Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51


Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.

Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N.

J Cell Biol. 2019 Feb 4;218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2.


IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex.

Pua KH, Stiles DT, Sowa ME, Verdine GL.

Cell Rep. 2017 Jan 10;18(2):432-442. doi: 10.1016/j.celrep.2016.12.030.


A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS.

Sci Rep. 2016 Jun 3;6:27114. doi: 10.1038/srep27114.


The BioPlex Network: A Systematic Exploration of the Human Interactome.

Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, Dong R, Guarani V, Vaites LP, Ordureau A, Rad R, Erickson BK, Wühr M, Chick J, Zhai B, Kolippakkam D, Mintseris J, Obar RA, Harris T, Artavanis-Tsakonas S, Sowa ME, De Camilli P, Paulo JA, Harper JW, Gygi SP.

Cell. 2015 Jul 16;162(2):425-440. doi: 10.1016/j.cell.2015.06.043.


Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.

Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18631-6. doi: 10.1073/pnas.1422488112. Epub 2014 Dec 15.


Prevention of metabolic decompensation in an infant with mutase deficient methylmalonic aciduria undergoing cardiopulmonary bypass.

Wang RY, Chang RC, Sowa ME, Chang AC, Abdenur JE.

World J Pediatr. 2014 Feb;10(1):83-5. doi: 10.1007/s12519-014-0458-0. Epub 2014 Jan 25.


The histone demethylase LSD1/KDM1A promotes the DNA damage response.

Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y.

J Cell Biol. 2013 Nov 11;203(3):457-70. doi: 10.1083/jcb.201302092.


Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.

Nature. 2013 Apr 18;496(7445):372-6. doi: 10.1038/nature12043. Epub 2013 Mar 17.


Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

Martínez-Noël G, Galligan JT, Sowa ME, Arndt V, Overton TM, Harper JW, Howley PM.

Mol Cell Biol. 2012 Aug;32(15):3095-106. doi: 10.1128/MCB.00201-12. Epub 2012 May 29.


Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.

Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1473-80. doi: 10.1073/pnas.1205991109. Epub 2012 Apr 30.


M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.

Ma H, Chen H, Guo X, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y, Shi Y.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4828-33. doi: 10.1073/pnas.1116349109. Epub 2012 Mar 12.


Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.

White EA, Sowa ME, Tan MJ, Jeudy S, Hayes SD, Santha S, Münger K, Harper JW, Howley PM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E260-7. doi: 10.1073/pnas.1116776109. Epub 2012 Jan 9.


Defining human ERAD networks through an integrative mapping strategy.

Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR.

Nat Cell Biol. 2011 Nov 27;14(1):93-105. doi: 10.1038/ncb2383.


DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.

Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y.

Mol Cell. 2011 Nov 4;44(3):373-84. doi: 10.1016/j.molcel.2011.08.039.


Evaluation of HCD- and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics.

Jedrychowski MP, Huttlin EL, Haas W, Sowa ME, Rad R, Gygi SP.

Mol Cell Proteomics. 2011 Dec;10(12):M111.009910. doi: 10.1074/mcp.M111.009910. Epub 2011 Sep 13.


Systematic and quantitative assessment of the ubiquitin-modified proteome.

Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.

Mol Cell. 2011 Oct 21;44(2):325-40. doi: 10.1016/j.molcel.2011.08.025. Epub 2011 Sep 8.


Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

Lee PC, Sowa ME, Gygi SP, Harper JW.

Mol Cell. 2011 Aug 5;43(3):392-405. doi: 10.1016/j.molcel.2011.05.034.


A large-scale method to measure absolute protein phosphorylation stoichiometries.

Wu R, Haas W, Dephoure N, Huttlin EL, Zhai B, Sowa ME, Gygi SP.

Nat Methods. 2011 Jul 3;8(8):677-83. doi: 10.1038/nmeth.1636.


A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW, Elledge SJ.

Science. 2011 Jun 10;332(6035):1313-7. doi: 10.1126/science.1203430.


An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.

Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A.

PLoS Biol. 2011 May;9(5):e1001060. doi: 10.1371/journal.pbio.1001060. Epub 2011 May 10.


The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM.

Mol Cell Biol. 2011 Jul;31(13):2641-52. doi: 10.1128/MCB.01341-10. Epub 2011 May 9.


Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changes.

Wu R, Dephoure N, Haas W, Huttlin EL, Zhai B, Sowa ME, Gygi SP.

Mol Cell Proteomics. 2011 Aug;10(8):M111.009654. doi: 10.1074/mcp.M111.009654. Epub 2011 May 7.


A tissue-specific atlas of mouse protein phosphorylation and expression.

Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP.

Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001.


A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.

Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 Nov 4.


A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.

Mol Cell. 2010 Jul 9;39(1):36-47. doi: 10.1016/j.molcel.2010.06.023.


Network organization of the human autophagy system.

Behrends C, Sowa ME, Gygi SP, Harper JW.

Nature. 2010 Jul 1;466(7302):68-76. doi: 10.1038/nature09204. Epub 2010 Jun 20.


Maple syrup urine disease: further evidence that newborn screening may fail to identify variant forms.

Puckett RL, Lorey F, Rinaldo P, Lipson MH, Matern D, Sowa ME, Levine S, Chang R, Wang RY, Abdenur JE.

Mol Genet Metab. 2010 Jun;100(2):136-42. doi: 10.1016/j.ymgme.2009.11.010. Epub 2009 Dec 5.


NCoR1 mediates papillomavirus E8;E2C transcriptional repression.

Powell ML, Smith JA, Sowa ME, Harper JW, Iftner T, Stubenrauch F, Howley PM.

J Virol. 2010 May;84(9):4451-60. doi: 10.1128/JVI.02390-09. Epub 2010 Feb 24.


Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.

Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3752-7. doi: 10.1073/pnas.0914818107. Epub 2010 Feb 2.


The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.

Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ.

Genes Dev. 2009 Oct 15;23(20):2415-25. doi: 10.1101/gad.1832309. Epub 2009 Sep 30.


Defining the human deubiquitinating enzyme interaction landscape.

Sowa ME, Bennett EJ, Gygi SP, Harper JW.

Cell. 2009 Jul 23;138(2):389-403. doi: 10.1016/j.cell.2009.04.042. Epub 2009 Jul 16.


Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.

Cell. 2009 Jul 10;138(1):63-77. doi: 10.1016/j.cell.2009.06.030.


An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

Xu L, Sowa ME, Chen J, Li X, Gygi SP, Harper JW.

Mol Biol Cell. 2008 Dec;19(12):5059-71. doi: 10.1091/mbc.E08-05-0473. Epub 2008 Sep 17.


Cancer proliferation gene discovery through functional genomics.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.

Science. 2008 Feb 1;319(5863):620-4. doi: 10.1126/science.1149200. Erratum in: Science.2008 Apr 18;320(5874):316.


The tumor suppressor CYLD regulates entry into mitosis.

Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8869-74. Epub 2007 May 10.


Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.

Nature. 2007 Apr 19;446(7138):876-81.


Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.

Mol Cell. 2007 Apr 13;26(1):131-43.


A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.

Nat Cell Biol. 2007 May;9(5):556-64. Epub 2007 Apr 8.


Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.

Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS.

J Mol Biol. 2004 Nov 19;344(2):303-10.


The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine.

Lee S, Sowa ME, Choi JM, Tsai FT.

J Struct Biol. 2004 Apr-May;146(1-2):99-105. Review.


The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state.

Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT.

Cell. 2003 Oct 17;115(2):229-40.


Acceleration of key reactions as a strategy to elucidate the rate-limiting chemistry underlying phototransduction inactivation.

Kennedy MJ, Sowa ME, Wensel TG, Hurley JB.

Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1016-22.


An accurate, sensitive, and scalable method to identify functional sites in protein structures.

Yao H, Kristensen DM, Mihalek I, Sowa ME, Shaw C, Kimmel M, Kavraki L, Lichtarge O.

J Mol Biol. 2003 Feb 7;326(1):255-61.


Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man.

Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K.

Eur J Neurosci. 2002 Jan;15(1):63-78.


Evolutionary predictions of binding surfaces and interactions.

Lichtarge O, Sowa ME.

Curr Opin Struct Biol. 2002 Feb;12(1):21-7. Review.


Structural clusters of evolutionary trace residues are statistically significant and common in proteins.

Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O.

J Mol Biol. 2002 Feb 8;316(1):139-54.


Evolutionary traces of functional surfaces along G protein signaling pathway.

Lichtarge O, Sowa ME, Philippi A.

Methods Enzymol. 2002;344:536-56. No abstract available.


Prediction and confirmation of a site critical for effector regulation of RGS domain activity.

Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG.

Nat Struct Biol. 2001 Mar;8(3):234-7.


A regulator of G protein signaling interaction surface linked to effector specificity.

Sowa ME, He W, Wensel TG, Lichtarge O.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1483-8.

Supplemental Content

Support Center