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Items: 9

1.

Macrolactamization Approaches to Arylomycin Antibiotics Core.

Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F.

Org Lett. 2019 Jan 4;21(1):147-151. doi: 10.1021/acs.orglett.8b03603. Epub 2018 Dec 19.

PMID:
30565949
2.

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines.

Zhang H, Li BX, Wong B, Stumpf A, Sowell CG, Gosselin F.

J Org Chem. 2019 Apr 19;84(8):4796-4802. doi: 10.1021/acs.joc.8b02751. Epub 2018 Dec 27.

PMID:
30543748
3.

Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody-Antibiotic Conjugate.

Linghu X, Segraves NL, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig SG, Gosselin F.

Chemistry. 2018 Feb 26;24(12):2837-2840. doi: 10.1002/chem.201705392. Epub 2017 Dec 8.

PMID:
29164727
4.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Sowell CG, Wang X, Wong H, Xiong JM, Xu J, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7. doi: 10.1016/j.bmcl.2015.01.032. Epub 2015 Feb 7.

PMID:
25701252
5.

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.

Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8.

PMID:
21742900
6.

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.

Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.

J Immunol. 2003 Mar 1;170(5):2647-54.

7.

The novel glycolipid RC-552 attenuates myocardial stunning and reduces infarct size in dogs.

Elliott GT, Sowell CG, Walker EB, Weber PA, Moore J, Gross GJ.

J Mol Cell Cardiol. 2000 Jul;32(7):1327-39.

PMID:
10860773
8.

3-O-Desacyl monophosphoryl lipid A derivatives: synthesis and immunostimulant activities.

Johnson DA, Keegan DS, Sowell CG, Livesay MT, Johnson CL, Taubner LM, Harris A, Myers KR, Thompson JD, Gustafson GL, Rhodes MJ, Ulrich JT, Ward JR, Yorgensen YM, Cantrell JL, Brookshire VG.

J Med Chem. 1999 Nov 4;42(22):4640-9.

PMID:
10579826
9.

Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).

Johnson DA, Sowell CG, Johnson CL, Livesay MT, Keegan DS, Rhodes MJ, Ulrich JT, Ward JR, Cantrell JL, Brookshire VG.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2273-8.

PMID:
10465560

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