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Items: 1 to 50 of 76

1.

Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial.

Cox MC, Castiello L, Mattei M, Santodonato L, D'Agostino G, Muraro E, Martorelli D, Lapenta C, Di Napoli A, Di Landro F, Cangemi M, Pavan A, Castaldo P, Hohaus S, Donati S, Montefiore E, Berdini C, Carlei D, Monque DM, Ruco L, Prosperi D, Tafuri A, Spadaro F, Sestili P, Spada M, Dolcetti R, Santini SM, Rozera C, Aricò E, Capone I, Belardelli F.

Clin Cancer Res. 2019 Sep 1;25(17):5231-5241. doi: 10.1158/1078-0432.CCR-19-0709. Epub 2019 Jun 6.

PMID:
31171545
2.

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis.

Lande R, Lee EY, Palazzo R, Marinari B, Pietraforte I, Santos GS, Mattenberger Y, Spadaro F, Stefanantoni K, Iannace N, Dufour AM, Falchi M, Bianco M, Botti E, Bianchi L, Alvarez M, Riccieri V, Truchetet ME, C L Wong G, Chizzolini C, Frasca L.

Nat Commun. 2019 May 1;10(1):1731. doi: 10.1038/s41467-019-09683-z.

3.

Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer.

Chellini L, Caprara V, Spadaro F, Sestito R, Bagnato A, Rosanò L.

Matrix Biol. 2019 Aug;81:17-33. doi: 10.1016/j.matbio.2018.10.005. Epub 2018 Oct 25.

4.

Anti-LL37 Antibodies Are Present in Psoriatic Arthritis (PsA) Patients: New Biomarkers in PsA.

Frasca L, Palazzo R, Chimenti MS, Alivernini S, Tolusso B, Bui L, Botti E, Giunta A, Bianchi L, Petricca L, Auteri SE, Spadaro F, Fonti GL, Falchi M, Evangelista A, Marinari B, Pietraforte I, Spinelli FR, Colasanti T, Alessandri C, Conti F, Gremese E, Costanzo A, Valesini G, Perricone R, Lande R.

Front Immunol. 2018 Sep 12;9:1936. doi: 10.3389/fimmu.2018.01936. eCollection 2018.

5.

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L.

Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8.

6.

hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process.

Di Modugno F, Caprara V, Chellini L, Tocci P, Spadaro F, Ferrandina G, Sacconi A, Blandino G, Nisticò P, Bagnato A, Rosanò L.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3132-3137. doi: 10.1073/pnas.1715998115. Epub 2018 Feb 8.

7.

Understanding Complex Tribofilms by Means of H3BO3-B2O3 Model Glasses.

Spadaro F, Rossi A, Ramakrishna SN, Lainé E, Woodward P, Spencer ND.

Langmuir. 2018 Feb 13;34(6):2219-2234. doi: 10.1021/acs.langmuir.7b01795. Epub 2018 Jan 30.

PMID:
29334611
8.

Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model.

Paris L, Podo F, Spadaro F, Abalsamo L, Pisanu ME, Ricci A, Cecchetti S, Altabella L, Buoncervello M, Lozneanu L, Bagnoli M, Ramoni C, Canevari S, Mezzanzanica D, Iorio E, Canese R.

Oncotarget. 2017 Jul 5;8(33):55022-55038. doi: 10.18632/oncotarget.18992. eCollection 2017 Aug 15.

9.

Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection.

Spadaro F, Cecchetti S, Fantuzzi L.

Int J Mol Sci. 2017 Jun 29;18(7). pii: E1390. doi: 10.3390/ijms18071390. Review.

10.

Phospholipases: at the crossroads of the immune system and the pathogenesis of HIV-1 infection.

Cecchetti S, Spadaro F, Gessani S, Podo F, Fantuzzi L.

J Leukoc Biol. 2017 Jan;101(1):53-75. doi: 10.1189/jlb.3RU0316-148RR. Epub 2016 Nov 1. Review.

PMID:
27803127
11.

Key Players in Choline Metabolic Reprograming in Triple-Negative Breast Cancer.

Iorio E, Caramujo MJ, Cecchetti S, Spadaro F, Carpinelli G, Canese R, Podo F.

Front Oncol. 2016 Sep 30;6:205. eCollection 2016. Review.

12.

Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy.

Podo F, Paris L, Cecchetti S, Spadaro F, Abalsamo L, Ramoni C, Ricci A, Pisanu ME, Sardanelli F, Canese R, Iorio E.

Front Oncol. 2016 Aug 2;6:171. doi: 10.3389/fonc.2016.00171. eCollection 2016.

13.

NK Cell Activation in the Antitumor Response Induced by IFN-α Dendritic Cells Loaded with Apoptotic Cells from Follicular Lymphoma Patients.

Lapenta C, Donati S, Spadaro F, Castaldo P, Belardelli F, Cox MC, Santini SM.

J Immunol. 2016 Aug 1;197(3):795-806. doi: 10.4049/jimmunol.1600262. Epub 2016 Jun 29.

14.

The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis.

Spadaro F, Scoffone VC, Chiarelli LR, Fumagalli M, Buroni S, Riccardi G, Forneris F.

Biochemistry. 2016 Jun 14;55(23):3241-50. doi: 10.1021/acs.biochem.6b00178. Epub 2016 Jun 2.

PMID:
27198181
15.

Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.

Semprucci E, Tocci P, Cianfrocca R, Sestito R, Caprara V, Veglione M, Castro VD, Spadaro F, Ferrandina G, Bagnato A, Rosanò L.

Oncogene. 2016 Jun 30;35(26):3432-42. doi: 10.1038/onc.2015.403. Epub 2015 Nov 2.

PMID:
26522724
16.

Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.

Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T.

Antimicrob Agents Chemother. 2014 Dec;58(12):7424-9. doi: 10.1128/AAC.03800-14. Epub 2014 Sep 29.

17.

Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia.

Scoffone VC, Spadaro F, Udine C, Makarov V, Fondi M, Fani R, De Rossi E, Riccardi G, Buroni S.

Antimicrob Agents Chemother. 2014;58(4):2415-7. doi: 10.1128/AAC.02438-13. Epub 2014 Jan 6.

18.

Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages.

Spadaro F, Cecchetti S, Purificato C, Sabbatucci M, Podo F, Ramoni C, Gessani S, Fantuzzi L.

PLoS One. 2013;8(3):e59705. doi: 10.1371/journal.pone.0059705. Epub 2013 Mar 28.

19.

IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment.

Mattei F, Schiavoni G, Sestili P, Spadaro F, Fragale A, Sistigu A, Lucarini V, Spada M, Sanchez M, Scala S, Battistini A, Belardelli F, Gabriele L.

Neoplasia. 2012 Dec;14(12):1223-35.

20.

Hepatitis C virus core antigen test in monitoring of dialysis patients.

Li Cavoli G, Zagarrigo C, Schillaci O, Servillo F, Tralongo A, Coglitore M, Spadaro F, Scimeca C, Li Destri N, Rotolo U.

Hepat Res Treat. 2012;2012:832021. doi: 10.1155/2012/832021. Epub 2012 Dec 4.

21.

Volatile composition and biological activity of key lime Citrus aurantifolia essential oil.

Spadaro F, Costa R, Circosta C, Occhiuto F.

Nat Prod Commun. 2012 Nov;7(11):1523-6.

PMID:
23285822
22.

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.

Rosanò L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio AM, Natali PG, Bagnato A.

Oncogene. 2013 Oct 17;32(42):5066-77. doi: 10.1038/onc.2012.527. Epub 2012 Dec 3.

PMID:
23208497
23.
24.

Immune surveillance properties of human NK cell-derived exosomes.

Lugini L, Cecchetti S, Huber V, Luciani F, Macchia G, Spadaro F, Paris L, Abalsamo L, Colone M, Molinari A, Podo F, Rivoltini L, Ramoni C, Fais S.

J Immunol. 2012 Sep 15;189(6):2833-42. doi: 10.4049/jimmunol.1101988. Epub 2012 Aug 17.

25.

Insulin-like growth factor-II is a useful marker to detect hepatocellular carcinoma?

Morace C, Cucunato M, Bellerone R, De Caro G, Crinò S, Fortiguerra A, Spadaro F, Zirilli A, Alibrandi A, Consolo P, Luigiano C, Resta ML, Ferraù O, Spadaro A.

Eur J Intern Med. 2012 Sep;23(6):e157-61. doi: 10.1016/j.ejim.2012.04.014. Epub 2012 May 24.

PMID:
22863442
26.

Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells.

Abalsamo L, Spadaro F, Bozzuto G, Paris L, Cecchetti S, Lugini L, Iorio E, Molinari A, Ramoni C, Podo F.

Breast Cancer Res. 2012 Mar 19;14(2):R50.

27.

IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.

Spadaro F, Lapenta C, Donati S, Abalsamo L, Barnaba V, Belardelli F, Santini SM, Ferrantini M.

Blood. 2012 Feb 9;119(6):1407-17. doi: 10.1182/blood-2011-06-363564. Epub 2011 Dec 19.

28.

Rhodiola rosea extract protects human cortical neurons against glutamate and hydrogen peroxide-induced cell death through reduction in the accumulation of intracellular calcium.

Palumbo DR, Occhiuto F, Spadaro F, Circosta C.

Phytother Res. 2012 Jun;26(6):878-83. doi: 10.1002/ptr.3662. Epub 2011 Nov 15.

PMID:
22086763
29.

Exogenous HIV-1 Nef upsets the IFN-γ-induced impairment of human intestinal epithelial integrity.

Quaranta MG, Vincentini O, Felli C, Spadaro F, Silano M, Moricoli D, Giordani L, Viora M.

PLoS One. 2011;6(8):e23442. doi: 10.1371/journal.pone.0023442. Epub 2011 Aug 8.

30.

Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa.

Del Porto P, Cifani N, Guarnieri S, Di Domenico EG, Mariggiò MA, Spadaro F, Guglietta S, Anile M, Venuta F, Quattrucci S, Ascenzioni F.

PLoS One. 2011;6(5):e19970. doi: 10.1371/journal.pone.0019970. Epub 2011 May 18.

31.

Human melanoma cells express FGFR/Src/Rho signaling that entails an adhesion-independent caveolin-1 membrane association.

Fecchi K, Travaglione S, Spadaro F, Quattrini A, Parolini I, Piccaro G, Raggi C, Fabbri A, Felicetti F, Carè A, Fiorentini C, Sargiacomo M.

Int J Cancer. 2012 Mar 15;130(6):1273-83. doi: 10.1002/ijc.26092. Epub 2011 May 25.

32.

Type I IFNs control antigen retention and survival of CD8α(+) dendritic cells after uptake of tumor apoptotic cells leading to cross-priming.

Lorenzi S, Mattei F, Sistigu A, Bracci L, Spadaro F, Sanchez M, Spada M, Belardelli F, Gabriele L, Schiavoni G.

J Immunol. 2011 May 1;186(9):5142-50. doi: 10.4049/jimmunol.1004163. Epub 2011 Mar 25.

33.

Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

Santini SM, Lapenta C, Donati S, Spadaro F, Belardelli F, Ferrantini M.

PLoS One. 2011 Feb 28;6(2):e17364. doi: 10.1371/journal.pone.0017364.

34.

Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis.

Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F, Sanchez M, Lorenzi S, D'Urso MT, Belardelli F, Gabriele L, Proietti E, Bracci L.

Cancer Res. 2011 Feb 1;71(3):768-78. doi: 10.1158/0008-5472.CAN-10-2788. Epub 2010 Dec 13.

35.

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.

Paris L, Cecchetti S, Spadaro F, Abalsamo L, Lugini L, Pisanu ME, Iorio E, Natali PG, Ramoni C, Podo F.

Breast Cancer Res. 2010;12(3):R27. doi: 10.1186/bcr2575. Epub 2010 May 12.

36.

The effect of Na(2)CO(3), NaF and NH(4)OH on the stability and release behavior of sol-gel derived silica xerogels embedded with bioactive compounds.

Morpurgo M, Teoli D, Pignatto M, Attrezzi M, Spadaro F, Realdon N.

Acta Biomater. 2010 Jun;6(6):2246-53. doi: 10.1016/j.actbio.2009.12.021. Epub 2009 Dec 24.

PMID:
20035908
37.

LOX-1 as a natural IFN-alpha-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells.

Parlato S, Romagnoli G, Spadaro F, Canini I, Sirabella P, Borghi P, Ramoni C, Filesi I, Biocca S, Gabriele L, Belardelli F.

Blood. 2010 Feb 25;115(8):1554-63. doi: 10.1182/blood-2009-07-234468. Epub 2009 Dec 15.

38.

Caveolin-1 tumor-promoting role in human melanoma.

Felicetti F, Parolini I, Bottero L, Fecchi K, Errico MC, Raggi C, Biffoni M, Spadaro F, Lisanti MP, Sargiacomo M, Carè A.

Int J Cancer. 2009 Oct 1;125(7):1514-22. doi: 10.1002/ijc.24451.

39.

Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells.

Spadaro F, Ramoni C, Mezzanzanica D, Miotti S, Alberti P, Cecchetti S, Iorio E, Dolo V, Canevari S, Podo F.

Cancer Res. 2008 Aug 15;68(16):6541-9. doi: 10.1158/0008-5472.CAN-07-6763.

40.

Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages.

Fantuzzi L, Spadaro F, Purificato C, Cecchetti S, Podo F, Belardelli F, Gessani S, Ramoni C.

Blood. 2008 Apr 1;111(7):3355-63. doi: 10.1182/blood-2007-08-104901. Epub 2008 Jan 18.

41.

Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells.

Cecchetti S, Spadaro F, Lugini L, Podo F, Ramoni C.

Eur J Immunol. 2007 Oct;37(10):2912-22.

42.

Expression and role of phosphatidylcholine-specific phospholipase C in human NK and T lymphocyte subsets.

Spadaro F, Cecchetti S, Sanchez M, Ausiello CM, Podo F, Ramoni C.

Eur J Immunol. 2006 Dec;36(12):3277-87.

43.

Alterations of choline phospholipid metabolism in ovarian tumor progression.

Iorio E, Mezzanzanica D, Alberti P, Spadaro F, Ramoni C, D'Ascenzo S, Millimaggi D, Pavan A, Dolo V, Canevari S, Podo F.

Cancer Res. 2005 Oct 15;65(20):9369-76.

44.

IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages.

Puddu P, Carollo M, Pietraforte I, Spadaro F, Tombesi M, Ramoni C, Belardelli F, Gessani S.

J Leukoc Biol. 2005 Sep;78(3):686-95. Epub 2005 Jun 10.

PMID:
15951352
45.

Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts.

Ramoni C, Spadaro F, Barletta B, Dupuis ML, Podo F.

Exp Cell Res. 2004 Oct 1;299(2):370-82.

PMID:
15350536
46.

Dendritic cells derived from BCG-infected precursors induce Th2-like immune response.

Martino A, Sacchi A, Sanarico N, Spadaro F, Ramoni C, Ciaramella A, Pucillo LP, Colizzi V, Vendetti S.

J Leukoc Biol. 2004 Oct;76(4):827-34. Epub 2004 Jul 7.

PMID:
15240755
47.

Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state.

Calabrese V, Scapagnini G, Ravagna A, Colombrita C, Spadaro F, Butterfield DA, Giuffrida Stella AM.

Mech Ageing Dev. 2004 Apr;125(4):325-35.

PMID:
15063109
48.

HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells.

Quaranta MG, Mattioli B, Spadaro F, Straface E, Giordani L, Ramoni C, Malorni W, Viora M.

FASEB J. 2003 Nov;17(14):2025-36.

PMID:
14597672
49.

Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells.

Iorio E, Di Vito M, Spadaro F, Ramoni C, Lococo E, Carnevale R, Lenti L, Strom R, Podo F.

Biochim Biophys Acta. 2003 Oct 20;1634(1-2):1-14.

PMID:
14563408
50.

Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages.

Fantuzzi L, Spadaro F, Vallanti G, Canini I, Ramoni C, Vicenzi E, Belardelli F, Poli G, Gessani S.

Blood. 2003 Oct 1;102(7):2334-7. Epub 2003 Jun 12.

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