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Items: 10


Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes.

Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C.

J Virol. 2019 Aug 14. pii: JVI.01118-19. doi: 10.1128/JVI.01118-19. [Epub ahead of print]


Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN.

Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30.


Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation.

Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y.

Mol Cell. 2018 Jan 4;69(1):62-74.e4. doi: 10.1016/j.molcel.2017.11.031. Epub 2017 Dec 21.


Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.

Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M.

J Virol. 2016 May 27;90(12):5808-5823. doi: 10.1128/JVI.03116-15. Print 2016 Jun 15.


The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes.

Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J.

J Biol Chem. 2016 May 27;291(22):11809-19. doi: 10.1074/jbc.M116.721647. Epub 2016 Mar 18.


A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.

Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. doi: 10.1073/pnas.1524213113. Epub 2016 Feb 8.


SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

Sowd GA, Mody D, Eggold J, Cortez D, Friedman KL, Fanning E.

PLoS Pathog. 2014 Dec 4;10(12):e1004536. doi: 10.1371/journal.ppat.1004536. eCollection 2014 Dec.


ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication.

Sowd GA, Li NY, Fanning E.

PLoS Pathog. 2013;9(4):e1003283. doi: 10.1371/journal.ppat.1003283. Epub 2013 Apr 4.


A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNA.

Sowd GA, Fanning E.

PLoS Pathog. 2012;8(11):e1002994. doi: 10.1371/journal.ppat.1002994. Epub 2012 Nov 8. Review. No abstract available.


Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase α-primase.

Zhou B, Arnett DR, Yu X, Brewster A, Sowd GA, Xie CL, Vila S, Gai D, Fanning E, Chen XS.

J Biol Chem. 2012 Aug 3;287(32):26854-66. doi: 10.1074/jbc.M112.363655. Epub 2012 Jun 14.

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