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Items: 1 to 50 of 205

1.

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Schmidleithner L, Thabet Y, Schönfeld E, Köhne M, Sommer D, Abdullah Z, Sadlon T, Osei-Sarpong C, Subbaramaiah K, Copperi F, Haendler K, Varga T, Schanz O, Bourry S, Bassler K, Krebs W, Peters AE, Baumgart AK, Schneeweiss M, Klee K, Schmidt SV, Nüssing S, Sander J, Ohkura N, Waha A, Sparwasser T, Wunderlich FT, Förster I, Ulas T, Weighardt H, Sakaguchi S, Pfeifer A, Blüher M, Dannenberg AJ, Ferreirós N, Muglia LJ, Wickenhauser C, Barry SC, Schultze JL, Beyer M.

Immunity. 2019 May 21;50(5):1232-1248.e14. doi: 10.1016/j.immuni.2019.03.014. Epub 2019 Apr 23.

PMID:
31027998
2.

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

Steel N, Faniyi AA, Rahman S, Swietlik S, Czajkowska BI, Chan BT, Hardgrave A, Steel A, Sparwasser TD, Assas MB, Grencis RK, Travis MA, Worthington JJ.

PLoS Pathog. 2019 Apr 18;15(4):e1007657. doi: 10.1371/journal.ppat.1007657. eCollection 2019 Apr.

3.

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion.

Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M, Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen BE, Wagner H, Lang KS, Sparwasser TD.

Front Immunol. 2019 Mar 15;10:466. doi: 10.3389/fimmu.2019.00466. eCollection 2019.

4.

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.

Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, Sparwasser T, Bérard M, Cerf-Bensussan N, Eberl G.

Immunity. 2019 May 21;50(5):1276-1288.e5. doi: 10.1016/j.immuni.2019.02.014. Epub 2019 Mar 19.

PMID:
30902637
5.

Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape.

Ahmetlić F, Riedel T, Hömberg N, Bauer V, Trautwein N, Geishauser A, Sparwasser T, Stevanović S, Röcken M, Mocikat R.

Cancer Immunol Res. 2019 Apr;7(4):600-608. doi: 10.1158/2326-6066.CIR-18-0419. Epub 2019 Mar 20.

PMID:
30894379
6.

Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Mamareli P, Kruse F, Friedrich C, Smit N, Strowig T, Sparwasser T, Lochner M.

Eur J Immunol. 2019 May;49(5):747-757. doi: 10.1002/eji.201848022. Epub 2019 Mar 10.

PMID:
30802297
7.

C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function.

Wang Y, Dembowsky K, Chevalier E, Stüve P, Korf-Klingebiel M, Lochner M, Napp LC, Frank H, Brinkmann E, Kanwischer A, Bauersachs J, Gyöngyösi M, Sparwasser T, Wollert KC.

Circulation. 2019 Apr 9;139(15):1798-1812. doi: 10.1161/CIRCULATIONAHA.118.036053.

8.

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.

Serradell MC, Rupil LL, Martino RA, Prucca CG, Carranza PG, Saura A, Fernández EA, Gargantini PR, Tenaglia AH, Petiti JP, Tonelli RR, Reinoso-Vizcaino N, Echenique J, Berod L, Piaggio E, Bellier B, Sparwasser T, Klatzmann D, Luján HD.

Nat Commun. 2019 Jan 21;10(1):361. doi: 10.1038/s41467-018-08265-9.

9.

Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction.

Paul-Heng M, Leong M, Cunningham E, Bunker DLJ, Bremner K, Wang Z, Wang C, Tay SS, McGuffog C, Logan GJ, Alexander IE, Hu M, Alexander SI, Sparwasser TD, Bertolino P, Bowen DG, Bishop GA, Sharland A.

JCI Insight. 2018 Aug 9;3(15). pii: 97500. doi: 10.1172/jci.insight.97500. eCollection 2018 Aug 9.

10.

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.

Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L.

Cell Metab. 2018 Sep 4;28(3):504-515.e7. doi: 10.1016/j.cmet.2018.06.002. Epub 2018 Jun 28.

PMID:
30043753
11.

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.

Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN.

Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28.

PMID:
30043752
12.

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.

Stüve P, Minarrieta L, Erdmann H, Arnold-Schrauf C, Swallow M, Guderian M, Krull F, Hölscher A, Ghorbani P, Behrends J, Abraham WR, Hölscher C, Sparwasser TD, Berod L.

Front Immunol. 2018 Apr 5;9:495. doi: 10.3389/fimmu.2018.00495. eCollection 2018.

13.

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APCmin/+ mice.

Akeus P, Szeponik L, Ahlmanner F, Sundström P, Alsén S, Gustavsson B, Sparwasser T, Raghavan S, Quiding-Järbrink M.

Cancer Immunol Immunother. 2018 Jul;67(7):1067-1077. doi: 10.1007/s00262-018-2161-9. Epub 2018 Apr 18.

14.

Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts.

Raud B, McGuire PJ, Jones RG, Sparwasser T, Berod L.

Immunol Rev. 2018 May;283(1):213-231. doi: 10.1111/imr.12655. Review.

PMID:
29664569
15.

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses.

Velasquez LN, Stüve P, Gentilini MV, Swallow M, Bartel J, Lycke NY, Barkan D, Martina M, Lujan HD, Kalay H, van Kooyk Y, Sparwasser TD, Berod L.

Front Immunol. 2018 Mar 9;9:471. doi: 10.3389/fimmu.2018.00471. eCollection 2018.

16.

Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination.

Serradell MC, Gargantini PR, Saura A, Oms SR, Rupil LL, Berod L, Sparwasser T, Luján HD.

Infect Immun. 2018 May 22;86(6). pii: e00773-17. doi: 10.1128/IAI.00773-17. Print 2018 Jun.

17.

A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.

Andreas N, Riemann M, Castro CN, Groth M, Koliesnik I, Engelmann C, Sparwasser T, Kamradt T, Haenold R, Weih F.

Eur J Immunol. 2018 Jun;48(6):923-936. doi: 10.1002/eji.201747332. Epub 2018 Apr 6.

18.

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease.

Alissafi T, Kourepini E, Simoes DCM, Paschalidis N, Aggelakopoulou M, Sparwasser T, Boon L, Hammad H, Lambrecht BN, Panoutsakopoulou V.

J Immunol. 2018 Feb 15;200(4):1270-1282. doi: 10.4049/jimmunol.1701345. Epub 2018 Jan 12.

19.

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases.

Bieber K, Sun S, Witte M, Kasprick A, Beltsiou F, Behnen M, Laskay T, Schulze FS, Pipi E, Reichhelm N, Pagel R, Zillikens D, Schmidt E, Sparwasser T, Kalies K, Ludwig RJ.

Front Immunol. 2017 Nov 24;8:1628. doi: 10.3389/fimmu.2017.01628. eCollection 2017.

20.

Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells.

Singpiel A, Kramer J, Maus R, Stolper J, Bittersohl LF, Gauldie J, Kolb M, Welte T, Sparwasser T, Maus UA.

Immunobiology. 2018 Mar;223(3):331-341. doi: 10.1016/j.imbio.2017.10.042. Epub 2017 Oct 26.

PMID:
29089144
21.

The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.

Zischke J, Mamareli P, Pokoyski C, Gabaev I, Buyny S, Jacobs R, Falk CS, Lochner M, Sparwasser T, Schulz TF, Kay-Fedorov PC.

PLoS Pathog. 2017 Jun 19;13(6):e1006454. doi: 10.1371/journal.ppat.1006454. eCollection 2017 Jun.

22.

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P.

J Clin Invest. 2017 Jun 30;127(7):2789-2804. doi: 10.1172/JCI92079. Epub 2017 Jun 5.

23.

Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma.

Semitekolou M, Morianos I, Banos A, Konstantopoulos D, Adamou-Tzani M, Sparwasser T, Xanthou G.

J Allergy Clin Immunol. 2018 Feb;141(2):671-684.e7. doi: 10.1016/j.jaci.2017.03.047. Epub 2017 Jun 1.

PMID:
28579377
24.

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

Friedrich C, Mamareli P, Thiemann S, Kruse F, Wang Z, Holzmann B, Strowig T, Sparwasser T, Lochner M.

PLoS Pathog. 2017 May 16;13(5):e1006357. doi: 10.1371/journal.ppat.1006357. eCollection 2017 May.

25.

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

Popovic B, Golemac M, Podlech J, Zeleznjak J, Bilic-Zulle L, Lukic ML, Cicin-Sain L, Reddehase MJ, Sparwasser T, Krmpotic A, Jonjic S.

PLoS Pathog. 2017 Apr 27;13(4):e1006345. doi: 10.1371/journal.ppat.1006345. eCollection 2017 Apr.

26.

Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function.

van der Vlugt LEPM, Obieglo K, Ozir-Fazalalikhan A, Sparwasser T, Haeberlein S, Smits HH.

Int J Parasitol. 2017 Aug;47(9):545-554. doi: 10.1016/j.ijpara.2017.02.002. Epub 2017 Apr 4.

PMID:
28385494
27.

Metabolites: deciphering the molecular language between DCs and their environment.

Minarrieta L, Ghorbani P, Sparwasser T, Berod L.

Semin Immunopathol. 2017 Feb;39(2):177-198. doi: 10.1007/s00281-016-0609-6. Epub 2016 Dec 5. Review.

PMID:
27921148
28.

Metabolic pathways in T cell activation and lineage differentiation.

Almeida L, Lochner M, Berod L, Sparwasser T.

Semin Immunol. 2016 Oct;28(5):514-524. doi: 10.1016/j.smim.2016.10.009. Epub 2016 Nov 4. Review.

29.

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K.

Sci Transl Med. 2016 Oct 26;8(362):362ra146.

PMID:
27797962
30.

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A.

Sci Transl Med. 2016 Oct 26;8(362):362ra143.

PMID:
27797959
31.

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling.

Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T.

Cell Rep. 2016 Oct 18;17(4):1113-1127. doi: 10.1016/j.celrep.2016.09.055.

32.

Immunometabolism and autoimmunity.

Freitag J, Berod L, Kamradt T, Sparwasser T.

Immunol Cell Biol. 2016 Nov;94(10):925-934. doi: 10.1038/icb.2016.77. Epub 2016 Aug 26. Review.

PMID:
27562063
33.

Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.

Raha S, Raud B, Oberdörfer L, Castro CN, Schreder A, Freitag J, Longerich T, Lochner M, Sparwasser T, Berod L, Koenecke C, Prinz I.

Eur J Immunol. 2016 Sep;46(9):2233-8. doi: 10.1002/eji.201546152. Epub 2016 Jul 18.

34.

pDCs Take a Deep Breath to Fight Viruses.

Berod L, Sparwasser T.

Immunity. 2016 Jun 21;44(6):1246-8. doi: 10.1016/j.immuni.2016.06.005.

35.

Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.

Knuschke T, Rotan O, Bayer W, Sokolova V, Hansen W, Sparwasser T, Dittmer U, Epple M, Buer J, Westendorf AM.

Retrovirology. 2016 Apr 14;13:24. doi: 10.1186/s12977-016-0258-9. Review.

36.

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells.

Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LA, Schetters ST, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WW.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3329-34. doi: 10.1073/pnas.1507706113. Epub 2016 Mar 3.

37.

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.

Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M.

Nat Commun. 2015 Oct 13;6:8576. doi: 10.1038/ncomms9576.

38.

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.

Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T.

Eur J Immunol. 2016 May;46(5):1193-202. doi: 10.1002/eji.201546104. Epub 2016 Jan 20.

39.

Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.

Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T.

Mucosal Immunol. 2016 Sep;9(5):1288-302. doi: 10.1038/mi.2015.128. Epub 2015 Dec 2.

40.

The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells.

Lochner M, Wang Z, Sparwasser T.

Prog Mol Biol Transl Sci. 2015;136:99-129. doi: 10.1016/bs.pmbts.2015.07.013. Epub 2015 Aug 18. Review.

PMID:
26615094
41.

CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.

Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ.

Immunity. 2015 Nov 17;43(5):896-908. doi: 10.1016/j.immuni.2015.10.011. Epub 2015 Nov 10.

42.

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.

Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y.

Oncoimmunology. 2014 Oct 31;4(8):e970462. eCollection 2015 Aug.

43.

Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming.

Mahapatra S, Albrecht M, Baru AM, Sparwasser T, Herrick C, Dittrich AM.

J Invest Dermatol. 2015 Oct;135(10):2418-26. doi: 10.1038/jid.2015.191. Epub 2015 May 22.

44.

Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function.

Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T.

Mol Immunol. 2015 Dec;68(2 Pt C):575-84. doi: 10.1016/j.molimm.2015.07.025. Epub 2015 Aug 28. Review.

PMID:
26320629
45.

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M.

Mucosal Immunol. 2016 Mar;9(2):444-57. doi: 10.1038/mi.2015.74. Epub 2015 Aug 26.

PMID:
26307665
46.

Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.

Bolton HA, Zhu E, Terry AM, Guy TV, Koh WP, Tan SY, Power CA, Bertolino P, Lahl K, Sparwasser T, Shklovskaya E, Fazekas de St Groth B.

J Clin Invest. 2015 Sep;125(9):3627-41. doi: 10.1172/JCI76031. Epub 2015 Aug 24.

47.

Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.

Smith KA, Filbey KJ, Reynolds LA, Hewitson JP, Harcus Y, Boon L, Sparwasser T, Hämmerling G, Maizels RM.

Mucosal Immunol. 2016 Mar;9(2):428-43. doi: 10.1038/mi.2015.73. Epub 2015 Aug 19.

48.

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Förster R, Pabst O, Hornef MW.

Nat Commun. 2015 Jul 21;6:7725. doi: 10.1038/ncomms8725.

49.

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.

Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R.

J Immunol. 2015 Aug 15;195(4):1753-62. doi: 10.4049/jimmunol.1400658. Epub 2015 Jul 13.

50.

Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.

Molina MA, Díaz AM, Hesse C, Ginter W, Gentilini MV, Nuñez GG, Canellada AM, Sparwasser T, Berod L, Castro MS, Manghi MA.

PLoS One. 2015 May 15;10(5):e0127262. doi: 10.1371/journal.pone.0127262. eCollection 2015.

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