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2-μm double-pulse single-frequency Tm:fiber laser pumped Ho:YLF laser for a space-borne CO2 lidar.

Gibert F, Pellegrino J, Edouart D, Cénac C, Lombard L, Le Gouët J, Nuns T, Cosentino A, Spano P, Di Nepi G.

Appl Opt. 2018 Dec 20;57(36):10370-10379. doi: 10.1364/AO.57.010370.


The association between seatbelt use and trauma outcomes: Does body mass index matter?

Elkbuli A, Dowd B, Spano PJ 2nd, Hai S, Boneva D, McKenney M.

Am J Emerg Med. 2018 Dec 13. pii: S0735-6757(18)30985-9. doi: 10.1016/j.ajem.2018.12.023. [Epub ahead of print]


Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.

Faustini G, Longhena F, Varanita T, Bubacco L, Pizzi M, Missale C, Benfenati F, Björklund A, Spano P, Bellucci A.

Acta Neuropathol. 2018 Oct;136(4):621-639. doi: 10.1007/s00401-018-1892-1. Epub 2018 Jul 25.


Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling.

Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi RW, Gennarelli M, Piovani G, Kunath T, Millan MJ, Merlo Pich E, Spano P.

Neural Plast. 2018 Feb 4;2018:4196961. doi: 10.1155/2018/4196961. eCollection 2018.


Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.

Longhena F, Faustini G, Varanita T, Zaltieri M, Porrini V, Tessari I, Poliani PL, Missale C, Borroni B, Padovani A, Bubacco L, Pizzi M, Spano P, Bellucci A.

Brain Pathol. 2018 Nov;28(6):875-888. doi: 10.1111/bpa.12587. Epub 2018 Feb 23.


Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke.

Faggi L, Pignataro G, Parrella E, Porrini V, Vinciguerra A, Cepparulo P, Cuomo O, Lanzillotta A, Mota M, Benarese M, Tonin P, Annunziato L, Spano P, Pizzi M.

Int J Mol Sci. 2018 Jan 6;19(1). pii: E172. doi: 10.3390/ijms19010172.


Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?

Faustini G, Bono F, Valerio A, Pizzi M, Spano P, Bellucci A.

Genes (Basel). 2017 Dec 8;8(12). pii: E377. doi: 10.3390/genes8120377. Review.


Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling.

Cavalleri L, Merlo Pich E, Millan MJ, Chiamulera C, Kunath T, Spano PF, Collo G.

Mol Psychiatry. 2018 Apr;23(4):812-823. doi: 10.1038/mp.2017.241. Epub 2017 Nov 21.


The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging.

Bellucci A, Antonini A, Pizzi M, Spano P.

Front Aging Neurosci. 2017 Oct 10;9:330. doi: 10.3389/fnagi.2017.00330. eCollection 2017.


Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.

Longhena F, Spano P, Bellucci A.

Handb Exp Pharmacol. 2018;245:85-110. doi: 10.1007/164_2017_60. Review.


Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons.

Longhena F, Zaltieri M, Grigoletto J, Faustini G, La Via L, Ghidoni R, Benussi L, Missale C, Spano P, Bellucci A.

J Pharmacol Exp Ther. 2017 Nov;363(2):164-175. doi: 10.1124/jpet.117.242164. Epub 2017 Sep 12.


Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism.

Porrini V, Mota M, Parrella E, Bellucci A, Benarese M, Faggi L, Tonin P, Spano PF, Pizzi M.

Front Aging Neurosci. 2017 Jul 19;9:229. doi: 10.3389/fnagi.2017.00229. eCollection 2017.


The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.

Longhena F, Faustini G, Missale C, Pizzi M, Spano P, Bellucci A.

Neural Plast. 2017;2017:5012129. doi: 10.1155/2017/5012129. Epub 2017 Jan 3. Review.


Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.

Porrini V, Sarnico I, Benarese M, Branca C, Mota M, Lanzillotta A, Bellucci A, Parrella E, Faggi L, Spano P, Imbimbo BP, Pizzi M.

Int J Mol Sci. 2017 Jan 18;18(1). pii: E184. doi: 10.3390/ijms18010184.


Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons.

Bono F, Savoia P, Guglielmi A, Gennarelli M, Piovani G, Sigala S, Leo D, Espinoza S, Gainetdinov RR, Devoto P, Spano P, Missale C, Fiorentini C.

Mol Neurobiol. 2018 Feb;55(2):1054-1067. doi: 10.1007/s12035-016-0376-3. Epub 2017 Jan 14.


PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia.

Parrella E, Porrini V, Iorio R, Benarese M, Lanzillotta A, Mota M, Fusco M, Tonin P, Spano P, Pizzi M.

Brain Res. 2016 Oct 1;1648(Pt A):409-417. doi: 10.1016/j.brainres.2016.07.014. Epub 2016 Jul 14.


Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells.

Fragni M, Bonini SA, Stabile A, Bodei S, Cristinelli L, Simeone C, Zani D, Spano PF, Berruti A, Memo M, Sigala S.

Anticancer Res. 2016 Mar;36(3):913-20.


The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines.

Fragni M, Bonini SA, Bettinsoli P, Bodei S, Generali D, Bottini A, Spano PF, Memo M, Sigala S.

Naunyn Schmiedebergs Arch Pharmacol. 2016 May;389(5):529-38. doi: 10.1007/s00210-016-1224-8. Epub 2016 Feb 24.


Review: Parkinson's disease: from synaptic loss to connectome dysfunction.

Bellucci A, Mercuri NB, Venneri A, Faustini G, Longhena F, Pizzi M, Missale C, Spano P.

Neuropathol Appl Neurobiol. 2016 Feb;42(1):77-94. doi: 10.1111/nan.12297. Review.


Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model.

Guarienti M, Giacopuzzi E, Gianoncelli A, Sigala S, Spano P, Pecorelli S, Pani L, Memo M.

Pharmacol Res. 2015 Dec;102:12-21. doi: 10.1016/j.phrs.2015.09.004. Epub 2015 Sep 8.


An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin.

Gianoncelli A, Bonini SA, Bertuzzi M, Guarienti M, Vezzoli S, Kumar R, Delbarba A, Mastinu A, Sigala S, Spano P, Pani L, Pecorelli S, Memo M.

BioDrugs. 2015 Aug;29(4):285-300. doi: 10.1007/s40259-015-0136-3.


NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases.

Lanzillotta A, Porrini V, Bellucci A, Benarese M, Branca C, Parrella E, Spano PF, Pizzi M.

Front Neurol. 2015 May 20;6:98. doi: 10.3389/fneur.2015.00098. eCollection 2015. Review.


α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.

Zaltieri M, Grigoletto J, Longhena F, Navarria L, Favero G, Castrezzati S, Colivicchi MA, Della Corte L, Rezzani R, Pizzi M, Benfenati F, Spillantini MG, Missale C, Spano P, Bellucci A.

J Cell Sci. 2015 Jul 1;128(13):2231-43. doi: 10.1242/jcs.157867. Epub 2015 May 12.


Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?

Zaltieri M, Longhena F, Pizzi M, Missale C, Spano P, Bellucci A.

Parkinsons Dis. 2015;2015:108029. doi: 10.1155/2015/108029. Epub 2015 Mar 31. Review.


Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure.

Navarria L, Zaltieri M, Longhena F, Spillantini MG, Missale C, Spano P, Bellucci A.

Neurochem Int. 2015 Jun-Jul;85-86:14-23. doi: 10.1016/j.neuint.2015.03.008. Epub 2015 Apr 3.


Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine.

Collo G, Cavalleri L, Spano P.

Front Pharmacol. 2014 Nov 25;5:259. doi: 10.3389/fphar.2014.00259. eCollection 2014. Review.


CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.

Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, Calzà L, Flaibani R, Spano PF, Imbimbo BP, Pizzi M.

Neuroscience. 2015 Aug 27;302:112-20. doi: 10.1016/j.neuroscience.2014.10.029. Epub 2014 Oct 22.


Preface. Dopamine.

Di Chiara G, Diana M, Spano P.

Prog Brain Res. 2014;211:ix. doi: 10.1016/B978-0-444-63425-2.10000-5. No abstract available.


The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues.

Bellucci A, Fiorentini C, Zaltieri M, Missale C, Spano P.

Methods Mol Biol. 2014;1174:397-405. doi: 10.1007/978-1-4939-0944-5_27.


GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity.

Fiorentini C, Bodei S, Bedussi F, Fragni M, Bonini SA, Simeone C, Zani D, Berruti A, Missale C, Memo M, Spano P, Sigala S.

Exp Cell Res. 2014 Apr 15;323(1):100-11. doi: 10.1016/j.yexcr.2014.02.025. Epub 2014 Feb 28.


Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.

Arrighi N, Bodei S, Zani D, Michel MC, Simeone C, Cosciani Cunico S, Spano P, Sigala S.

Pharmacol Res. 2013 Aug;74:1-6. doi: 10.1016/j.phrs.2013.04.007. Epub 2013 Apr 28.


Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling.

Collo G, Bono F, Cavalleri L, Plebani L, Mitola S, Merlo Pich E, Millan MJ, Zoli M, Maskos U, Spano P, Missale C.

Mol Pharmacol. 2013 Jun;83(6):1176-89. doi: 10.1124/mol.113.084863. Epub 2013 Mar 29.


Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.

Lanzillotta A, Pignataro G, Branca C, Cuomo O, Sarnico I, Benarese M, Annunziato L, Spano P, Pizzi M.

Neurobiol Dis. 2013 Jan;49:177-89. doi: 10.1016/j.nbd.2012.08.018. Epub 2012 Aug 30.


Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.

Baiguera C, Alghisi M, Pinna A, Bellucci A, De Luca MA, Frau L, Morelli M, Ingrassia R, Benarese M, Porrini V, Pellitteri M, Bertini G, Fabene PF, Sigala S, Spillantini MG, Liou HC, Spano PF, Pizzi M.

Brain. 2012 Sep;135(Pt 9):2750-65. doi: 10.1093/brain/aws193. Epub 2012 Aug 21.


1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310.

Ingrassia R, Lanzillotta A, Sarnico I, Benarese M, Blasi F, Borgese L, Bilo F, Depero L, Chiarugi A, Spano PF, Pizzi M.

PLoS One. 2012;7(5):e38019. doi: 10.1371/journal.pone.0038019. Epub 2012 May 29.


[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].

Arrighi N, Bodei S, Zani D, Simeone C, Cunico SC, Spano PF, Sigala S.

Urologia. 2012 Apr-Jun;79(2):102-8. doi: 10.5301/RU.2012.9272. Italian.


NF-κB and epigenetic mechanisms as integrative regulators of brain resilience to anoxic stress.

Sarnico I, Branca C, Lanzillotta A, Porrini V, Benarese M, Spano PF, Pizzi M.

Brain Res. 2012 Oct 2;1476:203-10. doi: 10.1016/j.brainres.2012.04.013. Epub 2012 Apr 17. Review.


From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease.

Bellucci A, Zaltieri M, Navarria L, Grigoletto J, Missale C, Spano P.

Brain Res. 2012 Oct 2;1476:183-202. doi: 10.1016/j.brainres.2012.04.014. Epub 2012 Apr 17. Review.


Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes.

Ettorre M, Lorenzetto E, Laperchia C, Baiguera C, Branca C, Benarese M, Spano P, Pizzi M, Buffelli M.

PLoS One. 2012;7(2):e31451. doi: 10.1371/journal.pone.0031451. Epub 2012 Feb 9. Erratum in: PLoS One. 2012;7(3):10.1371/annotation/e8dec728-6aa1-4581-9f5d-31a39d107f88. PLoS One. 2012;7(3):10.1371/annotation/f3df15fa-6983-4410-a27a-f4b8238ba18a.


Involvement of target gene polymorphisms in 5-Fluorouracil toxicity: a case report.

Scalvini A, Ferrari V, Bodei S, Arcangeli G, Consoli F, Spano P, Sigala S.

Pharmacology. 2012;89(1-2):99-102. doi: 10.1159/000335784. Epub 2012 Feb 15.


Clinical outcome after extended endovascular recanalization in Buerger's disease in 20 consecutive cases.

Graziani L, Morelli L, Parini F, Franceschini L, Spano P, Calza S, Sigala S.

Ann Vasc Surg. 2012 Apr;26(3):387-95. doi: 10.1016/j.avsg.2011.08.014. Epub 2012 Jan 30.


Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease.

Bellucci A, Navarria L, Falarti E, Zaltieri M, Bono F, Collo G, Spillantini MG, Missale C, Spano P.

PLoS One. 2011;6(12):e27959. doi: 10.1371/journal.pone.0027959. Epub 2011 Dec 7. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/58679d17-c619-4f13-b11f-146dacfe7e92. Grazia, Maria [corrected to Spillantini, Maria Grazia].


α-Synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease.

Bellucci A, Navarria L, Zaltieri M, Missale C, Spano P.

Brain Res. 2012 Jan 13;1432:95-113. doi: 10.1016/j.brainres.2011.11.031. Epub 2011 Nov 19. Review.


Pre-synaptic dopamine D(3) receptor mediates cocaine-induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways.

Collo G, Bono F, Cavalleri L, Plebani L, Merlo Pich E, Millan MJ, Spano PF, Missale C.

J Neurochem. 2012 Mar;120(5):765-78. doi: 10.1111/j.1471-4159.2011.07618.x. Epub 2012 Jan 23.


Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms.

Agnati LF, Guidolin D, Leo G, Guescini M, Pizzi M, Stocchi V, Spano PF, Ghidoni R, Ciruela F, Genedani S, Fuxe K.

J Recept Signal Transduct Res. 2011 Oct;31(5):315-31. doi: 10.3109/10799893.2011.599393.


Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa.

Arrighi N, Bodei S, Lucente A, Michel MC, Zani D, Simeone C, Cunico SC, Spano P, Sigala S.

Pharmacol Res. 2011 Oct;64(4):420-5. doi: 10.1016/j.phrs.2011.06.009. Epub 2011 Jun 28.


The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons.

Fiorentini C, Mattanza C, Collo G, Savoia P, Spano P, Missale C.

J Neurochem. 2011 Apr;117(2):253-63. doi: 10.1111/j.1471-4159.2011.07196.x. Epub 2011 Feb 24.


Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.

Valerio A, Bertolotti P, Delbarba A, Perego C, Dossena M, Ragni M, Spano P, Carruba MO, De Simoni MG, Nisoli E.

J Neurochem. 2011 Mar;116(6):1148-59. doi: 10.1111/j.1471-4159.2011.07171.x. Epub 2011 Jan 28.


The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

Lanzillotta A, Sarnico I, Benarese M, Branca C, Baiguera C, Hutter-Paier B, Windisch M, Spano P, Imbimbo BP, Pizzi M.

J Mol Neurosci. 2011 Sep;45(1):22-31. doi: 10.1007/s12031-010-9482-2. Epub 2010 Dec 22.


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