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Items: 42

1.

Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies.

Silbaugh SA, Stengel PW, Cockerham SL, Froelich LL, Bendele AM, Spaethe SM, Sofia MJ, Sawyer JS, Jackson WT.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361(4):397-404.

PMID:
10763854
2.

Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies.

Jackson WT, Froelich LL, Boyd RJ, Schrementi JP, Saussy DL Jr, Schultz RM, Sawyer JS, Sofia MJ, Herron DK, Goodson T Jr, Snyder DW, Pechous PA, Spaethe SM, Roman CR, Fleisch JH.

J Pharmacol Exp Ther. 1999 Jan;288(1):286-94.

PMID:
9862783
3.

The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111).

van Pelt JP, de Jong EM, van Erp PE, Mitchell MI, Marder P, Spaethe SM, van Hooijdonk CA, Kuijpers AL, van de Kerkhof PC.

Biochem Pharmacol. 1997 Apr 4;53(7):1005-12.

PMID:
9174114
4.

The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.

Sofia MJ, Floreancig P, Bach N, Baker SR, Nelson K, Sawyer JS, Baldwin R, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, Saussy DL Jr, Silbaugh SA, Spaethe SM, Stengel PW.

Adv Exp Med Biol. 1997;400A:381-6. No abstract available.

PMID:
9547580
5.

Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma.

Evans DJ, Barnes PJ, Spaethe SM, van Alstyne EL, Mitchell MI, O'Connor BJ.

Thorax. 1996 Dec;51(12):1178-84.

6.

Inhibition of ex vivo neutrophil activation by oral LY293111, a novel leukotriene B4 receptor antagonist.

Marder P, Spaethe SM, Froelich LL, Cerimele BJ, Petersen BH, Tanner T, Lucas RA.

Br J Clin Pharmacol. 1996 Oct;42(4):457-64.

7.

Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor.

Fleisch JH, Armstrong CT, Roman CR, Mihelich ED, Spaethe SM, Jackson WT, Bobbitt JL, Draheim S, Bach NJ, Dillard RD, Martinelli M, Fouts R, Snyder DW.

J Pharmacol Exp Ther. 1996 Jul;278(1):252-7.

PMID:
8764358
9.
10.

Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4.

Munoz NM, Vita AJ, Neeley SP, McAllister K, Spaethe SM, White SR, Leff AR.

J Pharmacol Exp Ther. 1994 Jan;268(1):139-43.

PMID:
8301549
11.

Role of eicosanoids in hyperpnea-induced airway responses in guinea pigs.

Garland A, Jordan JE, Ray DW, Spaethe SM, Alger L, Solway J.

J Appl Physiol (1985). 1993 Dec;75(6):2797-804.

PMID:
8125904
12.

Bronchopulmonary actions of 1-(1,2,3,4-tetrahydro-1-naphthylenyl)-1H-imidazole, nitric acid salt (LY150310), a substituted imidazole, in the guinea pig.

Stengel PW, Dillard RD, Cho HL, Snyder DW, Spaethe SM, Pechous PA, Obenchain RL, Cockerham SL, Silbaugh SA.

J Pharmacol Exp Ther. 1993 Nov;267(2):596-603.

PMID:
8246133
13.

Contraction of guinea pig inferior vena cava by eicosanoids.

Rinkema LE, Roman CR, VanAlstyne EL, Spaethe SM, Fleisch JH.

Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):520-5.

PMID:
8114952
14.

Prostaglandin secretion by guinea pig tracheal epithelial cells caused by eosinophil major basic protein.

White SR, Sigrist KS, Spaethe SM.

Am J Physiol. 1993 Sep;265(3 Pt 1):L234-42.

PMID:
8214083
15.

Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.

White SR, Strek ME, Kulp GV, Spaethe SM, Burch RA, Neeley SP, Leff AR.

J Clin Invest. 1993 May;91(5):2118-25.

16.

Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.

Silbaugh SA, Stengel PW, Cockerham SL, Roman CR, Saussy DL Jr, Spaethe SM, Goodson T Jr, Herron DK, Fleisch JH.

Eur J Pharmacol. 1992 Nov 13;223(1):57-64.

PMID:
1335877
17.

Contributory role of lung pleura to release of anaphylactic mediators from guinea pig lung in response to ovalbumin or A23187.

Wong WS, Spaethe SM, Henry DP, Fleisch JH.

Biochem Pharmacol. 1992 Oct 20;44(8):1609-15.

PMID:
1417984
19.
20.

Topographic distribution of prostaglandin secretion caused by bradykinin in canine tracheal epithelial cells.

White SR, Sigrist KS, Spaethe SM.

Am J Respir Cell Mol Biol. 1992 Apr;6(4):375-81.

PMID:
1550682
21.

Correlation of anti-inflammatory activity with peak tissue rather than peak plasma levels of BF389.

Bendele AM, Ruterbories KJ, Spaethe SM, Benslay DN, Lindstrom TD, Lee SJ, Naismith RW.

J Pharmacol Exp Ther. 1992 Mar;260(3):1194-8.

PMID:
1545387
22.

Effect of age on leukotriene B4 production in guinea pig whole blood.

Spaethe SM, Scaife CL, Pechous PA, VanAlstyne EL.

Biochem Pharmacol. 1992 Feb 18;43(4):837-43.

PMID:
1311591
23.

Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors.

Spaethe SM, Snyder DW, Pechous PA, Clarke T, VanAlstyne EL.

Biochem Pharmacol. 1992 Jan 22;43(2):377-82.

PMID:
1310855
24.

Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.

Bendele AM, Benslay DN, Hom JT, Spaethe SM, Ruterbories KJ, Lindstrom TD, Lee SJ, Naismith RW.

J Pharmacol Exp Ther. 1992 Jan;260(1):300-5.

PMID:
1309875
25.

A kinetic assay for eosinophil peroxidase activity in eosinophils and eosinophil conditioned media.

White SR, Kulp GV, Spaethe SM, Van Alstyne E, Leff AR.

J Immunol Methods. 1991 Nov 22;144(2):257-63.

PMID:
1660059
26.

Anti-inflammatory activity of pergolide, a dopamine receptor agonist.

Bendele AM, Spaethe SM, Benslay DN, Bryant HU.

J Pharmacol Exp Ther. 1991 Oct;259(1):169-75.

PMID:
1681083
27.

Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production.

Schultz RM, Marder P, Spaethe SM, Herron DK, Sofia MJ.

Prostaglandins Leukot Essent Fatty Acids. 1991 Aug;43(4):267-71.

PMID:
1658812
28.

Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.

Rinkema LE, Roman CR, Russell WL, Spaethe SM, Bemis KG, Henry DP, Marshall WS, Fleisch JH.

J Pharm Pharmacol. 1990 Sep;42(9):620-5.

PMID:
1706765
29.

Essential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts.

Freed MS, Spaethe SM, Lefkowith JB, Saffitz JE, Needleman P.

Prostaglandins. 1989 Jul;38(1):33-44.

PMID:
2546188
30.

Effect of cobalt protoporphyrin on hepatic drug-metabolizing enzymes. Specificity for cytochrome P-450.

Spaethe SM, Jollow DJ.

Biochem Pharmacol. 1989 Jun 15;38(12):2027-38.

PMID:
2742604
32.

Differentiation in vivo of the sequential blood cell invasion following ureter obstruction of the rabbit kidney.

Mathias CJ, Welch MJ, Schwartz DB, Spaethe SM, Needleman P.

Int J Rad Appl Instrum B. 1989;16(1):25-32.

PMID:
2714997
33.

Essential fatty acid deficiency reduces the inflammatory cell invasion in rabbit hydronephrosis resulting in suppression of the exaggerated eicosanoid production.

Spaethe SM, Freed MS, De Schryver-Kecskemeti K, Lefkowith JB, Needleman P.

J Pharmacol Exp Ther. 1988 Jun;245(3):1088-94.

PMID:
3133463
34.

Mechanism of fasting-induced suppression of acetaminophen glucuronidation in the rat.

Price VF, Schulte JM, Spaethe SM, Jollow DJ.

Adv Exp Med Biol. 1986;197:697-706.

PMID:
2945409
35.

Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release.

Fleisch JH, Haisch KD, Spaethe SM, Rinkema LE, Cullinan GJ, Schmidt MJ, Marshall WS.

J Pharmacol Exp Ther. 1984 Jun;229(3):681-9.

PMID:
6202867
36.
37.

Schultz-Dale reaction in mouse trachea.

Koppel GA, Haisch KD, Spaethe SM, Schmidtke JR, Fleisch JH.

J Pharmacol Methods. 1981 Aug;6(1):39-43.

PMID:
7265992
39.

Drug-induced effects on the longitudinal smooth muscle of rat bronchus.

Fleisch JH, Spaethe SM, Johnson WD.

Proc Soc Exp Biol Med. 1980 Jun;164(2):196-8. No abstract available.

PMID:
7393925
40.

Ethanol inhibition of antigen-induced histamine release from guinea pig lung: correlation with intracellular levels of cyclic nucleotides.

Schmidt MJ, Truex LL, Hooker CS, Spaethe SM, Fleisch JH.

Life Sci. 1979 Jun 18;24(25):2321-31. No abstract available.

PMID:
90324
41.

Computerization of a bioassay: quantitation of slow reacting substance of anaphylaxis (SRS-A).

Fleisch JH, Zaborowsky BR, Cerimele BJ, Spaethe SM.

J Pharmacol Exp Ther. 1979 May;209(2):238-43.

PMID:
86610
42.

Improved methodology for evaluating release of mediators of anaphylaxis from guinea pig lung.

Fleisch JH, Spaethe SM.

Monogr Allergy. 1979;14:185-8. No abstract available.

PMID:
91947

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