yang R, Pirozzi CJ, Wang Z, Spasojevic I, Waitkus MS, He Y, Yan H.

Mol Cancer Res. 2019 Oct;17(10):2042-2050. doi: 10.1158/1541-7786.MCR-19-0309. Epub 2019 Jul 10.


Pharmacokinetic Analysis of a Novel Human EGFRvIII:CD3 Bispecific Antibody in Plasma and Whole Blood Using a High-Resolution Targeted Mass Spectrometry Approach.

Schaller TH, Foster MW, Thompson JW, Spasojevic I, Normantaite D, Moseley MA, Sanchez-Perez L, Sampson JH.

J Proteome Res. 2019 Aug 2;18(8):3032-3041. doi: 10.1021/acs.jproteome.9b00145. Epub 2019 Jul 19.


MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.

Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, Moure CJ, Hemphill C, Carpenter AB, Healy P, Ruger RC, Chen CJ, Greer PK, Zhao F, Spasojevic I, Grenier C, Huang Z, Murphy SK, McLendon RE, Friedman HS, Friedman AH, Herndon JE 2nd, Sampson JH, Keir ST, Bigner DD, Yan H, He Y.

Cancer Res. 2019 Jul 1;79(13):3383-3394. doi: 10.1158/0008-5472.CAN-18-1010. Epub 2019 Apr 30.


Enhancing Analytical Performance of (Mg,Fe)₃O₄/Glassy Carbon Electrodes by Tailoring Chemical Composition of (Mg,Fe)₃O₄ Nanoparticles.

Ognjanović M, Spasojević I, Stanković DM, Ming Y, Jančar B, Dojčinović B, Spasojević V, Antić B.

J Nanosci Nanotechnol. 2019 Jul 1;19(7):4205-4213. doi: 10.1166/jnn.2019.16284.


Biliverdin-copper complex at physiological pH.

Dimitrijević MS, Bogdanović Pristov J, žiŽić M, Stanković DM, Bajuk-Bogdanović D, Stanić M, Spasić S, Hagen W, Spasojević I.

Dalton Trans. 2019 May 7;48(18):6061-6070. doi: 10.1039/c8dt04724c.


Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.

MacKinney A, Woska E, Spasojevic I, Batinic-Haberle I, Zennadi R.

Redox Biol. 2019 Jan 11:101097. doi: 10.1016/j.redox.2019.101097. [Epub ahead of print]


Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.

Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK, Hsu D, Chen W.

Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442. doi: 10.1016/j.bmc.2018.09.016. Epub 2018 Sep 17.


Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity.

Božić B, Korać J, Stanković DM, Stanić M, Romanović M, Pristov JB, Spasić S, Popović-Bijelić A, Spasojević I, Bajčetić M.

Free Radic Biol Med. 2018 Dec;129:279-285. doi: 10.1016/j.freeradbiomed.2018.09.038. Epub 2018 Sep 26.


Anti-cancer effects of wedelolactone: interactions with copper and subcellular localization.

Kučírková T, Stiborek M, Dúcka M, Navrátilová J, Bogdanović Pristov J, Popović-Bijelić A, Vojvodić S, Preisler J, Kanický V, Šmarda J, Spasojević I, Beneš P.

Metallomics. 2018 Oct 17;10(10):1524-1531. doi: 10.1039/c8mt00191j. Epub 2018 Sep 21.


Enhanced Drug Delivery to the Skin Using Liposomes.

Blueschke G, Boico A, Negussie AH, Yarmolenko P, Wood BJ, Spasojevic I, Fan P, Erdmann D, Schroeder T, Sauerbier M, Klitzman B.

Plast Reconstr Surg Glob Open. 2018 Jul 9;6(7):e1739. doi: 10.1097/GOX.0000000000001739. eCollection 2018 Jul.


A One-Step Staining Protocol for In-Gel Fluorescent Visualization of Proteins.

Bogdanović Pristov J, Spasojević I.

Methods Mol Biol. 2018;1853:149-158. doi: 10.1007/978-1-4939-8745-0_18.


Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Antioxid Redox Signal. 2018 Dec 1;29(16):1691-1724. doi: 10.1089/ars.2017.7453. Epub 2018 Aug 28. Review.


A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.

Abaffy T, Bain JR, Muehlbauer MJ, Spasojevic I, Lodha S, Bruguera E, O'Neal SK, Kim SY, Matsunami H.

Front Oncol. 2018 May 28;8:162. doi: 10.3389/fonc.2018.00162. eCollection 2018.


Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z.

Antioxidants (Basel). 2018 Mar 7;7(3). pii: E40. doi: 10.3390/antiox7030040.


Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH.

Korać J, Stanković DM, Stanić M, Bajuk-Bogdanović D, Žižić M, Pristov JB, Grgurić-Šipka S, Popović-Bijelić A, Spasojević I.

Sci Rep. 2018 Feb 23;8(1):3530. doi: 10.1038/s41598-018-21940-7.


Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.

Il'yasova D, Fontana L, Bhapkar M, Pieper CF, Spasojevic I, Redman LM, Das SK, Huffman KM, Kraus WE; CALERIE Study Investigators.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12719. Epub 2018 Feb 9.


Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.

Tovmasyan A, Bueno-Janice JC, Jaramillo MC, Sampaio RS, Reboucas JS, Kyui N, Benov L, Deng B, Huang TT, Tome ME, Spasojevic I, Batinic-Haberle I.

Antioxid Redox Signal. 2018 Nov 1;29(13):1196-1214. doi: 10.1089/ars.2017.7218. Epub 2018 Mar 27.


Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis?

Opačić M, Stević Z, Baščarević V, Živić M, Spasić M, Spasojević I.

Antioxid Redox Signal. 2018 Jun 10;28(17):1570-1575. doi: 10.1089/ars.2017.7433. Epub 2017 Dec 12.


Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

Waitkus MS, Pirozzi CJ, Moure CJ, Diplas BH, Hansen LJ, Carpenter AB, Yang R, Wang Z, Ingram BO, Karoly ED, Mohney RP, Spasojevic I, McLendon RE, Friedman HS, He Y, Bigner DD, Yan H.

Cancer Res. 2018 Jan 1;78(1):36-50. doi: 10.1158/0008-5472.CAN-17-1352. Epub 2017 Nov 2.


Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine.

Božić B, Korać J, Stanković DM, Stanić M, Popović-Bijelić A, Bogdanović Pristov J, Spasojević I, Bajčetić M.

Chem Biol Interact. 2017 Dec 25;278:129-134. doi: 10.1016/j.cbi.2017.10.022. Epub 2017 Oct 26.


Apple pectin-derived oligosaccharides produce carbon dioxide radical anion in Fenton reaction and prevent growth of Escherichia coli and Staphylococcus aureus.

Martinov J, Krstić M, Spasić S, Miletić S, Stefanović-Kojić J, Nikolić-Kokić A, Blagojević D, Spasojević I, Spasić MB.

Food Res Int. 2017 Oct;100(Pt 2):132-136. doi: 10.1016/j.foodres.2017.08.040. Epub 2017 Aug 19.


Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.

Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W.

Nanoscale. 2017 Aug 31;9(34):12709-12717. doi: 10.1039/c7nr01973d.


Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Boss MK, Dewhirst MW, Sampaio RS, Bennett A, Tovmasyan A, Berman KG, Beaven AW, Rizzieri DA, Batinic-Haberle I, Hauck ML, Spasojevic I.

Cancer Chemother Pharmacol. 2017 Aug;80(2):421-431. doi: 10.1007/s00280-017-3372-z. Epub 2017 Jul 6.


Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.

Tang X, Ding CK, Wu J, Sjol J, Wardell S, Spasojevic I, George D, McDonnell DP, Hsu DS, Chang JT, Chi JT.

Oncogene. 2017 Jul 27;36(30):4379. doi: 10.1038/onc.2017.192. Epub 2017 Jun 12.


A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.

Becher OJ, Millard NE, Modak S, Kushner BH, Haque S, Spasojevic I, Trippett TM, Gilheeney SW, Khakoo Y, Lyden DC, De Braganca KC, Kolesar JM, Huse JT, Kramer K, Cheung NV, Dunkel IJ.

PLoS One. 2017 Jun 5;12(6):e0178593. doi: 10.1371/journal.pone.0178593. eCollection 2017.


Urinary F2-isoprostanes and the risk of hypertension.

Melton CD, Luo R, Wong BJ, Spasojevic I, Wagenknecht LE, D'Agostino RB Jr, Il'yasova D.

Ann Epidemiol. 2017 Jun;27(6):391-396. doi: 10.1016/j.annepidem.2017.05.005. Epub 2017 May 17.


Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Birer SR, Lee CT, Choudhury KR, Young KH, Spasojevic I, Batinic-Haberle I, Crapo JD, Dewhirst MW, Ashcraft KA.

Radiat Res. 2017 Jul;188(1):94-104. doi: 10.1667/RR14757.1.S1. Epub 2017 May 18.


CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

Leu D, Spasojevic I, Nguyen H, Deng B, Tovmasyan A, Weitner T, Sampaio RS, Batinic-Haberle I, Huang TT.

Redox Biol. 2017 Aug;12:864-871. doi: 10.1016/j.redox.2017.04.027. Epub 2017 Apr 22.


Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells.

Nehybová T, Šmarda J, Daniel L, Stiborek M, Kanický V, Spasojevič I, Preisler J, Damborský J, Beneš P.

Int J Mol Sci. 2017 Mar 29;18(4). pii: E729. doi: 10.3390/ijms18040729.


Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.

Pirozzi CJ, Carpenter AB, Waitkus MS, Wang CY, Zhu H, Hansen LJ, Chen LH, Greer PK, Feng J, Wang Y, Bock CB, Fan P, Spasojevic I, McLendon RE, Bigner DD, He Y, Yan H.

Mol Cancer Res. 2017 May;15(5):507-520. doi: 10.1158/1541-7786.MCR-16-0485. Epub 2017 Feb 1.


Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.

Rajic Z, Tovmasyan A, de Santana OL, Peixoto IN, Spasojevic I, do Monte SA, Ventura E, Rebouças JS, Batinic-Haberle I.

J Inorg Biochem. 2017 Apr;169:50-60. doi: 10.1016/j.jinorgbio.2017.01.003. Epub 2017 Jan 5.


Metal maps of sclerotic hippocampi of patients with mesial temporal lobe epilepsy.

Opačić M, Ristić AJ, Savić D, Šelih VS, Živin M, Sokić D, Raičević S, Baščarević V, Spasojević I.

Metallomics. 2017 Feb 22;9(2):141-148. doi: 10.1039/c6mt00293e.


A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors.

Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH, Kramer K, Spasojevic I, Dunkel IJ.

Pediatr Blood Cancer. 2017 Jul;64(7). doi: 10.1002/pbc.26409. Epub 2016 Dec 30.


Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.

Tang X, Ding CK, Wu J, Sjol J, Wardell S, Spasojevic I, George D, McDonnell DP, Hsu DS, Chang JT, Chi JT.

Oncogene. 2017 Jul 27;36(30):4235-4242. doi: 10.1038/onc.2016.394. Epub 2016 Nov 21. Erratum in: Oncogene. 2017 Jun 12;:.



Spasojevic I, Hajdukovic D, Komarcevic M, Petrovic S, Jovanovic J, Ciric A.

Med Pregl. 2016 Sep;69(9-10):305-311.


Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.

Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD.

Nat Chem Biol. 2016 Oct;12(10):795-801. doi: 10.1038/nchembio.2131. Epub 2016 Aug 8.


Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung.

Zhang X, Hadley C, Jackson IL, Zhang Y, Zhang A, Spasojevic I, Haberle IB, Vujaskovic Z.

Free Radic Res. 2016 Aug;50(8):875-86. doi: 10.1080/10715762.2016.1189078. Epub 2016 Jul 1.


Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury.

Kezic A, Spasojevic I, Lezaic V, Bajcetic M.

Oxid Med Cell Longev. 2016;2016:2950503. doi: 10.1155/2016/2950503. Epub 2016 May 24. Review.


Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.

Kanju P, Chen Y, Lee W, Yeo M, Lee SH, Romac J, Shahid R, Fan P, Gooden DM, Simon SA, Spasojevic I, Mook RA, Liddle RA, Guilak F, Liedtke WB.

Sci Rep. 2016 Jun 1;6:26894. doi: 10.1038/srep26894.


Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Weitzel DH, Tovmasyan A, Ashcraft KA, Boico A, Birer SR, Roy Choudhury K, Herndon J 2nd, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Environ Mol Mutagen. 2016 Jun;57(5):372-81. doi: 10.1002/em.22021. Epub 2016 May 25.


Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001).

Gad SC, Sullivan DW Jr, Spasojevic I, Mujer CV, Spainhour CB, Crapo JD.

Int J Toxicol. 2016 Jul;35(4):438-53. doi: 10.1177/1091581816642766. Epub 2016 Apr 20.


SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.

Jacobsen JP, Rudder ML, Roberts W, Royer EL, Robinson TJ, Oh A, Spasojevic I, Sachs BD, Caron MG.

Neuropsychopharmacology. 2016 Aug;41(9):2324-34. doi: 10.1038/npp.2016.35. Epub 2016 Mar 2.


Opinion on Schmidt et al.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Antioxid Redox Signal. 2016 Mar 20;24(9):518-24. doi: 10.1089/ars.2015.6623. No abstract available.


Antioxidative Activity of Colostrum and Human Milk: Effects of Pasteurization and Storage.

Marinković V, Ranković-Janevski M, Spasić S, Nikolić-Kokić A, Lugonja N, Djurović D, Miletić S, Vrvić MM, Spasojević I.

J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):901-6. doi: 10.1097/MPG.0000000000001090.


A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG 3rd, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE.

Sci Transl Med. 2016 Jan 6;8(320):320ra4. doi: 10.1126/scitranslmed.aad0293.


Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Ashcraft KA, Boss MK, Tovmasyan A, Roy Choudhury K, Fontanella AN, Young KH, Palmer GM, Birer SR, Landon CD, Park W, Das SK, Weitner T, Sheng H, Warner DS, Brizel DM, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):892-900. doi: 10.1016/j.ijrobp.2015.07.2283. Epub 2015 Jul 29.


Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Dec;89:1231-47. doi: 10.1016/j.freeradbiomed.2015.10.416. Epub 2015 Oct 20.


Reactions of superoxide dismutases with HS(-)/H2S and superoxide radical anion: An in vitro EPR study.

Bolić B, Mijušković A, Popović-Bijelić A, Nikolić-Kokić A, Spasić S, Blagojević D, Spasić MB, Spasojević I.

Nitric Oxide. 2015 Dec 1;51:19-23. doi: 10.1016/j.niox.2015.09.008. Epub 2015 Oct 3.


Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W.

Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10.


A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.

Bhattacharyya J, Bellucci JJ, Weitzhandler I, McDaniel JR, Spasojevic I, Li X, Lin CC, Chi JT, Chilkoti A.

Nat Commun. 2015 Aug 4;6:7939. doi: 10.1038/ncomms8939.

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