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Items: 22


GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.

Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L; BIOS Consortium, Soukas AA, Kuivenhoven JA, Kathiresan S, Cowan CA.

Cell. 2019 Nov 27;179(6):1276-1288.e14. doi: 10.1016/j.cell.2019.10.034.


Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.

Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22322-22330. doi: 10.1073/pnas.1909666116. Epub 2019 Oct 14.


Metformin as Anti-Aging Therapy: Is It for Everyone?

Soukas AA, Hao H, Wu L.

Trends Endocrinol Metab. 2019 Oct;30(10):745-755. doi: 10.1016/j.tem.2019.07.015. Epub 2019 Aug 9. Review.


Suppressing the dark side of autophagy.

Zhou B, Soukas AA.

Autophagy. 2019 Oct;15(10):1852-1853. doi: 10.1080/15548627.2019.1644077. Epub 2019 Jul 18.


The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans.

Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R.

PLoS Pathog. 2019 Jun 17;15(6):e1007893. doi: 10.1371/journal.ppat.1007893. eCollection 2019 Jun.


Surviving starvation simply without TFEB.

Soukas AA, Zhou B.

PLoS Biol. 2019 May 28;17(5):e3000285. doi: 10.1371/journal.pbio.3000285. eCollection 2019 May.


Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension.

Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA.

Cell. 2019 Apr 4;177(2):299-314.e16. doi: 10.1016/j.cell.2019.02.013. Epub 2019 Mar 28.


Metformin: Mechanisms in Human Obesity and Weight Loss.

Yerevanian A, Soukas AA.

Curr Obes Rep. 2019 Jun;8(2):156-164. doi: 10.1007/s13679-019-00335-3. Review.


Biguanides enhance antifungal activity against Candida glabrata.

Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK.

Virulence. 2018;9(1):1150-1162. doi: 10.1080/21505594.2018.1475798.


Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival.

Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Curran SP, Soukas AA.

Cell Rep. 2017 Jul 18;20(3):627-640. doi: 10.1016/j.celrep.2017.06.068.


An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.

Wu L, Zhou B, Oshiro-Rapley N, Li M, Paulo JA, Webster CM, Mou F, Kacergis MC, Talkowski ME, Carr CE, Gygi SP, Zheng B, Soukas AA.

Cell. 2016 Dec 15;167(7):1705-1718.e13. doi: 10.1016/j.cell.2016.11.055.


Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans.

Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran SP.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15378-83. doi: 10.1073/pnas.1514012112. Epub 2015 Nov 30.


β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE.

Cell Metab. 2014 Jan 7;19(1):96-108. doi: 10.1016/j.cmet.2013.12.003.


Genetic regulation of Caenorhabditis elegans lysosome related organelle function.

Soukas AA, Carr CE, Ruvkun G.

PLoS Genet. 2013 Oct;9(10):e1003908. doi: 10.1371/journal.pgen.1003908. Epub 2013 Oct 24.


A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2.

Webster CM, Wu L, Douglas D, Soukas AA.

Development. 2013 Sep;140(17):3601-12. doi: 10.1242/dev.094292. Epub 2013 Jul 24.


Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans.

Pino EC, Webster CM, Carr CE, Soukas AA.

J Vis Exp. 2013 Mar 30;(73). doi: 10.3791/50180.


Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.

Yuan M, Pino E, Wu L, Kacergis M, Soukas AA.

J Biol Chem. 2012 Aug 24;287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7.


C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.

O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G.

Cell Metab. 2009 Nov;10(5):430-5. doi: 10.1016/j.cmet.2009.10.002.


Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G.

Genes Dev. 2009 Feb 15;23(4):496-511. doi: 10.1101/gad.1775409.


Induction of leptin receptor expression in the liver by leptin and food deprivation.

Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C.

J Biol Chem. 2005 Mar 18;280(11):10034-9. Epub 2005 Jan 11.


Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.

Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM.

J Clin Invest. 2004 Feb;113(3):414-24.


Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.

Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM.

Science. 2002 Jul 12;297(5579):240-3.

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