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Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.

Mothé BR, Southwood S, Sidney J, English AM, Wriston A, Hoof I, Shabanowitz J, Hunt DF, Sette A.

Immunogenetics. 2013 May;65(5):371-86. doi: 10.1007/s00251-013-0686-9. Epub 2013 Feb 17.


A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.

McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A.

Immunogenetics. 2013 May;65(5):357-70. doi: 10.1007/s00251-013-0684-y. Epub 2013 Feb 8.


Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture.

Sidney J, Southwood S, Moore C, Oseroff C, Pinilla C, Grey HM, Sette A.

Curr Protoc Immunol. 2013 Feb;Chapter 18:Unit 18.3.. doi: 10.1002/0471142735.im1803s100.


T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.

Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A.

J Immunol. 2012 Aug 15;189(4):1800-11. doi: 10.4049/jimmunol.1200850. Epub 2012 Jul 11.


Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.

Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64. doi: 10.1073/pnas.1207934109. Epub 2012 May 29.


A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules.

Sette A, Sidney J, Southwood S, Moore C, Berry J, Dow C, Bradley K, Hoof I, Lewis MG, Hildebrand WH, McMurtrey CP, Wilson NA, Watkins DI, Mothé BR.

Immunogenetics. 2012 Jun;64(6):421-34. doi: 10.1007/s00251-011-0598-5. Epub 2012 Feb 10.


Identification of the peptide-binding motif recognized by the pigtail macaque class I MHC molecule Mane-A1*082:01 (Mane A*0301).

Moore C, Sidney J, English AM, Wriston A, Hunt DF, Shabanowitz J, Southwood S, Bradley K, Lafont BA, Mothé BR, Sette A.

Immunogenetics. 2012 Jun;64(6):461-8. doi: 10.1007/s00251-012-0600-x. Epub 2012 Jan 26.


Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities.

Southwood S, Solomon C, Hoof I, Rudersdorf R, Sidney J, Peters B, Wahl A, Hawkins O, Hildebrand W, Mothé BR, Sette A.

Immunogenetics. 2011 May;63(5):275-90. doi: 10.1007/s00251-010-0502-8. Epub 2011 Jan 28.


The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype.

Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR.

Immunogenetics. 2010 Jul;62(7):451-64. doi: 10.1007/s00251-010-0450-3. Epub 2010 May 18.


Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus.

Alexander J, Bilsel P, del Guercio MF, Marinkovic-Petrovic A, Southwood S, Stewart S, Ishioka G, Kotturi MF, Botten J, Sidney J, Newman M, Sette A.

Hum Immunol. 2010 May;71(5):468-74. doi: 10.1016/j.humimm.2010.02.014. Epub 2010 Mar 10.


Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice.

Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S, Crimi C, Vang L, Walker L, Ishioka G, Chitnis V, Sette A, Assarsson E, Hannaman D, Botten J, Newman MJ.

Vaccine. 2010 Jan 8;28(3):664-72. doi: 10.1016/j.vaccine.2009.10.103. Epub 2009 Nov 4.


T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome.

Kouiavskaia DV, Southwood S, Berard CA, Klyushnenkova EN, Alexander RB.

J Urol. 2009 Nov;182(5):2483-9. doi: 10.1016/j.juro.2009.07.067. Epub 2009 Sep 17.


Measurement of MHC/peptide interactions by gel filtration.

Sidney J, Southwood S, Oseroff C, del Guercio MF, Sette A, Grey HM.

Curr Protoc Immunol. 2001 May;Chapter 18:Unit 18.3. doi: 10.1002/0471142735.im1803s31.


Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections.

Depla E, Van der Aa A, Livingston BD, Crimi C, Allosery K, De Brabandere V, Krakover J, Murthy S, Huang M, Power S, Babé L, Dahlberg C, McKinney D, Sette A, Southwood S, Philip R, Newman MJ, Meheus L.

J Virol. 2008 Jan;82(1):435-50. Epub 2007 Oct 17.


Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site.

Neumann-Haefelin C, Killinger T, Timm J, Southwood S, McKinney D, Blum HE, Thimme R.

J Gen Virol. 2007 Jul;88(Pt 7):1986-91.


Identification of protective Lassa virus epitopes that are restricted by HLA-A2.

Botten J, Alexander J, Pasquetto V, Sidney J, Barrowman P, Ting J, Peters B, Southwood S, Stewart B, Rodriguez-Carreno MP, Mothe B, Whitton JL, Sette A, Buchmeier MJ.

J Virol. 2006 Sep;80(17):8351-61.


Predicting population coverage of T-cell epitope-based diagnostics and vaccines.

Bui HH, Sidney J, Dinh K, Southwood S, Newman MJ, Sette A.

BMC Bioinformatics. 2006 Mar 17;7:153.


Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs.

Mimura K, Kono K, Southwood S, Fikes J, Takahashi A, Miyagawa N, Sugai H, Fujii H.

Cancer Immunol Immunother. 2006 Nov;55(11):1358-66. Epub 2006 Jan 25.


HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.

Pasquetto V, Bui HH, Giannino R, Banh C, Mirza F, Sidney J, Oseroff C, Tscharke DC, Irvine K, Bennink JR, Peters B, Southwood S, Cerundolo V, Grey H, Yewdell JW, Sette A.

J Immunol. 2005 Oct 15;175(8):5504-15. Erratum in: J Immunol. 2005 Dec 15;175(12):8440. Banh, Cindy [added].


HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation.

Oseroff C, Kos F, Bui HH, Peters B, Pasquetto V, Glenn J, Palmore T, Sidney J, Tscharke DC, Bennink JR, Southwood S, Grey HM, Yewdell JW, Sette A.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13980-5. Epub 2005 Sep 19.


Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis.

Robertson J, Wu J, Arends J, Glass W 2nd, Southwood S, Sette A, Lou YH.

Kidney Int. 2005 Sep;68(3):1061-70.


Classification of A1- and A24-supertype molecules by analysis of their MHC-peptide binding repertoires.

Sidney J, Southwood S, Sette A.

Immunogenetics. 2005 Jul;57(6):393-408. Epub 2005 Jul 8.


Rationally engineered therapeutic proteins with reduced immunogenicity.

Tangri S, Mothé BR, Eisenbraun J, Sidney J, Southwood S, Briggs K, Zinckgraf J, Bilsel P, Newman M, Chesnut R, Licalsi C, Sette A.

J Immunol. 2005 Mar 15;174(6):3187-96.


Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells.

Lou Q, Kelleher RJ Jr, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH.

Blood. 2004 Aug 1;104(3):752-9. Epub 2004 Mar 30.


Improved immunogenicity of an immunodominant epitope of the HER-2/neu protooncogene by alterations of MHC contact residues.

Vertuani S, Sette A, Sidney J, Southwood S, Fikes J, Keogh E, Lindencrona JA, Ishioka G, Levitskaya J, Kiessling R.

J Immunol. 2004 Mar 15;172(6):3501-8.


Immunization of cancer patients with HER-2/neu-derived peptides demonstrating high-affinity binding to multiple class II alleles.

Salazar LG, Fikes J, Southwood S, Ishioka G, Knutson KL, Gooley TA, Schiffman K, Disis ML.

Clin Cancer Res. 2003 Nov 15;9(15):5559-65.


Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertype.

Sidney J, Southwood S, Pasquetto V, Sette A.

J Immunol. 2003 Dec 1;171(11):5964-74.


Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1.

Wilson CC, McKinney D, Anders M, MaWhinney S, Forster J, Crimi C, Southwood S, Sette A, Chesnut R, Newman MJ, Livingston BD.

J Immunol. 2003 Nov 15;171(10):5611-23.


Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.

Doolan DL, Southwood S, Freilich DA, Sidney J, Graber NL, Shatney L, Bebris L, Florens L, Dobano C, Witney AA, Appella E, Hoffman SL, Yates JR 3rd, Carucci DJ, Sette A.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9952-7. Epub 2003 Jul 28.


Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution.

Sette A, Sidney J, Livingston BD, Dzuris JL, Crimi C, Walker CM, Southwood S, Collins EJ, Hughes AL.

Immunogenetics. 2003 Mar;54(12):830-41. Epub 2003 Feb 14.


Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope.

Gianfrani C, Troncone R, Mugione P, Cosentini E, De Pascale M, Faruolo C, Senger S, Terrazzano G, Southwood S, Auricchio S, Sette A.

J Immunol. 2003 Mar 1;170(5):2719-26.


Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1.

Touloukian CE, Leitner WW, Schnur RE, Robbins PF, Li Y, Southwood S, Sette A, Rosenberg SA, Restifo NP.

J Immunol. 2003 Feb 1;170(3):1579-85.


The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity.

Sidney J, del Guercio MF, Southwood S, Sette A.

J Immunol. 2002 Nov 1;169(9):5098-108.


Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.

Sundberg EJ, Sawicki MW, Southwood S, Andersen PS, Sette A, Mariuzza RA.

J Mol Biol. 2002 May 31;319(2):449-61.


Majority of peptides binding HLA-A*0201 with high affinity crossreact with other A2-supertype molecules.

Sidney J, Southwood S, Mann DL, Fernandez-Vina MA, Newman MJ, Sette A.

Hum Immunol. 2001 Nov;62(11):1200-16.


T-cell reactivity against streptococcal antigens in the periphery mirrors reactivity of heart-infiltrating T lymphocytes in rheumatic heart disease patients.

Guilherme L, Oshiro SE, Faé KC, Cunha-Neto E, Renesto G, Goldberg AC, Tanaka AC, Pomerantzeff PM, Kiss MH, Silva C, Guzman F, Patarroyo ME, Southwood S, Sette A, Kalil J.

Infect Immun. 2001 Sep;69(9):5345-51.


Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.

Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT.

J Infect Dis. 2001 Jul 15;184(2):119-26. Epub 2001 Jun 18.


Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes.

Wilson CC, Palmer B, Southwood S, Sidney J, Higashimoto Y, Appella E, Chesnut R, Sette A, Livingston BD.

J Virol. 2001 May;75(9):4195-207.


HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein.

Kumar A, Kumar S, Le TP, Southwood S, Sidney J, Cohen J, Sette A, Hoffman SL.

Infect Immun. 2001 Apr;69(4):2766-71.


Supermotif peptide binding and degeneracy of MHC: peptide recognition in an EBV peptide-specific CTL response with highly restricted TCR usage.

Levitsky V, Liu D, Southwood S, Levitskaya J, Sette A, Masucci MG.

Hum Immunol. 2000 Oct;61(10):972-84.


Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse.

Maverakis E, Mendoza R, Southwood S, Raja-Gabaglia C, Abromson-Leeman S, Campagnoni AT, Sette A, Sercarz EE.

J Autoimmun. 2000 Nov;15(3):315-22.


Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.

Cho S, Mehra V, Thoma-Uszynski S, Stenger S, Serbina N, Mazzaccaro RJ, Flynn JL, Barnes PF, Southwood S, Celis E, Bloom BR, Modlin RL, Sette A.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12210-5.


HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles.

Doolan DL, Southwood S, Chesnut R, Appella E, Gomez E, Richards A, Higashimoto YI, Maewal A, Sidney J, Gramzinski RA, Mason C, Koech D, Hoffman SL, Sette A.

J Immunol. 2000 Jul 15;165(2):1123-37.


Conserved hepatitis C virus sequences are highly immunogenic for CD4(+) T cells: implications for vaccine development.

Lamonaca V, Missale G, Urbani S, Pilli M, Boni C, Mori C, Sette A, Massari M, Southwood S, Bertoni R, Valli A, Fiaccadori F, Ferrari C.

Hepatology. 1999 Oct;30(4):1088-98.


Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins.

Mamula MJ, Gee RJ, Elliott JI, Sette A, Southwood S, Jones PJ, Blier PR.

J Biol Chem. 1999 Aug 6;274(32):22321-7.

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