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Items: 36

1.

The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.

Raselli T, Wyss A, Gonzalez Alvarado MN, Weder B, Mamie C, Spalinger MR, Van Haaften WT, Dijkstra G, Sailer AW, Imenez Silva PH, Wagner CA, Tosevski V, Leibl S, Scharl M, Rogler G, Hausmann M, Misselwitz B.

J Crohns Colitis. 2019 Apr 11. pii: jjz039. doi: 10.1093/ecco-jcc/jjz039. [Epub ahead of print]

PMID:
31220227
2.

Stepwise Development of an in vitro Continuous Fermentation Model for the Murine Caecal Microbiota.

Poeker SA, Lacroix C, de Wouters T, Spalinger MR, Scharl M, Geirnaert A.

Front Microbiol. 2019 May 29;10:1166. doi: 10.3389/fmicb.2019.01166. eCollection 2019.

3.

Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23.

Ulugöl S, Hering L, Manzini R, Montalban Arques A, Gottier C, Lang S, Scharl M, Spalinger MR.

Inflamm Intest Dis. 2019 May;4(1):14-26. doi: 10.1159/000499157. Epub 2019 Apr 10.

4.

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.

Raselli T, Hearn T, Wyss A, Atrott K, Peter A, Frey-Wagner I, Spalinger MR, Maggio EM, Sailer AW, Schmitt J, Schreiner P, Moncsek A, Mertens J, Scharl M, Griffiths WJ, Bueter M, Geier A, Rogler G, Wang Y, Misselwitz B.

J Lipid Res. 2019 Jul;60(7):1270-1283. doi: 10.1194/jlr.M093229. Epub 2019 May 21.

5.

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.

Spalinger MR, Schmidt TS, Schwarzfischer M, Hering L, Atrott K, Lang S, Gottier C, Geirnaert A, Lacroix C, Dai X, Rawlings DJ, Chan AC, von Mering C, Rogler G, Scharl M.

J Clin Invest. 2019 May 20;129(6):2527-2541. doi: 10.1172/JCI123263. eCollection 2019 May 20.

6.

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.

Wyss A, Raselli T, Perkins N, Ruiz F, Schmelczer G, Klinke G, Moncsek A, Roth R, Spalinger MR, Hering L, Atrott K, Lang S, Frey-Wagner I, Mertens JC, Scharl M, Sailer AW, Pabst O, Hersberger M, Pot C, Rogler G, Misselwitz B.

Mucosal Immunol. 2019 May;12(3):733-745. doi: 10.1038/s41385-019-0140-x. Epub 2019 Feb 11.

7.

β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M.

Int J Cancer. 2019 Aug 1;145(3):678-685. doi: 10.1002/ijc.32137. Epub 2019 Jan 29.

PMID:
30653264
8.

Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis.

Spalinger MR, Atrott K, Baebler K, Schwarzfischer M, Melhem H, Peres DR, Lalazar G, Rogler G, Scharl M, Frey-Wagner I.

J Crohns Colitis. 2019 May 27;13(6):785-797. doi: 10.1093/ecco-jcc/jjy213.

PMID:
30590526
9.

Transplantation of Human Intestine Into the Mouse: A Novel Platform for Study of Inflammatory Enterocutaneous Fistulas.

Bruckner RS, Nissim-Eliraz E, Marsiano N, Nir E, Shemesh H, Leutenegger M, Gottier C, Lang S, Spalinger MR, Leibl S, Rogler G, Yagel S, Scharl M, Shpigel NY.

J Crohns Colitis. 2019 May 27;13(6):798-806. doi: 10.1093/ecco-jcc/jjy226.

PMID:
30590414
10.

PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.

Spalinger MR, Scharl M.

Mol Cell Oncol. 2018 Jun 6;5(4):e1465013. doi: 10.1080/23723556.2018.1465013. eCollection 2018.

11.

Eribulin Does Not Prevent Epithelial-to-Mesenchymal Transition in HT-29 Intestinal Epithelial Cells.

Leutenegger M, Bruckner R, Spalinger MR, Lang S, Rogler G, Scharl M.

Inflamm Intest Dis. 2018 Jul;2(4):211-218. doi: 10.1159/000490052. Epub 2018 Jul 10.

12.

The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.

Yilmaz B, Spalinger MR, Biedermann L, Franc Y, Fournier N, Rossel JB, Juillerat P, Rogler G, Macpherson AJ, Scharl M.

PLoS One. 2018 Jul 2;13(7):e0199664. doi: 10.1371/journal.pone.0199664. eCollection 2018.

13.

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Cosin-Roger J, Spalinger MR, Ruiz PA, Stanzel C, Terhalle A, Wolfram L, Melhem H, Atrott K, Lang S, Frey-Wagner I, Fried M, Scharl M, Hausmann M, Rogler G.

PLoS One. 2018 Feb 15;13(2):e0193003. doi: 10.1371/journal.pone.0193003. eCollection 2018.

14.

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.

Spalinger MR, Manzini R, Hering L, Riggs JB, Gottier C, Lang S, Atrott K, Fettelschoss A, Olomski F, Kündig TM, Fried M, McCole DF, Rogler G, Scharl M.

Cell Rep. 2018 Feb 13;22(7):1835-1848. doi: 10.1016/j.celrep.2018.01.052.

15.

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M.

Autophagy. 2017 Sep 2;13(9):1590-1601. doi: 10.1080/15548627.2017.1341453. Epub 2017 Aug 8.

16.

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA.

Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3.

17.

Gastroresistant oral peptide for fluorescence imaging of colonic inflammation.

Luciani P, Estella-Hermoso de Mendoza A, Casalini T, Lang S, Atrott K, Spalinger MR, Pratsinis A, Sobek J, Frey-Wagner I, Schumacher J, Leroux JC, Rogler G.

J Control Release. 2017 Sep 28;262:118-126. doi: 10.1016/j.jconrel.2017.07.024. Epub 2017 Jul 19.

PMID:
28734901
18.

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms.

Melhem H, Spalinger MR, Cosin-Roger J, Atrott K, Lang S, Wojtal KA, Vavricka SR, Rogler G, Frey-Wagner I.

J Crohns Colitis. 2017 Jul 1;11(7):871-884. doi: 10.1093/ecco-jcc/jjx016.

PMID:
28199527
19.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.

20.

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.

Spalinger MR, Zeitz J, Biedermann L, Rossel JB, Sulz MC, Frei P, Scharl S, Vavricka SR, Fried M, Rogler G, Scharl M; Swiss IBD Cohort Study Group.

PLoS One. 2016 Jul 28;11(7):e0160215. doi: 10.1371/journal.pone.0160215. eCollection 2016.

21.

The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis.

Spalinger MR, Scharl M.

United European Gastroenterol J. 2016 Jun;4(3):325-32. doi: 10.1177/2050640615600115. Epub 2015 Aug 6. Review.

22.

Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis.

Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M.

PLoS One. 2016 May 6;11(5):e0154817. doi: 10.1371/journal.pone.0154817. eCollection 2016.

23.

Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.

Kasper SH, Spalinger MR, Leonardi I, Gerstgrasser A, Raselli T, Gottier C, Atrott K, Frey-Wagner I, Fischbeck-Terhalle A, Rogler G, Scharl M.

Digestion. 2016;93(4):249-59. doi: 10.1159/000445289. Epub 2016 Apr 27.

24.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4388.

25.

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.

Spalinger MR, Voegelin M, Biedermann L, Zeitz J, Rossel JB, Sulz MC, Frei P, Scharl S, Vavricka SR, Fried M, Rogler G, Scharl M; Swiss IBD Cohort Study Group.

Digestion. 2016;93(3):182-92. doi: 10.1159/000444479. Epub 2016 Feb 27.

26.

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome.

Ruiz PA, Morón B, Becker HM, Lang S, Atrott K, Spalinger MR, Scharl M, Wojtal KA, Fischbeck-Terhalle A, Frey-Wagner I, Hausmann M, Kraemer T, Rogler G.

Gut. 2017 Jul;66(7):1216-1224. doi: 10.1136/gutjnl-2015-310297. Epub 2016 Feb 4.

27.

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.

Spalinger MR, McCole DF, Rogler G, Scharl M.

World J Gastroenterol. 2016 Jan 21;22(3):1034-44. doi: 10.3748/wjg.v22.i3.1034. Review.

28.

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.

de Vallière C, Wang Y, Eloranta JJ, Vidal S, Clay I, Spalinger MR, Tcymbarevich I, Terhalle A, Ludwig MG, Suply T, Fried M, Kullak-Ublick GA, Frey-Wagner I, Scharl M, Seuwen K, Wagner CA, Rogler G.

Inflamm Bowel Dis. 2015 Jun;21(6):1269-81. doi: 10.1097/MIB.0000000000000375.

29.

A cell type-specific role of protein tyrosine phosphatase non-receptor type 2 in regulating ER stress signalling.

Kasper SH, Spalinger MR, Raselli T, Scharl M.

Digestion. 2015;91(3):248-56. doi: 10.1159/000375459. Epub 2015 Mar 25.

PMID:
25823847
30.

Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.

Spalinger MR, McCole DF, Rogler G, Scharl M.

Inflamm Bowel Dis. 2015 Mar;21(3):645-55. doi: 10.1097/MIB.0000000000000297. Review.

31.

PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis.

Spalinger MR, Kasper S, Chassard C, Raselli T, Frey-Wagner I, Gottier C, Lang S, Atrott K, Vavricka SR, Mair F, Becher B, Lacroix C, Fried M, Rogler G, Scharl M.

Mucosal Immunol. 2015 Jul;8(4):918-29. doi: 10.1038/mi.2014.122. Epub 2014 Dec 10.

PMID:
25492475
32.

Bilberry-derived anthocyanins prevent IFN-γ-induced pro-inflammatory signalling and cytokine secretion in human THP-1 monocytic cells.

Roth S, Spalinger MR, Müller I, Lang S, Rogler G, Scharl M.

Digestion. 2014;90(3):179-89. doi: 10.1159/000366055. Epub 2014 Nov 12.

33.

Crohn's disease: loss of tolerance or a disorder of autophagy?

Spalinger MR, Rogler G, Scharl M.

Dig Dis. 2014;32(4):370-7. doi: 10.1159/000358140. Epub 2014 Jun 23. Review.

34.

A distinct pattern of disease-associated single nucleotide polymorphisms in IBD risk genes in a family with Crohn's disease.

Barthel C, Spalinger MR, Brunner J, Lang S, Fried M, Rogler G, Scharl M.

Eur J Gastroenterol Hepatol. 2014 Jul;26(7):803-6. doi: 10.1097/MEG.0000000000000083.

35.

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.

Spalinger MR, Lang S, Vavricka SR, Fried M, Rogler G, Scharl M.

PLoS One. 2013 Aug 26;8(8):e72384. doi: 10.1371/journal.pone.0072384. eCollection 2013.

36.

Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes.

Spalinger MR, Lang S, Weber A, Frei P, Fried M, Rogler G, Scharl M.

Gastroenterology. 2013 May;144(5):978-988.e10. doi: 10.1053/j.gastro.2013.01.048. Epub 2013 Feb 1.

PMID:
23380085

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