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Items: 34


Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.

Cook JA, Naz S, Anver MR, Sowers AL, Fabre K, Krishna MC, Mitchell JB.

Radiat Res. 2018 May;189(5):490-496. doi: 10.1667/RR14987.1. Epub 2018 Mar 12.


SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers AL, Hernandez L, Mitchell JB, Annunziata CM, Chen Z, Van Waes C.

Cancer Res. 2016 Sep 15;76(18):5442-5454. doi: 10.1158/0008-5472.CAN-15-3317. Epub 2016 Jul 28.


Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD.

Cancer Res. 2016 Mar 15;76(6):1569-77. doi: 10.1158/0008-5472.CAN-15-2416. Epub 2016 Feb 15.


NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.

Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA.

Cancer Res. 2015 Jul 15;75(14):2788-99. doi: 10.1158/0008-5472.CAN-14-3011. Epub 2015 May 19.


The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.

Kim CH, Mitchell JB, Bursill CA, Sowers AL, Thetford A, Cook JA, van Reyk DM, Davies MJ.

Atherosclerosis. 2015 May;240(1):234-41. doi: 10.1016/j.atherosclerosis.2015.03.012. Epub 2015 Mar 16.


Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.

Leiker AJ, DeGraff W, Choudhuri R, Sowers AL, Thetford A, Cook JA, Van Waes C, Mitchell JB.

Clin Cancer Res. 2015 Jun 15;21(12):2792-801. doi: 10.1158/1078-0432.CCR-14-3279. Epub 2015 Feb 27.


PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer.

Herzog A, Bian Y, Vander Broek R, Hall B, Coupar J, Cheng H, Sowers AL, Cook JD, Mitchell JB, Chen Z, Kulkarni AB, Van Waes C.

Clin Cancer Res. 2013 Jul 15;19(14):3808-19. doi: 10.1158/1078-0432.CCR-12-2716. Epub 2013 May 2.


Metabolomics reveals that tumor xenografts induce liver dysfunction.

Li F, Patterson AD, Krausz KW, Jiang C, Bi H, Sowers AL, Cook JA, Mitchell JB, Gonzalez FJ.

Mol Cell Proteomics. 2013 Aug;12(8):2126-35. doi: 10.1074/mcp.M113.028324. Epub 2013 May 1.


The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

Mitchell JB, Anver MR, Sowers AL, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA.

Cancer Res. 2012 Sep 15;72(18):4846-55. doi: 10.1158/0008-5472.CAN-12-1879. Epub 2012 Jul 17.


Pharmacological protection from radiation ± cisplatin-induced oral mucositis.

Cotrim AP, Yoshikawa M, Sunshine AN, Zheng C, Sowers AL, Thetford AD, Cook JA, Mitchell JB, Baum BJ.

Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1284-90. doi: 10.1016/j.ijrobp.2011.09.026. Epub 2011 Dec 22.


The effects of resveratrol and selected metabolites on the radiation and antioxidant response.

Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.

Cancer Biol Ther. 2011 Nov 15;12(10):915-23. doi: 10.4161/cbt.12.10.17714. Epub 2011 Nov 15.


A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

Davis RM, Sowers AL, DeGraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2011 Aug 1;51(3):780-90. doi: 10.1016/j.freeradbiomed.2011.05.019. Epub 2011 May 25.


Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.

Matsumoto A, Matsumoto K, Matsumoto S, Hyodo F, Sowers AL, Koscielniak JW, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Biol Pharm Bull. 2011;34(1):142-5.


Inhibition of adipogenesis by Tempol in 3T3-L1 cells.

Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2010 Aug 15;49(4):667-73. doi: 10.1016/j.freeradbiomed.2010.05.028. Epub 2010 Jun 16.


Evaluation of the fullerene compound DF-1 as a radiation protector.

Brown AP, Chung EJ, Urick ME, Shield WP 3rd, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.

Radiat Oncol. 2010 May 11;5:34. doi: 10.1186/1748-717X-5-34.


In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA.

Clin Cancer Res. 2010 Apr 1;16(7):2076-84. doi: 10.1158/1078-0432.CCR-09-3277. Epub 2010 Mar 16.


Halofuginone mediated protection against radiation-induced leg contracture.

Ishii H, Choudhuri R, Mathias A, Sowers AL, Flanders KC, Cook JA, Mitchell JB.

Int J Oncol. 2009 Aug;35(2):315-9.


Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging.

Hyodo F, Soule BP, Matsumoto K, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB.

J Pharm Pharmacol. 2008 Aug;60(8):1049-60. doi: 10.1211/jpp.60.8.0011. Review.


Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging.

Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB.

Clin Cancer Res. 2007 Aug 15;13(16):4928-33.


Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD.

Br J Pharmacol. 2007 May;151(1):63-72. Epub 2007 Mar 12.


The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.

Matsumoto K, Szajek L, Krishna MC, Cook JA, Seidel J, Grimes K, Carson J, Sowers AL, English S, Green MV, Bacharach SL, Eckelman WC, Mitchell JB.

Int J Oncol. 2007 Apr;30(4):873-81.


Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo.

Cook JA, Chuang EY, Tsai MH, Coffin D, Degraff W, Sowers AL, Mitchell JB.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1263-72.


The influence of tumor oxygenation on (18)F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET).

Chan LW, Hapdey S, English S, Seidel J, Carson J, Sowers AL, Krishna MC, Green MV, Mitchell JB, Bacharach SL.

Radiat Oncol. 2006 Feb 28;1:3.


High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.

Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC.

Clin Cancer Res. 2006 Apr 15;12(8):2455-62.


Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.

Matsumoto A, Matsumoto S, Sowers AL, Koscielniak JW, Trigg NJ, Kuppusamy P, Mitchell JB, Subramanian S, Krishna MC, Matsumoto K.

Magn Reson Med. 2005 Dec;54(6):1530-5.


Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.

Cotrim AP, Sowers AL, Lodde BM, Vitolo JM, Kingman A, Russo A, Mitchell JB, Baum BJ.

Clin Cancer Res. 2005 Oct 15;11(20):7564-8.


Evaluation of radiation-induced oral mucositis by optical coherence tomography.

Muanza TM, Cotrim AP, McAuliffe M, Sowers AL, Baum BJ, Cook JA, Feldchtein F, Amazeen P, Coleman CN, Mitchell JB.

Clin Cancer Res. 2005 Jul 15;11(14):5121-7.


Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging.

Matsumoto S, Utsumi H, Aravalluvan T, Matsumoto K, Matsumoto A, Devasahayam N, Sowers AL, Mitchell JB, Subramanian S, Krishna MC.

Magn Reson Med. 2005 Jul;54(1):213-7.


Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.

Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.

Clin Cancer Res. 2004 Nov 15;10(22):7712-20.


CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

Mamura M, Lee W, Sullivan TJ, Felici A, Sowers AL, Allison JP, Letterio JJ.

Blood. 2004 Jun 15;103(12):4594-601. Epub 2004 Mar 11.


The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model.

Vitolo JM, Cotrim AP, Sowers AL, Russo A, Wellner RB, Pillemer SR, Mitchell JB, Baum BJ.

Clin Cancer Res. 2004 Mar 1;10(5):1807-12.


Influence of body temperature on the BOLD effect in murine SCC tumors.

Reijnders K, English SJ, Krishna MC, Cook JA, Sowers AL, Mitchell JB, Zhang Y.

Magn Reson Med. 2004 Feb;51(2):389-93.


A low molecular weight antioxidant decreases weight and lowers tumor incidence.

Mitchell JB, Xavier S, DeLuca AM, Sowers AL, Cook JA, Krishna MC, Hahn SM, Russo A.

Free Radic Biol Med. 2003 Jan 1;34(1):93-102.


Urinary Bladder Catheterization of Female Mice and Rats.

St Clair MB, Sowers AL, Davis JA, Rhodes LL.

Contemp Top Lab Anim Sci. 1999 May;38(3):78-79.


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