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Items: 10


How to Determine the Role of the Microbiome in Drug Disposition.

Bisanz JE, Spanogiannopoulos P, Pieper LM, Bustion AE, Turnbaugh PJ.

Drug Metab Dispos. 2018 Nov;46(11):1588-1595. doi: 10.1124/dmd.118.083402. Epub 2018 Aug 15. Review.


Broad collateral damage of drugs against the gut microbiome.

Spanogiannopoulos P, Turnbaugh PJ.

Nat Rev Gastroenterol Hepatol. 2018 Aug;15(8):457-458. doi: 10.1038/s41575-018-0028-3. No abstract available.


Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD.

Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.


The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism.

Spanogiannopoulos P, Bess EN, Carmody RN, Turnbaugh PJ.

Nat Rev Microbiol. 2016 Apr;14(5):273-87. doi: 10.1038/nrmicro.2016.17. Epub 2016 Mar 14. Review.


A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.

Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111. Epub 2014 Apr 28.


Identifying producers of antibacterial compounds by screening for antibiotic resistance.

Thaker MN, Wang W, Spanogiannopoulos P, Waglechner N, King AM, Medina R, Wright GD.

Nat Biotechnol. 2013 Oct;31(10):922-7. doi: 10.1038/nbt.2685. Epub 2013 Sep 22.


Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.

Stogios PJ, Spanogiannopoulos P, Evdokimova E, Egorova O, Shakya T, Todorovic N, Capretta A, Wright GD, Savchenko A.

Biochem J. 2013 Sep 1;454(2):191-200. doi: 10.1042/BJ20130317.


The comprehensive antibiotic resistance database.

McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O'Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD.

Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.


Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes.

Spanogiannopoulos P, Thaker M, Koteva K, Waglechner N, Wright GD.

Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. Epub 2012 Jul 16.


The tetracycline resistome.

Thaker M, Spanogiannopoulos P, Wright GD.

Cell Mol Life Sci. 2010 Feb;67(3):419-31. doi: 10.1007/s00018-009-0172-6. Epub 2009 Oct 28. Review.


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