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Items: 1 to 50 of 70

1.

The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System.

van der Burg M, Kalina T, Perez-Andres M, Vlkova M, Lopez-Granados E, Blanco E, Bonroy C, Sousa AE, Kienzler AK, Wentink M, Mejstríková E, Šinkorova V, Stuchly J, van Zelm MC, Orfao A, van Dongen JJM.

Front Immunol. 2019 Mar 4;10:246. doi: 10.3389/fimmu.2019.00246. eCollection 2019.

2.

Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies.

Blanco E, Pérez-Andrés M, Arriba-Méndez S, Serrano C, Criado I, Del Pino-Molina L, Silva S, Madruga I, Bakardjieva M, Martins C, Serra-Caetano A, Romero A, Contreras-Sanfeliciano T, Bonroy C, Sala F, Martín A, Bastida JM, Lorente F, Prieto C, Dávila I, Marcos M, Kalina T, Vlkova M, Chovancova Z, Cordeiro AI, Philippé J, Haerynck F, López-Granados E, Sousa AE, van der Burg M, van Dongen JJM, Orfao A; EuroFlow PID group.

J Allergy Clin Immunol. 2019 Feb 28. pii: S0091-6749(19)30280-5. doi: 10.1016/j.jaci.2019.02.017. [Epub ahead of print]

3.

Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season.

Santos MCP, Serra-Caetano A, Pedro E, Melo A, Caramalho I, Barbosa MP, Victorino RMM, Sousa AE.

Allergy. 2019 Jun;74(6):1182-1184. doi: 10.1111/all.13713. Epub 2019 Jan 17. No abstract available.

PMID:
30593677
4.

MDSCs in infectious diseases: regulation, roles, and readjustment.

Dorhoi A, Glaría E, Garcia-Tellez T, Nieuwenhuizen NE, Zelinskyy G, Favier B, Singh A, Ehrchen J, Gujer C, Münz C, Saraiva M, Sohrabi Y, Sousa AE, Delputte P, Müller-Trutwin M, Valledor AF.

Cancer Immunol Immunother. 2019 Apr;68(4):673-685. doi: 10.1007/s00262-018-2277-y. Epub 2018 Dec 19. Review.

PMID:
30569204
5.

Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood.

Blanco E, Pérez-Andrés M, Arriba-Méndez S, Contreras-Sanfeliciano T, Criado I, Pelak O, Serra-Caetano A, Romero A, Puig N, Remesal A, Torres Canizales J, López-Granados E, Kalina T, Sousa AE, van Zelm M, van der Burg M, van Dongen JJM, Orfao A; EuroFlow PID group.

J Allergy Clin Immunol. 2018 Jun;141(6):2208-2219.e16. doi: 10.1016/j.jaci.2018.02.017. Epub 2018 Mar 2.

6.

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells.

Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, Valadas E, Sousa AE, Taveira N.

AIDS. 2017 Nov 13;31(17):2431-2433. doi: 10.1097/QAD.0000000000001661.

PMID:
29028655
7.

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

Fonseca VR, Agua-Doce A, Maceiras AR, Pierson W, Ribeiro F, Romão VC, Pires AR, da Silva SL, Fonseca JE, Sousa AE, Linterman MA, Graca L.

Sci Immunol. 2017 Aug 11;2(14). pii: eaan1487. doi: 10.1126/sciimmunol.aan1487.

PMID:
28802258
8.

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy.

Silva SL, Albuquerque A, Amaral AJ, Li QZ, Mota C, Cheynier R, Victorino RMM, Pereira-Santos MC, Sousa AE.

PLoS One. 2017 Jul 7;12(7):e0180385. doi: 10.1371/journal.pone.0180385. eCollection 2017.

9.

Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease.

Albuquerque AS, Fernandes SM, Tendeiro R, Cheynier R, Lucas M, Silva SL, Victorino RMM, Sousa AE.

Front Immunol. 2017 May 11;8:543. doi: 10.3389/fimmu.2017.00543. eCollection 2017.

10.

HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication.

Fernandes SM, Pires AR, Matoso P, Ferreira C, Nunes-Cabaço H, Correia L, Valadas E, Poças J, Pacheco P, Veiga-Fernandes H, Foxall RB, Sousa AE.

Mucosal Immunol. 2018 Jan;11(1):236-248. doi: 10.1038/mi.2017.44. Epub 2017 May 17.

PMID:
28513595
11.

Quantification of cell cycle kinetics by EdU (5-ethynyl-2'-deoxyuridine)-coupled-fluorescence-intensity analysis.

Pereira PD, Serra-Caetano A, Cabrita M, Bekman E, Braga J, Rino J, Santus R, Filipe PL, Sousa AE, Ferreira JA.

Oncotarget. 2017 Jun 20;8(25):40514-40532. doi: 10.18632/oncotarget.17121.

12.

Control of browning of minimally processed mangoes subjected to ultraviolet radiation pulses.

de Sousa AED, Fonseca KS, da Silva Gomes WK, Monteiro da Silva AP, de Oliveira Silva E, Puschmann R.

J Food Sci Technol. 2017 Jan;54(1):253-259. doi: 10.1007/s13197-016-2457-8. Epub 2016 Dec 23.

13.

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity.

Silva SL, Albuquerque AS, Matoso P, Charmeteau-de-Muylder B, Cheynier R, Ligeiro D, Abecasis M, Anjos R, Barata JT, Victorino RM, Sousa AE.

Front Immunol. 2017 Jan 19;8:20. doi: 10.3389/fimmu.2017.00020. eCollection 2017.

14.

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

Amaral AJ, Andrade J, Foxall RB, Matoso P, Matos AM, Soares RS, Rocha C, Ramos CG, Tendeiro R, Serra-Caetano A, Guerra-Assunção JA, Santa-Marta M, Gonçalves J, Gama-Carvalho M, Sousa AE.

EMBO J. 2017 Feb 1;36(3):346-360. doi: 10.15252/embj.201694335. Epub 2016 Dec 19.

15.

Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment.

Silva SL, Sousa AE.

Front Pediatr. 2016 Oct 31;4:119. eCollection 2016. Review.

16.

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.

Silva SL, Albuquerque AS, Serra-Caetano A, Foxall RB, Pires AR, Matoso P, Fernandes SM, Ferreira J, Cheynier R, Victorino RM, Caramalho I, Barata JT, Sousa AE.

Oncotarget. 2016 Mar 15;7(11):12163-75. doi: 10.18632/oncotarget.7512.

17.

Regulatory T-Cell Development in the Human Thymus.

Caramalho Í, Nunes-Cabaço H, Foxall RB, Sousa AE.

Front Immunol. 2015 Aug 3;6:395. doi: 10.3389/fimmu.2015.00395. eCollection 2015. Review.

18.

Bee venom enhances the differentiation of human regulatory T cells.

Caramalho I, Melo A, Pedro E, Barbosa MM, Victorino RM, Pereira Santos MC, Sousa AE.

Allergy. 2015 Oct;70(10):1340-5. doi: 10.1111/all.12691. Epub 2015 Jul 30.

PMID:
26179427
19.

Thymic stromal alterations and genetic disorders of immune system.

Pignata C, D'Assante R, Sousa AE.

Front Immunol. 2015 Feb 25;6:81. doi: 10.3389/fimmu.2015.00081. eCollection 2015. No abstract available.

20.

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus.

Caramalho I, Nunes-Silva V, Pires AR, Mota C, Pinto AI, Nunes-Cabaço H, Foxall RB, Sousa AE.

J Autoimmun. 2015 Jan;56:98-110. doi: 10.1016/j.jaut.2014.11.002. Epub 2014 Dec 4.

PMID:
25481744
21.

Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

Nunes-Cabaço H, Matoso P, Foxall RB, Tendeiro R, Pires AR, Carvalho T, Pinheiro AI, Soares RS, Sousa AE.

J Virol. 2015 Feb;89(4):2201-8. doi: 10.1128/JVI.03047-14. Epub 2014 Dec 3.

22.

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Mota C, Nunes-Silva V, Pires AR, Matoso P, Victorino RM, Sousa AE, Caramalho I.

J Immunol. 2014 Dec 15;193(12):5854-62. doi: 10.4049/jimmunol.1400198. Epub 2014 Nov 3.

23.

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen.

Tsuji S, Stein L, Kamada N, Nuñez G, Bram R, Vallance BA, Sousa AE, Platt JL, Cascalho M.

J Clin Invest. 2014 Nov;124(11):4857-66. doi: 10.1172/JCI74428. Epub 2014 Oct 1.

24.

Reduced BAFF-R and increased TACI expression in common variable immunodeficiency.

Barbosa RR, Silva SL, Silva SP, Melo AC, Pereira-Santos MC, Barata JT, Hammarström L, Cascalho M, Sousa AE.

J Clin Immunol. 2014 Jul;34(5):573-83. doi: 10.1007/s10875-014-0047-y. Epub 2014 May 9.

PMID:
24809296
25.

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection.

Jorge I, Amaral B, Soares-Almeida LM, Foxall RB, Tendeiro R, Santos JM, Sousa AE, Victorino RM.

AIDS. 2014 Apr 24;28(7):1075-7. doi: 10.1097/QAD.0000000000000205. No abstract available.

PMID:
24685745
26.

Enteric mucosa integrity in the presence of a preserved innate interleukin 22 compartment in HIV type 1-treated individuals.

Fernandes SM, Pires AR, Ferreira C, Foxall RB, Rino J, Santos C, Correia L, Poças J, Veiga-Fernandes H, Sousa AE.

J Infect Dis. 2014 Aug 15;210(4):630-40. doi: 10.1093/infdis/jiu126. Epub 2014 Mar 5.

PMID:
24604817
27.

Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

Ribot JC, Ribeiro ST, Correia DV, Sousa AE, Silva-Santos B.

J Immunol. 2014 Mar 1;192(5):2237-43. doi: 10.4049/jimmunol.1303119. Epub 2014 Jan 31.

28.

Gut disruption in HIV-2 infection despite reduced viremia.

Fernandes SM, Pires AR, Ferreira C, Tendeiro R, Correia L, Paulo SE, Victorino RM, Sousa AE.

AIDS. 2014 Jan 14;28(2):290-2. doi: 10.1097/QAD.0000000000000114. No abstract available.

PMID:
24413316
29.

Repairing thymic function.

Nunes-Cabaço H, Sousa AE.

Curr Opin Organ Transplant. 2013 Jun;18(3):363-8. doi: 10.1097/MOT.0b013e3283615df9. Review.

PMID:
23660780
30.

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery.

Paiva RS, Lino AC, Bergman ML, Caramalho I, Sousa AE, Zelenay S, Demengeot J.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6494-9. doi: 10.1073/pnas.1221955110. Epub 2013 Apr 1.

31.

Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.

Cavaleiro R, Tendeiro R, Foxall RB, Soares RS, Baptista AP, Gomes P, Valadas E, Victorino RM, Sousa AE.

J Infect Dis. 2013 Jun 1;207(11):1730-42. doi: 10.1093/infdis/jit085. Epub 2013 Mar 4.

PMID:
23460749
32.

Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation.

Azevedo RI, Soares MV, Albuquerque AS, Tendeiro R, Soares RS, Martins M, Ligeiro D, Victorino RM, Lacerda JF, Sousa AE.

Biol Blood Marrow Transplant. 2013 May;19(5):703-12. doi: 10.1016/j.bbmt.2013.01.017. Epub 2013 Feb 8.

33.

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection.

Tendeiro R, Albuquerque AS, Foxall RB, Cavaleiro R, Soares RS, Baptista AP, Soares MV, Gomes P, Sousa AE.

AIDS. 2013 Jan 14;27(2):289-92. doi: 10.1097/QAD.0b013e32835ab234.

PMID:
23032416
34.

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels.

Barbosa RR, Silva SP, Silva SL, Tendeiro R, Melo AC, Pedro E, Barbosa MP, Santos MC, Victorino RM, Sousa AE.

Clin Exp Immunol. 2012 Sep;169(3):263-72. doi: 10.1111/j.1365-2249.2012.04620.x.

35.

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

Tendeiro R, Fernandes S, Foxall RB, Marcelino JM, Taveira N, Soares RS, Baptista AP, Cavaleiro R, Gomes P, Victorino RM, Sousa AE.

AIDS. 2012 Aug 24;26(13):1607-17.

PMID:
22695303
36.

Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.

Albuquerque AS, Marques JG, Silva SL, Ligeiro D, Devlin BH, Dutrieux J, Cheynier R, Pignata C, Victorino RM, Markert ML, Sousa AE.

PLoS One. 2012;7(5):e37042. doi: 10.1371/journal.pone.0037042. Epub 2012 May 10.

37.

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.

Tendeiro R, Foxall RB, Baptista AP, Pinto F, Soares RS, Cavaleiro R, Valadas E, Gomes P, Victorino RM, Sousa AE.

AIDS. 2012 Jun 1;26(9):1065-71. doi: 10.1097/QAD.0b013e32835374db.

PMID:
22441249
38.

Differentiation of human thymic regulatory T cells at the double positive stage.

Nunes-Cabaço H, Caramalho I, Sepúlveda N, Sousa AE.

Eur J Immunol. 2011 Dec;41(12):3604-14. doi: 10.1002/eji.201141614. Epub 2011 Oct 24.

39.

Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.

Barbosa RR, Silva SP, Silva SL, Melo AC, Pedro E, Barbosa MP, Pereira-Santos MC, Victorino RM, Sousa AE.

PLoS One. 2011;6(8):e22848. doi: 10.1371/journal.pone.0022848. Epub 2011 Aug 3.

40.

Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia.

Foxall RB, Albuquerque AS, Soares RS, Baptista AP, Cavaleiro R, Tendeiro R, Gomes P, Victorino RM, Sousa AE.

AIDS. 2011 Oct 23;25(16):1961-70. doi: 10.1097/QAD.0b013e32834b3554.

PMID:
21811143
41.

Strategies to quantify unspliced and multiply spliced mRNA expression in HIV-2 infection.

Soares RS, Matoso P, Calado M, Sousa AE.

J Virol Methods. 2011 Jul;175(1):38-45. doi: 10.1016/j.jviromet.2011.04.012. Epub 2011 Apr 22.

PMID:
21540056
42.

CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis.

Fabre-Mersseman V, Dutrieux J, Louise A, Rozlan S, Lamine A, Parker R, Rancez M, Nunes-Cabaço H, Sousa AE, Lambotte O, Cheynier R.

AIDS. 2011 Jun 1;25(9):1153-62. doi: 10.1097/QAD.0b013e3283471e89.

PMID:
21505308
43.

Cell-associated viral burden provides evidence of ongoing viral replication in aviremic HIV-2-infected patients.

Soares RS, Tendeiro R, Foxall RB, Baptista AP, Cavaleiro R, Gomes P, Camacho R, Valadas E, Doroana M, Lucas M, Antunes F, Victorino RM, Sousa AE.

J Virol. 2011 Mar;85(5):2429-38. doi: 10.1128/JVI.01921-10. Epub 2010 Dec 15.

44.

First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases.

Markert ML, Marques JG, Neven B, Devlin BH, McCarthy EA, Chinn IK, Albuquerque AS, Silva SL, Pignata C, de Saint Basile G, Victorino RM, Picard C, Debre M, Mahlaoui N, Fischer A, Sousa AE.

Blood. 2011 Jan 13;117(2):688-96. doi: 10.1182/blood-2010-06-292490. Epub 2010 Oct 26.

45.

Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression.

Nunes-Cabaço H, Ribot JC, Caramalho I, Serra-Caetano A, Silva-Santos B, Sousa AE.

Immunol Cell Biol. 2010 Jul;88(5):523-8. doi: 10.1038/icb.2010.4. Epub 2010 Feb 9.

PMID:
20142839
46.

Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease.

Cavaleiro R, Baptista AP, Soares RS, Tendeiro R, Foxall RB, Gomes P, Victorino RM, Sousa AE.

PLoS Pathog. 2009 Nov;5(11):e1000667. doi: 10.1371/journal.ppat.1000667. Epub 2009 Nov 20.

47.

Dendritic cell differentiation and maturation in the presence of HIV type 2 envelope.

Cavaleiro R, Baptista AP, Foxall RB, Victorino RM, Sousa AE.

AIDS Res Hum Retroviruses. 2009 Apr;25(4):425-31. doi: 10.1089/aid.2008.0247.

PMID:
19320568
48.

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

Azevedo RI, Soares MV, Barata JT, Tendeiro R, Serra-Caetano A, Victorino RM, Sousa AE.

Blood. 2009 Mar 26;113(13):2999-3007. doi: 10.1182/blood-2008-07-166223. Epub 2008 Nov 13.

49.

Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1.

Foxall RB, Cortesão CS, Albuquerque AS, Soares RS, Victorino RM, Sousa AE.

J Virol. 2008 Oct;82(19):9795-9. doi: 10.1128/JVI.01217-08. Epub 2008 Jul 23.

50.

Increased frequency of CD25dimCD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1.

Foxall RB, Soares RS, Albuquerque AS, Cortesão CS, Victorino RM, Sousa AE.

Clin Immunol. 2008 May;127(2):158-67. doi: 10.1016/j.clim.2008.01.008. Epub 2008 Mar 3.

PMID:
18313362

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