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Items: 18


Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.

Constantinou JK, Southam AD, Kvist J, Jones MR, Viant MR, Mirbahai L.

Sci Rep. 2020 Mar 27;10(1):5576. doi: 10.1038/s41598-020-62476-z.


International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis.

Thompson JW, Adams KJ, Adamski J, Asad Y, Borts D, Bowden JA, Byram G, Dang V, Dunn WB, Fernandez F, Fiehn O, Gaul DA, Hühmer AF, Kalli A, Koal T, Koeniger S, Mandal R, Meier F, Naser FJ, O'Neil D, Pal A, Patti GJ, Pham-Tuan H, Prehn C, Raynaud FI, Shen T, Southam AD, St John-Williams L, Sulek K, Vasilopoulou CG, Viant M, Winder CL, Wishart D, Zhang L, Zheng J, Moseley MA.

Anal Chem. 2019 Nov 19;91(22):14407-14416. doi: 10.1021/acs.analchem.9b02908. Epub 2019 Nov 8.


Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.

Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, Roberts S, Khanim F, Spruce R, Mehanna H.

Oncotarget. 2019 Aug 27;10(50):5229-5244. doi: 10.18632/oncotarget.27156. eCollection 2019 Aug 27.


Multiple metabolic pathways are predictive of ricin intoxication in a rat model.

D'Elia RV, Goodchild SA, Winder CL, Southam AD, Weber RJM, Stahl FM, Docx C, Patel V, Green AC, Viant MR, Lukaszewski RA, Dunn WB.

Metabolomics. 2019 Jul 3;15(7):102. doi: 10.1007/s11306-019-1547-9.


Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.

Denbigh JL, Perez-Guaita D, Vernooij RR, Tobin MJ, Bambery KR, Xu Y, Southam AD, Khanim FL, Drayson MT, Lockyer NP, Goodacre R, Wood BR.

Sci Rep. 2017 Jun 1;7(1):2649. doi: 10.1038/s41598-017-02069-5.


A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics.

Southam AD, Weber RJ, Engel J, Jones MR, Viant MR.

Nat Protoc. 2016 Feb;12(2):310–328. doi: 10.1038/nprot.2016.156. Epub 2017 Jan 12.


Cryptococcal 3-Hydroxy Fatty Acids Protect Cells Against Amoebal Phagocytosis.

Madu UL, Ogundeji AO, Mochochoko BM, Pohl CH, Albertyn J, Swart CW, Allwood JW, Southam AD, Dunn WB, May RC, Sebolai OM.

Front Microbiol. 2015 Dec 9;6:1351. doi: 10.3389/fmicb.2015.01351. eCollection 2015.


Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.

Southam AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT, Bunce CM.

Cancer Res. 2015 Jun 15;75(12):2530-40. doi: 10.1158/0008-5472.CAN-15-0202. Epub 2015 May 5.


Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics.

Southam AD, Lange A, Al-Salhi R, Hill EM, Tyler CR, Viant MR.

Metabolomics. 2014;10(6):1050-1058. doi: 10.1007/s11306-014-0693-3. Epub 2014 Jul 15.


Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish.

Mirbahai L, Southam AD, Sommer U, Williams TD, Bignell JP, Lyons BP, Viant MR, Chipman JK.

J Proteome Res. 2013 Jun 7;12(6):2895-904. doi: 10.1021/pr400195u. Epub 2013 May 6.


Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification.

Weber RJ, Southam AD, Sommer U, Viant MR.

Anal Chem. 2011 May 15;83(10):3737-43. doi: 10.1021/ac2001803. Epub 2011 Apr 19.


Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): implications for biomonitoring.

Southam AD, Lange A, Hines A, Hill EM, Katsu Y, Iguchi T, Tyler CR, Viant MR.

Environ Sci Technol. 2011 Apr 15;45(8):3759-67. doi: 10.1021/es103814d. Epub 2011 Mar 16.


Gene expression analyses of hepatocellular adenoma and hepatocellular carcinoma from the marine flatfish Limanda limanda.

Small HJ, Williams TD, Sturve J, Chipman JK, Southam AD, Bean TP, Lyons BP, Stentiford GD.

Dis Aquat Organ. 2010 Jan 25;88(2):127-41. doi: 10.3354/dao02148.


Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks.

Southam AD, Easton JM, Stentiford GD, Ludwig C, Arvanitis TN, Viant MR.

J Proteome Res. 2008 Dec;7(12):5277-85. doi: 10.1021/pr800353t.


A signal filtering method for improved quantification and noise discrimination in fourier transform ion cyclotron resonance mass spectrometry-based metabolomics data.

Payne TG, Southam AD, Arvanitis TN, Viant MR.

J Am Soc Mass Spectrom. 2009 Jun;20(6):1087-95. doi: 10.1016/j.jasms.2009.02.001. Epub 2009 Feb 7.


High-throughput tissue extraction protocol for NMR- and MS-based metabolomics.

Wu H, Southam AD, Hines A, Viant MR.

Anal Biochem. 2008 Jan 15;372(2):204-12. Epub 2007 Oct 9.


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