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Items: 1 to 50 of 133

1.

High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination.

Arlt A, von Bonin F, Rehberg T, Perez-Rubio P, Engelmann JC, Limm K, Reinke S, Dullin C, Sun X, Specht R, Maulhardt M, Linke F, Bunt G, Klapper W, Vockerodt M, Wilting J, Pukrop T, Dettmer K, Gronwald W, Oefner PJ, Spang R, Kube D.

Mol Oncol. 2019 Dec 11. doi: 10.1002/1878-0261.12616. [Epub ahead of print]

2.

A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study.

Altenbuchinger M, Zacharias HU, Solbrig S, Schäfer A, Büyüközkan M, Schultheiß UT, Kotsis F, Köttgen A, Spang R, Oefner PJ, Krumsiek J, Gronwald W.

Sci Rep. 2019 Sep 27;9(1):13954. doi: 10.1038/s41598-019-50346-2.

3.

A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL.

Staiger AM, Altenbuchinger M, Ziepert M, Kohler C, Horn H, Huttner M, Hüttl KS, Glehr G, Klapper W, Szczepanowski M, Richter J, Stein H, Feller AC, Möller P, Hansmann ML, Poeschel V, Held G, Loeffler M, Schmitz N, Trümper L, Pukrop T, Rosenwald A, Ott G, Spang R; Emed Demonstrator Project; German High Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL).

Leukemia. 2019 Sep 17. doi: 10.1038/s41375-019-0573-y. [Epub ahead of print]

PMID:
31530861
4.

Value of computerized shunt infusion study in assessment of pediatric hydrocephalus shunt function-a two center cross-sectional study.

Dias SF, Lalou AD, Spang R, Haas-Lude K, Garnett M, Fernandez H, Czosnyka M, Schuhmann MU, Czosnyka Z.

Childs Nerv Syst. 2019 Aug 1. doi: 10.1007/s00381-019-04264-3. [Epub ahead of print]

PMID:
31372736
5.

Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach.

Wagner M, Hänsel R, Reinke S, Richter J, Altenbuchinger M, Braumann UD, Spang R, Löffler M, Klapper W.

Biol Proced Online. 2019 Jul 1;21:13. doi: 10.1186/s12575-019-0098-9. eCollection 2019.

6.

Modelling cancer progression using Mutual Hazard Networks.

Schill R, Solbrig S, Wettig T, Spang R.

Bioinformatics. 2019 Jun 28. pii: btz513. doi: 10.1093/bioinformatics/btz513. [Epub ahead of print]

PMID:
31250881
7.

Random gene sets in predicting survival of patients with hepatocellular carcinoma.

Itzel T, Spang R, Maass T, Munker S, Roessler S, Ebert MP, Schlitt HJ, Herr W, Evert M, Teufel A.

J Mol Med (Berl). 2019 Jun;97(6):879-888. doi: 10.1007/s00109-019-01764-2. Epub 2019 Apr 17.

PMID:
31001651
8.

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma.

Kleo K, Dimitrova L, Oker E, Tomaszewski N, Berg E, Taruttis F, Engelmann JC, Schwarzfischer P, Reinders J, Spang R, Gronwald W, Oefner PJ, Hummel M.

BMC Cancer. 2019 Apr 5;19(1):322. doi: 10.1186/s12885-019-5537-0.

9.

A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease.

Zacharias HU, Altenbuchinger M, Schultheiss UT, Samol C, Kotsis F, Poguntke I, Sekula P, Krumsiek J, Köttgen A, Spang R, Oefner PJ, Gronwald W.

J Proteome Res. 2019 Apr 5;18(4):1796-1805. doi: 10.1021/acs.jproteome.8b00983. Epub 2019 Mar 12.

PMID:
30817158
10.

The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.

Ziegler C, Graf J, Faderl S, Schedlbauer J, Strieder N, Förstl B, Spang R, Bruckmann A, Merkl R, Hombach S, Kretz M.

EMBO Rep. 2019 Feb;20(2). pii: e46612. doi: 10.15252/embr.201846612. Epub 2019 Jan 8.

PMID:
30622217
11.

Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR.

Heinrich P, Kohler C, Ellmann L, Kuerner P, Spang R, Oefner PJ, Dettmer K.

Sci Rep. 2018 Dec 17;8(1):17910. doi: 10.1038/s41598-018-36293-4.

12.

Combined Reconstruction of the Medial Patellofemoral Ligament (MPFL) and Medial Quadriceps Tendon-Femoral Ligament (MQTFL) for Patellar Instability in Children and Adolescents: Surgical Technique and Outcomes.

Spang RC, Tepolt FA, Paschos NK, Redler LH, Davis EA, Kocher MS.

J Pediatr Orthop. 2019 Jan;39(1):e54-e61. doi: 10.1097/BPO.0000000000001259.

PMID:
30300273
13.

Jones Fractures Identified at the National Football League Scouting Combine: Assessment of Prognostic Factors, Computed Tomography Findings, and Initial Career Performance.

Spang RC, Haber DB, Beaulieu-Jones BR, Stupay KL, Sanchez G, Sanchez A, Murphy CP, Whalen JM, Van Allen JJ, Price MD, Clanton TO, Provencher MT.

Orthop J Sports Med. 2018 Aug 28;6(8):2325967118790740. doi: 10.1177/2325967118790740. eCollection 2018 Aug.

14.

From hype to reality: data science enabling personalized medicine.

Fröhlich H, Balling R, Beerenwinkel N, Kohlbacher O, Kumar S, Lengauer T, Maathuis MH, Moreau Y, Murphy SA, Przytycka TM, Rebhan M, Röst H, Schuppert A, Schwab M, Spang R, Stekhoven D, Sun J, Weber A, Ziemek D, Zupan B.

BMC Med. 2018 Aug 27;16(1):150. doi: 10.1186/s12916-018-1122-7.

15.

Principles of Systems Biology, No. 31.

Cho H, Berger B, Peng J, Galitzine C, Vitek O, Beltran PMJ, Cristea IM, Görtler F, Solbrig S, Wettig T, Oefner PJ, Spang R, Altenbuchinger M, Basso RS, Hochbaum D, Vandin F, Silverbush D, Cristea S, Yanovich G, Geiger T, Beerenwinkel N, Sharan R, Zhou Z, Luhmann N, Alikhan NF, Achtman M.

Cell Syst. 2018 Aug 22;7(2):133-135. doi: 10.1016/j.cels.2018.08.005.

16.

TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity.

Riquelme P, Haarer J, Kammler A, Walter L, Tomiuk S, Ahrens N, Wege AK, Goecze I, Zecher D, Banas B, Spang R, Fändrich F, Lutz MB, Sawitzki B, Schlitt HJ, Ochando J, Geissler EK, Hutchinson JA.

Nat Commun. 2018 Jul 20;9(1):2858. doi: 10.1038/s41467-018-05167-8.

17.

Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma-a feasibility study using full slide staining.

Reinke S, Richter J, Fend F, Feller A, Hansmann ML, Hüttl K, Oschlies I, Ott G, Möller P, Rosenwald A, Stein H, Altenbuchinger M, Spang R, Klapper W.

Virchows Arch. 2018 Sep;473(3):341-349. doi: 10.1007/s00428-018-2367-4. Epub 2018 May 5.

PMID:
29730836
18.

Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.

Feist M, Schwarzfischer P, Heinrich P, Sun X, Kemper J, von Bonin F, Perez-Rubio P, Taruttis F, Rehberg T, Dettmer K, Gronwald W, Reinders J, Engelmann JC, Dudek J, Klapper W, Trümper L, Spang R, Oefner PJ, Kube D.

Nat Commun. 2018 Apr 17;9(1):1514. doi: 10.1038/s41467-018-03803-x.

19.

Individuals, institutions, and innovation in the debates of the French Revolution.

Barron ATJ, Huang J, Spang RL, DeDeo S.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4607-4612. doi: 10.1073/pnas.1717729115. Epub 2018 Apr 17.

20.

Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2.

Horn H, Kohler C, Witzig R, Kreuz M, Leich E, Klapper W, Hummel M, Loeffler M, Trümper L, Spang R, Rosenwald A, Ott G; Molecular Mechanisms in Malignant Lymphomas (MMML) Network Project.

Haematologica. 2018 Jul;103(7):1182-1190. doi: 10.3324/haematol.2017.181024. Epub 2018 Mar 22.

21.

Revision Acromioclavicular-Coracoclavicular Reconstruction: Use of Precontoured Button and 2 Allografts.

Haber DB, Spang RC, Sanchez G, Sanchez A, Ferrari MB, Provencher MT.

Arthrosc Tech. 2017 Nov 27;6(6):e2283-e2288. doi: 10.1016/j.eats.2017.08.039. eCollection 2017 Dec.

22.

Molecular signatures that can be transferred across different omics platforms.

Altenbuchinger M, Schwarzfischer P, Rehberg T, Reinders J, Kohler CW, Gronwald W, Richter J, Szczepanowski M, Masqué-Soler N, Klapper W, Oefner PJ, Spang R.

Bioinformatics. 2017 Sep 1;33(17):2790. doi: 10.1093/bioinformatics/btx488. No abstract available.

23.

Molecular signatures that can be transferred across different omics platforms.

Altenbuchinger M, Schwarzfischer P, Rehberg T, Reinders J, Kohler CW, Gronwald W, Richter J, Szczepanowski M, Masqué-Soler N, Klapper W, Oefner PJ, Spang R.

Bioinformatics. 2017 Jul 15;33(14):i333-i340. doi: 10.1093/bioinformatics/btx241. Erratum in: Bioinformatics. 2017 Sep 1;33(17 ):2790.

24.

Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC.

Paul U, Richter J, Stuhlmann-Laiesz C, Kreuz M, Nagel I, Horn H, Staiger AM, Aukema SM, Hummel M, Ott G, Spang R, Rosenwald A, Feller AC, Cogliatti S, Stein H, Hansmann ML, Moller P, Szczepanowski M, Burkhardt B, Pfreundschuh M, Schmitz N, Loeffler M, Trümper L, Siebert R, Klapper W.

Leuk Lymphoma. 2018 May;59(5):1213-1221. doi: 10.1080/10428194.2017.1365851. Epub 2017 Aug 25.

PMID:
28838257
25.

Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints.

Zacharias HU, Rehberg T, Mehrl S, Richtmann D, Wettig T, Oefner PJ, Spang R, Gronwald W, Altenbuchinger M.

J Proteome Res. 2017 Oct 6;16(10):3596-3605. doi: 10.1021/acs.jproteome.7b00325. Epub 2017 Sep 7.

PMID:
28825821
26.

Spindle-Cell Variants of Primary Cutaneous Follicle Center B-Cell Lymphomas Are Germinal Center B-Cell Lymphomas by Gene Expression Profiling Using a Formalin-Fixed Paraffin-Embedded Specimen.

Oschlies I, Kohler CW, Szczepanowski M, Koch K, Gontarewicz A, Metze D, Hillen U, Richter J, Spang R, Klapper W.

J Invest Dermatol. 2017 Nov;137(11):2450-2453. doi: 10.1016/j.jid.2017.06.016. Epub 2017 Jul 3. No abstract available.

27.

Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents.

Szczepanowski M, Lange J, Kohler CW, Masque-Soler N, Zimmermann M, Aukema SM, Altenbuchinger M, Rehberg T, Mahn F, Siebert R, Spang R, Burkhardt B, Klapper W.

Br J Haematol. 2017 Oct;179(1):116-119. doi: 10.1111/bjh.14812. Epub 2017 Jun 23.

PMID:
28643426
28.

External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data.

Taruttis F, Feist M, Schwarzfischer P, Gronwald W, Kube D, Spang R, Engelmann JC.

Biotechniques. 2017 Feb 1;62(2):53-61. doi: 10.2144/000114514.

29.

Comprehensive Metaboproteomics of Burkitt's and Diffuse Large B-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct Differences in Pyruvate Content and Metabolism.

Schwarzfischer P, Reinders J, Dettmer K, Kleo K, Dimitrova L, Hummel M, Feist M, Kube D, Szczepanowski M, Klapper W, Taruttis F, Engelmann JC, Spang R, Gronwald W, Oefner PJ.

J Proteome Res. 2017 Mar 3;16(3):1105-1120. doi: 10.1021/acs.jproteome.6b00164. Epub 2017 Feb 16.

PMID:
28161958
30.

Early dissemination seeds metastasis in breast cancer.

Hosseini H, Obradović MMS, Hoffmann M, Harper KL, Sosa MS, Werner-Klein M, Nanduri LK, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G, Gužvić M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf AD, Taran FA, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA, Klein CA.

Nature. 2016 Dec 22;540(7634):552-558. doi: 10.1038/nature20785. Epub 2016 Dec 14.

31.

High-Dimensional Profiling for Computational Diagnosis.

Lottaz C, Gronwald W, Spang R, Engelmann JC.

Methods Mol Biol. 2017;1526:205-229.

PMID:
27896744
32.

Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis.

Feist M, Kemper J, Taruttis F, Rehberg T, Engelmann JC, Gronwald W, Hummel M, Spang R, Kube D.

Int J Cancer. 2017 Mar 1;140(5):1147-1158. doi: 10.1002/ijc.30444. Epub 2016 Oct 17.

33.

Reference point insensitive molecular data analysis.

Altenbuchinger M, Rehberg T, Zacharias HU, Stämmler F, Dettmer K, Weber D, Hiergeist A, Gessner A, Holler E, Oefner PJ, Spang R.

Bioinformatics. 2017 Jan 15;33(2):219-226. doi: 10.1093/bioinformatics/btw598. Epub 2016 Sep 15.

PMID:
27634945
34.

Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.

Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R.

Microbiome. 2016 Jun 21;4(1):28. doi: 10.1186/s40168-016-0175-0.

35.

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients.

Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W, Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R, Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J.

Gastroenterology. 2016 Sep;151(3):513-525.e0. doi: 10.1053/j.gastro.2016.05.051. Epub 2016 Jun 16.

PMID:
27318147
36.

Refining Pathways: A Model Comparison Approach.

Moffa G, Erdmann G, Voloshanenko O, Hundsrucker C, Sadeh MJ, Boutros M, Spang R.

PLoS One. 2016 Jun 1;11(6):e0155999. doi: 10.1371/journal.pone.0155999. eCollection 2016.

37.

Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data.

Schrader A, Meyer K, Walther N, Stolz A, Feist M, Hand E, von Bonin F, Evers M, Kohler C, Shirneshan K, Vockerodt M, Klapper W, Szczepanowski M, Murray PG, Bastians H, Trümper L, Spang R, Kube D.

Oncotarget. 2016 Jul 26;7(30):47061-47081. doi: 10.18632/oncotarget.9219.

38.

Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro.

Moeckel S, Vollmann-Zwerenz A, Proescholdt M, Brawanski A, Riemenschneider MJ, Bogdahn U, Bosserhoff AK, Spang R, Hau P.

PLoS One. 2016 Mar 15;11(3):e0151312. doi: 10.1371/journal.pone.0151312. eCollection 2016.

39.

Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models.

Pirkl M, Hand E, Kube D, Spang R.

Bioinformatics. 2016 Mar 15;32(6):893-900. doi: 10.1093/bioinformatics/btv680. Epub 2015 Nov 17.

40.

A statistical approach to virtual cellular experiments: improved causal discovery using accumulation IDA (aIDA).

Taruttis F, Spang R, Engelmann JC.

Bioinformatics. 2015 Dec 1;31(23):3807-14. doi: 10.1093/bioinformatics/btv461. Epub 2015 Aug 6.

41.

Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.

Masqué-Soler N, Szczepanowski M, Kohler CW, Aukema SM, Nagel I, Richter J, Siebert R, Spang R, Burkhardt B, Klapper W.

Br J Haematol. 2015 Nov;171(4):501-8. doi: 10.1111/bjh.13624. Epub 2015 Jul 27.

PMID:
26218299
42.

Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome.

Weber D, Oefner PJ, Hiergeist A, Koestler J, Gessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, Holler E.

Blood. 2015 Oct 1;126(14):1723-8. doi: 10.1182/blood-2015-04-638858. Epub 2015 Jul 24.

PMID:
26209659
43.

Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation.

Hochrein J, Zacharias HU, Taruttis F, Samol C, Engelmann JC, Spang R, Oefner PJ, Gronwald W.

J Proteome Res. 2015 Aug 7;14(8):3217-28. doi: 10.1021/acs.jproteome.5b00192. Epub 2015 Jul 22.

PMID:
26147738
44.

Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma.

Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ, Spang R, Hellerbrand C.

PLoS Comput Biol. 2015 May 28;11(5):e1004293. doi: 10.1371/journal.pcbi.1004293. eCollection 2015 May.

45.

Response-predictive gene expression profiling of glioma progenitor cells in vitro.

Moeckel S, Meyer K, Leukel P, Heudorfer F, Seliger C, Stangl C, Bogdahn U, Proescholdt M, Brawanski A, Vollmann-Zwerenz A, Riemenschneider MJ, Bosserhoff AK, Spang R, Hau P.

PLoS One. 2014 Sep 30;9(9):e108632. doi: 10.1371/journal.pone.0108632. eCollection 2014.

46.

ACGME Duty Hour Requirements: Perceptions and Impact on Resident Training and Patient Care.

Levine WN, Spang RC 3rd.

J Am Acad Orthop Surg. 2014 Sep;22(9):535-44. doi: 10.5435/JAAOS-22-09-535.

PMID:
25157035
47.

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.

Hannus M, Beitzinger M, Engelmann JC, Weickert MT, Spang R, Hannus S, Meister G.

Nucleic Acids Res. 2014 Jul;42(12):8049-61. doi: 10.1093/nar/gku480. Epub 2014 May 29.

48.

Increased expression of c-Jun in nonalcoholic fatty liver disease.

Dorn C, Engelmann JC, Saugspier M, Koch A, Hartmann A, Müller M, Spang R, Bosserhoff A, Hellerbrand C.

Lab Invest. 2014 Apr;94(4):394-408. doi: 10.1038/labinvest.2014.3. Epub 2014 Feb 3.

49.

Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease.

Holler E, Butzhammer P, Schmid K, Hundsrucker C, Koestler J, Peter K, Zhu W, Sporrer D, Hehlgans T, Kreutz M, Holler B, Wolff D, Edinger M, Andreesen R, Levine JE, Ferrara JL, Gessner A, Spang R, Oefner PJ.

Biol Blood Marrow Transplant. 2014 May;20(5):640-5. doi: 10.1016/j.bbmt.2014.01.030. Epub 2014 Jan 31.

50.

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, Damm-Welk C, Drexler HG, Hummel M, Jaffe ES, Küppers R, Lefebvre C, Lisfeld J, Löffler M, Macleod RA, Nagel I, Oschlies I, Rosolowski M, Russell RB, Rymkiewicz G, Schindler D, Schlesner M, Scholtysik R, Schwaenen C, Spang R, Szczepanowski M, Trümper L, Vater I, Wessendorf S, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphoma Network Project; Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group.

Blood. 2014 Feb 20;123(8):1187-98. doi: 10.1182/blood-2013-06-507996. Epub 2014 Jan 7.

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