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Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation.

Kim HM, He L, Lee S, Park C, Kim DH, Han HJ, Han J, Hwang J, Cha-Molstad H, Lee KH, Ko SK, Jang JH, Ryoo IJ, Blenis J, Lee HG, Ahn JS, Kwon YT, Soung NK, Kim BY.

Bone. 2020 Feb;131:115153. doi: 10.1016/j.bone.2019.115153. Epub 2019 Nov 12.


Vitamin E-Conjugated Phosphopeptide Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1.

Yim MS, Soung NK, Han EH, Min JY, Han H, Son EJ, Kim HN, Kim B, Bang JK, Ryu EK.

Mol Pharm. 2019 Nov 11. doi: 10.1021/acs.molpharmaceut.9b00757. [Epub ahead of print]


Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.

Kim DH, Ahn JS, Han HJ, Kim HM, Hwang J, Lee KH, Cha-Molstad H, Ryoo IJ, Jang JH, Ko SK, Yang JO, Lee HG, Lee S, Song EJ, Kim JY, Huh YH, Kwon YT, Soung NK, Kim BY.

Cell Death Dis. 2019 Jul 29;10(8):570. doi: 10.1038/s41419-019-1778-8.


Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.

Kim DH, Kim HM, Huong PTT, Han HJ, Hwang J, Cha-Molstad H, Lee KH, Ryoo IJ, Kim KE, Huh YH, Ahn JS, Kwon YT, Soung NK, Kim BY.

BMB Rep. 2019 May;52(5):342-347.


Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.

Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS.

Exp Mol Med. 2019 Feb 12;51(2):10. doi: 10.1038/s12276-018-0200-4.


Peptide nucleic acid (PNA) probe-based analysis to detect filaggrin mutations in atopic dermatitis patients.

Hwang J, Lee S, Kim D, Han G, Soung NK, Cha-Molstad H, Lee KH, Ryoo IJ, Ahn MJ, Kim ST, Lee MJ, Yoo YD, Lee HG, Hong JT, Kim H, Choi EH, Kim SC, Kwon YT, Ahn JS, Kim BY.

Exp Dermatol. 2018 Nov;27(11):1304-1308. doi: 10.1111/exd.13765. Epub 2018 Sep 13.


The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.

Park JJ, Park MH, Oh EH, Soung NK, Lee SJ, Jung JK, Lee OJ, Yun SJ, Kim WJ, Shin EY, Kim EG.

Oncogene. 2018 Sep;37(38):5147-5159. doi: 10.1038/s41388-018-0327-8. Epub 2018 May 30.


A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.

Hwang J, Soung NK, Han HJ, Lee Y, Choi TW, Mun J, Cha-Molstad H, Lee KH, Kim HJ, Lee HG, Hong JT, Ahn JS, Kwon YT, Kim BY.

Exp Dermatol. 2018 Mar;27(3):285-288. doi: 10.1111/exd.13506.


Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.

Lee KH, Hwang JA, Kim SO, Kim JH, Shin SC, Kim EE, Lee KS, Rhee K, Jeon BH, Bang JK, Cha-Molstad H, Soung NK, Jang JH, Ko SK, Lee HG, Ahn JS, Kwon YT, Kim BY.

J Biol Chem. 2018 Jan 19;293(3):847-862. doi: 10.1074/jbc.M117.802587. Epub 2017 Nov 30.


Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.

Jang JP, Jung HJ, Han JM, Jung N, Kim Y, Kwon HJ, Ko SK, Soung NK, Jang JH, Ahn JS.

PLoS One. 2017 Sep 26;12(9):e0184339. doi: 10.1371/journal.pone.0184339. eCollection 2017.


Anticancer activity of a novel small molecule tubulin inhibitor STK899704.

Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY.

PLoS One. 2017 Mar 15;12(3):e0173311. doi: 10.1371/journal.pone.0173311. eCollection 2017.


Ginsenoside Re Promotes Osteoblast Differentiation in Mouse Osteoblast Precursor MC3T3-E1 Cells and a Zebrafish Model.

Kim HM, Kim DH, Han HJ, Park CM, Ganipisetti SR, Valan Arasu M, Kim YO, Park CG, Kim BY, Soung NK.

Molecules. 2016 Dec 29;22(1). pii: E42. doi: 10.3390/molecules22010042.


Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model.

Park CM, Kim HM, Kim DH, Han HJ, Noh H, Jang JH, Park SH, Chae HJ, Chae SW, Ryu EK, Lee S, Liu K, Liu H, Ahn JS, Kim YO, Kim BY, Soung NK.

Mol Cells. 2016 Dec;39(12):855-861. doi: 10.14348/molcells.2016.0111. Epub 2016 Dec 6.


Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.

Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS.

J Nat Prod. 2016 Oct 28;79(10):2703-2708. Epub 2016 Oct 11.


Ulleungamides A and B, Modified α,β-Dehydropipecolic Acid Containing Cyclic Depsipeptides from Streptomyces sp. KCB13F003.

Son S, Ko SK, Jang M, Lee JK, Ryoo IJ, Lee JS, Lee KH, Soung NK, Oh H, Hong YS, Kim BY, Jang JH, Ahn JS.

Org Lett. 2015 Aug 21;17(16):4046-9. doi: 10.1021/acs.orglett.5b01969. Epub 2015 Aug 11.


Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.

Cha-Molstad H, Sung KS, Hwang J, Kim KA, Yu JE, Yoo YD, Jang JM, Han DH, Molstad M, Kim JG, Lee YJ, Zakrzewska A, Kim SH, Kim ST, Kim SY, Lee HG, Soung NK, Ahn JS, Ciechanover A, Kim BY, Kwon YT.

Nat Cell Biol. 2015 Jul;17(7):917-29. doi: 10.1038/ncb3177. Epub 2015 Jun 15.


A Pectate Lyase-Coding Gene Abundantly Expressed during Early Stages of Infection Is Required for Full Virulence in Alternaria brassicicola.

Cho Y, Jang M, Srivastava A, Jang JH, Soung NK, Ko SK, Kang DO, Ahn JS, Kim BY.

PLoS One. 2015 May 21;10(5):e0127140. doi: 10.1371/journal.pone.0127140. eCollection 2015.


Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.

Park CH, Park JE, Kim TS, Kang YH, Soung NK, Zhou M, Kim NH, Bang JK, Lee KS.

J Biol Chem. 2015 Mar 27;290(13):8569-81. doi: 10.1074/jbc.M114.623546. Epub 2015 Feb 10.


Synthesis and antitumor activity of natural compound aloe emodin derivatives.

Thimmegowda NR, Park C, Shwetha B, Sakchaisri K, Liu K, Hwang J, Lee S, Jeong SJ, Soung NK, Jang JH, Ryoo IJ, Ahn JS, Erikson RL, Kim BY.

Chem Biol Drug Des. 2015 May;85(5):638-44. doi: 10.1111/cbdd.12448. Epub 2014 Nov 5.


Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling.

Liu K, Park C, Chen H, Hwang J, Thimmegowda NR, Bae EY, Lee KW, Kim HG, Liu H, Soung NK, Peng C, Jang JH, Kim KE, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.

Mol Carcinog. 2015 Sep;54(9):751-60. doi: 10.1002/mc.22139. Epub 2014 Apr 4.


Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.

Oh M, Jang JH, Choo SJ, Kim SO, Kim JW, Ko SK, Soung NK, Lee JS, Kim CJ, Oh H, Hong YS, Ueki M, Hirota H, Osada H, Kim BY, Ahn JS.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1802-4. doi: 10.1016/j.bmcl.2014.02.022. Epub 2014 Feb 22.


Illudins C2 and C3 stimulate lipolysis in 3T3-L1 adipocytes and suppress adipogenesis in 3T3-L1 preadipocytes.

Kim SO, Sakchaisri K, Asami Y, Ryoo IJ, Choo SJ, Yoo ID, Soung NK, Kim YS, Jang JH, Kim BY, Ahn JS.

J Nat Prod. 2014 Apr 25;77(4):744-50. doi: 10.1021/np400520a. Epub 2014 Mar 5.


Inhibition of indoleamine 2,3-dioxygenase by thielavin derivatives from a soil fungus, Coniochaeta sp. 10F058.

Jang JP, Jang JH, Oh M, Son S, Kim SM, Kim HM, Shin KS, Oh H, Soung NK, Hong YS, Kim BY, Ahn JS.

J Antibiot (Tokyo). 2014 Apr;67(4):331-3. doi: 10.1038/ja.2013.134. Epub 2013 Dec 11. No abstract available.


A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

Liu H, Liu K, Huang Z, Park CM, Thimmegowda NR, Jang JH, Ryoo IJ, He L, Kim SO, Oi N, Lee KW, Soung NK, Bode AM, Yang Y, Zhou X, Erikson RL, Ahn JS, Hwang J, Kim KE, Dong Z, Kim BY.

J Biol Chem. 2013 Sep 6;288(36):25924-37. doi: 10.1074/jbc.M113.464669. Epub 2013 Jul 25.


UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.

Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, Kim BY, Kwon YT.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5. doi: 10.1073/pnas.1217358110. Epub 2013 Feb 19.


STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.

Kim SO, Sakchaisri K, Thimmegowda NR, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, Kim BY.

PLoS One. 2013;8(1):e53908. doi: 10.1371/journal.pone.0053908. Epub 2013 Jan 22. Erratum in: PLoS One. 2013;8(6): 10.1371/annotation/c5f432f6-1e92-42c0-8727-7ae972215d6f. N R, Thimmegowda [corrected to Thimmegowda, N R].


Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast.

He L, Lee J, Jang JH, Sakchaisri K, Hwang J, Cha-Molstad HJ, Kim KA, Ryoo IJ, Lee HG, Kim SO, Soung NK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY.

Cell Signal. 2013 Feb;25(2):552-60. doi: 10.1016/j.cellsig.2012.11.015. Epub 2012 Nov 23.


Regulation of CEP131 gene expression by SP1.

Huong PT, Soung NK, Jang JH, Cha-Molstad HJ, Sakchaisri K, Kim SO, Jang JM, Kim KE, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY.

Gene. 2013 Jan 15;513(1):75-81. doi: 10.1016/j.gene.2012.10.074. Epub 2012 Nov 5.


Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells.

Asami Y, Jang JH, Soung NK, He L, Moon DO, Kim JW, Oh H, Muroi M, Osada H, Kim BY, Ahn JS.

Bioorg Med Chem. 2012 Jun 15;20(12):3799-806. doi: 10.1016/j.bmc.2012.04.039. Epub 2012 Apr 27.


Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2.

Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.

Carcinogenesis. 2012 Jul;33(7):1406-11. doi: 10.1093/carcin/bgs156. Epub 2012 Apr 24.


Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos.

He L, Lee J, Jang JH, Lee SH, Nan MH, Oh BC, Lee SG, Kim HH, Soung NK, Ahn JS, Kim BY.

Bone. 2012 Jun;50(6):1207-13. doi: 10.1016/j.bone.2012.03.022. Epub 2012 Mar 28.


Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315.

Jang JP, Jang JH, Soung NK, Kim HM, Jeong SJ, Asami Y, Shin KS, Kim MR, Oh H, Kim BY, Ahn JS.

J Antibiot (Tokyo). 2012 Apr;65(4):215-7. doi: 10.1038/ja.2011.141. Epub 2012 Feb 8. No abstract available.


Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.

Kwon O, Soung NK, Thimmegowda NR, Jeong SJ, Jang JH, Moon DO, Chung JK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY.

Cell Signal. 2012 Apr;24(4):943-50. doi: 10.1016/j.cellsig.2011.12.017. Epub 2011 Dec 30.


Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.

Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, Lee KS.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11446-51. doi: 10.1073/pnas.1106223108. Epub 2011 Jun 20.


Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.

Kang YH, Park CH, Kim TS, Soung NK, Bang JK, Kim BY, Park JE, Lee KS.

J Biol Chem. 2011 Jun 3;286(22):19744-57. doi: 10.1074/jbc.M111.224105. Epub 2011 Mar 30.


Polo-box domain: a versatile mediator of polo-like kinase function.

Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, Lee KS.

Cell Mol Life Sci. 2010 Jun;67(12):1957-70. doi: 10.1007/s00018-010-0279-9. Epub 2010 Feb 11. Review.


Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.

Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR Jr, Yaffe MB, Wlodawer A, Lee KS.

Nat Struct Mol Biol. 2009 Aug;16(8):876-82. doi: 10.1038/nsmb.1628. Epub 2009 Jul 13. Erratum in: Nat Struct Mol Biol. 2011 Apr;18(4):516.


Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.

Soung NK, Park JE, Yu LR, Lee KH, Lee JM, Bang JK, Veenstra TD, Rhee K, Lee KS.

Dev Cell. 2009 Apr;16(4):539-50. doi: 10.1016/j.devcel.2009.02.004.


Sanguibacter soli sp. nov., isolated from soil of a ginseng field.

Kim MK, Pulla RK, Kim SY, Yi TH, Soung NK, Yang DC.

Int J Syst Evol Microbiol. 2008 Mar;58(Pt 3):538-41. doi: 10.1099/ijs.0.65399-0.


Microbacterium ginsengisoli sp. nov., a beta-glucosidase-producing bacterium isolated from soil of a ginseng field.

Park MJ, Kim MK, Kim HB, Im WT, Yi TH, Kim SY, Soung NK, Yang DC.

Int J Syst Evol Microbiol. 2008 Feb;58(Pt 2):429-33. doi: 10.1099/ijs.0.65226-0.


Parapedobacter soli sp. nov., isolated from soil of a ginseng field.

Kim MK, Kim YA, Kim YJ, Soung NK, Yi TH, Kim SY, Yang DC.

Int J Syst Evol Microbiol. 2008 Feb;58(Pt 2):337-40. doi: 10.1099/ijs.0.65249-0.


Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming.

Lee KS, Park JE, Kang YH, Zimmerman W, Soung NK, Seong YS, Kwak SJ, Erikson RL.

Cell Cycle. 2008 Jan 15;7(2):141-5. Epub 2007 Oct 16.


Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics.

Park CJ, Park JE, Karpova TS, Soung NK, Yu LR, Song S, Lee KH, Xia X, Kang E, Dabanoglu I, Oh DY, Zhang JY, Kang YH, Wincovitch S, Huffaker TC, Veenstra TD, McNally JG, Lee KS.

Eukaryot Cell. 2008 Mar;7(3):444-53. doi: 10.1128/EC.00283-07. Epub 2008 Jan 4.


Solimonas soli gen. nov., sp. nov., isolated from soil of a ginseng field.

Kim MK, Kim YJ, Cho DH, Yi TH, Soung NK, Yang DC.

Int J Syst Evol Microbiol. 2007 Nov;57(Pt 11):2591-4.


Solirubrobacter soli sp. nov., isolated from soil of a ginseng field.

Kim MK, Na JR, Lee TH, Im WT, Soung NK, Yang DC.

Int J Syst Evol Microbiol. 2007 Jul;57(Pt 7):1453-5.


Parapedobacter koreensis gen. nov., sp. nov.

Kim MK, Na JR, Cho DH, Soung NK, Yang DC.

Int J Syst Evol Microbiol. 2007 Jun;57(Pt 6):1336-41.


Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.

Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.

Mol Cell. 2006 Nov 3;24(3):409-22.


Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes.

Soung NK, Kang YH, Kim K, Kamijo K, Yoon H, Seong YS, Kuo YL, Miki T, Kim SR, Kuriyama R, Giam CZ, Ahn CH, Lee KS.

Mol Cell Biol. 2006 Nov;26(22):8316-35. Epub 2006 Sep 11.


Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth.

Shin EY, Shin KS, Lee CS, Woo KN, Quan SH, Soung NK, Kim YG, Cha CI, Kim SR, Park D, Bokoch GM, Kim EG.

J Biol Chem. 2002 Nov 15;277(46):44417-30. Epub 2002 Sep 10.


Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells.

Shin KS, Shin EY, Lee CS, Quan SH, Woo KN, Soung NK, Kwak SJ, Kim SR, Kim EG.

Exp Mol Med. 2002 May 31;34(2):172-6.


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