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Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M.

J Biol Chem. 2019 Dec 13;294(50):18952-18966. doi: 10.1074/jbc.RA119.009432. Epub 2019 Oct 2.


Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity.

Lempart J, Tse E, Lauer JA, Ivanova MI, Sutter A, Yoo N, Huettemann P, Southworth D, Jakob U.

Life Sci Alliance. 2019 Sep 18;2(5). pii: e201900486. doi: 10.26508/lsa.201900486. Print 2019 Oct.


Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.

Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J.

Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069.


Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR.

Nat Commun. 2019 Jun 3;10(1):2393. doi: 10.1038/s41467-019-10150-y.


Allosteric Regulation of Oligomerization by a B12 Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria.

Ruetz M, Campanello GC, McDevitt L, Yokom AL, Yadav PK, Watkins D, Rosenblatt DS, Ohi MD, Southworth DR, Banerjee R.

Cell Chem Biol. 2019 Jul 18;26(7):960-969.e4. doi: 10.1016/j.chembiol.2019.03.014. Epub 2019 May 2.


Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase.

Shorter J, Southworth DR.

Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8). pii: a034033. doi: 10.1101/cshperspect.a034033. Review.


Chaperone activation and client binding of a 2-cysteine peroxiredoxin.

Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U.

Nat Commun. 2019 Feb 8;10(1):659. doi: 10.1038/s41467-019-08565-8.


Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE.

Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4.


Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers.

Yoo NG, Dogra S, Meinen BA, Tse E, Haefliger J, Southworth DR, Gray MJ, Dahl JU, Jakob U.

J Mol Biol. 2018 Oct 19;430(21):4195-4208. doi: 10.1016/j.jmb.2018.08.016. Epub 2018 Aug 18.


Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.

Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y.

Mol Pharmacol. 2018 Sep;94(3):984-991. doi: 10.1124/mol.118.112516. Epub 2018 Jun 25.


The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.

Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y.

J Biol Chem. 2018 May 18;293(20):7727-7736. doi: 10.1074/jbc.RA117.000600. Epub 2018 Apr 4.


X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE.

J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18.


Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex.

Campanello GC, Lofgren M, Yokom AL, Southworth DR, Banerjee R.

J Biol Chem. 2017 Oct 27;292(43):17617-17625. doi: 10.1074/jbc.M117.786095. Epub 2017 Sep 7.


Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR.

Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15.


Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.

Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ.

FEBS Lett. 2017 Jun;591(11):1601-1610. doi: 10.1002/1873-3468.12627. Epub 2017 May 22.


BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE.

J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21.


Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.

Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U.

Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25.


Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.

Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR.

Nat Struct Mol Biol. 2016 Sep;23(9):830-7. doi: 10.1038/nsmb.3277. Epub 2016 Aug 1.


Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.

Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR.

Structure. 2016 May 3;24(5):657-666. doi: 10.1016/j.str.2016.03.018. Epub 2016 Apr 21.


Single-particle cryo-electron microscopy of macromolecular complexes.

Skiniotis G, Southworth DR.

Microscopy (Oxf). 2016 Feb;65(1):9-22. doi: 10.1093/jmicro/dfv366. Epub 2015 Nov 25. Review.


Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE.

Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25.


A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.

Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE.

Elife. 2015 May 11;4. doi: 10.7554/eLife.07304.


Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.

Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA 4th, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP.

Biochim Biophys Acta. 2015 Jun;1850(6):1310-8. doi: 10.1016/j.bbagen.2015.03.002. Epub 2015 Mar 14.


Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.

Teixeira F, Castro H, Cruz T, Tse E, Koldewey P, Southworth DR, Tomás AM, Jakob U.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E616-24. doi: 10.1073/pnas.1419682112. Epub 2015 Feb 2.


The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.

Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U.

Mol Cell. 2014 Oct 2;56(1):116-27. doi: 10.1016/j.molcel.2014.08.017. Epub 2014 Sep 18.


Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.

Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA.

Cell. 2014 Jun 19;157(7):1685-97. doi: 10.1016/j.cell.2014.04.038.


Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain.

Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR.

J Biol Chem. 2014 Jun 13;289(24):16855-65. doi: 10.1074/jbc.M114.564005. Epub 2014 Apr 15.


KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.

Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D.

Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184.


The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D.

J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10.


The root microbiome influences scales from molecules to ecosystems: The unseen majority.

Rout ME, Southworth D.

Am J Bot. 2013 Sep;100(9):1689-91. doi: 10.3732/ajb.1300291. Epub 2013 Sep 5.


The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.

Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER.

Biochemistry. 2013 Aug 13;52(32):5354-64. doi: 10.1021/bi4009209. Epub 2013 Aug 2.


The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.

Cunningham CN, Southworth DR, Krukenberg KA, Agard DA.

Protein Sci. 2012 Aug;21(8):1162-71. doi: 10.1002/pro.2103.


Linking mycorrhizas to sporocarps: a new species, Geopora cercocarpi, on Cercocarpus ledifolius (Rosaceae).

Southworth D, Frank JL.

Mycologia. 2011 Nov-Dec;103(6):1194-200. doi: 10.3852/11-053. Epub 2011 Jun 23.


Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex.

Southworth DR, Agard DA.

Mol Cell. 2011 Jun 24;42(6):771-81. doi: 10.1016/j.molcel.2011.04.023.


Ectomycorrhizas of Cercocarpus ledifolius (Rosaceae).

McDonald KR, Pennell J, Frank JL, Southworth D.

Am J Bot. 2010 Nov;97(11):1867-72. doi: 10.3732/ajb.0900357. Epub 2010 Oct 8.


High-Q nanomechanics via destructive interference of elastic waves.

Wilson-Rae I, Barton RA, Verbridge SS, Southworth DR, Ilic B, Craighead HG, Parpia JM.

Phys Rev Lett. 2011 Jan 28;106(4):047205. Epub 2011 Jan 27.


Real-time synchronous imaging of electromechanical resonator mode and equilibrium profiles.

Linzon Y, Krylov S, Ilic B, Southworth DR, Barton RA, Cipriany BR, Cross JD, Parpia JM, Craighead HG.

Opt Lett. 2010 Aug 1;35(15):2654-6. doi: 10.1364/OL.35.002654.


Aquatic gilled mushrooms: Psathyrella fruiting in the Rogue River in southern Oregon.

Frank JL, Coffan RA, Southworth D.

Mycologia. 2010 Jan-Feb;102(1):93-107.


Stress and silicon nitride: a crack in the universal dissipation of glasses.

Southworth DR, Barton RA, Verbridge SS, Ilic B, Fefferman AD, Craighead HG, Parpia JM.

Phys Rev Lett. 2009 Jun 5;102(22):225503. Epub 2009 Jun 5.


Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide.

Krukenberg KA, Böttcher UM, Southworth DR, Agard DA.

Protein Sci. 2009 Sep;18(9):1815-27. doi: 10.1002/pro.191.


pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation.

Krukenberg KA, Southworth DR, Street TO, Agard DA.

J Mol Biol. 2009 Jul 10;390(2):278-91. doi: 10.1016/j.jmb.2009.04.080. Epub 2009 May 7.


Mycorrhizas on nursery and field seedlings of Quercus garryana.

Southworth D, Carrington EM, Frank JL, Gould P, Harrington CA, Devine WD.

Mycorrhiza. 2009 Mar;19(3):149-158. doi: 10.1007/s00572-008-0222-1. Epub 2009 Jan 13.


Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle.

Southworth DR, Agard DA.

Mol Cell. 2008 Dec 5;32(5):631-40. doi: 10.1016/j.molcel.2008.10.024.


Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome.

Sharma D, Cukras AR, Rogers EJ, Southworth DR, Green R.

J Mol Biol. 2007 Dec 7;374(4):1065-76. Epub 2007 Oct 6.


Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.

Shiau AK, Harris SF, Southworth DR, Agard DA.

Cell. 2006 Oct 20;127(2):329-40.


Application of network theory to potential mycorrhizal networks.

Southworth D, He XH, Swenson W, Bledsoe CS, Horwath WR.

Mycorrhiza. 2005 Nov;15(8):589-595. doi: 10.1007/s00572-005-0368-z. Epub 2005 Nov 9.


Comparison of ectomycorrhizas of Quercus garryana (Fagaceae) on serpentine and non-serpentine soils in southwestern Oregon.

Moser AM, Petersen CA, D'Allura JA, Southworth D.

Am J Bot. 2005 Feb;92(2):224-30. doi: 10.3732/ajb.92.2.224.

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