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Classical polarimetry with a twist: a compact, geometric approach.

Sparks WB, Germer TA, Sparks RM.

Publ Astron Soc Pac. 2019;131. doi: 10.1088/1538-3873/ab1933.


A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.

Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA.

J Biol Chem. 2019 Sep 12. pii: jbc.RA119.008865. doi: 10.1074/jbc.RA119.008865. [Epub ahead of print]


Computer-Assisted Planning for Stereoelectroencephalography (SEEG).

Vakharia VN, Sparks R, Miserocchi A, Vos SB, O'Keeffe A, Rodionov R, McEvoy AW, Ourselin S, Duncan JS.

Neurotherapeutics. 2019 Aug 20. doi: 10.1007/s13311-019-00774-9. [Epub ahead of print]


A specific small-molecule inhibitor of protein kinase CδI activity improves metabolic dysfunction in human adipocytes from obese individuals.

Sparks R, Lui A, Bader D, Patel R, Murr M, Guida W, Fratti R, Patel NA.

J Biol Chem. 2019 Oct 11;294(41):14896-14910. doi: 10.1074/jbc.RA119.008777. Epub 2019 Aug 14.


Multicenter validation of automated trajectories for selective laser amygdalohippocampectomy.

Vakharia VN, Sparks RE, Li K, O'Keeffe AG, Pérez-García F, França LGS, Ko AL, Wu C, Aronson JP, Youngerman BE, Sharan A, McKhann G 2nd, Ourselin S, Duncan JS.

Epilepsia. 2019 Sep;60(9):1949-1959. doi: 10.1111/epi.16307. Epub 2019 Aug 7.


Computer-Assisted Versus Manual Planning for Stereotactic Brain Biopsy: A Retrospective Comparative Pilot Study.

Marcus HJ, Vakharia VN, Sparks R, Rodionov R, Kitchen N, McEvoy AW, Miserocchi A, Thorne L, Ourselin S, Duncan JS.

Oper Neurosurg (Hagerstown). 2019 Aug 5. pii: opz177. doi: 10.1093/ons/opz177. [Epub ahead of print]


Stereoelectroencephalography electrode placement: Detection of blood vessel conflicts.

Li K, Vakharia VN, Sparks R, Rodionov R, Vos SB, McEvoy AW, Miserocchi A, Wang M, Ourselin S, Duncan JS.

Epilepsia. 2019 Sep;60(9):1942-1948. doi: 10.1111/epi.16294. Epub 2019 Jul 22.


Automated fiber tract reconstruction for surgery planning: Extensive validation in language-related white matter tracts.

Mancini M, Vos SB, Vakharia VN, O'Keeffe AG, Trimmel K, Barkhof F, Dorfer C, Soman S, Winston GP, Wu C, Duncan JS, Sparks R, Ourselin S.

Neuroimage Clin. 2019;23:101883. doi: 10.1016/j.nicl.2019.101883. Epub 2019 May 28.


Formation and dynamics of magma reservoirs.

Sparks RSJ, Annen C, Blundy JD, Cashman KV, Rust AC, Jackson MD.

Philos Trans A Math Phys Eng Sci. 2019 Feb 25;377(2139):20180019. doi: 10.1098/rsta.2018.0019.


Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy.

Galovic M, Baudracco I, Wright-Goff E, Pillajo G, Nachev P, Wandschneider B, Woermann F, Thompson P, Baxendale S, McEvoy AW, Nowell M, Mancini M, Vos SB, Winston GP, Sparks R, Prados F, Miserocchi A, de Tisi J, Van Graan LA, Rodionov R, Wu C, Alizadeh M, Kozlowski L, Sharan AD, Kini LG, Davis KA, Litt B, Ourselin S, Moshé SL, Sander JWA, Löscher W, Duncan JS, Koepp MJ.

JAMA Neurol. 2019 Jun 1;76(6):690-700. doi: 10.1001/jamaneurol.2019.0204.


Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming.

Starr ML, Sparks RP, Arango AS, Hurst LR, Zhao Z, Lihan M, Jenkins JL, Tajkhorshid E, Fratti RA.

J Biol Chem. 2019 Mar 1;294(9):3100-3116. doi: 10.1074/jbc.RA118.006552. Epub 2019 Jan 7.


Optimizing Trajectories for Cranial Laser Interstitial Thermal Therapy Using Computer-Assisted Planning: A Machine Learning Approach.

Li K, Vakharia VN, Sparks R, França LGS, Granados A, McEvoy AW, Miserocchi A, Wang M, Ourselin S, Duncan JS.

Neurotherapeutics. 2019 Jan;16(1):182-191. doi: 10.1007/s13311-018-00693-1.


Chemical differentiation, cold storage and remobilization of magma in the Earth's crust.

Jackson MD, Blundy J, Sparks RSJ.

Nature. 2018 Dec;564(7736):405-409. doi: 10.1038/s41586-018-0746-2. Epub 2018 Dec 3.


Dosimetry, biodistribution, and safety of flurpiridaz F 18 in healthy subjects undergoing rest and exercise or pharmacological stress PET myocardial perfusion imaging.

Maddahi J, Bengel F, Czernin J, Crane P, Dahlbom M, Schelbert H, Sparks R, Phelps M, Lazewatsky J.

J Nucl Cardiol. 2018 Nov 28. doi: 10.1007/s12350-018-01484-z. [Epub ahead of print]


Use of Surface Plasmon Resonance (SPR) to Determine Binding Affinities and Kinetic Parameters Between Components Important in Fusion Machinery.

Sparks RP, Jenkins JL, Fratti R.

Methods Mol Biol. 2019;1860:199-210. doi: 10.1007/978-1-4939-8760-3_12.


Use of Microscale Thermophoresis (MST) to Measure Binding Affinities of Components of the Fusion Machinery.

Sparks RP, Fratti R.

Methods Mol Biol. 2019;1860:191-198. doi: 10.1007/978-1-4939-8760-3_11.


The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.

Stubbs MC, Burn TC, Sparks R, Maduskuie T, Diamond S, Rupar M, Wen X, Volgina A, Zolotarjova N, Waeltz P, Favata M, Jalluri R, Liu H, Liu XM, Li J, Collins R, Falahatpisheh N, Polam P, DiMatteo D, Feldman P, Dostalik V, Thekkat P, Gardiner C, He X, Li Y, Covington M, Wynn R, Ruggeri B, Yeleswaram S, Xue CB, Yao W, Combs AP, Huber R, Hollis G, Scherle P, Liu PCC.

Clin Cancer Res. 2019 Jan 1;25(1):300-311. doi: 10.1158/1078-0432.CCR-18-0098. Epub 2018 Sep 11.


Single port laparoscopic surgery for steroid-refractory ulcerative colitis after kidney transplantation - a video vignette.

Sparks R, Cahill RA.

Colorectal Dis. 2018 Aug;20(8):731-733. doi: 10.1111/codi.14269. Epub 2018 Jun 6. No abstract available.


Automatic segmentation of stereoelectroencephalography (SEEG) electrodes post-implantation considering bending.

Granados A, Vakharia V, Rodionov R, Schweiger M, Vos SB, O'Keeffe AG, Li K, Wu C, Miserocchi A, McEvoy AW, Clarkson MJ, Duncan JS, Sparks R, Ourselin S.

Int J Comput Assist Radiol Surg. 2018 Jun;13(6):935-946. doi: 10.1007/s11548-018-1740-8. Epub 2018 May 7.


Computer-assisted planning for the insertion of stereoelectroencephalography electrodes for the investigation of drug-resistant focal epilepsy: an external validation study.

Vakharia VN, Sparks R, Rodionov R, Vos SB, Dorfer C, Miller J, Nilsson D, Tisdall M, Wolfsberger S, McEvoy AW, Miserocchi A, Winston GP, O'Keeffe AG, Ourselin S, Duncan JS.

J Neurosurg. 2018 Apr 1:1-10. doi: 10.3171/2017.10.JNS171826. [Epub ahead of print]


Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy.

Vakharia VN, Sparks R, Li K, O'Keeffe AG, Miserocchi A, McEvoy AW, Sperling MR, Sharan A, Ourselin S, Duncan JS, Wu C.

Epilepsia. 2018 Apr;59(4):814-824. doi: 10.1111/epi.14034. Epub 2018 Mar 12.


Improving patient safety during introduction of novel medical devices through cumulative summation analysis.

Vakharia VN, Rodionov R, McEvoy AW, Miserocchi A, Sparks R, O'Keeffe AG, Ourselin S, Duncan JS.

J Neurosurg. 2018 Feb 16;130(1):213-219. doi: 10.3171/2017.8.JNS17936.


Impact of At-Home Telemonitoring on Health Services Expenditure and Hospital Admissions in Patients With Chronic Conditions: Before and After Control Intervention Analysis.

Celler B, Varnfield M, Nepal S, Sparks R, Li J, Jayasena R.

JMIR Med Inform. 2017 Sep 8;5(3):e29. doi: 10.2196/medinform.7308.


Displacement effects of heavy human use on coral reef predators within the Molokini Marine Life Conservation District.

Filous A, Friedlander AM, Koike H, Lammers M, Wong A, Stone K, Sparks RT.

Mar Pollut Bull. 2017 Aug 15;121(1-2):274-281. doi: 10.1016/j.marpolbul.2017.06.032. Epub 2017 Jun 13.


Anatomy-driven multiple trajectory planning (ADMTP) of intracranial electrodes for epilepsy surgery.

Sparks R, Vakharia V, Rodionov R, Vos SB, Diehl B, Wehner T, Miserocchi A, McEvoy AW, Duncan JS, Ourselin S.

Int J Comput Assist Radiol Surg. 2017 Aug;12(8):1245-1255. doi: 10.1007/s11548-017-1628-z. Epub 2017 Jun 15.


Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons.

Sparks R, Koelle DM, Stern JE, Dhanireddy S.

Open Forum Infect Dis. 2017 Jun 7;4(2):ofx055. doi: 10.1093/ofid/ofx055. eCollection 2017 Spring.


INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.

Yue EW, Sparks R, Polam P, Modi D, Douty B, Wayland B, Glass B, Takvorian A, Glenn J, Zhu W, Bower M, Liu X, Leffet L, Wang Q, Bowman KJ, Hansbury MJ, Wei M, Li Y, Wynn R, Burn TC, Koblish HK, Fridman JS, Emm T, Scherle PA, Metcalf B, Combs AP.

ACS Med Chem Lett. 2017 Mar 6;8(5):486-491. doi: 10.1021/acsmedchemlett.6b00391. eCollection 2017 May 11.


Meta-analysis of crowdsourced data compendia suggests pan-disease transcriptional signatures of autoimmunity.

Lau WW, Sparks R; OMiCC Jamboree Working Group, Tsang JS.

F1000Res. 2016 Dec 20;5:2884. doi: 10.12688/f1000research.10465.1. eCollection 2016.


Connecting Markov random fields and active contour models: application to gland segmentation and classification.

Xu J, Monaco JP, Sparks R, Madabhushi A.

J Med Imaging (Bellingham). 2017 Apr;4(2):021107. doi: 10.1117/1.JMI.4.2.021107. Epub 2017 Mar 28.


How Many U.S. High School Students Have a Foreign Language Reading "Disability"? Reading Without Meaning and the Simple View.

Sparks RL, Luebbers J.

J Learn Disabil. 2018 Mar/Apr;51(2):194-208. doi: 10.1177/0022219417704168. Epub 2017 Apr 5.


Vertically extensive and unstable magmatic systems: A unified view of igneous processes.

Cashman KV, Sparks RS, Blundy JD.

Science. 2017 Mar 24;355(6331). pii: eaag3055. doi: 10.1126/science.aag3055. Review.


Alcohol Industry Sponsorship of University Student Sports Clubs in Brazil.

Pinsky I, Noto AR, Botéquio de Moraes MC, Lucas Dos Santos E, Sparks R, O'Brien K.

J Stud Alcohol Drugs. 2017 Mar;78(2):306-312.


Accuracy of intracranial electrode placement for stereoencephalography: A systematic review and meta-analysis.

Vakharia VN, Sparks R, O'Keeffe AG, Rodionov R, Miserocchi A, McEvoy A, Ourselin S, Duncan J.

Epilepsia. 2017 Jun;58(6):921-932. doi: 10.1111/epi.13713. Epub 2017 Mar 6. Review.


Expanding the Immunology Toolbox: Embracing Public-Data Reuse and Crowdsourcing.

Sparks R, Lau WW, Tsang JS.

Immunity. 2016 Dec 20;45(6):1191-1204. doi: 10.1016/j.immuni.2016.12.008. Review.


Resection planning in extratemporal epilepsy surgery using 3D multimodality imaging and intraoperative MRI.

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, White M, Ourselin S, McEvoy A, Duncan J.

Br J Neurosurg. 2017 Aug;31(4):468-470. doi: 10.1080/02688697.2016.1265086. Epub 2016 Dec 8.


Working together: Using a unique approach to evaluate an interactive and clinic-based longitudinal interprofessional education experience with 13 professions.

Thompson BM, Bratzler DW, Fisher MJ, Torres A, Faculty E, Sparks RA.

J Interprof Care. 2016 Nov;30(6):754-761.


Modelling hospital length of stay using convolutive mixtures distributions.

Ickowicz A, Sparks R.

Stat Med. 2017 Jan 15;36(1):122-135. doi: 10.1002/sim.7135. Epub 2016 Oct 5.


Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.

Sparks RP, Jenkins JL, Miner GE, Wang Y, Guida WC, Sparks CE, Fratti RA, Sparks JD.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):551-556. doi: 10.1016/j.bbrc.2016.09.108. Epub 2016 Sep 22.


Increased rates of large-magnitude explosive eruptions in Japan in the late Neogene and Quaternary.

Mahony SH, Sparks RS, Wallace LM, Engwell SL, Scourse EM, Barnard NH, Kandlbauer J, Brown SK.

Geochem Geophys Geosyst. 2016 Jul;17(7):2467-2479. Epub 2016 Jul 1.


Investigating functional redundancy versus complementarity in Hawaiian herbivorous coral reef fishes.

Kelly EL, Eynaud Y, Clements SM, Gleason M, Sparks RT, Williams ID, Smith JE.

Oecologia. 2016 Dec;182(4):1151-1163. Epub 2016 Sep 20.


GLOBAL CHANGE RESEARCH. The challenge of climate-change neoskepticism.

Stern PC, Perkins JH, Sparks RE, Knox RA.

Science. 2016 Aug 12;353(6300):653-4. doi: 10.1126/science.aaf6675. No abstract available.


Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells.

Sparks RP, Guida WC, Sowden MP, Jenkins JL, Starr ML, Fratti RA, Sparks CE, Sparks JD.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):546-52. doi: 10.1016/j.bbrc.2016.07.096. Epub 2016 Aug 2.


Responses of Herbivorous Fishes and Benthos to 6 Years of Protection at the Kahekili Herbivore Fisheries Management Area, Maui.

Williams ID, White DJ, Sparks RT, Lino KC, Zamzow JP, Kelly EL, Ramey HL.

PLoS One. 2016 Jul 27;11(7):e0159100. doi: 10.1371/journal.pone.0159100. eCollection 2016.


Automated multiple trajectory planning algorithm for the placement of stereo-electroencephalography (SEEG) electrodes in epilepsy treatment.

Sparks R, Zombori G, Rodionov R, Nowell M, Vos SB, Zuluaga MA, Diehl B, Wehner T, Miserocchi A, McEvoy AW, Duncan JS, Ourselin S.

Int J Comput Assist Radiol Surg. 2017 Jan;12(1):123-136. doi: 10.1007/s11548-016-1452-x. Epub 2016 Jul 1.


The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain.

Miner GE, Starr ML, Hurst LR, Sparks RP, Padolina M, Fratti RA.

J Biol Chem. 2016 Aug 19;291(34):17651-63. doi: 10.1074/jbc.M116.725366. Epub 2016 Jun 30.


A crowdsourcing approach for reusing and meta-analyzing gene expression data.

Shah N, Guo Y, Wendelsdorf KV, Lu Y, Sparks R, Tsang JS.

Nat Biotechnol. 2016 Aug;34(8):803-6. doi: 10.1038/nbt.3603. Epub 2016 Jun 20. No abstract available.


Cupriphilic compounds to aid in proteasome inhibition.

Mukherjee S, Sparks R, Metcalf R, Brooks W, Daniel K, Guida WC.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3826-9. doi: 10.1016/j.bmcl.2016.04.075. Epub 2016 Apr 25.


A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery.

Nowell M, Rodionov R, Zombori G, Sparks R, Rizzi M, Ourselin S, Miserocchi A, McEvoy A, Duncan J.

J Vis Exp. 2016 May 20;(111). doi: 10.3791/53450.


The enigmatic role of sortilin in lipoprotein metabolism.

Sparks CE, Sparks RP, Sparks JD.

Curr Opin Lipidol. 2015 Dec;26(6):598-600. doi: 10.1097/MOL.0000000000000244. No abstract available.

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