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Items: 34

1.

Transgenic expression of the positive selected human GLUD2 gene improves in vivo glucose homeostasis by regulating basic insulin secretion.

Petraki Z, Droubogiannis S, Mylonaki K, Chlouverakis G, Plaitakis A, Spanaki C.

Metabolism. 2019 Aug 7;100:153958. doi: 10.1016/j.metabol.2019.153958. [Epub ahead of print]

PMID:
31400387
2.

Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution.

Plaitakis A, Kotzamani D, Petraki Z, Delidaki M, Rinotas V, Zaganas I, Douni E, Sidiropoulou K, Spanaki C.

Neurochem Res. 2019 Jan;44(1):154-169. doi: 10.1007/s11064-018-2546-3. Epub 2018 May 18.

PMID:
29777493
3.

The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.

Plaitakis A, Kalef-Ezra E, Kotzamani D, Zaganas I, Spanaki C.

Biology (Basel). 2017 Feb 8;6(1). pii: E11. doi: 10.3390/biology6010011. Review.

4.

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

Spanaki C, Kotzamani D, Plaitakis A.

Neurochem Res. 2017 Jan;42(1):92-107. doi: 10.1007/s11064-016-1986-x. Epub 2016 Jul 16.

PMID:
27422263
5.

Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons.

Spanaki C, Kotzamani D, Kleopa K, Plaitakis A.

Mol Neurobiol. 2016 Oct;53(8):5140-8. doi: 10.1007/s12035-015-9429-2. Epub 2015 Sep 23.

PMID:
26399640
6.

Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

Spanaki C, Kotzamani D, Petraki Z, Drakos E, Plaitakis A.

Mol Cell Endocrinol. 2015 Nov 5;415:1-11. doi: 10.1016/j.mce.2015.07.020. Epub 2015 Aug 1.

PMID:
26241911
7.

The Relationship of Common Risk Variants and Polygenic Risk for Schizophrenia to Sensorimotor Gating.

Roussos P, Giakoumaki SG, Zouraraki C, Fullard JF, Karagiorga VE, Tsapakis EM, Petraki Z, Siever LJ, Lencz T, Malhotra A, Spanaki C, Bitsios P.

Biol Psychiatry. 2016 Jun 15;79(12):988-96. doi: 10.1016/j.biopsych.2015.06.019. Epub 2015 Jun 27.

PMID:
26212897
8.

Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues.

Spanaki C, Kotzamani D, Petraki Z, Drakos E, Plaitakis A.

Neurochem Res. 2014;39(3):500-15. doi: 10.1007/s11064-013-1235-5. Epub 2014 Jan 17. Review.

PMID:
24436052
9.

Assessment of Parkinson's disease risk loci in Greece.

Kara E, Xiromerisiou G, Spanaki C, Bozi M, Koutsis G, Panas M, Dardiotis E, Ralli S, Bras J, Letson C, Edsall C, Pliner H, Arepalli S, Kalinderi K, Fidani L, Bostantjopoulou S, Keller MF, Wood NW, Hardy J, Houlden H, Stefanis L, Plaitakis A, Hernandez D, Hadjigeorgiou GM, Nalls MA, Singleton AB.

Neurobiol Aging. 2014 Feb;35(2):442.e9-442.e16. doi: 10.1016/j.neurobiolaging.2013.07.011. Epub 2013 Sep 27.

10.

Deregulation of glutamate dehydrogenase in human neurologic disorders.

Plaitakis A, Zaganas I, Spanaki C.

J Neurosci Res. 2013 Aug;91(8):1007-17. doi: 10.1002/jnr.23176. Epub 2013 Mar 6. Review.

PMID:
23463419
11.

Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.

Zaganas I, Spanaki C, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):455-62. doi: 10.1016/j.neuint.2012.06.007. Epub 2012 Jun 16.

PMID:
22709674
12.

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

Spanaki C, Zaganas I, Kounoupa Z, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):470-81. doi: 10.1016/j.neuint.2012.05.020. Epub 2012 May 30.

PMID:
22658952
13.

Rising incidence of multiple sclerosis in females associated with urbanization.

Kotzamani D, Panou T, Mastorodemos V, Tzagournissakis M, Nikolakaki H, Spanaki C, Plaitakis A.

Neurology. 2012 May 29;78(22):1728-35. doi: 10.1212/WNL.0b013e31825830a9. Epub 2012 May 16.

PMID:
22592376
14.

The role of glutamate dehydrogenase in mammalian ammonia metabolism.

Spanaki C, Plaitakis A.

Neurotox Res. 2012 Jan;21(1):117-27. doi: 10.1007/s12640-011-9285-4. Epub 2011 Oct 29. Review.

PMID:
22038055
15.

The human GLUD2 glutamate dehydrogenase and its regulation in health and disease.

Plaitakis A, Latsoudis H, Spanaki C.

Neurochem Int. 2011 Sep;59(4):495-509. doi: 10.1016/j.neuint.2011.03.015. Epub 2011 Mar 21. Review.

PMID:
21420458
16.

Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.

Borompokas N, Papachatzaki MM, Kanavouras K, Mastorodemos V, Zaganas I, Spanaki C, Plaitakis A.

J Biol Chem. 2010 Oct 8;285(41):31380-7. doi: 10.1074/jbc.M110.146084. Epub 2010 Jul 13.

17.

Benign multiple sclerosis in Crete.

Mastorodemos V, Nikolakaki H, Tzagournissakis M, Kotzamani D, Panou T, Spanaki C, Klados G, Maris T, Kontolaimaki E, Psaroudaki K, Chlouverakis G, Georgakakis G, Plaitakis A.

Mult Scler. 2010 Jun;16(6):701-6. doi: 10.1177/1352458510364631. Epub 2010 Mar 17.

PMID:
20237192
18.

Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells.

Spanaki C, Zaganas I, Kleopa KA, Plaitakis A.

J Biol Chem. 2010 May 28;285(22):16748-56. doi: 10.1074/jbc.M109.092999. Epub 2010 Mar 1.

19.

Levodopa-aggravated lateral flexion of the neck and trunk as a delayed phenomenon of unilateral pallidotomy.

Spanaki C, Zafeiris S, Plaitakis A.

Mov Disord. 2010 Apr 15;25(5):655-6. doi: 10.1002/mds.22988. No abstract available.

PMID:
20131399
20.

Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset.

Plaitakis A, Latsoudis H, Kanavouras K, Ritz B, Bronstein JM, Skoula I, Mastorodemos V, Papapetropoulos S, Borompokas N, Zaganas I, Xiromerisiou G, Hadjigeorgiou GM, Spanaki C.

Eur J Hum Genet. 2010 Mar;18(3):336-41. doi: 10.1038/ejhg.2009.179. Epub 2009 Oct 14.

21.

Essential tremor in Parkinson's disease kindreds from a population of similar genetic background.

Spanaki C, Plaitakis A.

Mov Disord. 2009 Aug 15;24(11):1662-8. doi: 10.1002/mds.22655.

PMID:
19514058
22.

The human GLUD2 glutamate dehydrogenase: localization and functional aspects.

Zaganas I, Kanavouras K, Mastorodemos V, Latsoudis H, Spanaki C, Plaitakis A.

Neurochem Int. 2009 Jul-Aug;55(1-3):52-63. doi: 10.1016/j.neuint.2009.03.001. Epub 2009 Mar 13.

PMID:
19428807
23.

Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.

Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ.

Parkinsonism Relat Disord. 2009 Jul;15(6):466-7. doi: 10.1016/j.parkreldis.2008.09.001. Epub 2008 Oct 26.

24.

Mitochondrial DNA polymorphisms and haplogroups in Parkinson's disease and control individuals with a similar genetic background.

Latsoudis H, Spanaki C, Chlouverakis G, Plaitakis A.

J Hum Genet. 2008;53(4):349-56. doi: 10.1007/s10038-008-0259-1. Epub 2008 Feb 20.

PMID:
18286226
25.

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K, Mastorodemos V, Borompokas N, Spanaki C, Plaitakis A.

J Neurosci Res. 2007 Nov 15;85(15):3398-406.

PMID:
17924438
26.

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K, Mastorodemos V, Borompokas N, Spanaki C, Plaitakis A.

J Neurosci Res. 2007 Apr;85(5):1101-9.

PMID:
17253646
27.

LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP.

Spanaki C, Latsoudis H, Plaitakis A.

Neurology. 2006 Oct 24;67(8):1518-9. No abstract available.

PMID:
17060595
28.

Late-onset and typical Huntington disease families from Crete have distinct genetic origins.

Kartsaki E, Spanaki C, Tzagournissakis M, Petsakou A, Moschonas N, Macdonald M, Plaitakis A.

Int J Mol Med. 2006 Feb;17(2):335-46.

PMID:
16391835
29.

Genetic basis of common diseases: the general theory of Mendelian recessive genetics.

Hutchinson M, Spanaki C, Lebedev S, Plaitakis A.

Med Hypotheses. 2005;65(2):282-6.

PMID:
15922101
30.

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

Mastorodemos V, Zaganas I, Spanaki C, Bessa M, Plaitakis A.

J Neurosci Res. 2005 Jan 1-15;79(1-2):65-73.

PMID:
15578726
31.

Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance.

Spanaki C, Plaitakis A.

Neurology. 2004 Mar 9;62(5):815-7.

PMID:
15007141
32.

Human X-chromosomal lineages in Europe reveal Middle Eastern and Asiatic contacts.

Xiao FX, Yotova V, Zietkiewicz E, Lovell A, Gehl D, Bourgeois S, Moreau C, Spanaki C, Plaitakis A, Moisan JP, Labuda D.

Eur J Hum Genet. 2004 Apr;12(4):301-11.

33.

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