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Items: 12

1.

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Thorpe LM, Spangle JM, Ohlson CE, Cheng H, Roberts TM, Cantley LC, Zhao JJ.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7095-7100. doi: 10.1073/pnas.1704706114. Epub 2017 Jun 19.

2.

Epigenetic regulation of RTK signaling.

Spangle JM, Roberts TM.

J Mol Med (Berl). 2017 Aug;95(8):791-798. doi: 10.1007/s00109-017-1546-0. Epub 2017 Jun 6. Review.

3.

The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.

Spangle JM, Roberts TM, Zhao JJ.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):123-131. doi: 10.1016/j.bbcan.2017.03.002. Epub 2017 Mar 14. Review.

4.

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Spangle JM, Dreijerink KM, Groner AC, Cheng H, Ohlson CE, Reyes J, Lin CY, Bradner J, Zhao JJ, Roberts TM, Brown M.

Cell Rep. 2016 Jun 21;15(12):2692-704. doi: 10.1016/j.celrep.2016.05.046. Epub 2016 Jun 9.

5.

PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.

Wang Q, Liu P, Spangle JM, Von T, Roberts TM, Lin NU, Krop IE, Winer EP, Zhao JJ.

Oncogene. 2016 Jul 7;35(27):3607-12. doi: 10.1038/onc.2015.406. Epub 2015 Oct 26.

6.

The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species.

Spangle JM, Munger K.

PLoS Pathog. 2013 Mar;9(3):e1003237. doi: 10.1371/journal.ppat.1003237. Epub 2013 Mar 14.

7.

The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.

Meyers JM, Spangle JM, Munger K.

J Virol. 2013 Apr;87(8):4762-7. doi: 10.1128/JVI.02527-12. Epub 2013 Jan 30.

8.

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M.

Nature. 2012 Jul 26;487(7408):491-5. doi: 10.1038/nature11288.

9.

Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.

Spangle JM, Ghosh-Choudhury N, Munger K.

J Virol. 2012 Jul;86(14):7466-72. doi: 10.1128/JVI.00487-12. Epub 2012 May 2.

10.

The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.

Spangle JM, Münger K.

J Virol. 2010 Sep;84(18):9398-407. doi: 10.1128/JVI.00974-10. Epub 2010 Jul 14.

11.
12.

Climate and life-history evolution in evening primroses (Oenothera, Onagraceae): a phylogenetic comparative analysis.

Evans ME, Hearn DJ, Hahn WJ, Spangle JM, Venable DL.

Evolution. 2005 Sep;59(9):1914-27.

PMID:
16261729

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