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Items: 37

1.

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA.

Nat Neurosci. 2016 Mar;19(3):443-53. doi: 10.1038/nn.4225. Epub 2016 Jan 18.

PMID:
26780512
2.

Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential.

Marshall J, Wong KY, Rupasinghe CN, Tiwari R, Zhao X, Berberoglu ED, Sinkler C, Liu J, Lee I, Parang K, Spaller MR, Hüttemann M, Goebel DJ.

J Biol Chem. 2015 Sep 4;290(36):22030-48. doi: 10.1074/jbc.M115.662791. Epub 2015 Jun 22.

3.

Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer.

Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D.

ACS Chem Biol. 2019 Oct 18;14(10):2327. doi: 10.1021/cb500865a. Epub 2015 Mar 10. No abstract available.

4.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

Bhattacharya S, Pal K, Sharma AK, Dutta SK, Lau JS, Yan IK, Wang E, Elkhanany A, Alkharfy KM, Sanyal A, Patel TC, Chari ST, Spaller MR, Mukhopadhyay D.

PLoS One. 2014 Dec 3;9(12):e114409. doi: 10.1371/journal.pone.0114409. eCollection 2014.

5.

Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain.

Amacher JF, Zhao R, Spaller MR, Madden DR.

PLoS One. 2014 Aug 19;9(8):e103650. doi: 10.1371/journal.pone.0103650. eCollection 2014.

6.

Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.

Pal K, Pletnev AA, Dutta SK, Wang E, Zhao R, Baral A, Yadav VK, Aggarwal S, Krishnaswamy S, Alkharfy KM, Chowdhury S, Spaller MR, Mukhopadhyay D.

Mol Cancer Ther. 2014 Oct;13(10):2264-75. doi: 10.1158/1535-7163.MCT-14-0291. Epub 2014 Aug 14.

7.

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

Yedidi RS, Muhuhi JM, Liu Z, Bencze KZ, Koupparis K, O'Connor CE, Kovari IA, Spaller MR, Kovari LC.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):703-8. doi: 10.1016/j.bbrc.2013.07.117. Epub 2013 Aug 3.

8.

Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

Cao C, Rioult-Pedotti MS, Migani P, Yu CJ, Tiwari R, Parang K, Spaller MR, Goebel DJ, Marshall J.

PLoS Biol. 2013;11(2):e1001478. doi: 10.1371/journal.pbio.1001478. Epub 2013 Feb 12. Erratum in: PLoS Biol. 2014;12(4):e1001848. PLoS Biol. 2013 Mar 5;11(3):.

9.

Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA.

Kaur M, Rupasinghe CN, Klosi E, Spaller MR, Chow CS.

Bioorg Med Chem. 2013 Mar 1;21(5):1240-7. doi: 10.1016/j.bmc.2012.12.048. Epub 2013 Jan 10.

10.

Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.

Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D.

ACS Chem Biol. 2012 Apr 20;7(4):770-9. doi: 10.1021/cb200536r. Epub 2012 Feb 15. Erratum in: ACS Chem Biol. 2019 Oct 18;14(10):2327.

11.

RGS-GAIP-interacting protein controls breast cancer progression.

Wang L, Lau JS, Patra CR, Cao Y, Bhattacharya S, Dutta S, Nandy D, Wang E, Rupasinghe CN, Vohra P, Spaller MR, Mukhopadhyay D.

Mol Cancer Res. 2010 Dec;8(12):1591-600. doi: 10.1158/1541-7786.MCR-10-0209. Epub 2010 Oct 27.

12.

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia.

LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY.

Neuroscience. 2010 May 5;167(2):490-500. doi: 10.1016/j.neuroscience.2010.02.031. Epub 2010 Feb 16.

13.

Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.

Rubini C, Ruzza P, Spaller MR, Siligardi G, Hussain R, Udugamasooriya DG, Bellanda M, Mammi S, Borgogno A, Calderan A, Cesaro L, Brunati AM, Donella-Deana A.

Biopolymers. 2010;94(3):298-306. doi: 10.1002/bip.21350.

PMID:
19921743
14.

Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.

Li M, Duc AC, Klosi E, Pattabiraman S, Spaller MR, Chow CS.

Biochemistry. 2009 Sep 8;48(35):8299-311. doi: 10.1021/bi900982t.

15.

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.

Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D.

Clin Cancer Res. 2009 Jun 15;15(12):4095-103. doi: 10.1158/1078-0432.CCR-08-2837. Epub 2009 Jun 9. Erratum in: Clin Cancer Res. 2009 Jul 15;15(14):4786. Rupashinghe, Chamila N [corrected to Rupasinghe, Chamila N].

16.

T7 phage display as a method of peptide ligand discovery for PDZ domain proteins.

Sharma SC, Memic A, Rupasinghe CN, Duc AC, Spaller MR.

Biopolymers. 2009;92(3):183-93. doi: 10.1002/bip.21172.

PMID:
19235856
17.

How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.

Memic A, Spaller MR.

Chembiochem. 2008 Nov 24;9(17):2793-5. doi: 10.1002/cbic.200800572. No abstract available.

PMID:
18985647
18.

A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation.

Udugamasooriya DG, Sharma SC, Spaller MR.

Chembiochem. 2008 Jul 2;9(10):1587-9. doi: 10.1002/cbic.200800126. No abstract available.

19.

Conformational constraint in protein ligand design and the inconsistency of binding entropy.

Udugamasooriya DG, Spaller MR.

Biopolymers. 2008 Aug;89(8):653-67. doi: 10.1002/bip.20983.

PMID:
18335423
20.

[GIPC: a new target for therapy in pancreatic adenocarcinoma?].

Muders MH, Baretton GB, Aust DE, Dutta SK, Wang E, Ikeda Y, Spaller MR, Datta K, Mukhopadhyay D.

Verh Dtsch Ges Pathol. 2007;91:286-93. German.

PMID:
18314626
21.

Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.

Sharma SC, Rupasinghe CN, Parisien RB, Spaller MR.

Biochemistry. 2007 Nov 6;46(44):12709-20. Epub 2007 Oct 16.

PMID:
17939682
22.

Bivalent peptides as PDZ domain ligands.

Klosi E, Saro D, Spaller MR.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6147-50. Epub 2007 Sep 12.

23.

A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.

Saro D, Li T, Rupasinghe C, Paredes A, Caspers N, Spaller MR.

Biochemistry. 2007 May 29;46(21):6340-52. Epub 2007 May 3.

24.

Act globally, think locally: systems biology addresses the PDZ domain.

Spaller MR.

ACS Chem Biol. 2006 May 23;1(4):207-10. Review. Erratum in: ACS Chem Biol. 2010 Jul 16;5(7):713.

PMID:
17163673
25.
26.

Monomeric yeast frataxin is an iron-binding protein.

Cook JD, Bencze KZ, Jankovic AD, Crater AK, Busch CN, Bradley PB, Stemmler AJ, Spaller MR, Stemmler TL.

Biochemistry. 2006 Jun 27;45(25):7767-77.

27.

The interplay between structure-based design and combinatorial chemistry.

Rupasinghe CN, Spaller MR.

Curr Opin Chem Biol. 2006 Jun;10(3):188-93. Epub 2006 Apr 17. Review.

PMID:
16616591
28.

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA.

EMBO J. 2006 Apr 19;25(8):1623-34. Epub 2006 Apr 6.

29.

Bridged peptide macrocycles as ligands for PDZ domain proteins.

Udugamasooriya G, Saro D, Spaller MR.

Org Lett. 2005 Mar 31;7(7):1203-6.

PMID:
15787467
30.

(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.

Ukpabi N, Sharma S, Spaller MR, Tsang P.

J Biomol NMR. 2004 Sep;30(1):111-2. No abstract available.

PMID:
15452444
31.

Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands.

Saro D, Klosi E, Paredes A, Spaller MR.

Org Lett. 2004 Sep 30;6(20):3429-32.

PMID:
15387515
32.

Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.

Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF.

Chem Biol. 2004 Apr;11(4):469-73.

33.

Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain.

Li T, Saro D, Spaller MR.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1385-8.

PMID:
15006367
34.
35.

Synthetic strategies in combinatorial chemistry.

Spaller MR, Burger MT, Fardis M, Bartlett PA.

Curr Opin Chem Biol. 1997 Jun;1(1):47-53. Review.

PMID:
9667834
36.
37.

Chromogenic assay for phospholipase C from Bacillus cereus.

Hergenrother PJ, Spaller MR, Haas MK, Martin SF.

Anal Biochem. 1995 Aug 10;229(2):313-6.

PMID:
7485988

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