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Items: 1 to 50 of 283

1.

C-Fos marking of identified midbrain neurons co-active after nicotine administration in-vivo.

Lingelbach K, Hach A, Bernardi RE, Spanagel R, Bading H, Bengtson CP.

J Comp Neurol. 2018 Jun 11. doi: 10.1002/cne.24471. [Epub ahead of print]

PMID:
29888787
2.

Alterations of the Biological Clock May Contribute to the Emergence of Mental Disorders During Adolescence.

Spanagel R.

Biol Psychiatry. 2018 Jun 15;83(12):978-980. doi: 10.1016/j.biopsych.2018.04.004. No abstract available.

PMID:
29804587
3.

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I.

J Neurochem. 2018 May 10. doi: 10.1111/jnc.14460. [Epub ahead of print]

PMID:
29747224
4.

Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior.

Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC.

Psychopharmacology (Berl). 2018 Jun;235(6):1821-1833. doi: 10.1007/s00213-018-4908-6. Epub 2018 Apr 26.

PMID:
29700576
5.

Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain.

Bilbao A, Falfán-Melgoza C, Leixner S, Becker R, Singaravelu SK, Sack M, Sartorius A, Spanagel R, Weber-Fahr W.

Neuroscience. 2018 Apr 22. pii: S0306-4522(18)30271-9. doi: 10.1016/j.neuroscience.2018.04.020. [Epub ahead of print]

6.

Efficacy and side effects of baclofen and the novel GABAB receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction.

Vengeliene V, Takahashi TT, Dravolina OA, Belozertseva I, Zvartau E, Bespalov AY, Spanagel R.

Psychopharmacology (Berl). 2018 Apr 12. doi: 10.1007/s00213-018-4893-9. [Epub ahead of print]

PMID:
29651507
7.

Choice for Drug or Natural Reward Engages Largely Overlapping Neuronal Ensembles in the Infralimbic Prefrontal Cortex.

Pfarr S, Schaaf L, Reinert JK, Paul E, Herrmannsdörfer F, Roßmanith M, Kuner T, Hansson AC, Spanagel R, Körber C, Sommer WH.

J Neurosci. 2018 Apr 4;38(14):3507-3519. doi: 10.1523/JNEUROSCI.0026-18.2018. Epub 2018 Feb 26.

PMID:
29483279
8.

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovleva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G.

Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-017-0844-4. [Epub ahead of print]

PMID:
29383684
9.

Targeting Glycine Reuptake in Alcohol Seeking and Relapse.

Vengeliene V, Roßmanith M, Takahashi TT, Alberati D, Behl B, Bespalov A, Spanagel R.

J Pharmacol Exp Ther. 2018 Apr;365(1):202-211. doi: 10.1124/jpet.117.244822. Epub 2018 Jan 24.

PMID:
29367277
10.

Animal models of addiction.

Spanagel R.

Dialogues Clin Neurosci. 2017 Sep;19(3):247-258.

11.

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior.

Bernardi RE, Broccoli L, Hirth N, Justice NJ, Deussing JM, Hansson AC, Spanagel R.

Front Behav Neurosci. 2017 Nov 13;11:221. doi: 10.3389/fnbeh.2017.00221. eCollection 2017.

12.

[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior.

Cannella N, Cosa-Linan A, Roscher M, Takahashi TT, Vogler N, Wängler B, Spanagel R.

Front Psychiatry. 2017 Nov 1;8:218. doi: 10.3389/fpsyt.2017.00218. eCollection 2017.

13.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

PMID:
29144972
14.

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans.

Hansson AC, Koopmann A, Uhrig S, Bühler S, Domi E, Kiessling E, Ciccocioppo R, Froemke RC, Grinevich V, Kiefer F, Sommer WH, Vollstädt-Klein S, Spanagel R.

Neuropsychopharmacology. 2018 May;43(6):1235-1246. doi: 10.1038/npp.2017.257. Epub 2017 Nov 1.

PMID:
29090683
15.

Mechanismen der Suchtentwicklung.

Spanagel R.

Drug Res (Stuttg). 2017 Nov;67(S 01):S17. doi: 10.1055/s-0043-116532. Epub 2017 Oct 25. German. No abstract available.

PMID:
29069680
Free Article
16.

Dynamical state transitions into addictive behaviour and their early-warning signals.

Foo JC, Noori HR, Yamaguchi I, Vengeliene V, Cosa-Linan A, Nakamura T, Morita K, Spanagel R, Yamamoto Y.

Proc Biol Sci. 2017 Aug 16;284(1860). pii: 20170882. doi: 10.1098/rspb.2017.0882.

17.

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.

Treutlein J, Frank J, Streit F, Reinbold CS, Juraeva D, Degenhardt F, Rietschel L, Witt SH, Forstner AJ, Ridinger M, Strohmaier J, Wodarz N, Dukal H, Foo JC, Hoffmann P, Herms S, Heilmann-Heimbach S, Soyka M, Maier W, Gaebel W, Dahmen N, Scherbaum N, Müller-Myhsok B, Lucae S, Ising M, Stickel F, Berg T, Roggenbuck U, Jöckel KH, Scholz H, Zimmermann US, Buch S, Sommer WH, Spanagel R, Brors B, Cichon S, Mann K, Kiefer F, Hampe J, Rosendahl J, Nöthen MM, Rietschel M.

Genes (Basel). 2017 Jul 17;8(7). pii: E183. doi: 10.3390/genes8070183.

18.

A multiscale cerebral neurochemical connectome of the rat brain.

Noori HR, Schöttler J, Ercsey-Ravasz M, Cosa-Linan A, Varga M, Toroczkai Z, Spanagel R.

PLoS Biol. 2017 Jul 3;15(7):e2002612. doi: 10.1371/journal.pbio.2002612. eCollection 2017 Jul.

19.

Adaptive dynamics of the 5-HT systems following chronic administration of selective serotonin reuptake inhibitors: a meta-analysis.

Fritze S, Spanagel R, Noori HR.

J Neurochem. 2017 Sep;142(5):747-755. doi: 10.1111/jnc.14114. Epub 2017 Jul 14.

PMID:
28653748
20.

Changes in cerebral [18F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism.

Gispert JD, Figueiras FP, Vengeliene V, Herance JR, Rojas S, Spanagel R.

Behav Brain Res. 2017 Jun 1;327:29-33. doi: 10.1016/j.bbr.2017.03.038. Epub 2017 Mar 27.

PMID:
28347826
21.

Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats.

Takahashi TT, Vengeliene V, Spanagel R.

Psychopharmacology (Berl). 2017 Jun;234(11):1741-1748. doi: 10.1007/s00213-017-4576-y. Epub 2017 Feb 28.

PMID:
28246896
22.

mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity.

Perreau-Lenz S, Hoelters LS, Leixner S, Sanchis-Segura C, Hansson A, Bilbao A, Spanagel R.

Psychopharmacology (Berl). 2017 Jun;234(11):1713-1724. doi: 10.1007/s00213-017-4574-0. Epub 2017 Feb 28.

PMID:
28243713
23.

In vivo structural imaging in rats reveals neuroanatomical correlates of behavioral sub-dimensions of cocaine addiction.

Cannella N, Cosa-Linan A, Büchler E, Falfan-Melgoza C, Weber-Fahr W, Spanagel R.

Addict Biol. 2018 Jan;23(1):182-195. doi: 10.1111/adb.12500. Epub 2017 Feb 23.

PMID:
28231635
24.

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.

Vengeliene V, Bespalov A, Roßmanith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R.

Dis Model Mech. 2017 Apr 1;10(4):451-461. doi: 10.1242/dmm.027623. Epub 2017 Feb 6.

25.

Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.

Frischknecht U, Hermann D, Tunc-Skarka N, Wang GY, Sack M, van Eijk J, Demirakca T, Falfan-Melgoza C, Krumm B, Dieter S, Spanagel R, Kiefer F, Mann KF, Sommer WH, Ende G, Weber-Fahr W.

Alcohol Clin Exp Res. 2017 Feb;41(2):323-333. doi: 10.1111/acer.13308. Epub 2017 Jan 18.

PMID:
28098946
26.

The Cannabinoid Receptor 1 as a Key Mediator of Adolescent Behavior.

Spanagel R, Kiefer F.

Neuropsychopharmacology. 2017 Jan;42(1):367. doi: 10.1038/npp.2016.159. No abstract available.

27.

Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence.

Uhrig S, Vandael D, Marcantoni A, Dedic N, Bilbao A, Vogt MA, Hirth N, Broccoli L, Bernardi RE, Schönig K, Gass P, Bartsch D, Spanagel R, Deussing JM, Sommer WH, Carbone E, Hansson AC.

Neuropsychopharmacology. 2017 Apr;42(5):1058-1069. doi: 10.1038/npp.2016.266. Epub 2016 Dec 1.

28.

Association of plasma calcium concentrations with alcohol craving: New data on potential pathways.

Schuster R, Koopmann A, Grosshans M, Reinhard I, Spanagel R, Kiefer F.

Eur Neuropsychopharmacol. 2017 Jan;27(1):42-47. doi: 10.1016/j.euroneuro.2016.11.007. Epub 2016 Nov 25.

PMID:
27890540
29.

Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling.

Schneider P, Bindila L, Schmahl C, Bohus M, Meyer-Lindenberg A, Lutz B, Spanagel R, Schneider M.

Front Behav Neurosci. 2016 Oct 20;10:203. eCollection 2016.

30.

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.

Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M.

J Neurosci. 2016 Dec 14;36(50):12611-12623. Epub 2016 Nov 3.

31.

Persistent strengthening of the prefrontal cortex - nucleus accumbens pathway during incubation of cocaine-seeking behavior.

Luís C, Cannella N, Spanagel R, Köhr G.

Neurobiol Learn Mem. 2017 Feb;138:281-290. doi: 10.1016/j.nlm.2016.10.003. Epub 2016 Oct 5.

PMID:
27720809
32.

Altered neural oscillations and elevated dopamine levels in the reward pathway during alcohol relapse.

Hadar R, Voget M, Vengeliene V, Haumesser JK, van Riesen C, Avchalumov Y, Spanagel R, Winter C.

Behav Brain Res. 2017 Jan 1;316:131-135. doi: 10.1016/j.bbr.2016.08.045. Epub 2016 Aug 25.

PMID:
27569184
33.

Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors.

Papale A, Morella IM, Indrigo MT, Bernardi RE, Marrone L, Marchisella F, Brancale A, Spanagel R, Brambilla R, Fasano S.

Elife. 2016 Aug 24;5. pii: e17111. doi: 10.7554/eLife.17111.

34.

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.

Hermann D, Hirth N, Reimold M, Batra A, Smolka MN, Hoffmann S, Kiefer F, Noori HR, Sommer WH, Reischl G, la Fougère C, Mann K, Spanagel R, Hansson AC.

Neuropsychopharmacology. 2017 Feb;42(3):606-614. doi: 10.1038/npp.2016.145. Epub 2016 Aug 11.

35.

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse.

Vengeliene V, Cannella N, Takahashi T, Spanagel R.

Psychopharmacology (Berl). 2016 Sep;233(18):3449-59. doi: 10.1007/s00213-016-4384-9. Epub 2016 Jul 30.

PMID:
27475106
36.

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.

Bernardi RE, Zohsel K, Hirth N, Treutlein J, Heilig M, Laucht M, Spanagel R, Sommer WH.

Transl Psychiatry. 2016 Jul 26;6(7):e861. doi: 10.1038/tp.2016.132.

37.

Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis.

Noori HR, Cosa Linan A, Spanagel R.

Eur Neuropsychopharmacol. 2016 Sep;26(9):1419-1430. doi: 10.1016/j.euroneuro.2016.06.013. Epub 2016 Jul 7.

PMID:
27397863
38.

Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4.

Degenhardt F, Krämer L, Frank J, Treutlein J, Heilmann-Heimbach S, Hecker J, Fier HL, Lang M, Witt SH, Koller AC, Mann K, Hoffmann S, Kiefer F, Spanagel R, Rietschel M, Nöthen MM.

Alcohol Clin Exp Res. 2016 Aug;40(8):1627-32. doi: 10.1111/acer.13125. Epub 2016 Jul 4.

39.

Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens.

Hadar R, Vengeliene V, Barroeta Hlusicke E, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C.

Transl Psychiatry. 2016 Jun 21;6(6):e840. doi: 10.1038/tp.2016.100.

40.

The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research.

Heilig M, Sommer WH, Spanagel R.

Curr Top Behav Neurosci. 2016;28:151-71. doi: 10.1007/7854_2015_5006. Review.

PMID:
27240677
41.

Adolescent social rejection alters pain processing in a CB1 receptor dependent manner.

Schneider P, Pätz M, Spanagel R, Schneider M.

Eur Neuropsychopharmacol. 2016 Jul;26(7):1201-12. doi: 10.1016/j.euroneuro.2016.04.007. Epub 2016 May 2.

PMID:
27157075
42.

Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study.

Uhrig S, Hirth N, Broccoli L, von Wilmsdorff M, Bauer M, Sommer C, Zink M, Steiner J, Frodl T, Malchow B, Falkai P, Spanagel R, Hansson AC, Schmitt A.

Schizophr Res. 2016 Nov;177(1-3):59-66. doi: 10.1016/j.schres.2016.04.019. Epub 2016 Apr 25.

PMID:
27132494
43.

Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence.

Hirth N, Meinhardt MW, Noori HR, Salgado H, Torres-Ramirez O, Uhrig S, Broccoli L, Vengeliene V, Roßmanith M, Perreau-Lenz S, Köhr G, Sommer WH, Spanagel R, Hansson AC.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3024-9. doi: 10.1073/pnas.1506012113. Epub 2016 Feb 22.

44.

Reply to: Does acamprosate really produce its anti-relapse effects via calcium? No support from the PREDICT study in human alcoholics.

Spanagel R, Vengeliene V, Kiefer F.

Neuropsychopharmacology. 2016 Feb;41(3):661-2. doi: 10.1038/npp.2015.263. No abstract available.

45.

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.

Stacey D, Lourdusamy A, Ruggeri B, Maroteaux M, Jia T, Cattrell A, Nymberg C, Banaschewski T, Bhattacharyya S, Band H, Barker G, Bokde A, Buchel C, Carvalho F, Conrod P, Desrivieres S, Easton A, Fauth-Buehler M, Fernandez-Medarde A, Flor H, Frouin V, Gallinat J, Garavanh H, Heinz A, Ittermann B, Lathrop M, Lawrence C, Loth E, Mann K, Martinot JL, Nees F, Paus T, Pausova Z, Rietschel M, Rotter A, Santos E, Smolka M, Sommer W, Mameli M, Spanagel R, Girault JA, Mueller C, Schumann G; IMAGEN consortium.

J Psychiatry Neurosci. 2016 Apr;41(3):192-202.

46.

Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.

Eisenhardt M, Leixner S, Luján R, Spanagel R, Bilbao A.

J Neurosci. 2015 Nov 25;35(47):15523-38. doi: 10.1523/JNEUROSCI.2970-15.2015.

47.

Quantification of alcohol drinking patterns in mice.

Eisenhardt M, Leixner S, Spanagel R, Bilbao A.

Addict Biol. 2015 Nov;20(6):1001-11. doi: 10.1111/adb.12325. Epub 2015 Oct 30.

PMID:
26515884
48.

Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.

Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, Spanagel R.

J Neurosci. 2015 Oct 14;35(41):13975-88. doi: 10.1523/JNEUROSCI.1937-15.2015.

49.

Sex differences in dopamine binding and modafinil conditioned place preference in mice.

Bernardi RE, Broccoli L, Spanagel R, Hansson AC.

Drug Alcohol Depend. 2015 Oct 1;155:37-44. doi: 10.1016/j.drugalcdep.2015.08.016. Epub 2015 Aug 28.

PMID:
26342627
50.

Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse.

Vengeliene V, Olevska A, Spanagel R.

J Neurochem. 2015 Dec;135(6):1080-5. doi: 10.1111/jnc.13350. Epub 2015 Sep 22.

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